PMC:7279430 / 53244-56478 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T177","span":{"begin":100,"end":105},"obj":"Body_part"},{"id":"T178","span":{"begin":162,"end":167},"obj":"Body_part"},{"id":"T179","span":{"begin":230,"end":236},"obj":"Body_part"},{"id":"T180","span":{"begin":244,"end":249},"obj":"Body_part"},{"id":"T181","span":{"begin":316,"end":321},"obj":"Body_part"},{"id":"T182","span":{"begin":393,"end":398},"obj":"Body_part"},{"id":"T183","span":{"begin":460,"end":465},"obj":"Body_part"},{"id":"T184","span":{"begin":529,"end":534},"obj":"Body_part"},{"id":"T185","span":{"begin":792,"end":797},"obj":"Body_part"},{"id":"T186","span":{"begin":867,"end":872},"obj":"Body_part"},{"id":"T187","span":{"begin":1013,"end":1018},"obj":"Body_part"},{"id":"T188","span":{"begin":1187,"end":1192},"obj":"Body_part"},{"id":"T189","span":{"begin":1249,"end":1254},"obj":"Body_part"},{"id":"T190","span":{"begin":1312,"end":1317},"obj":"Body_part"},{"id":"T191","span":{"begin":1378,"end":1383},"obj":"Body_part"},{"id":"T192","span":{"begin":1604,"end":1609},"obj":"Body_part"},{"id":"T193","span":{"begin":1682,"end":1687},"obj":"Body_part"},{"id":"T194","span":{"begin":1760,"end":1765},"obj":"Body_part"},{"id":"T195","span":{"begin":2138,"end":2143},"obj":"Body_part"},{"id":"T196","span":{"begin":2212,"end":2217},"obj":"Body_part"},{"id":"T197","span":{"begin":2414,"end":2419},"obj":"Body_part"},{"id":"T198","span":{"begin":2482,"end":2487},"obj":"Body_part"},{"id":"T199","span":{"begin":2798,"end":2803},"obj":"Body_part"},{"id":"T200","span":{"begin":2865,"end":2870},"obj":"Body_part"},{"id":"T201","span":{"begin":3042,"end":3047},"obj":"Body_part"},{"id":"T202","span":{"begin":3157,"end":3162},"obj":"Body_part"}],"attributes":[{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A178","pred":"fma_id","subj":"T178","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A189","pred":"fma_id","subj":"T189","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A190","pred":"fma_id","subj":"T190","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A191","pred":"fma_id","subj":"T191","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A192","pred":"fma_id","subj":"T192","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A193","pred":"fma_id","subj":"T193","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A194","pred":"fma_id","subj":"T194","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A195","pred":"fma_id","subj":"T195","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A196","pred":"fma_id","subj":"T196","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A197","pred":"fma_id","subj":"T197","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A198","pred":"fma_id","subj":"T198","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A199","pred":"fma_id","subj":"T199","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A200","pred":"fma_id","subj":"T200","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A201","pred":"fma_id","subj":"T201","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A202","pred":"fma_id","subj":"T202","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":230,"end":236},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}

{"project":"LitCovid-PubTator","denotations":[{"id":"2730","span":{"begin":928,"end":960},"obj":"Gene"},{"id":"2731","span":{"begin":2327,"end":2359},"obj":"Gene"},{"id":"2732","span":{"begin":2543,"end":2617},"obj":"Gene"},{"id":"2733","span":{"begin":2687,"end":2723},"obj":"Gene"},{"id":"2734","span":{"begin":2927,"end":2963},"obj":"Gene"},{"id":"2735","span":{"begin":108,"end":113},"obj":"Species"},{"id":"2736","span":{"begin":170,"end":175},"obj":"Species"},{"id":"2737","span":{"begin":223,"end":229},"obj":"Species"},{"id":"2738","span":{"begin":251,"end":256},"obj":"Species"},{"id":"2739","span":{"begin":324,"end":329},"obj":"Species"},{"id":"2740","span":{"begin":401,"end":406},"obj":"Species"},{"id":"2741","span":{"begin":468,"end":473},"obj":"Species"},{"id":"2742","span":{"begin":537,"end":542},"obj":"Species"},{"id":"2743","span":{"begin":593,"end":597},"obj":"Species"},{"id":"2744","span":{"begin":674,"end":678},"obj":"Species"},{"id":"2745","span":{"begin":706,"end":711},"obj":"Species"},{"id":"2746","span":{"begin":875,"end":880},"obj":"Species"},{"id":"2747","span":{"begin":914,"end":919},"obj":"Species"},{"id":"2748","span":{"begin":921,"end":926},"obj":"Species"},{"id":"2749","span":{"begin":1066,"end":1070},"obj":"Species"},{"id":"2750","span":{"begin":1124,"end":1128},"obj":"Species"},{"id":"2751","span":{"begin":1195,"end":1200},"obj":"Species"},{"id":"2752","span":{"begin":1257,"end":1262},"obj":"Species"},{"id":"2753","span":{"begin":1320,"end":1325},"obj":"Species"},{"id":"2754","span":{"begin":1386,"end":1391},"obj":"Species"},{"id":"2755","span":{"begin":1433,"end":1437},"obj":"Species"},{"id":"2756","span":{"begin