PMC:7278709 / 19385-20139 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7278709","sourcedb":"PMC","sourceid":"7278709","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7278709","text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 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