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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 92-99 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T2 140-172 Body_part denotes Nicotinic Acetylcholine Receptor http://purl.org/sig/ont/fma/fma61796
T3 150-172 Body_part denotes Acetylcholine Receptor http://purl.org/sig/ont/fma/fma67251
T4 150-163 Body_part denotes Acetylcholine http://purl.org/sig/ont/fma/fma61789
T5 518-521 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T6 672-675 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T7 720-752 Body_part denotes nicotinic acetylcholine receptor http://purl.org/sig/ont/fma/fma61796
T8 982-985 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T9 1136-1144 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T10 1188-1191 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T11 1505-1508 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T12 2626-2633 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T13 2822-2826 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T14 2861-2879 Body_part denotes alveolar epithelia http://purl.org/sig/ont/fma/fma63915
T15 2870-2879 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T16 2884-2893 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T17 2894-2899 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T18 3298-3317 Body_part denotes corticospinal tract http://purl.org/sig/ont/fma/fma265580
T19 3421-3425 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T20 3556-3559 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T21 3604-3636 Body_part denotes nicotinic acetylcholine receptor http://purl.org/sig/ont/fma/fma61796
T22 3868-3871 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T23 3952-3955 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T24 3968-3983 Body_part denotes olfactory nerve http://purl.org/sig/ont/fma/fma46787
T25 4006-4013 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T26 4098-4118 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T27 4108-4118 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T28 4267-4274 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T29 4349-4352 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T30 5020-5023 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T31 5302-5305 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T32 5531-5536 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T33 5537-5542 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T34 5622-5625 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T35 5813-5821 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T36 5865-5868 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T37 6075-6078 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T38 6228-6248 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T39 6238-6248 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T40 6260-6272 Body_part denotes nasal cavity http://purl.org/sig/ont/fma/fma54378
T41 6395-6412 Body_part denotes non-neuronal cell http://purl.org/sig/ont/fma/fma54536
T42 6408-6412 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T43 6499-6502 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T44 6534-6537 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T45 6681-6701 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T46 6691-6701 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T47 6818-6821 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T48 6925-6941 Body_part denotes trigeminal nerve http://purl.org/sig/ont/fma/fma50866
T49 6963-6983 Body_part denotes olfactory epithelium http://purl.org/sig/ont/fma/fma64803
T50 6973-6983 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T51 7006-7013 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T52 7103-7113 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T53 7136-7148 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T54 7150-7153 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T55 7222-7225 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T56 7333-7336 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T57 7581-7588 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 7626-7637 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T59 7883-7890 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T60 7895-7898 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T61 7983-7986 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T62 8203-8211 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T63 8265-8272 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 8282-8294 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T65 8509-8517 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T66 8549-8556 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T67 8887-8890 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T68 9264-9268 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T69 9964-9971 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T70 10024-10031 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T71 10193-10203 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T72 10381-10393 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T73 10429-10436 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2822-2826 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 2861-2879 Body_part denotes alveolar epithelia http://purl.obolibrary.org/obo/UBERON_0004821
T3 2870-2879 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483
T4 2884-2893 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T5 3298-3317 Body_part denotes corticospinal tract http://purl.obolibrary.org/obo/UBERON_0002707
T6 3968-3983 Body_part denotes olfactory nerve http://purl.obolibrary.org/obo/UBERON_0001579
T7 3978-3983 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T8 4098-4118 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T9 4108-4118 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T10 5531-5550 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T11 5531-5536 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T12 5537-5542 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T13 6228-6248 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T14 6238-6248 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T15 6260-6272 Body_part denotes nasal cavity http://purl.obolibrary.org/obo/UBERON_0001707
T16 6476-6493 Body_part denotes olfactory pathway http://purl.obolibrary.org/obo/UBERON_0013201
T17 6681-6701 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T18 6691-6701 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T19 6925-6941 Body_part denotes trigeminal nerve http://purl.obolibrary.org/obo/UBERON_0001645
T20 6936-6941 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T21 6963-6983 Body_part denotes olfactory epithelium http://purl.obolibrary.org/obo/UBERON_0001997