":1492,"end":1496},"obj":"Species"},{"id":"2757","span":{"begin":1543,"end":1553},"obj":"Species"},{"id":"2758","span":{"begin":1612,"end":1617},"obj":"Species"},{"id":"2759","span":{"begin":1690,"end":1695},"obj":"Species"},{"id":"2760","span":{"begin":1768,"end":1773},"obj":"Species"},{"id":"2761","span":{"begin":1812,"end":1816},"obj":"Species"},{"id":"2762","span":{"begin":1834,"end":1843},"obj":"Species"},{"id":"2763","span":{"begin":1871,"end":1875},"obj":"Species"},{"id":"2764","span":{"begin":1912,"end":1921},"obj":"Species"},{"id":"2765","span":{"begin":1949,"end":1953},"obj":"Species"},{"id":"2766","span":{"begin":1968,"end":1977},"obj":"Species"},{"id":"2767","span":{"begin":2005,"end":2009},"obj":"Species"},{"id":"2768","span":{"begin":2033,"end":2038},"obj":"Species"},{"id":"2769","span":{"begin":2146,"end":2151},"obj":"Species"},{"id":"2770","span":{"begin":2261,"end":2265},"obj":"Species"},{"id":"2771","span":{"begin":2313,"end":2318},"obj":"Species"},{"id":"2772","span":{"begin":2320,"end":2325},"obj":"Species"},{"id":"2773","span":{"begin":2422,"end":2427},"obj":"Species"},{"id":"2774","span":{"begin":2490,"end":2495},"obj":"Species"},{"id":"2775","span":{"begin":2529,"end":2534},"obj":"Species"},{"id":"2776","span":{"begin":2536,"end":2541},"obj":"Species"},{"id":"2777","span":{"begin":2619,"end":2623},"obj":"Species"},{"id":"2778","span":{"begin":2673,"end":2678},"obj":"Species"},{"id":"2779","span":{"begin":2680,"end":2685},"obj":"Species"},{"id":"2780","span":{"begin":2806,"end":2811},"obj":"Species"},{"id":"2781","span":{"begin":2873,"end":2878},"obj":"Species"},{"id":"2782","span":{"begin":2913,"end":2918},"obj":"Species"},{"id":"2783","span":{"begin":2920,"end":2925},"obj":"Species"},{"id":"2784","span":{"begin":3050,"end":3055},"obj":"Species"},{"id":"2785","span":{"begin":3093,"end":3097},"obj":"Species"},{"id":"2786","span":{"begin":3165,"end":3170},"obj":"Species"},{"id":"2787","span":{"begin":3213,"end":3217},"obj":"Species"},{"id":"2788","span":{"begin":575,"end":584},"obj":"Species"},{"id":"2789","span":{"begin":903,"end":912},"obj":"Species"},{"id":"2790","span":{"begin":1106,"end":1115},"obj":"Species"},{"id":"2791","span":{"begin":1415,"end":1424},"obj":"Species"},{"id":"2792","span":{"begin":1474,"end":1483},"obj":"Species"},{"id":"2793","span":{"begin":1528,"end":1537},"obj":"Species"},{"id":"2794","span":{"begin":1794,"end":1803},"obj":"Species"},{"id":"2795","span":{"begin":1853,"end":1862},"obj":"Species"},{"id":"2796","span":{"begin":1931,"end":1940},"obj":"Species"},{"id":"2797","span":{"begin":1987,"end":1996},"obj":"Species"},{"id":"2798","span":{"begin":2243,"end":2252},"obj":"Species"},{"id":"2799","span":{"begin":2302,"end":2311},"obj":"Species"},{"id":"2800","span":{"begin":2518,"end":2527},"obj":"Species"},{"id":"2801","span":{"begin":2662,"end":2671},"obj":"Species"},{"id":"2802","span":{"begin":2725,"end":2734},"obj":"Species"},{"id":"2803","span":{"begin":2902,"end":2911},"obj":"Species"},{"id":"2804","span":{"begin":2965,"end":2974},"obj":"Species"},{"id":"2805","span":{"begin":3075,"end":3084},"obj":"Species"},{"id":"2806","span":{"begin":3195,"end":3204},"obj":"Species"},{"id":"2807","span":{"begin":781,"end":784},"obj":"Species"}],"attributes":[{"id":"A2735","pred":"tao:has_database_id","subj":"2735","obj":"Tax:10298"},{"id":"A2736","pred":"tao:has_database_id","subj":"2736","obj":"Tax:10298"},{"id":"A2737","pred":"tao:has_database_id","subj":"2737","obj":"Tax:9913"},{"id":"A2738","pred":"tao:has_database_id","subj":"2738","obj":"Tax:10298"},{"id":"A2739","pred":"tao:has_database_id","subj":"2739","obj":"Tax:10298"},{"id":"A2740","pred":"tao:has_database_id","subj":"2740","obj":"Tax:10298"},{"id":"A2741","pred":"tao:has_database_id","subj":"2741","obj":"Tax:10298"},{"id":"A2742","pred":"tao:has_database_id","subj":"2742","obj":"Tax:10298"},{"id":"A2743","pred":"tao:has_database_id","subj":"2743","obj":"Tax:114727"},{"id":"A2744","pred":"tao:has_database_id","subj":"2744","obj":"Tax:114727"},{"id":"A2745","pred":"tao:has_database_id","subj":"2745","obj":"Tax:10090"},{"id":"A2746","pred":"tao:has_database_id","subj":"2746","obj":"Tax:10298"},{"id":"A2747","pred":"tao:has_database_id","subj":"2747","obj":"Tax:10298"},{"id":"A2748","pred":"tao:has_database_id","subj":"2748","obj":"Tax:10310"},{"id":"A2749","pred":"tao:has_database_id","subj":"2749","obj":"Tax:114727"},{"id":"A2750","pred":"tao:has_database_id","subj":"2750","obj":"Tax:114727"},{"id":"A2751","pred":"tao:has_database_id","subj":"2751","obj":"Tax:10298"},{"id":"A2752","pred":"tao:has_database_id","subj":"2752","obj":"Tax:10298"},{"id":"A2753","pred":"tao:has_database_id","subj":"2753","obj":"Tax:10298"},{"id":"A2754","pred":"tao:has_database_id","subj":"2754","obj":"Tax:10298"},{"id":"A2755","pred":"tao:has_database_id","subj":"2755","obj":"Tax:114727"},{"id":"A2756","pred":"tao:has_database_id