PMC:7272971 / 9727-10654 JSONTXT

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    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"329","span":{"begin":201,"end":205},"obj":"Gene"},{"id":"330","span":{"begin":350,"end":357},"obj":"Gene"},{"id":"331","span":{"begin":366,"end":371},"obj":"Gene"},{"id":"332","span":{"begin":395,"end":399},"obj":"Gene"},{"id":"333","span":{"begin":429,"end":434},"obj":"Gene"},{"id":"334","span":{"begin":94,"end":107},"obj":"Species"},{"id":"335","span":{"begin":127,"end":132},"obj":"Species"},{"id":"336","span":{"begin":194,"end":199},"obj":"Species"},{"id":"337","span":{"begin":524,"end":532},"obj":"Species"},{"id":"338","span":{"begin":133,"end":152},"obj":"Disease"},{"id":"339","span":{"begin":244,"end":253},"obj":"Disease"},{"id":"340","span":{"begin":299,"end":317},"obj":"Disease"},{"id":"341","span":{"begin":468,"end":485},"obj":"Disease"},{"id":"342","span":{"begin":577,"end":586},"obj":"Disease"},{"id":"343","span":{"begin":694,"end":715},"obj":"Disease"},{"id":"347","span":{"begin":23,"end":33},"obj":"Species"},{"id":"348","span":{"begin":35,"end":43},"obj":"Species"},{"id":"349","span":{"begin":48,"end":56},"obj":"Species"}],"attributes":[{"id":"A329","pred":"tao:has_database_id","subj":"329","obj":"Gene:59272"},{"id":"A330","pred":"tao:has_database_id","subj":"330","obj":"Gene:7113"},{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Gene:43740568"},{"id":"A332","pred":"tao:has_database_id","subj":"332","obj":"Gene:59272"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"Gene:30835"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"Tax:11118"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"Tax:9606"},{"id":"A336","pred":"tao:has_database_id","subj":"336","obj":"Tax:2697049"},{"id":"A337","pred":"tao:has_database_id","subj":"337","obj":"Tax:1335626"},{"id":"A338","pred":"tao:has_database_id","subj":"338","obj":"MESH:C000657245"},{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"MESH:D007239"},{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"MESH:D003316"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"MESH:D003316"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"MESH:D007239"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"MESH:C563620"},{"id":"A347","pred":"tao:has_database_id","subj":"347","obj":"Tax:2697049"},{"id":"A348","pred":"tao:has_database_id","subj":"348","obj":"Tax:694009"},{"id":"A349","pred":"tao:has_database_id","subj":"349","obj":"Tax:1335626"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 1 Comparison of SARS‐CoV‐2, SARS‐CoV and MERS‐CoV receptors on ocular surface and lung\nCoronaviruses Receptor Role in human CoV disease Ocular surface (cell types) Lung\nSARS‐CoV\nSARS‐CoV‐2 ACE2 Host cell receptor and essential for infection + (conjunctival epithelium and fibroblasts; corneal epithelium) 31 + (airway epithelia)32, 33\nTMPRSS2 Primes spike protein for binding to ACE2 – + (airway epithelium) 34\nCD209 Cell‐to‐cell viral transfer + (corneal dendritic cells) 35 + (alveola macrophages) 36\nMERS‐CoV CD26 Host cell receptor and essential for infection +/− (conjunctival vascular endothelium) 37 + (lung epithelia and endothelia) 38\nCD66e Co‐receptor +/− (palpebral conjunctiva) 39 + (bronchial and alveolar epithelium) 32\n+: the receptor has been found, −: there are no reports of the receptor on the ocular surface, +/−: found in tissue but only on non‐virally‐mediated inflamed tissue."}