T22 6973-6983 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T23 7167-7178 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T24 7173-7178 Body_part denotes venom http://purl.obolibrary.org/obo/UBERON_0007113
T25 7439-7450 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T26 7445-7450 Body_part denotes venom http://purl.obolibrary.org/obo/UBERON_0007113

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 86-91 Gene denotes Spike Gene:43740568
5 42-54 Species denotes Rabies Virus Tax:11292
6 75-85 Species denotes SARS-CoV-2 Tax:2697049
7 150-163 Chemical denotes Acetylcholine MESH:D000109
30 754-759 Gene denotes nAChR Gene:1137
31 1546-1551 Gene denotes nAChR Gene:1137
32 220-233 Species denotes β-coronavirus Tax:694002
33 235-282 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
34 284-294 Species denotes SARS-CoV-2 Tax:2697049
35 625-637 Species denotes rabies virus Tax:11292
36 882-892 Species denotes SARS-CoV-2 Tax:2697049
37 1230-1238 Species denotes MERS-CoV Tax:1335626
38 1257-1274 Species denotes hepatitis C virus Tax:11103
39 1445-1455 Species denotes SARS-CoV-2 Tax:2697049
40 639-643 Species denotes RABV Tax:11292
41 1014-1018 Species denotes RABV Tax:11292
42 1094-1098 Species denotes RABV Tax:11292
43 1276-1279 Species denotes HCV Tax:11103
44 1381-1385 Species denotes RABV Tax:11292
45 730-743 Chemical denotes acetylcholine MESH:D000109
46 334-358 Disease denotes coronavirus disease 2019 MESH:C000657245
47 360-368 Disease denotes COVID-19 MESH:C000657245
48 428-449 Disease denotes neurological symptoms MESH:D009422
49 470-490 Disease denotes SARS-CoV-2 infection MESH:C000657245
50 645-655 Disease denotes infections MESH:D007239
51 1162-1228 Disease denotes immunodeficiency virus 1 (HIV-1), Middle East respiratory syndrome MESH:D018352
62 1600-1613 Species denotes β-coronavirus Tax:694002
63 1615-1662 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
64 1664-1674 Species denotes SARS-CoV-2 Tax:2697049
65 2010-2021 Species denotes coronavirus Tax:11118
66 1714-1738 Disease denotes coronavirus disease 2019 MESH:C000657245
67 1740-1748 Disease denotes COVID-19 MESH:C000657245
68 1827-1835 Disease denotes COVID-19 MESH:C000657245
69 1853-1859 Disease denotes deaths MESH:D003643
70 1867-1875 Disease denotes COVID-19 MESH:C000657245
71 1904-1912 Disease denotes COVID-19 MESH:C000657245
97 2722-2753 Gene denotes angiotensin-converting enzyme-2 Gene:59272
98 2755-2759 Gene denotes ACE2 Gene:59272
99 2853-2857 Gene denotes ACE2 Gene:59272
100 2620-2625 Gene denotes spike Gene:43740568
101 2284-2294 Species denotes SARS-CoV-2 Tax:2697049
102 2354-2399 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
103 2401-2409 Species denotes SARS-CoV Tax:694009
104 2449-2457 Species denotes MERS-CoV Tax:1335626
105 2501-2509 Species denotes SARS-CoV Tax:694009
106 2514-2524 Species denotes SARS-CoV-2 Tax:2697049
107 3166-3174 Species denotes patients Tax:9606
108 2236-2244 Disease denotes COVID-19 MESH:C000657245
109 2269-2278 Disease denotes infection MESH:D007239
110 2415-2447 Disease denotes Middle East respiratory syndrome MESH:D018352
111 2918-2927 Disease denotes infection MESH:D007239
112 2983-3002 Disease denotes respiratory disease MESH:D012140
113 3064-3084 Disease denotes SARS-CoV-2 infection MESH:C000657245
114 3140-3159 Disease denotes respiratory disease MESH:D012140
115 3207-3213 Disease denotes nausea MESH:D009325
116 3215-3223 Disease denotes vomiting MESH:D014839
117 3225-3232 Disease denotes anosmia MESH:D000857
118 3249-3271 Disease denotes impaired consciousness MESH:D003244
119 3273-3282 Disease denotes agitation MESH:D011595
120 3329-3353 Disease denotes cerebrovascular diseases MESH:D002561
121 3365-3379 Disease denotes encephalopathy MESH:D001927
143 3638-3643 Gene denotes nAChR Gene:1137
144 3927-3932 Gene denotes nAChR Gene:1137
145 4195-4200 Gene denotes nAChR Gene:1137
146 4416-4421 Gene denotes nAChR Gene:1137
147 4652-4657 Gene denotes nAChR Gene:1137
148 5061-5066 Gene denotes nAChR Gene:1137
149 3509-3521 Species denotes rabies virus Tax:11292
150 3768-3778 Species denotes SARS-CoV-2 Tax:2697049
151 3916-3926 Species denotes SARS-CoV-2 Tax:2697049
152 4314-4324 Species denotes SARS-CoV-2 Tax:2697049
153 4405-4415 Species denotes SARS-CoV-2 Tax:2697049
154 4641-4651 Species denotes SARS-CoV-2 Tax:2697049
155 4797-4808 Species denotes coronavirus Tax:11118
156 4960-4970 Species denotes SARS-CoV-2 Tax:2697049
157 3523-3527 Species denotes RABV Tax:11292
158 4896-4900 Species denotes RABV Tax:11292
159 3614-3627 Chemical denotes acetylcholine MESH:D000109
160 3529-3539 Disease denotes infections MESH:D007239
161 4522-4530 Disease denotes COVID-19 MESH:C000657245
162 4531-4540 Disease denotes infection MESH:D007239
163 4686-4694 Disease denotes COVID-19 MESH:C000657245
168 5133-5138 Gene denotes nAChR Gene:1137
169 5081-5085 Gene denotes Case
170 5118-5128 Species denotes SARS-CoV-2 Tax:2697049
171 5165-5173 Disease denotes COVID-19 MESH:C000657245
183 5227-5232 Gene denotes nAChR Gene:1137
184 5833-5863 Species denotes human immunodeficiency virus 1 Tax:11676
185 5865-5870 Species denotes HIV-1 Tax:11676
186 5881-5889 Species denotes MERS-CoV Tax:1335626
187 5907-5924 Species denotes hepatitis C virus Tax:11103
188 5269-5273 Species denotes RABV Tax:11292
189 5481-5485 Species denotes RABV Tax:11292
190 5570-5574 Species denotes RABV Tax:11292
191 5691-5695 Species denotes RABV Tax:11292
192 5771-5775 Species denotes RABV Tax:11292
193 5926-5929 Species denotes HCV Tax:11103
207 6363-6367 Gene denotes ACE2 Gene:59272
208 6558-6563 Gene denotes nAChR Gene:1137
209 6855-6860 Gene denotes nAChR Gene:1137
210 6080-6088 Species denotes Patients Tax:9606
211 6547-6557 Species denotes SARS-CoV-2 Tax:2697049
212 6792-6796 Species denotes RABV Tax:11292
213 6850-6854 Species denotes RABV Tax:11292
214 6043-6063 Disease denotes SARS-CoV-2 infection MESH:C000657245
215 6094-6102 Disease denotes COVID-19 MESH:C000657245
216 6125-6154 Disease denotes sensory neurological symptoms MESH:D009422
217 6168-6175 Disease denotes anosmia MESH:D000857
218 6309-6329 Disease denotes SARS-CoV-2 infection MESH:C000657245
219 6797-6806 Disease denotes infection MESH:D007239
240 7156-7161 Gene denotes gp120 Gene:3700
241 7238-7243 Gene denotes gp120 Gene:3700
242 7532-7537 Gene denotes nAChR Gene:1137
243 7575-7580 Gene denotes spike Gene:43740568
244 7877-7882 Gene denotes spike Gene:43740568
245 7901-7906 Gene denotes gp120 Gene:3700
246 8259-8264 Gene denotes spike Gene:43740568
247 7150-7155 Species denotes HIV-1 Tax:11676
248 7222-7227 Species denotes HIV-1 Tax:11676
249 7319-7327 Species denotes patients Tax:9606
250 7564-7574 Species denotes SARS-CoV-2 Tax:2697049
251 7866-7876 Species denotes SARS-CoV-2 Tax:2697049
252 7895-7900 Species denotes HIV-1 Tax:11676
253 8248-8258 Species denotes SARS-CoV-2 Tax:2697049
254 7131-7135 Species denotes RABV Tax:11292