","subj":"2756","obj":"Tax:119210"},{"id":"A2757","pred":"tao:has_database_id","subj":"2757","obj":"Tax:396034"},{"id":"A2758","pred":"tao:has_database_id","subj":"2758","obj":"Tax:10298"},{"id":"A2759","pred":"tao:has_database_id","subj":"2759","obj":"Tax:10298"},{"id":"A2760","pred":"tao:has_database_id","subj":"2760","obj":"Tax:10298"},{"id":"A2761","pred":"tao:has_database_id","subj":"2761","obj":"Tax:114727"},{"id":"A2762","pred":"tao:has_database_id","subj":"2762","obj":"Tax:28511"},{"id":"A2763","pred":"tao:has_database_id","subj":"2763","obj":"Tax:114727"},{"id":"A2764","pred":"tao:has_database_id","subj":"2764","obj":"Tax:28511"},{"id":"A2765","pred":"tao:has_database_id","subj":"2765","obj":"Tax:114729"},{"id":"A2766","pred":"tao:has_database_id","subj":"2766","obj":"Tax:28511"},{"id":"A2767","pred":"tao:has_database_id","subj":"2767","obj":"Tax:114729"},{"id":"A2768","pred":"tao:has_database_id","subj":"2768","obj":"Tax:10090"},{"id":"A2769","pred":"tao:has_database_id","subj":"2769","obj":"Tax:10298"},{"id":"A2770","pred":"tao:has_database_id","subj":"2770","obj":"Tax:114727"},{"id":"A2771","pred":"tao:has_database_id","subj":"2771","obj":"Tax:10298"},{"id":"A2772","pred":"tao:has_database_id","subj":"2772","obj":"Tax:10310"},{"id":"A2773","pred":"tao:has_database_id","subj":"2773","obj":"Tax:10298"},{"id":"A2774","pred":"tao:has_database_id","subj":"2774","obj":"Tax:10298"},{"id":"A2775","pred":"tao:has_database_id","subj":"2775","obj":"Tax:10298"},{"id":"A2776","pred":"tao:has_database_id","subj":"2776","obj":"Tax:10310"},{"id":"A2777","pred":"tao:has_database_id","subj":"2777","obj":"Tax:114727"},{"id":"A2778","pred":"tao:has_database_id","subj":"2778","obj":"Tax:10298"},{"id":"A2779","pred":"tao:has_database_id","subj":"2779","obj":"Tax:10310"},{"id":"A2780","pred":"tao:has_database_id","subj":"2780","obj":"Tax:10298"},{"id":"A2781","pred":"tao:has_database_id","subj":"2781","obj":"Tax:10298"},{"id":"A2782","pred":"tao:has_database_id","subj":"2782","obj":"Tax:10298"},{"id":"A2783","pred":"tao:has_database_id","subj":"2783","obj":"Tax:10310"},{"id":"A2784","pred":"tao:has_database_id","subj":"2784","obj":"Tax:10298"},{"id":"A2785","pred":"tao:has_database_id","subj":"2785","obj":"Tax:114727"},{"id":"A2786","pred":"tao:has_database_id","subj":"2786","obj":"Tax:10298"},{"id":"A2787","pred":"tao:has_database_id","subj":"2787","obj":"Tax:114727"},{"id":"A2788","pred":"tao:has_database_id","subj":"2788","obj":"Tax:11520"},{"id":"A2789","pred":"tao:has_database_id","subj":"2789","obj":"Tax:11520"},{"id":"A2790","pred":"tao:has_database_id","subj":"2790","obj":"Tax:11520"},{"id":"A2791","pred":"tao:has_database_id","subj":"2791","obj":"Tax:11520"},{"id":"A2792","pred":"tao:has_database_id","subj":"2792","obj":"Tax:11520"},{"id":"A2793","pred":"tao:has_database_id","subj":"2793","obj":"Tax:11520"},{"id":"A2794","pred":"tao:has_database_id","subj":"2794","obj":"Tax:11520"},{"id":"A2795","pred":"tao:has_database_id","subj":"2795","obj":"Tax:11520"},{"id":"A2796","pred":"tao:has_database_id","subj":"2796","obj":"Tax:11520"},{"id":"A2797","pred":"tao:has_database_id","subj":"2797","obj":"Tax:11520"},{"id":"A2798","pred":"tao:has_database_id","subj":"2798","obj":"Tax:11520"},{"id":"A2799","pred":"tao:has_database_id","subj":"2799","obj":"Tax:11520"},{"id":"A2800","pred":"tao:has_database_id","subj":"2800","obj":"Tax:11520"},{"id":"A2801","pred":"tao:has_database_id","subj":"2801","obj":"Tax:11520"},{"id":"A2802","pred":"tao:has_database_id","subj":"2802","obj":"Tax:11520"},{"id":"A2803","pred":"tao:has_database_id","subj":"2803","obj":"Tax:11520"},{"id":"A2804","pred":"tao:has_database_id","subj":"2804","obj":"Tax:11520"},{"id":"A2805","pred":"tao:has_database_id","subj":"2805","obj":"Tax:11520"},{"id":"A2806","pred":"tao:has_database_id","subj":"2806","obj":"Tax:11520"},{"id":"A2807","pred":"tao:has_database_id","subj":"2807","obj":"Tax:11089"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T198","span":{"begin":199,"end":202},"obj":"Disease"},{"id":"T199","span":{"begin":575,"end":584},"obj":"Disease"},{"id":"T200","span":{"begin":767,"end":779},"obj":"Disease"},{"id":"T201","span":{"begin":903,"end":912},"obj":"Disease"},{"id":"T202","span":{"begin":944,"end":949},"obj":"Disease"},{"id":"T203","span":{"begin":1048,"end":1057},"obj":"Disease"},{"id":"T204","span":{"begin":1106,"end":1115},"obj":"Disease"},{"id":"T205","span":{"begin":1415,"end":1424},"obj":"Disease"},{"id":"T206","span":{"begin":1474,"end":1483},"obj":"Disease"},{"id":"T207","span":{"begin":1528,"end":1537},"obj":"Disease"},{"id":"T208","span":{"begin":1794,"end":1803},"obj":"Disease"},{"id":"T209","span":{"begin":1853,"end":1862},"obj":"Disease"},{"id":"T210","span":{"begin":1931,"end":1940},"obj":"Disease"},{"id":"T211","span":{"begin":1987,"end":1996},"obj":"Disease"},{"id":"T212","span":{"begin":2243,"end":2252},"obj":"Disease"},