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T68","span":{"begin":77,"end":93},"obj":"Body_part"},{"id":"T69","span":{"begin":89,"end":93},"obj":"Body_part"},{"id":"T70","span":{"begin":162,"end":166},"obj":"Body_part"},{"id":"T71","span":{"begin":175,"end":179},"obj":"Body_part"},{"id":"T72","span":{"begin":212,"end":216},"obj":"Body_part"},{"id":"T73","span":{"begin":271,"end":281},"obj":"Body_part"},{"id":"T74","span":{"begin":286,"end":297},"obj":"Body_part"},{"id":"T75","span":{"begin":299,"end":317},"obj":"Body_part"},{"id":"T76","span":{"begin":307,"end":317},"obj":"Body_part"},{"id":"T77","span":{"begin":333,"end":342},"obj":"Body_part"},{"id":"T78","span":{"begin":372,"end":379},"obj":"Body_part"},{"id":"T79","span":{"begin":414,"end":424},"obj":"Body_part"},{"id":"T80","span":{"begin":436,"end":440},"obj":"Body_part"},{"id":"T81","span":{"begin":444,"end":448},"obj":"Body_part"},{"id":"T82","span":{"begin":476,"end":491},"obj":"Body_part"},{"id":"T83","span":{"begin":486,"end":491},"obj":"Body_part"},{"id":"T84","span":{"begin":508,"end":519},"obj":"Body_part"},{"id":"T85","span":{"begin":545,"end":549},"obj":"Body_part"},{"id":"T86","span":{"begin":615,"end":626},"obj":"Body_part"},{"id":"T87","span":{"begin":635,"end":639},"obj":"Body_part"},{"id":"T88","span":{"begin":640,"end":649},"obj":"Body_part"},{"id":"T89","span":{"begin":694,"end":715},"obj":"Body_part"},{"id":"T90","span":{"begin":738,"end":757},"obj":"Body_part"},{"id":"T91","span":{"begin":747,"end":757},"obj":"Body_part"},{"id":"T92","span":{"begin":871,"end":877},"obj":"Body_part"},{"id":"T93","span":{"begin":920,"end":926},"obj":"Body_part"}],"attributes":[{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma17530"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma63877"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma58263"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma63916"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma59025"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma63915"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A92","pred":"fma_id","subj":"T92","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"Table 1 Comparison of SARS‐CoV‐2, SARS‐CoV and MERS‐CoV receptors on ocular surface and lung\nCoronaviruses Receptor Role in human CoV disease Ocular surface (cell types) Lung\nSARS‐CoV\nSARS‐CoV‐2 ACE2 Host cell receptor and essential for infection + (conjunctival epithelium and fibroblasts; corneal epithelium) 31 + (airway epithelia)32, 33\nTMPRSS2 Primes spike protein for binding to ACE2 – + (airway epithelium) 34\nCD209 Cell‐to‐cell viral transfer + (corneal dendritic cells) 35 + (alveola macrophages) 36\nMERS‐CoV CD26 Host cell receptor and essential for infection +/− (conjunctival vascular endothelium) 37 + (lung epithelia and endothelia) 38\nCD66e Co‐receptor +/− (palpebral conjunctiva) 39 + (bronchial and alveolar epithelium) 32\n+: the receptor has been found, −: there are no reports of the receptor on the ocular surface, +/−: found in tissue but only on non‐virally‐mediated inflamed tissue."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T11","span":{"begin":89,"end":93},"obj":"Body_part"},{"id":"T12","span":{"begin":175,"end":179},"obj":"Body_part"},{"id":"T13","span":{"begin":271,"end":281},"obj":"Body_part"},{"id":"T14","span":{"begin":299,"end":317},"obj":"Body_part"},{"id":"T15","span":{"begin":307,"end":317},"obj":"Body_part"},{"id":"T16","span":{"begin":333,"end":342},"obj":"Body_part"},{"id":"T17","span":{"begin":414,"end":424},"obj":"Body_part"},{"id":"T18","span":{"begin":615,"end":626},"obj":"Body_part"},{"id":"T19","span":{"begin":635,"end":639},"obj":"Body_part"},{"id":"T20","span":{"begin":640,"end":649},"obj":"Body_part"},{"id":"T21","span":{"begin":694,"end":715},"obj":"Body_part"},{"id":"T22","span":{"begin":704,"end":715},"obj":"Body_part"},{"id":"T23","span":{"begin":747,"end":757},"obj":"Body_part"},{"id":"T24","span":{"begin":871,"end":877},"obj":"Body_part"},{"id":"T25","span":{"begin":920,"end":926},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0001772"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0001812"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0001811"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Table 1 Comparison of SARS‐CoV‐2, SARS‐CoV and MERS‐CoV receptors on ocular surface and lung\nCoronaviruses Receptor Role in human CoV disease Ocular surface (cell types) Lung\nSARS‐CoV\nSARS‐CoV‐2 ACE2 Host cell receptor and essential for infection + (conjunctival epithelium and fibroblasts; corneal epithelium) 31 + (airway epithelia)32, 33\nTMPRSS2 Primes spike protein for binding to ACE2 – + (airway epithelium) 34\nCD209 Cell‐to‐cell viral transfer + (corneal dendritic cells) 35 + (alveola macrophages) 36\nMERS‐CoV CD26 Host cell receptor and essential for infection +/− (conjunctival vascular endothelium) 37 + (lung epithelia and endothelia) 38\nCD66e Co‐receptor +/− (palpebral conjunctiva) 39 + (bronchial and alveolar epithelium) 32\n+: the receptor has been found, −: there are no reports of the receptor on the ocular surface, +/−: found in tissue but only on non‐virally‐mediated inflamed tissue."