PMC:7279430 / 10047-11389 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7279430","sourcedb":"PMC","sourceid":"7279430","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7279430","text":"Yellow fever (YF), caused by yellow fever virus (YFV), has historically been considered one of the most dangerous infectious diseases. YFV is transmitted to humans via mosquitoes of the Haemogogus, Sabethes, and Aedes genera. Annually, there are approximately 80,000–200,000 YFV cases worldwide, with a case fatality rate (CFR) ranging from 20–60% [93,94]. Essential oils of Lippia species and their main compounds have been tested against yellow fever virus (YFV) in Vero cells. The oil of Lippia origanoides showed carvacrol (44.0%), thymol (15.0%), and γ-terpinene (10.0%) as the main compounds and displayed 100% inhibition at a concentration of 11.1 μg/mL [43]. However, in the same study, the oil of L. alba displayed 100% inhibition at a concentration of 100.0 μg/mL. The major compounds were carvone (51.0%), limonene (33.0%), and bicyclosesquiphellandrene (7.0%). The essential oil of L. alba with a similar chemical composition, carvone (39.7%), limonene (30.6%), and bicyclosesquiphellandrene (8.9%), displayed an IC50 value of 4.3 μg/mL against YFV when tested in Vero cells using the MTT assay [62]. The essential oil of L. citriodora, dominated by geranial (18.9%), neral (15.6%), and limonene (10.7%), did not display a statistical difference in comparison to citral, with IC50 values of 19.4 and 17.6 μg/mL, respectively 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