255 8161-8165 Species denotes RABV Tax:11292
256 8277-8281 Species denotes RABV Tax:11292
257 7833-7838 Gene denotes nAChR Gene:1137
258 7064-7069 Gene denotes nAChR Gene:1137
259 7333-7374 Disease denotes HIV-1-associated neurocognitive disorders MESH:D019965
289 8543-8548 Gene denotes spike Gene:43740568
290 9290-9295 Gene denotes nAChR Gene:1137
291 10268-10273 Gene denotes nAChR Gene:1137
292 10423-10428 Gene denotes spike Gene:43740568
293 10018-10023 Gene denotes spike Gene:43740568
294 8532-8542 Species denotes SARS-CoV-2 Tax:2697049
295 8865-8875 Species denotes SARS-CoV-2 Tax:2697049
296 8971-8976 Species denotes human Tax:9606
297 9076-9081 Species denotes human Tax:9606
298 9213-9223 Species denotes SARS-CoV-2 Tax:2697049
299 9249-9254 Species denotes human Tax:9606
300 9386-9391 Species denotes human Tax:9606
301 9488-9496 Species denotes SARS-CoV Tax:694009
302 9502-9532 Species denotes canine respiratory coronavirus Tax:215681
303 9580-9586 Species denotes canine Tax:9615
304 9699-9703 Species denotes dogs Tax:9615
305 9954-9963 Species denotes mammalian Tax:9606
306 10007-10017 Species denotes SARS-CoV-2 Tax:2697049
307 10412-10422 Species denotes SARS-CoV-2 Tax:2697049
308 8458-8462 Species denotes RABV Tax:11292
309 9027-9031 Species denotes RABV Tax:11292
310 9098-9102 Species denotes RABV Tax:11292
311 9534-9539 Species denotes CRCoV Tax:215681
312 9719-9724 Species denotes CRCoV Tax:215681
313 9784-9788 Species denotes RABV Tax:11292
314 10369-10373 Species denotes RABV Tax:11292
315 9862-9867 Gene denotes nAChR Gene:1137
316 8657-8665 Disease denotes COVID 19 MESH:C000657245
317 9598-9617 Disease denotes respiratory disease MESH:D012140

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 42-48 Disease denotes Rabies http://purl.obolibrary.org/obo/MONDO_0019173
T2 75-83 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 235-282 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 235-268 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 284-292 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 334-358 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T7 360-368 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 470-478 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 481-490 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 625-631 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T11 645-655 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T12 882-890 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 1162-1178 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T14 1257-1268 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T15 1257-1266 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T16 1445-1453 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 1615-1662 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T18 1615-1648 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T19 1664-1672 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 1714-1738 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T21 1740-1748 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 1827-1835 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T23 1867-1875 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 1904-1912 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 2236-2244 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 2269-2278 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 2284-2292 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 2354-2387 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T29 2401-2409 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 2501-2509 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 2514-2522 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 2912-2927 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T33 2918-2927 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 2983-3002 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T35 3064-3072 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 3075-3084 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 3140-3159 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T38 3225-3232 Disease denotes anosmia http://purl.obolibrary.org/obo/MONDO_0010528
T39 3329-3353 Disease denotes cerebrovascular diseases http://purl.obolibrary.org/obo/MONDO_0011057
T40 3365-3379 Disease denotes encephalopathy http://purl.obolibrary.org/obo/MONDO_0005560
T41 3509-3515 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T42 3529-3539 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T43 3768-3776 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 3916-3924 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 4314-4322 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 4405-4413 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 4522-4530 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 4531-4540 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 4641-4649 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 4686-4694 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T51 4960-4968 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 5118-5126 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 5165-5173 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T54 5839-5855 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T55 5907-5918 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T56 5907-5916 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T57 6043-6051 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 6054-6063 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 6094-6102 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T60 6168-6175 Disease denotes anosmia http://purl.obolibrary.org/obo/MONDO_0010528
T61 6309-6317 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 6320-6329 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T63 6547-6555 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 6797-6806 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65 7564-7572 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 7866-7874 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 8248-8256 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 8532-8540 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 8657-8665 Disease denotes COVID 19 http://purl.obolibrary.org/obo/MONDO_0100096
T70 8865-8873 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T71 8977-8983 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T72 9213-9221 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 9477-9487 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T74 9488-9496 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 9587-9597 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T76 9598-9617 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T77 10007-10015 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 10412-10420 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T2 49-54 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T3 164-182 http://purl.obolibrary.org/obo/GO_0043235 denotes Receptor Complexes