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T58","span":{"begin":23,"end":27},"obj":"Disease"},{"id":"T59","span":{"begin":35,"end":39},"obj":"Disease"},{"id":"T60","span":{"begin":180,"end":184},"obj":"Disease"},{"id":"T61","span":{"begin":189,"end":193},"obj":"Disease"},{"id":"T62","span":{"begin":244,"end":253},"obj":"Disease"},{"id":"T63","span":{"begin":577,"end":586},"obj":"Disease"}],"attributes":[{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Table 1 Comparison of SARS‐CoV‐2, SARS‐CoV and MERS‐CoV receptors on ocular surface and lung\nCoronaviruses Receptor Role in human CoV disease Ocular surface (cell types) Lung\nSARS‐CoV\nSARS‐CoV‐2 ACE2 Host cell receptor and essential for infection + (conjunctival epithelium and fibroblasts; corneal epithelium) 31 + (airway epithelia)32, 33\nTMPRSS2 Primes spike protein for binding to ACE2 – + (airway epithelium) 34\nCD209 Cell‐to‐cell viral transfer + (corneal dendritic cells) 35 + (alveola macrophages) 36\nMERS‐CoV CD26 Host cell receptor and essential for infection +/− (conjunctival vascular endothelium) 37 + (lung epithelia and endothelia) 38\nCD66e Co‐receptor +/− (palpebral conjunctiva) 39 + (bronchial and alveolar epithelium) 32\n+: the receptor has been found, −: there are no reports of the receptor on the ocular surface, +/−: found in tissue but only on non‐virally‐mediated inflamed tissue."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T100","span":{"begin":89,"end":93},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T101","span":{"begin":89,"end":93},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T102","span":{"begin":127,"end":132},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T103","span":{"begin":162,"end":172},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T104","span":{"begin":175,"end":179},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T105","span":{"begin":175,"end":179},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T106","span":{"begin":212,"end":216},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T107","span":{"begin":271,"end":281},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T108","span":{"begin":286,"end":297},"obj":"http://purl.obolibrary.org/obo/CL_0000057"},{"id":"T109","span":{"begin":307,"end":317},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T110","span":{"begin":326,"end":332},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T111","span":{"begin":407,"end":413},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T112","span":{"begin":414,"end":424},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T113","span":{"begin":426,"end":428},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T114","span":{"begin":436,"end":440},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T115","span":{"begin":444,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T116","span":{"begin":476,"end":491},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T117","span":{"begin":493,"end":495},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T118","span":{"begin":521,"end":523},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T119","span":{"begin":545,"end":549},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T120","span":{"begin":615,"end":626},"obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"id":"T121","span":{"begin":635,"end":639},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T122","span":{"begin":635,"end":639},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T123","span":{"begin":704,"end":715},"obj":"http://purl.obolibrary.org/obo/UBERON_0001811"},{"id":"T124","span":{"begin":704,"end":715},"obj":"http://www.ebi.ac.uk/efo/EFO_0000374"},{"id":"T125","span":{"begin":747,"end":757},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T126","span":{"begin":778,"end":781},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"Table 