PMC:7278709 / 19385-20139 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T409","span":{"begin":86,"end":96},"obj":"SP_7"},{"id":"T410","span":{"begin":234,"end":239},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T411","span":{"begin":240,"end":248},"obj":"GO:0016020"},{"id":"T412","span":{"begin":305,"end":318},"obj":"GO:0016020"},{"id":"T413","span":{"begin":369,"end":380},"obj":"GO:0005737"},{"id":"T414","span":{"begin":414,"end":427},"obj":"GO:0005576"},{"id":"T415","span":{"begin":428,"end":434},"obj":"SO:0000417"},{"id":"T416","span":{"begin":442,"end":447},"obj":"PG_18;PG_1"},{"id":"T417","span":{"begin":448,"end":460},"obj":"PG_18;PG_1;CHEBI:17089;BV_11;CHEBI:17089"},{"id":"T418","span":{"begin":488,"end":494},"obj":"SO:0000417"},{"id":"T419","span":{"begin":599,"end":605},"obj":"SO:0000417"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T145","span":{"begin":44,"end":54},"obj":"Body_part"},{"id":"T146","span":{"begin":234,"end":239},"obj":"Body_part"},{"id":"T147","span":{"begin":369,"end":380},"obj":"Body_part"},{"id":"T148","span":{"begin":448,"end":460},"obj":"Body_part"},{"id":"T149","span":{"begin":577,"end":581},"obj":"Body_part"}],"attributes":[{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A149","pred":"fma_id","subj":"T149","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T18","span":{"begin":381,"end":385},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0002415"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T58","span":{"begin":86,"end":94},"obj":"Disease"},{"id":"T59","span":{"begin":499,"end":502},"obj":"Disease"},{"id":"T61","span":{"begin":694,"end":697},"obj":"Disease"}],"attributes":[{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A60","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A62","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T229","span":{"begin":44,"end":63},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T230","span":{"begin":44,"end":63},"obj":"http://purl.obolibrary.org/obo/PR_000036907"},{"id":"T231","span":{"begin":168,"end":174},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T232","span":{"begin":175,"end":182},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T233","span":{"begin":240,"end":248},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T234","span":{"begin":381,"end":385},"obj":"http://purl.obolibrary.org/obo/UBERON_0002415"},{"id":"T235","span":{"begin":496,"end":498},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T236","span":{"begin":577,"end":581},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T237","span":{"begin":691,"end":693},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T238","span":{"begin":717,"end":719},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T239","span":{"begin":717,"end":719},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T249","span":{"begin":44,"end":54},"obj":"Chemical"},{"id":"T250","span":{"begin":44,"end":49},"obj":"Chemical"},{"id":"T251","span":{"begin":50,"end":54},"obj":"Chemical"},{"id":"T252","span":{"begin":175,"end":182},"obj":"Chemical"},{"id":"T253","span":{"begin":184,"end":186},"obj":"Chemical"},{"id":"T254","span":{"begin":234,"end":239},"obj":"Chemical"},{"id":"T255","span":{"begin":327,"end":329},"obj":"Chemical"},{"id":"T257","span":{"begin":448,"end":460},"obj":"Chemical"},{"id":"T258","span":{"begin":717,"end":719},"obj":"Chemical"},{"id":"T259","span":{"begin":729,"end":731},"obj":"Chemical"}],"attributes":[{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_74820"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_55460"},{"id":"A256","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_74861"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_55460"},{"id":"A260","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_74861"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}

{"project":"LitCovid-sentences","denotations":[{"id":"T111","span":{"begin":0,"end":97},"obj":"Sentence"},{"id":"T112","span":{"begin":98,"end":163},"obj":"Sentence"},{"id":"T113","span":{"begin":164,"end":212},"obj":"Sentence"},{"id":"T114","span":{"begin":213,"end":409},"obj":"Sentence"},{"id":"T115","span":{"begin":410,"end":567},"obj":"Sentence"},{"id":"T116","span":{"begin":568,"end":640},"obj":"Sentence"},{"id":"T117","span":{"begin":641,"end":690},"obj":"Sentence"},{"id":"T118","span":{"begin":691,"end":704},"obj":"Sentence"},{"id":"T119","span":{"begin":705,"end":716},"obj":"Sentence"},{"id":"T120","span":{"begin":717,"end":728},"obj":"Sentence"},{"id":"T121","span":{"begin":729,"end":741},"obj":"Sentence"},{"id":"T122","span":{"begin":742,"end":754},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}

{"project":"LitCovid-PubTator","denotations":[{"id":"427","span":{"begin":86,"end":96},"obj":"Species"}],"attributes":[{"id":"A427","pred":"tao:has_database_id","subj":"427","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The following locations in the sequences of amino acid residues apply specifically to SARS-CoV-2. These vary somewhat with author, and the following are used here. The signal peptide (SP) comprises residues 1–19. On the inside of the lipid membrane, the carboxyl terminus (C-terminus) is comprised of the transmembrane region (TM) comprising residues 1214–1236 and the cytoplasmic tail (CT) residues1237-1273. The extracellular domain of the spike glycoprotein is comprised of N-terminal domain (S1-NTD) comprising residues 20–286, and is of particular interest here. The host cell receptor binding domain (RBD) comprising residues 319–541. In summary the key regions are as follows.SP 1-19\nS1-NTD 20–286\nRBD 319-541\nS2 686-1213\nTM 1214-1236\nCT 1237-1273"}