T4 297-300 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 313-314 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 518-521 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T7 518-521 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T8 541-546 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 632-637 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T10 672-675 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T11 672-675 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T12 693-698 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T13 780-783 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T14 807-808 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 982-985 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T16 982-985 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T17 1019-1022 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T18 1156-1161 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T19 1179-1184 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T20 1269-1274 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T21 1316-1317 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 1424-1425 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 1443-1444 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 1505-1508 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T25 1505-1508 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T26 1524-1525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 1677-1680 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T28 1693-1694 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 2079-2087 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T30 2617-2619 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T31 2822-2826 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T32 2822-2826 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T33 2894-2899 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T34 3085-3088 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T35 3407-3408 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 3447-3450 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T37 3516-3521 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 3556-3559 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T39 3556-3559 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T40 3577-3582 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T41 3649-3652 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T42 3690-3691 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 3868-3871 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T44 3868-3871 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T45 3952-3955 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T46 3952-3955 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T47 3978-3983 http://purl.obolibrary.org/obo/UBERON_0001021 denotes nerve
T48 4108-4118 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T49 4166-4170 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T50 4349-4352 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T51 4349-4352 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T52 4363-4364 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 4446-4447 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 4621-4622 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 4739-4741 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T56 4831-4832 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 4939-4940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 4958-4959 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 5020-5023 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T60 5020-5023 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T61 5039-5040 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 5090-5091 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 5244-5245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T64 5302-5305 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T65 5302-5305 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T66 5531-5536 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T67 5531-5536 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T68 5537-5542 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T69 5537-5542 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T70 5622-5625 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T71 5622-5625 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T72 5696-5699 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T73 5833-5838 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T74 5856-5861 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T75 5919-5924 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T76 5973-5974 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 6075-6078 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T78 6075-6078 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T79 6201-6204 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T80 6238-6248 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T81 6266-6272 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T82 6382-6383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 6408-6418 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T84 6499-6502 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T85 6499-6502 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T86 6534-6537 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T87 6534-6537 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T88 6691-6701 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T89 6776-6777 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 6818-6821 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T91 6818-6821 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T92 6936-6941 http://purl.obolibrary.org/obo/UBERON_0001021 denotes nerve
T93 6973-6983 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T94 7025-7026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 7052-7053 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 7191-7194 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T97 7245-7248 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T98 7421-7423 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T99 7622-7625 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4-5
