Essential Oil Component Assay IC50 (μg/mL) Reference (E)−Anethole Plaque reduction assay (RC-37 cells), HSV-1 20 [59] Camphor Plaque reduction assay (Vero cells), HSV-1 2600 [72] Carvacrol MTT assay (Mardin−Darby bovine kidney (MDBK) cells, HSV-1 48.6 [63] β-Caryophyllene Plaque reduction assay (RC-37 cells), HSV-1 0.25 [59] Caryophyllene oxide Plaque reduction assay (RC-37 cells), HSV-1 0.7 [59] 1,8-Cineole Plaque reduction assay (Vero cells), HSV-1 1800 [72] 1,8-Cineole Plaque reduction assay (RC-37 cells), HSV-1 1200 [52] (E)-Cinnamaldehyde Influenza type A (H1N1) virus 70% at a concentration of 0.53% after 3 h [95] (E)-Cinnamaldehyde H1N1 in-vivo by inhalation in a mouse model 89% inhibition [95] Citral (Geranial + Neral) Yellow fever (YFV), Vero cells 17.6 [62] Citral (Geranial + Neral) Plaque reduction assay (RC-37 cells), HSV-1 3.50 [52] p-Cymene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 6 >500 [31] p-Cymene Plaque reduction assay (RC-37 cells), HSV-1 16 [52] p-Cymene Influenza type A (H1N1) virus Inactive [25] Dodecanal Influenza type A (H1N1) virus 51 [54] β-Eudesmol Plaque reduction assay (Vero cells), HSV-1 6 [59] Eugenol Plaque reduction assay (RC-37 cells), HSV-1 35 [59] Eugenol Plaque reduction assay (RC-37 cells), HSV-1 25.6 [96] Farnesol Plaque reduction assay (RC-37 cells), HSV-1 3.5 [59] Germacrone Influenza type A (H1N1) virus 1.22–1.55 [97] Germacrone Influenza type A (H3N2) virus 0.34 [97] Germacrone Influenza type B virus 1.38 [97] Isoborneol Plaque reduction assay (Vero cells), HSV-1 <1000 [98] Nerolidol (natural) Plaque reduction assay (RC-37 cells), HSV-1 4.2 [99] Nerolidol (synthetic) Plaque reduction assay (RC-37 cells), HSV-1 1.5 [99] Octanal Influenza type A (H1N1) virus 15 [54] Patchouli alcohol Influenza type A (H1N1) 89% inhibition at 10 μg/mL [100] Patchouli alcohol Influenza type A (H2N2) 0.89 [101] Patchouli alcohol Influenza type A (H2N2), in-vivo test using a mouse model 70% survival rate at a dose of 5 mg/(kg day) [101] α-Pinene Plaque reduction assay (RC-37 cells), HSV-1 4.5 [52] Piperitenone oxide Plaque reduction assay (Vero cells) 1.4 [64] α-Terpinene Influenza type A (H1N1) virus Inactive [25] α-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 4 >12 [31] α-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 8.5 [52] γ-Terpinene Plaque reduction assay (RC-37 cells), HSV-1 7 [52] γ-Terpinene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 5 >120 [31] γ-Terpinene influenza type A (H1N1) virus inactive [25] Terpinen-4-ol Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 2 25 (influenza)>50 (others) [31] Terpinen-4-ol Plaque reduction assay (Vero cells), HSV-1 60 [52] α-Terpineol Plaque reduction assay (RC-37 cells), HSV-1 22 [52] Terpinolene Influenza, HSV-1, HSV-2, ECHO 9, Cox B1, Polio 1, Adeno 3 12 (influenza)>12 (others) [31] Thujones (α & β) Plaque reduction assay (RC-37 cells), HSV-1 400 [72] Thymol Influenza type A (H1N1) virus Active [25] Thymol Plaque reduction assay (RC-37 cells), HSV-1 30 [52] 2-Undecanone influenza type A (H1N1) virus 62 [54]