PMC:7275193 / 10998-11914 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T159","span":{"begin":46,"end":54},"obj":"SP_7"},{"id":"T160","span":{"begin":184,"end":202},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T161","span":{"begin":204,"end":216},"obj":"CHEBI:2955;DG_6;CHEBI:2955"},{"id":"T162","span":{"begin":222,"end":233},"obj":"CHEBI:7798;CHEBI:7798"},{"id":"T163","span":{"begin":311,"end":316},"obj":"NCBITaxon:10239"},{"id":"T164","span":{"begin":418,"end":426},"obj":"SP_7"},{"id":"T165","span":{"begin":491,"end":502},"obj":"DG_35"},{"id":"T166","span":{"begin":504,"end":511},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T167","span":{"begin":813,"end":827},"obj":"GO:0030097"},{"id":"T168","span":{"begin":852,"end":863},"obj":"UBERON:0002371"},{"id":"T29028","span":{"begin":46,"end":54},"obj":"SP_7"},{"id":"T5694","span":{"begin":184,"end":202},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T16745","span":{"begin":204,"end":216},"obj":"CHEBI:2955;DG_6;CHEBI:2955"},{"id":"T78383","span":{"begin":222,"end":233},"obj":"CHEBI:7798;CHEBI:7798"},{"id":"T84544","span":{"begin":311,"end":316},"obj":"NCBITaxon:10239"},{"id":"T41104","span":{"begin":418,"end":426},"obj":"SP_7"},{"id":"T25638","span":{"begin":491,"end":502},"obj":"DG_35"},{"id":"T50679","span":{"begin":504,"end":511},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T8877","span":{"begin":813,"end":827},"obj":"GO:0030097"},{"id":"T6676","span":{"begin":852,"end":863},"obj":"UBERON:0002371"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T43","span":{"begin":427,"end":435},"obj":"Body_part"},{"id":"T44","span":{"begin":600,"end":608},"obj":"Body_part"},{"id":"T45","span":{"begin":682,"end":694},"obj":"Body_part"},{"id":"T46","span":{"begin":852,"end":863},"obj":"Body_part"}],"attributes":[{"id":"A43","pred":"fma_id","subj":"T43","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma9608"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T40","span":{"begin":852,"end":863},"obj":"Body_part"}],"attributes":[{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0002371"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T65","span":{"begin":427,"end":441},"obj":"Phenotype"},{"id":"T66","span":{"begin":600,"end":614},"obj":"Phenotype"},{"id":"T67","span":{"begin":864,"end":874},"obj":"Phenotype"}],"attributes":[{"id":"A65","pred":"hp_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A67","pred":"hp_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/HP_0002835"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T124","span":{"begin":46,"end":54},"obj":"Disease"},{"id":"T125","span":{"begin":368,"end":370},"obj":"Disease"},{"id":"T126","span":{"begin":381,"end":385},"obj":"Disease"},{"id":"T127","span":{"begin":418,"end":426},"obj":"Disease"},{"id":"T128","span":{"begin":450,"end":468},"obj":"Disease"},{"id":"T129","span":{"begin":813,"end":847},"obj":"Disease"}],"attributes":[{"id":"A124","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A125","pred":"mondo_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/MONDO_0017319"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A127","pred":"mondo_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A128","pred":"mondo_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A129","pred":"mondo_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/MONDO_0015540"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T130","span":{"begin":133,"end":134},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T131","span":{"begin":250,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T132","span":{"begin":301,"end":302},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T133","span":{"begin":341,"end":342},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T134","span":{"begin":409,"end":410},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T135","span":{"begin":798,"end":799},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T136","span":{"begin":852,"end":856},"obj":"http://purl.obolibrary.org/obo/UBERON_0002481"},{"id":"T137","span":{"begin":903,"end":906},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T73","span":{"begin":145,"end":150},"obj":"Chemical"},{"id":"T74","span":{"begin":184,"end":202},"obj":"Chemical"},{"id":"T75","span":{"begin":204,"end":216},"obj":"Chemical"},{"id":"T76","span":{"begin":222,"end":233},"obj":"Chemical"},{"id":"T77","span":{"begin":491,"end":502},"obj":"Chemical"},{"id":"T78","span":{"begin":504,"end":511},"obj":"Chemical"},{"id":"T79","span":{"begin":523,"end":532},"obj":"Chemical"},{"id":"T80","span":{"begin":682,"end":694},"obj":"Chemical"}],"attributes":[{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_7798"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-sentences","denotations":[{"id":"T91","span":{"begin":0,"end":151},"obj":"Sentence"},{"id":"T92","span":{"begin":152,"end":334},"obj":"Sentence"},{"id":"T93","span":{"begin":335,"end":550},"obj":"Sentence"},{"id":"T94","span":{"begin":551,"end":615},"obj":"Sentence"},{"id":"T95","span":{"begin":616,"end":742},"obj":"Sentence"},{"id":"T96","span":{"begin":743,"end":916},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"TEST0","denotations":[{"id":"32547383-178-184-2084740","span":{"begin":330,"end":332},"obj":"[\"32205204\"]"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"2_test","denotations":[{"id":"32547383-32205204-18888172","span":{"begin":330,"end":332},"obj":"32205204"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}

{"project":"LitCovid-PubTator","denotations":[{"id":"345","span":{"begin":753,"end":760},"obj":"Species"},{"id":"346","span":{"begin":895,"end":902},"obj":"Species"},{"id":"347","span":{"begin":184,"end":202},"obj":"Chemical"},{"id":"348","span":{"begin":204,"end":216},"obj":"Chemical"},{"id":"349","span":{"begin":222,"end":233},"obj":"Chemical"},{"id":"350","span":{"begin":491,"end":502},"obj":"Chemical"},{"id":"351","span":{"begin":504,"end":511},"obj":"Chemical"},{"id":"352","span":{"begin":46,"end":54},"obj":"Disease"},{"id":"353","span":{"begin":381,"end":385},"obj":"Disease"},{"id":"354","span":{"begin":418,"end":426},"obj":"Disease"},{"id":"355","span":{"begin":450,"end":468},"obj":"Disease"},{"id":"356","span":{"begin":813,"end":847},"obj":"Disease"},{"id":"357","span":{"begin":852,"end":874},"obj":"Disease"}],"attributes":[{"id":"A345","pred":"tao:has_database_id","subj":"345","obj":"Tax:9606"},{"id":"A346","pred":"tao:has_database_id","subj":"346","obj":"Tax:9606"},{"id":"A347","pred":"tao:has_database_id","subj":"347","obj":"MESH:D006886"},{"id":"A348","pred":"tao:has_database_id","subj":"348","obj":"MESH:D017963"},{"id":"A349","pred":"tao:has_database_id","subj":"349","obj":"MESH:D053139"},{"id":"A350","pred":"tao:has_database_id","subj":"350","obj":"MESH:C502936"},{"id":"A351","pred":"tao:has_database_id","subj":"351","obj":"MESH:D013256"},{"id":"A352","pred":"tao:has_database_id","subj":"352","obj":"MESH:C000657245"},{"id":"A353","pred":"tao:has_database_id","subj":"353","obj":"MESH:D012128"},{"id":"A354","pred":"tao:has_database_id","subj":"354","obj":"MESH:C000657245"},{"id":"A355","pred":"tao:has_database_id","subj":"355","obj":"MESH:D003141"},{"id":"A356","pred":"tao:has_database_id","subj":"356","obj":"MESH:D051359"},{"id":"A357","pred":"tao:has_database_id","subj":"357","obj":"MESH:D001855"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"While there is no evidence-based protocol for COVID-19 management, so far, we started the management based on our local protocol for a high-risk group. We administered him, initially, hydroxychloroquine, azithromycin, and oseltamivir, since there is a study showing that these combinations might have a role in viral eradication [25]. After a few days of improvement, he developed ARDS, which might be due to a severe COVID-19 cytokine storm, so the infectious disease team administered him tocilizumab, steroid, and other antiviral medications [26]. This rapid improvement supports our diagnosis of cytokine storm. However, we did not confirm the diagnosis by sending the level of interleukins because they are not available in our hospital. Also, the patient findings were not corresponding with a diagnosis of hemophagocytic lymphohistiocytosis and bone marrow aspiration was not done as the patient has improved."}