T100 7791-7793 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T101 7983-7986 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T102 7983-7986 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T103 8002-8004 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T104 8098-8105 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T105 8333-8336 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T106 8347-8348 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 8365-8366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 8434-8435 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 8579-8580 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 8887-8890 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T111 8887-8890 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T112 8971-8976 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T113 9066-9072 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T114 9076-9081 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T115 9249-9254 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T116 9264-9274 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T117 9386-9391 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T118 9468-9469 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T119 9549-9550 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T120 9627-9629 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T121 9732-9733 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 92-99 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T2 150-163 Chemical denotes Acetylcholine http://purl.obolibrary.org/obo/CHEBI_15355
T3 730-743 Chemical denotes acetylcholine http://purl.obolibrary.org/obo/CHEBI_15355
T4 1136-1144 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T5 2160-2174 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T6 2626-2633 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T7 2722-2733 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T8 3614-3627 Chemical denotes acetylcholine http://purl.obolibrary.org/obo/CHEBI_15355
T9 4258-4266 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T10 4267-4274 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 4609-4617 Chemical denotes nicotine http://purl.obolibrary.org/obo/CHEBI_18723
T12 5609-5614 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T13 5813-5821 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T14 7103-7113 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T15 7103-7108 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T16 7109-7113 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T17 7136-7148 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T18 7173-7178 Chemical denotes venom http://purl.obolibrary.org/obo/CHEBI_78505
T19 7179-7190 Chemical denotes neurotoxins http://purl.obolibrary.org/obo/CHEBI_50910
T20 7445-7450 Chemical denotes venom http://purl.obolibrary.org/obo/CHEBI_78505
T21 7451-7457 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
T22 7513-7524 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T23 7581-7588 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 7626-7637 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T25 7626-7631 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T26 7632-7637 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T27 7664-7669 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T28 7687-7692 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T29 7883-7890 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30 8203-8211 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T31 8265-8272 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 8282-8294 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T33 8509-8517 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T34 8549-8556 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 9964-9971 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T36 10024-10031 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37 10193-10203 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T38 10193-10198 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T39 10199-10203 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T40 10381-10393 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T41 10429-10436 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 676-698 http://purl.obolibrary.org/obo/GO_0046794 denotes transport of the virus
T2 676-685 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T3 754-759 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T4 963-972 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T5 1546-1551 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T6 2912-2927 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T7 3242-3247 http://purl.obolibrary.org/obo/GO_0050909 denotes taste
T8 3560-3582 http://purl.obolibrary.org/obo/GO_0046794 denotes transport of the virus
T9 3560-3569 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T10 3638-3643 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T11 3849-3858 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T12 3903-3912 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T13 3927-3932 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T14 4195-4200 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T15 4291-4300 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T16 4416-4421 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T17 4652-4657 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T18 5061-5066 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T19 5133-5138 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T20 5227-5232 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T21 5306-5315 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T22 6191-6196 http://purl.obolibrary.org/obo/GO_0050909 denotes taste
T23 6447-6456 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T24 6558-6563 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T25 6597-6606 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T26 6837-6846 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T27 6855-6860 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T28 7064-7069 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T29 7414-7419 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T30 7532-7537 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T31 7833-7838 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T32 9290-9295 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T33 9862-9867 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T34 10268-10273 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes A Novel Vaccine Employing Non-Replicating Rabies Virus Expressing Chimeric SARS-CoV-2 Spike Protein Domains:
T2 109-182 Sentence denotes Functional Inhibition of Viral/Nicotinic Acetylcholine Receptor Complexes
T3 184-192 Sentence denotes Abstract
T4 193-370 Sentence denotes The emergence of the novel β-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic of coronavirus disease 2019 (COVID-19).
T5 371-547 Sentence denotes Clinical studies have documented that potentially severe neurological symptoms are associated with SARS-CoV-2 infection, thereby suggesting direct CNS penetration by the virus.