{"id":"T213","span":{"begin":2302,"end":2311},"obj":"Disease"},{"id":"T214","span":{"begin":2343,"end":2348},"obj":"Disease"},{"id":"T215","span":{"begin":2518,"end":2527},"obj":"Disease"},{"id":"T216","span":{"begin":2559,"end":2564},"obj":"Disease"},{"id":"T217","span":{"begin":2601,"end":2610},"obj":"Disease"},{"id":"T218","span":{"begin":2662,"end":2671},"obj":"Disease"},{"id":"T219","span":{"begin":2703,"end":2708},"obj":"Disease"},{"id":"T220","span":{"begin":2725,"end":2734},"obj":"Disease"},{"id":"T221","span":{"begin":2902,"end":2911},"obj":"Disease"},{"id":"T222","span":{"begin":2943,"end":2948},"obj":"Disease"},{"id":"T223","span":{"begin":2965,"end":2974},"obj":"Disease"},{"id":"T224","span":{"begin":3075,"end":3084},"obj":"Disease"},{"id":"T225","span":{"begin":3195,"end":3204},"obj":"Disease"}],"attributes":[{"id":"A198","pred":"mondo_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/MONDO_0016757"},{"id":"A199","pred":"mondo_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A200","pred":"mondo_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/MONDO_0020502"},{"id":"A201","pred":"mondo_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0017373"},{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A206","pred":"mondo_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A208","pred":"mondo_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A209","pred":"mondo_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A210","pred":"mondo_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A211","pred":"mondo_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A212","pred":"mondo_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A213","pred":"mondo_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0017373"},{"id":"A215","pred":"mondo_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A216","pred":"mondo_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/MONDO_0017373"},{"id":"A217","pred":"mondo_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A218","pred":"mondo_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A219","pred":"mondo_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/MONDO_0017373"},{"id":"A220","pred":"mondo_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A221","pred":"mondo_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A222","pred":"mondo_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/MONDO_0017373"},{"id":"A223","pred":"mondo_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A224","pred":"mondo_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A225","pred":"mondo_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T594","span":{"begin":100,"end":105},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T595","span":{"begin":157,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T596","span":{"begin":157,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T597","span":{"begin":162,"end":167},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T598","span":{"begin":230,"end":236},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T599","span":{"begin":230,"end":236},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T600","span":{"begin":230,"end":236},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T601","span":{"begin":237,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0054315"},{"id":"T602","span":{"begin":238,"end":242},"obj":"http://purl.obolibrary.org/obo/CLO_0007642"},{"id":"T603","span":{"begin":238,"end":242},"obj":"http://purl.obolibrary.org/obo/CLO_0050865"},{"id":"T604","span":{"begin":316,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T605","span":{"begin":393,"end":398},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T606","span":{"begin":455,"end":459},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T607","span":{"begin":455,"end":459},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T608","span":{"begin":460,"end":465},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T609","span":{"begin":529,"end":534},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T610","span":{"begin":551,"end":553},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T611","span":{"begin":590,"end":591},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T612","span":{"begin":599,"end":604},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T613","span":{"begin":613,"end":614},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T614","span":{"begin":704,"end":705},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T615","span":{"begin":706,"end":711},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T616","span":{"begin":787,"end":791},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T617","span":{"begin":787,"end":791},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T618","span":{"begin":792,"end":797},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T619","span":{"