PMC:7274970 / 6622-8370 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7274970","sourcedb":"PMC","sourceid":"7274970","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7274970","text":"2.1 Study design and participants\nFor this single-center retrospective study, 449 hospitalized patients with laboratory confirmed COVID-19 admitted to the West District of Wuhan Union Hospital between January 25 and March 15, 2020 were screened using the following inclusion and exclusion criteria. The inclusion criteria included: (1) patients aged between 18 and 80 years; and (2) absolute counts of peripheral blood lymphocytes \u003c 1.1 × 109/L within 24 h of hospital admission. The exclusion criteria included: (1) duration of hospital stay \u003c 14 days or death during hospitalization; (2) pregnant or lactating women; (3) deterioration of the condition requiring ICU care within 14 days of admission; and (4) loss of consciousness during hospitalization. A total of 153 patients met these criteria and were included in the study (Fig. 1 ). The diagnosis, clinical classification, treatment, and discharge criteria of COVID-19 were based on the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (6th edition)” issued by the National Health and Family Planning Commission of China (NHPFC, 2020). COVID-19 was confirmed by real-time RT-PCR for throat-swab specimens from the upper respiratory tract. All the included patients had recovered from COVID-19.\nFig. 1 Study flow diagram. ALC, absolute lymphocyte count; COVID-19, coronavirus disease-2019; ICU, intensive care unit; PSQI, Pittsburgh Sleep Quality Index; RCSQ, Richards-Campbell sleep questionnaire.\nThe study was approved by the Ethics Committee of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (Permission number: 0173). Informed consent for this retrospective study was waived due to the rapid emergence of this infectious 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