T6 548-761 Sentence denotes Prior studies have demonstrated that the destructive neurological effects of rabies virus (RABV) infections are mediated by CNS transport of the virus tightly bound to the nicotinic acetylcholine receptor (nAChR).
T7 762-986 Sentence denotes By comparison, it has been hypothesized that a similar mechanism exists to explain the multiple neurological effects of SARS-CoV-2 via binding to peripheral nAChRs followed by orthograde or retrograde transport into the CNS.
T8 987-1291 Sentence denotes Genetic engineering of the RABV has been employed to generate novel vaccines consisting of non-replicating RABV particles expressing chimeric capsid proteins containing human immunodeficiency virus 1 (HIV-1), Middle East respiratory syndrome (MERS-CoV), Ebolavirus, and hepatitis C virus (HCV) sequences.
T9 1292-1560 Sentence denotes Accordingly, we present a critical discussion that integrates lessons learned from prior RABV research and vaccine development into a working model of a SARS-CoV-2 vaccine that selectively targets and neutralizes CNS penetration of a tightly bound viral nAChR complex.
T10 1562-1572 Sentence denotes Background
T11 1573-1754 Sentence denotes The emergence of the novel β-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic of coronavirus disease 2019 (COVID-19) [1].
T12 1755-2040 Sentence denotes Currently, in mid-May 2020, there are over 4,000,000 confirmed cases of COVID-19 and over 300,000 deaths due to COVID-19 worldwide, according to the COVID-19 Dashboard by the Center for Systems Science and Engineering at Johns Hopkins University (https://coronavirus.jhu.edu/map.html).
T13 2041-2299 Sentence denotes There is now increasing collaborative activity by governments, academic institutions, biotechnology companies, and the pharmaceutical industry to investigate the range of possible treatments for COVID-19 and vaccines to prevent infection from SARS-CoV-2 [1].
T14 2300-2463 Sentence denotes Current approaches are drawing on previous studies on severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV) [1].
T15 2464-2810 Sentence denotes For example, studies have shown that SARS-CoV and SARS-CoV-2 have structural similarities within their respective receptor-binding domains (RBDs) of the S1 spike protein subunit that mediate strong multi-point binding to the extracellular globular domain of angiotensin-converting enzyme-2 (ACE2), which may involve neurological expression [2–9].
T16 2811-3009 Sentence denotes Within the lung, widespread expression of ACE2 by alveolar epithelia and capillary cells facilitates viral infection via internalization and replication, leading to severe respiratory disease [2,3].
T17 3010-3386 Sentence denotes Recent evidence of co-morbid neurological sequelae of SARS-CoV-2 infection has been reported in the presence or absence of severe respiratory disease where patients have presented with symptoms of nausea, vomiting, anosmia, loss of taste, impaired consciousness, agitation and confusion, corticospinal tract signs, and cerebrovascular diseases, including encephalopathy [5–7].
T18 3387-3645 Sentence denotes As discussed below, a significant body of empirical studies has demonstrated that the destructive neurological effects of rabies virus (RABV) infections are mediated by CNS transport of the virus tightly bound to the nicotinic acetylcholine receptor (nAChR).
T19 3646-3880 Sentence denotes It has also been recently hypothesized that a similar mechanism may exist to explain the multiple neurological effects of SARS-CoV-2 via binding to peripheral nAChRs followed by orthograde or retrograde transport into the CNS [10,11].
T20 3881-4127 Sentence denotes Potential portals for transport of SARS-CoV-2/nAChR complexes into the CNS include the olfactory nerve and primary olfactory neurons [9,12], and/or peripheral trigeminal sensory terminal structures located within the olfactory epithelium [13,14].
T21 4128-4359 Sentence denotes Further studies are required to fully test the hypothesis that the nAChR receptor represents an obligate biochemical chaperone or effector protein responsible for transport of infective SARS-CoV-2 particles into discrete CNS areas.
T22 4360-4546 Sentence denotes As a corollary, pharmacological targeting of SARS-CoV-2/nAChR complexes may represent a novel vehicle for prevention and control of neurological comorbidities of COVID-19 infection [10].
T23 4547-4810 Sentence denotes There is the potential for new clinical trials to investigate nicotine as a means of blocking SARS-CoV-2-nAChR binding to prevent or treat COVID-19 (https://www.theguardian.com/world/2020/apr/22/french-study-suggests-smokers-at-lower-risk-of-getting-coronavirus).
T24 4811-5075 Sentence denotes As such, we present a critical discussion that integrates lessons learned from prior RABV research and vaccine development into a working model of a SARS-CoV-2 vaccine that selectively targets and neutralizes CNS penetration of a tightly bound viral nAChR complex.