1 Comparison of SARS‐CoV‐2, SARS‐CoV and MERS‐CoV receptors on ocular surface and lung\nCoronaviruses Receptor Role in human CoV disease Ocular surface (cell types) Lung\nSARS‐CoV\nSARS‐CoV‐2 ACE2 Host cell receptor and essential for infection + (conjunctival epithelium and fibroblasts; corneal epithelium) 31 + (airway epithelia)32, 33\nTMPRSS2 Primes spike protein for binding to ACE2 – + (airway epithelium) 34\nCD209 Cell‐to‐cell viral transfer + (corneal dendritic cells) 35 + (alveola macrophages) 36\nMERS‐CoV CD26 Host cell receptor and essential for infection +/− (conjunctival vascular endothelium) 37 + (lung epithelia and endothelia) 38\nCD66e Co‐receptor +/− (palpebral conjunctiva) 39 + (bronchial and alveolar epithelium) 32\n+: the receptor has been found, −: there are no reports of the receptor on the ocular surface, +/−: found in tissue but only on non‐virally‐mediated inflamed tissue."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T42","span":{"begin":372,"end":379},"obj":"Chemical"},{"id":"T43","span":{"begin":676,"end":678},"obj":"Chemical"}],"attributes":[{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_27638"}],"text":"Table 1 Comparison of SARS‐CoV‐2, SARS‐CoV and MERS‐CoV receptors on ocular surface and lung\nCoronaviruses Receptor Role in human CoV disease Ocular surface (cell types) Lung\nSARS‐CoV\nSARS‐CoV‐2 ACE2 Host cell receptor and essential for infection + (conjunctival epithelium and fibroblasts; corneal epithelium) 31 + (airway epithelia)32, 33\nTMPRSS2 Primes spike protein for binding to ACE2 – + (airway epithelium) 34\nCD209 Cell‐to‐cell viral transfer + (corneal dendritic cells) 35 + (alveola macrophages) 36\nMERS‐CoV CD26 Host cell receptor and essential for infection +/− (conjunctival vascular endothelium) 37 + (lung epithelia and endothelia) 38\nCD66e Co‐receptor +/− (palpebral conjunctiva) 39 + (bronchial and alveolar epithelium) 32\n+: the receptor has been found, −: there are no reports of the receptor on the ocular surface, +/−: found in tissue but only on non‐virally‐mediated inflamed tissue."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T67","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T68","span":{"begin":94,"end":179},"obj":"Sentence"},{"id":"T69","span":{"begin":180,"end":188},"obj":"Sentence"},{"id":"T70","span":{"begin":189,"end":349},"obj":"Sentence"},{"id":"T71","span":{"begin":350,"end":428},"obj":"Sentence"},{"id":"T72","span":{"begin":429,"end":523},"obj":"Sentence"},{"id":"T73","span":{"begin":524,"end":668},"obj":"Sentence"},{"id":"T74","span":{"begin":669,"end":761},"obj":"Sentence"},{"id":"T75","span":{"begin":762,"end":927},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 1 Comparison of SARS‐CoV‐2, SARS‐CoV and MERS‐CoV receptors on ocular surface and lung\nCoronaviruses Receptor Role in human CoV disease Ocular surface (cell types) Lung\nSARS‐CoV\nSARS‐CoV‐2 ACE2 Host cell receptor and essential for infection + (conjunctival epithelium and fibroblasts; corneal epithelium) 31 + (airway epithelia)32, 33\nTMPRSS2 Primes spike protein for binding to ACE2 – + (airway epithelium) 34\nCD209 Cell‐to‐cell viral transfer + (corneal dendritic cells) 35 + (alveola macrophages) 36\nMERS‐CoV CD26 Host cell receptor and essential for infection +/− (conjunctival vascular endothelium) 37 + (lung epithelia and endothelia) 38\nCD66e Co‐receptor +/− (palpebral conjunctiva) 39 + (bronchial and alveolar epithelium) 32\n+: the receptor has been found, −: there are no reports of the receptor on the ocular surface, +/−: found in tissue but only on non‐virally‐mediated inflamed tissue."}