begin":867,"end":872},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T620","span":{"begin":889,"end":891},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T621","span":{"begin":1013,"end":1018},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T622","span":{"begin":1025,"end":1030},"obj":"http://purl.obolibrary.org/obo/CLO_0001046"},{"id":"T623","span":{"begin":1033,"end":1035},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T624","span":{"begin":1063,"end":1064},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T625","span":{"begin":1072,"end":1077},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T626","span":{"begin":1121,"end":1122},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T627","span":{"begin":1130,"end":1135},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T628","span":{"begin":1182,"end":1186},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T629","span":{"begin":1182,"end":1186},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T630","span":{"begin":1187,"end":1192},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T631","span":{"begin":1249,"end":1254},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T632","span":{"begin":1264,"end":1266},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T633","span":{"begin":1312,"end":1317},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T634","span":{"begin":1378,"end":1383},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T635","span":{"begin":1430,"end":1431},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T636","span":{"begin":1439,"end":1444},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T637","span":{"begin":1489,"end":1490},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T638","span":{"begin":1498,"end":1503},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T639","span":{"begin":1543,"end":1544},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T640","span":{"begin":1545,"end":1550},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T641","span":{"begin":1599,"end":1603},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T642","span":{"begin":1599,"end":1603},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T643","span":{"begin":1604,"end":1609},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T644","span":{"begin":1682,"end":1687},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T645","span":{"begin":1760,"end":1765},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T646","span":{"begin":1809,"end":1810},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T647","span":{"begin":1818,"end":1823},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T648","span":{"begin":1868,"end":1869},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T649","span":{"begin":1946,"end":1947},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T650","span":{"begin":2002,"end":2003},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T651","span":{"begin":2020,"end":2024},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T652","span":{"begin":2031,"end":2032},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T653","span":{"begin":2033,"end":2038},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T654","span":{"begin":2067,"end":2068},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T655","span":{"begin":2138,"end":2143},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T656","span":{"begin":2159,"end":2161},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T657","span":{"begin":2207,"end":2211},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T658","span":{"begin":2207,"end":2211},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T659","span":{"begin":2212,"end":2217},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T660","span":{"begin":2258,"end":2259},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T661","span":{"begin":2267,"end":2272},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T662","span":{"begin":2358,"end":2364},"obj":"http://purl.obolibrary.org/obo/CLO_0001360"},{"id":"T663","span":{"begin":2414,"end":2419},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T664","span":{"begin":2435,"end":2437},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T665","span":{"begin":2482,"end":2487},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T666","span":{"begin":2501,"end":2503},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T667","span":{"begin":2616,"end":2617},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T668","span":{"begin":2625,"end":2630},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T669","span":{"begin":2718,"end":2723},"obj":"http://purl.obolibrary.org/obo/CLO_0001196"},{"id":"T670","span":{"begin":2793,"end":2797},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T671","span":{"begin":2793,"end":2797},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T672","span":{"begin":2798