T25 5077-5173 Sentence denotes The Case for a Functional Association of SARS-CoV-2-and nAChR in the Pathophysiology of COVID-19
T26 5174-5431 Sentence denotes Several empirical studies have demonstrated that the nAChR represents a major receptor for the RABV that mechanistically drives CNS transport of infective viral particles, leading to classic neurological sequelae associated with disease progression [15–17].
T27 5432-5650 Sentence denotes Due to the efficient neuroinvasive properties of RABV [18,19], including the ability to bypass the blood-brain barrier, studies have used RABV-based vectors for the delivery of drugs to the CNS, with some success [20].
T28 5651-5949 Sentence denotes Furthermore, genetic engineering of the RABV has been employed to generate novel vaccines consisting of non-replicating RABV particles expressing chimeric capsid proteins containing human immunodeficiency virus 1 (HIV-1) [21,22], MERS-CoV, Ebolavirus, and hepatitis C virus (HCV) sequences [23–25].
T29 5950-6079 Sentence denotes In light of the above, a similar mechanism may underlie the multiple neurological effects of SARS-CoV-2 infection within the CNS.
T30 6080-6197 Sentence denotes Patients with COVID-19 commonly present with sensory neurological symptoms that include anosmia and/or loss of taste.
T31 6198-6519 Sentence denotes It has been proposed that the olfactory epithelium within the nasal cavity represents an early-stage locus for SARS-CoV-2 infection and replication, as reflected by ACE2 expression by a variety of non-neuronal cell types [9], followed by orthograde transport within the primary olfactory pathway into CNS structures [12].
T32 6520-6716 Sentence denotes Additionally, CNS entry of SARS-CoV-2/nAChR complexes may involve retrograde transport from peripheral trigeminal sensory terminal structures located within the olfactory epithelium [13,14,26,27].
T33 6717-7019 Sentence denotes Interestingly, similar lines of empirical evidence support a mechanism for RABV infection within the CNS via retrograde transport of RABV/nAChR complexes from sensory terminals of trigeminal ganglia [28,29], trigeminal nerve terminals within the olfactory epithelium, or primary olfactory neurons [30].
T34 7020-7217 Sentence denotes From a biochemical perspective, a conserved nAChR-binding motif within the primary amino acid sequences of the RABV glycoprotein, HIV-1 gp120, and snake venom neurotoxins has been observed [31–33].
T35 7218-7425 Sentence denotes The HIV-1 envelope, gp120, has been reported to induce neuropathological changes similar to those in patients with HIV-1-associated neurocognitive disorders and triggers an upregulation of the α7-nAChR [34].
T36 7426-7538 Sentence denotes Importantly, snake venom toxins have been demonstrated to be high-affinity competitive antagonists of the nAChR.
T37 7539-7795 Sentence denotes Sequence analysis of the SARS-CoV-2 spike protein identified homologous regions of 4-5 amino acids with aligned sequences in alpha-bungarotoxin and alpha-cobratoxin, thereby suggesting potential binding affinity and antagonism of the α7-nACh receptor [11].
T38 7796-8006 Sentence denotes Sequence homologies between putative nAChR-binding domains within the SARS-CoV-2 spike protein and HIV-1 gp120 have yet to be determined, although there are recent indications for shared CNS comorbidities [35].
T39 8007-8295 Sentence denotes In sum, convergent lines of evidence presented here support the potential construction and testing of novel homologous vaccines employing non-replicating RABV particles expressing chimeric capsid proteins containing antigenic sequences from SARS-CoV-2 spike protein and RABV glycoprotein.
T40 8297-8308 Sentence denotes Conclusions
T41 8309-8666 Sentence denotes Our critical discussion has presented a hypothesis with a potentially high degree of biomedical feasibility, indicating that a novel non-replicating RABV vaccine engineered to contain chimeric capsid proteins with discrete SARS-CoV-2 spike protein domains may represent a highly efficacious preventive measure against neurological comorbidities of COVID 19.
T42 8667-8752 Sentence denotes This hypothesis is based on critical evaluation of the current biomedical literature.
T43 8753-8897 Sentence denotes Currently, however, there are no vaccines in development that are designed to specifically target or neutralize SARS-CoV-2 entry into CNS areas.
T44 8898-9103 Sentence denotes The accepted standard of clinical care employs passive immunization with human rabies immune globulin (HRIG) in conjunction with RABV vaccine administration to prevent animal-to-human transmission of RABV.
T45 9104-9408 Sentence denotes Positive results obtained from in vitro studies designed to evaluate potential inhibitory effects of HRIG on SARS-CoV-2 entry and replication in human neuronal cell lines expressing the nAChR may provide putative proof of principle of our testable hypothesis and justify subsequent human clinical trials.
