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PMC:7274950 / 6713-8204 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T108 104-113 UBERON:0002048 denotes pulmonary
T109 180-185 GO:0030431 denotes sleep
T110 344-348 UBERON:0002048 denotes Lung
T111 965-968 PR:Q9SMQ6 denotes Gb3
T112 979-985 UBERON:0001969 denotes plasma
T113 1241-1248 UBERON:0000948 denotes cardiac
T114 1333-1337 PR:000007465 denotes FEV1
T115 1446-1450 PR:000007465 denotes FEV1
T116 1472-1481 UBERON:0002048 denotes pulmonary
T88697 104-113 UBERON:0002048 denotes pulmonary
T47649 180-185 GO:0030431 denotes sleep
T42626 344-348 UBERON:0002048 denotes Lung
T90709 965-968 PR:Q9SMQ6 denotes Gb3
T66110 979-985 UBERON:0001969 denotes plasma
T17975 1241-1248 UBERON:0000948 denotes cardiac
T79801 1333-1337 PR:000007465 denotes FEV1
T74301 1446-1450 PR:000007465 denotes FEV1
T8462 1472-1481 UBERON:0002048 denotes pulmonary

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
190 232-240 Species denotes patients Tax:9606
191 315-323 Species denotes patients Tax:9606
192 376-384 Species denotes patients Tax:9606
193 475-483 Species denotes patients Tax:9606
194 611-618 Species denotes patient Tax:9606
195 770-778 Species denotes patients Tax:9606
196 854-861 Species denotes tobacco Tax:4097
197 1115-1123 Species denotes patients Tax:9606
198 1205-1212 Species denotes tobacco Tax:4097
199 1275-1282 Species denotes patient Tax:9606
200 960-968 Chemical denotes lyso-Gb3 MESH:C063288
201 104-125 Disease denotes pulmonary involvement MESH:D008171
202 129-142 Disease denotes Fabry disease MESH:D000795
203 161-172 Disease denotes obstruction MESH:D000402
204 186-191 Disease denotes apnea MESH:D001049
205 1241-1260 Disease denotes cardiac involvement MESH:D006331

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T48 344-348 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T49 979-985 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T24 344-348 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T44 129-142 Disease denotes Fabry disease http://purl.obolibrary.org/obo/MONDO_0010526
T45 180-191 Disease denotes sleep apnea http://purl.obolibrary.org/obo/MONDO_0005296

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T89 40-43 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T90 339-341 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T91 344-348 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T92 344-348 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T93 388-393 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T94 388-393 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T95 619-620 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 889-897 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T97 979-985 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T98 1112-1114 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T99 1188-1192 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T100 1188-1192 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T101 1198-1204 http://purl.obolibrary.org/obo/CLO_0001658 denotes active

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T21 965-968 Chemical denotes Gb3 http://purl.obolibrary.org/obo/CHEBI_18313
T22 1188-1192 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T32 161-191 Phenotype denotes obstruction and/or sleep apnea http://purl.obolibrary.org/obo/HP_0002870

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4 180-185 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T4 965-968 GlycoEpitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T49 0-200 Sentence denotes In two small retrospective studies, ERT has been reported to stabilize or even ameliorate the burden of pulmonary involvement in Fabry disease, mainly bronchial obstruction and/or sleep apnea [20,21].
T50 201-343 Sentence denotes An interventional study of six patients receiving either ERT or placebo showed an increased exercise tolerance in patients receiving ERT [22].
T51 344-465 Sentence denotes Lung function parameter in five patients (2 males) on ERT were followed longitudinally for an average of five years [17].
T52 466-670 Sentence denotes In three patients, FVC and FEV1 increased during the treatment period, in one patient slight decrease of FVC and FEV1 were registered and in one patient a slight decrease in FVC, with an increase in FEV1.
T53 671-779 Sentence denotes Recently, Franzen et al. [23] reported the change in z-scores of FEV1 and FEV1/FVC over time in 53 patients.
T54 780-1035 Sentence denotes In the same study, they investigated whether factors related to age, sex, tobacco, phenotype, residual α-gal activity, age at ERT initiation, Mainz Severity Score Index (MSSI) and lyso-Gb3 levels in plasma may affect change in FEV1 and FEV1/FVC over time.
T55 1036-1084 Sentence denotes Median spirometric follow-up time was 7.7 years.
T56 1085-1169 Sentence denotes When considering z-scores, 27 patients (51%) developed airflow limitation over time.
T57 1170-1373 Sentence denotes Factors including male sex, active tobacco or past history of smoking, cardiac involvement and increased patient age at ERT initiation were associated with faster FEV1 decline in the univariate analysis.
T58 1374-1491 Sentence denotes These results suggest that earlier ERT initiation may help to stabilize FEV1 decline and preserve pulmonary function.