,"end":2803},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T673","span":{"begin":2818,"end":2820},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T674","span":{"begin":2865,"end":2870},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T675","span":{"begin":2880,"end":2882},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T676","span":{"begin":2885,"end":2887},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T677","span":{"begin":3042,"end":3047},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T678","span":{"begin":3090,"end":3091},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T679","span":{"begin":3099,"end":3104},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T680","span":{"begin":3106,"end":3112},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T681","span":{"begin":3157,"end":3162},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T682","span":{"begin":3177,"end":3179},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T683","span":{"begin":3210,"end":3211},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T684","span":{"begin":3219,"end":3224},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2146","span":{"begin":60,"end":68},"obj":"Chemical"},{"id":"T76952","span":{"begin":124,"end":131},"obj":"Chemical"},{"id":"T22792","span":{"begin":188,"end":197},"obj":"Chemical"},{"id":"T65","span":{"begin":199,"end":202},"obj":"Chemical"},{"id":"T29653","span":{"begin":271,"end":284},"obj":"Chemical"},{"id":"T68024","span":{"begin":342,"end":361},"obj":"Chemical"},{"id":"T64087","span":{"begin":342,"end":355},"obj":"Chemical"},{"id":"T57996","span":{"begin":356,"end":361},"obj":"Chemical"},{"id":"T67088","span":{"begin":418,"end":429},"obj":"Chemical"},{"id":"T62419","span":{"begin":486,"end":497},"obj":"Chemical"},{"id":"T66018","span":{"begin":559,"end":573},"obj":"Chemical"},{"id":"T35449","span":{"begin":658,"end":672},"obj":"Chemical"},{"id":"T21666","span":{"begin":748,"end":756},"obj":"Chemical"},{"id":"T31759","span":{"begin":759,"end":764},"obj":"Chemical"},{"id":"T56397","span":{"begin":818,"end":826},"obj":"Chemical"},{"id":"T83279","span":{"begin":829,"end":834},"obj":"Chemical"},{"id":"T74838","span":{"begin":893,"end":901},"obj":"Chemical"},{"id":"T69560","span":{"begin":973,"end":981},"obj":"Chemical"},{"id":"T80740","span":{"begin":1037,"end":1045},"obj":"Chemical"},{"id":"T35132","span":{"begin":1210,"end":1217},"obj":"Chemical"},{"id":"T42537","span":{"begin":1273,"end":1280},"obj":"Chemical"},{"id":"T12047","span":{"begin":1338,"end":1346},"obj":"Chemical"},{"id":"T82134","span":{"begin":1403,"end":1413},"obj":"Chemical"},{"id":"T35165","span":{"begin":1462,"end":1472},"obj":"Chemical"},{"id":"T66174","span":{"begin":1516,"end":1526},"obj":"Chemical"},{"id":"T52800","span":{"begin":1631,"end":1640},"obj":"Chemical"},{"id":"T71405","span":{"begin":1707,"end":1716},"obj":"Chemical"},{"id":"T9925","span":{"begin":1834,"end":1851},"obj":"Chemical"},{"id":"T30165","span":{"begin":1844,"end":1851},"obj":"Chemical"},{"id":"T90923","span":{"begin":1912,"end":1929},"obj":"Chemical"},{"id":"T48416","span":{"begin":1922,"end":1929},"obj":"Chemical"},{"id":"T20016","span":{"begin":1968,"end":1985},"obj":"Chemical"},{"id":"T29549","span":{"begin":1978,"end":1985},"obj":"Chemical"},{"id":"T101","span":{"begin":2100,"end":2106},"obj":"Chemical"},{"id":"T71497","span":{"begin":2163,"end":2175},"obj":"Chemical"},{"id":"T67105","span":{"begin":2176,"end":2181},"obj":"Chemical"},{"id":"T69972","span":{"begin":2647,"end":2660},"obj":"Chemical"},{"id":"T33698","span":{"begin":2754,"end":2767},"obj":"Chemical"},{"id":"T13930","span":{"begin":2889,"end":2900},"obj":"Chemical"},{"id":"T45245","span":{"begin":3067,"end":3073},"obj":"Chemical"},{"id":"T37119","span":{"begin":3119,"end":3125},"obj":"Chemical"},{"id":"T34257","span":{"begin":3181,"end":3193},"obj":"Chemical"}],"attributes":[{"id":"A91617","pred":"chebi_id","subj":"T2146","obj":"http://purl.obolibrary.org/obo/CHEBI_35616"},{"id":"A82258","pred":"chebi_id","subj":"T76952","obj":"http://purl.obolibrary.org/obo/CHEBI_36773"},{"id":"A30301","pred":"chebi_id","subj":"T22792","obj":"http://purl.obolibrary.org/obo/CHEBI_3440"},{"id":"A71871","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_53233"},{"id":"A34534","pred":"chebi_id","subj":"T29653","obj":"http://purl.obolibrary.org/obo/CHEBI_10357"},{"id":"A80313","pred":"chebi_id","subj":"T29653","obj":"http://purl.obolibrary.org/obo/CHEBI_5993"},{"id":"A68080","pred":"chebi_id","subj":"T68024","obj":"http://purl.obolibrary.org/obo/CHEBI_67818"},{"id":"A83589","pred":"chebi_id","subj":"T64087","obj":"http://purl.obolibrary.org/obo/CHEBI_10357"},{"id":"A49559","pred":"chebi_id","subj":"T64087","obj":"http://purl.obolibrary.org/obo/CHEBI_5993"},{"id":"A67782","pred":"chebi_id","subj":"T57996","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A97557","