T46 9409-9631 Sentence denotes Recent studies in the veterinary literature have described a highly infectious SARS-CoV-like canine respiratory coronavirus (CRCoV) that is a major causative agent in the canine infectious respiratory disease complex [36].
T47 9632-9884 Sentence denotes We speculate that the absence of observed neurological sequelae in dogs afflicted with CRCoV may be a functional consequence of widespread prophylactic RABV vaccination that potentially engenders cross-reacting IgGs against viral nAChR-binding domains.
T48 9885-10154 Sentence denotes Finally, conformational matching and stereo-selective recognition of mammalian protein domains by discrete regions of the SARS-CoV-2 spike protein may have been acquired via evolutionary selection of randomly obtained genomic sequences by multiple recombination events.
T49 10155-10442 Sentence denotes Evolutionary conservation of multiple amino acid domains within the primary sequences of variant subtypes of the nAChR, which appears to be evolutionarily ancient, may underlie the observed functional targeting by RABV capsid glycoprotein and putatively by SARS-CoV-2 spike protein [37].
T50 10444-10453 Sentence denotes Statement
T51 10454-10529 Sentence denotes The views expressed here do not represent those of the Library of Congress.
T52 10530-10550 Sentence denotes Conflict of interest
T53 10551-10556 Sentence denotes None.
T54 10557-10575 Sentence denotes Source of support:
T55 10576-10590 Sentence denotes Self financing

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1162-1178 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T2 1257-1266 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T3 3207-3223 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T4 3225-3232 Phenotype denotes anosmia http://purl.obolibrary.org/obo/HP_0000458
T5 3234-3247 Phenotype denotes loss of taste http://purl.obolibrary.org/obo/HP_0000223
T6 3273-3282 Phenotype denotes agitation http://purl.obolibrary.org/obo/HP_0000713
T7 3365-3379 Phenotype denotes encephalopathy http://purl.obolibrary.org/obo/HP_0001298
T8 5839-5855 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T9 5907-5916 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T10 6168-6175 Phenotype denotes anosmia http://purl.obolibrary.org/obo/HP_0000458
T11 6183-6196 Phenotype denotes loss of taste http://purl.obolibrary.org/obo/HP_0000223

2_test

Id Subject Object Predicate Lexical cue
32463026-32105090-69142622 1751-1752 32105090 denotes 1
32463026-32105090-69142623 2296-2297 32105090 denotes 1
32463026-32105090-69142624 2460-2461 32105090 denotes 1
32463026-32155444-69142625 2805-2806 32155444 denotes 2
32463026-32125455-69142625 2805-2806 32125455 denotes 2
32463026-32007145-69142625 2805-2806 32007145 denotes 2
32463026-32283006-69142625 2805-2806 32283006 denotes 2
32463026-32155444-69142626 3004-3005 32155444 denotes 2
32463026-32125455-69142627 3006-3007 32125455 denotes 3
32463026-32283006-69142628 4015-4016 32283006 denotes 9
32463026-15210938-69142629 4017-4019 15210938 denotes 12
32463026-10667995-69142630 4120-4122 10667995 denotes 13
32463026-9853116-69142631 4123-4125 9853116 denotes 14
32463026-3448605-69142632 5424-5426 3448605 denotes 15
32463026-8887475-69142632 5424-5426 8887475 denotes 15
32463026-30772332-69142632 5424-5426 30772332 denotes 15
32463026-19946287-69142633 5487-5489 19946287 denotes 18
32463026-23602163-69142634 5490-5492 23602163 denotes 19
32463026-27581650-69142635 5646-5648 27581650 denotes 20
32463026-10706640-69142636 5873-5875 10706640 denotes 21
32463026-14610200-69142637 5876-5878 14610200 denotes 22
32463026-26063224-69142638 5942-5944 26063224 denotes 23
32463026-11878905-69142638 5942-5944 11878905 denotes 23
32463026-32283006-69142639 6420-6421 32283006 denotes 9
32463026-15210938-69142640 6515-6517 15210938 denotes 12
32463026-10667995-69142641 6703-6705 10667995 denotes 13
32463026-9853116-69142642 6706-6708 9853116 denotes 14
32463026-16885765-69142643 6709-6711 16885765 denotes 26
32463026-17150985-69142644 6712-6714 17150985 denotes 27
32463026-7941329-69142645 6917-6919 7941329 denotes 28
32463026-2016778-69142646 6920-6922 2016778 denotes 29
32463026-2053286-69142647 7015-7017 2053286 denotes 30
32463026-9345046-69142648 7210-7212 9345046 denotes 31
32463026-2241576-69142648 7210-7212 2241576 denotes 31
32463026-1397297-69142648 7210-7212 1397297 denotes 31
32463026-29379089-69142649 7421-7423 29379089 denotes 34