pred":"chebi_id","subj":"T57996","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A50330","pred":"chebi_id","subj":"T67088","obj":"http://purl.obolibrary.org/obo/CHEBI_27961"},{"id":"A20160","pred":"chebi_id","subj":"T62419","obj":"http://purl.obolibrary.org/obo/CHEBI_27961"},{"id":"A82446","pred":"chebi_id","subj":"T66018","obj":"http://purl.obolibrary.org/obo/CHEBI_16731"},{"id":"A54414","pred":"chebi_id","subj":"T35449","obj":"http://purl.obolibrary.org/obo/CHEBI_16731"},{"id":"A31753","pred":"chebi_id","subj":"T21666","obj":"http://purl.obolibrary.org/obo/CHEBI_16980"},{"id":"A72231","pred":"chebi_id","subj":"T31759","obj":"http://purl.obolibrary.org/obo/CHEBI_29020"},{"id":"A83057","pred":"chebi_id","subj":"T56397","obj":"http://purl.obolibrary.org/obo/CHEBI_16980"},{"id":"A27318","pred":"chebi_id","subj":"T83279","obj":"http://purl.obolibrary.org/obo/CHEBI_29020"},{"id":"A14628","pred":"chebi_id","subj":"T74838","obj":"http://purl.obolibrary.org/obo/CHEBI_28768"},{"id":"A8803","pred":"chebi_id","subj":"T69560","obj":"http://purl.obolibrary.org/obo/CHEBI_28768"},{"id":"A69641","pred":"chebi_id","subj":"T80740","obj":"http://purl.obolibrary.org/obo/CHEBI_28768"},{"id":"A22004","pred":"chebi_id","subj":"T35132","obj":"http://purl.obolibrary.org/obo/CHEBI_4917"},{"id":"A78112","pred":"chebi_id","subj":"T42537","obj":"http://purl.obolibrary.org/obo/CHEBI_4917"},{"id":"A40669","pred":"chebi_id","subj":"T12047","obj":"http://purl.obolibrary.org/obo/CHEBI_28600"},{"id":"A67981","pred":"chebi_id","subj":"T82134","obj":"http://purl.obolibrary.org/obo/CHEBI_80830"},{"id":"A99941","pred":"chebi_id","subj":"T35165","obj":"http://purl.obolibrary.org/obo/CHEBI_80830"},{"id":"A43100","pred":"chebi_id","subj":"T66174","obj":"http://purl.obolibrary.org/obo/CHEBI_80830"},{"id":"A36023","pred":"chebi_id","subj":"T52800","obj":"http://purl.obolibrary.org/obo/CHEBI_59958"},{"id":"A42005","pred":"chebi_id","subj":"T71405","obj":"http://purl.obolibrary.org/obo/CHEBI_59958"},{"id":"A70206","pred":"chebi_id","subj":"T9925","obj":"http://purl.obolibrary.org/obo/CHEBI_7940"},{"id":"A20244","pred":"chebi_id","subj":"T30165","obj":"http://purl.obolibrary.org/obo/CHEBI_16236"},{"id":"A83202","pred":"chebi_id","subj":"T30165","obj":"http://purl.obolibrary.org/obo/CHEBI_30879"},{"id":"A65873","pred":"chebi_id","subj":"T90923","obj":"http://purl.obolibrary.org/obo/CHEBI_7940"},{"id":"A49595","pred":"chebi_id","subj":"T48416","obj":"http://purl.obolibrary.org/obo/CHEBI_16236"},{"id":"A96437","pred":"chebi_id","subj":"T48416","obj":"http://purl.obolibrary.org/obo/CHEBI_30879"},{"id":"A59184","pred":"chebi_id","subj":"T20016","obj":"http://purl.obolibrary.org/obo/CHEBI_7940"},{"id":"A65578","pred":"chebi_id","subj":"T29549","obj":"http://purl.obolibrary.org/obo/CHEBI_16236"},{"id":"A19793","pred":"chebi_id","subj":"T29549","obj":"http://purl.obolibrary.org/obo/CHEBI_30879"},{"id":"A15804","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_17187"},{"id":"A86604","pred":"chebi_id","subj":"T71497","obj":"http://purl.obolibrary.org/obo/CHEBI_17304"},{"id":"A13870","pred":"chebi_id","subj":"T67105","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A47232","pred":"chebi_id","subj":"T67105","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A51538","pred":"chebi_id","subj":"T69972","obj":"http://purl.obolibrary.org/obo/CHEBI_78884"},{"id":"A14822","pred":"chebi_id","subj":"T33698","obj":"http://purl.obolibrary.org/obo/CHEBI_78884"},{"id":"A48702","pred":"chebi_id","subj":"T13930","obj":"http://purl.obolibrary.org/obo/CHEBI_9457"},{"id":"A56135","pred":"chebi_id","subj":"T45245","obj":"http://purl.obolibrary.org/obo/CHEBI_27607"},{"id":"A9117","pred":"chebi_id","subj":"T37119","obj":"http://purl.obolibrary.org/obo/CHEBI_27607"},{"id":"A8814","pred":"chebi_id","subj":"T34257","obj":"http://purl.obolibrary.org/obo/CHEBI_17700"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T20","span":{"begin":774,"end":779},"obj":"Phenotype"}],"attributes":[{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0001945"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T405","span":{"begin":0,"end":55},"obj":"Sentence"},{"id":"T406","span":{"begin":56,"end":123},"obj":"Sentence"},{"id":"T407","span":{"begin":124,"end":187},"obj":"Sentence"},{"id":"T408","span":{"begin":188,"end":268},"obj":"Sentence"},{"id":"T409","span":{"begin":269,"end":341},"obj":"Sentence"},{"id":"T410","span":{"begin":342,"end":417},"obj":"Sentence"},{"id":"T411","span":{"begin":418,"end":485},"obj":"Sentence"},{"id":"T412","span":{"begin":486,"end":554},"obj":"Sentence"},{"id":"T413","span":{"begin":555,"end":653},"obj":"Sentence"},{"id":"T414","span":{"begin":654,"end":739},"obj":"Sentence"},{"id":"T415","span":{"begin":740,"end":809},"obj":"Sentence"},{"id":"T416","span":{"begin":810,"end":892},"obj":"Sentence"},{"id":"T417","span":{"begin":893,"end":972},"obj":"Sentence"},{"id":"T418","span":{"begin":973,"end":1036},"obj":"Sentence"},{"id":"T419","span":{"begin":1037,"end":1093},"obj":"Sentence"},{"id":"T420","span":{"begin":1094,"end":1145},"obj":"Sentence"},{"id":"T421","span":{"begin":1146,"end":1209},"obj":"Sentence"},{"id":"T422","span":{"begin":1210,"end":1272},"obj":"Sentence"},{"id":"T423","span":{"begin":1273,"end":1337},"obj":"Sentence"},{"id":"T424","span":{"begin":1338,"end":1402},"obj":"Sentence"},{"id":"T425","span":{"begin":1403,"end":1461},"obj":"Sentence"},{"id":"T426","span":{"begin":1462,"end":1515},"obj":"Sentence"},{"id":"T427","span":{"begin":1516,"end":1562},"obj":"Sentence"},{"id":"T428","span":{"begin":1563,"end":1630},"obj":"Sentence"},{"id":"T429","span":{"begin":1631,"end":1706},"obj":"Sentence"},{"id":"T430","span":{"begin":1707,"end":1784},"obj":"Sentence"},{"id":"T431","span":{"begin":1785,"end":1833},"obj":"Sentence"},{"id":"T432","span":{"begin":1834,"end":1911},"obj":"Sentence"},{"id":"T433","span":{"begin":1912,"end":1967},"obj":"Sentence"},{"id":"T434","span":{"begin":1968,"end":2097},"obj":"Sentence"},{"id":"T435","span":{"begin":2098,"end":2162},"obj":"Sentence"},{"id":"T436","span":{"begin":2163,"end":2229},"obj":"Sentence"},{"id":"T437","span":{"begin":2230,"end":2288},"obj":"Sentence"},{"id":"T438","span":{"begin":2289,"end":2370},"obj":"Sentence"},{"id":"T439","span":{"begin":2371,"end":2438},"obj":"Sentence"},{"id":"T440","span":{"begin":2439,"end":2504},"obj":"Sentence"},{"id":"T441","span":{"begin":2505,"end":2587},"obj":"Sentence"},{"id":"T442","span":{"begin":2588,"end":2646},"obj":"Sentence"},{"id":"T443","span":{"begin":2647,"end":2753},"obj":"Sentence"},{"id":"T444","span":{"begin":2754,"end":2821},"obj":"Sentence"},{"id":"T445","span":{"begin":2822,"end":2888},"obj":"Sentence"},{"id":"T446","span":{"begin":2889,"end":2993},"obj":"Sentence"},{"id":"T447","span":{"begin":2994,"end":3066},"obj":"Sentence"},{"id":"T448","span":{"begin":3067,"end":3118},"obj":"Sentence"},{"id":"T449","span":{"begin":3119,"end":3180},"obj":"Sentence"},{"id":"T450","span":{"begin":3181,"end":3234},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Essential Oil Component Assay IC50 (μg/mL) Reference\n(E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59]\nCamphor Plaque reduction assay (Vero cells), HSV-1 2600 [72]\nCarvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63]\nβ-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59]\nCaryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59]\n1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72]\n1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52]\n(E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95]\n(E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95]\nCitral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62]\nCitral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52]\np-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 \u003e500 [31]\np-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52]\np-Cymene Influenza type A (H1N1) virus Inactive [25]\nDodecanal Influenza type A (H1N1) virus 51 [54]\nβ-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59]\nEugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96]\nFarnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59]\nGermacrone Influenza type A (H1N1) virus 1.22–1.55 [97]\nGermacrone Influenza type A (H3N2) virus 0.34 [97]\nGermacrone Influenza type B virus 1.38 [97]\nIsoborneol Plaque reduction assay (Vero cells), HSV-1 \u003c1000 [98]\nNerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99]\nNerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99]\nOctanal Influenza type A (H1N1) virus 15 [54]\nPatchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100]\nPatchouli alcohol Influenza type A (H2N2) 0.89 [101]\nPatchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101]\nα-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52]\nPiperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64]\nα-Terpinene Influenza type A (H1N1) virus Inactive [25]\nα-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 \u003e12 [31]\nα-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52]\nγ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52]\nγ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 \u003e120 [31]\nγ-Terpinene influenza type A (H1N1) virus inactive [25]\nTerpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)\u003e50 (others) [31]\nTerpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52]\nα-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52]\nTerpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)\u003e12 (others) [31]\nThujones (α \u0026 β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72]\nThymol Influenza type A (H1N1) virus Active [25]\nThymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52]\n2-Undecanone influenza type A (H1N1) virus 62 [54]"}