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PMC:7272971 / 10655-12462 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
374 27-31 Gene denotes ACE2 Gene:59272
375 374-378 Gene denotes ACE2 Gene:59272
376 448-452 Gene denotes ACE2 Gene:59272
377 508-512 Gene denotes ACE2 Gene:59272
378 752-756 Gene denotes ACE2 Gene:103231639
379 868-872 Gene denotes ACE2 Gene:103231639
380 1105-1112 Gene denotes TMPRSS2 Gene:103219191
381 1116-1121 Gene denotes Furin Gene:103231185
382 1149-1154 Gene denotes spike Gene:43740568
383 1358-1365 Gene denotes TMPRSS2 Gene:103219191
384 1516-1523 Gene denotes TMPRSS2 Gene:103219191
385 1528-1532 Gene denotes ACE2 Gene:103231639
386 1575-1579 Gene denotes ACE2 Gene:103231639
387 1583-1590 Gene denotes TMPRSS2 Gene:103219191
388 239-247 Species denotes SARS‐CoV Tax:694009
389 1089-1095 Chemical denotes serine MESH:D012694
390 50-57 Disease denotes corneal MESH:D003316
391 309-316 Disease denotes corneal MESH:D003316
392 543-550 Disease denotes corneal MESH:D003316
393 760-778 Disease denotes corneal epithelium MESH:D003316
394 880-887 Disease denotes corneal MESH:D003316
395 1201-1208 Disease denotes corneal MESH:D003316
396 622-624 CellLine denotes E6 CVCL:4582
397 680-682 CellLine denotes E6 CVCL:4582

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T94 18-22 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T95 62-91 Body_part denotes conjunctival epithelial cells http://purl.org/sig/ont/fma/fma70552
T96 86-91 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T97 161-168 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T98 191-196 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T99 223-230 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T100 288-298 Body_part denotes fibroblast http://purl.org/sig/ont/fma/fma63877
T101 299-304 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T102 309-333 Body_part denotes corneal epithelial cells http://purl.org/sig/ont/fma/fma70551
T103 328-333 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T104 435-447 Body_part denotes cell‐surface http://purl.org/sig/ont/fma/fma67653
T105 435-439 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T106 551-556 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T107 561-568 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T108 593-598 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T109 600-604 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T110 605-612 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T111 625-630 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T112 683-688 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T113 743-747 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T114 760-778 Body_part denotes corneal epithelium http://purl.org/sig/ont/fma/fma58263
T115 768-778 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T116 808-812 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T117 822-833 Body_part denotes conjunctiva http://purl.org/sig/ont/fma/fma59011
T118 899-903 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T119 984-999 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T120 1000-1014 Body_part denotes terminal ileum http://purl.org/sig/ont/fma/fma14966
T121 1038-1043 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T122 1044-1058 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T123 1089-1095 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T124 1155-1162 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T125 1189-1194 Body_part denotes tears http://purl.org/sig/ont/fma/fma59756
T126 1225-1230 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T127 1281-1286 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T128 1349-1353 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T129 1385-1390 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T130 1406-1417 Body_part denotes conjunctiva http://purl.org/sig/ont/fma/fma59011
T131 1457-1462 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T132 1566-1570 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T133 1605-1611 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T134 1726-1733 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T135 1743-1755 Body_part denotes nasal cavity http://purl.org/sig/ont/fma/fma54378
T136 1757-1772 Body_part denotes lung parenchyma http://purl.org/sig/ont/fma/fma27360
T137 1774-1779 Body_part denotes ileum http://purl.org/sig/ont/fma/fma7208
T138 1781-1786 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T139 1788-1793 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T26 593-598 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T27 600-604 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T28 760-778 Body_part denotes corneal epithelium http://purl.obolibrary.org/obo/UBERON_0001772
T29 768-778 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T30 822-833 Body_part denotes conjunctiva http://purl.obolibrary.org/obo/UBERON_0001811
T31 984-999 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T32 990-999 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T33 1009-1014 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T34 1038-1058 Body_part denotes heart left ventricle http://purl.obolibrary.org/obo/UBERON_0002084
T35 1038-1043 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T36 1406-1417 Body_part denotes conjunctiva http://purl.obolibrary.org/obo/UBERON_0001811
T37 1605-1611 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T38 1743-1755 Body_part denotes nasal cavity http://purl.obolibrary.org/obo/UBERON_0001707
T39 1757-1772 Body_part denotes lung parenchyma http://purl.obolibrary.org/obo/UBERON_0008946
T40 1757-1761 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T41 1762-1772 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T42 1774-1779 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T43 1781-1786 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T44 1788-1793 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T64 239-243 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T127 18-22 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T128 32-35 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T129 75-85 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T130 86-91 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T131 118-121 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T132 191-196 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T133 273-283 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T134 288-298 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblast
T135 299-304 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T136 317-327 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T137 328-333 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T138 435-439 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T139 551-556 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T140 593-598 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T141 593-598 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T142 593-598 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T143 593-598 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T144 600-604 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T145 600-604 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T146 617-630 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T147 675-688 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T148 768-778 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T149 822-833 http://purl.obolibrary.org/obo/UBERON_0001811 denotes conjunctiva
T150 822-833 http://www.ebi.ac.uk/efo/EFO_0000374 denotes conjunctiva
T151 835-837 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T152 888-898 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T153 957-963 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testes
T154 984-999 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T155 1009-1014 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T156 1038-1043 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T157 1038-1043 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T158 1038-1043 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T159 1038-1043 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T160 1060-1062 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T161 1225-1230 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T162 1281-1286 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T163 1349-1353 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T164 1385-1390 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T165 1406-1417 http://purl.obolibrary.org/obo/UBERON_0001811 denotes conjunctiva
T166 1406-1417 http://www.ebi.ac.uk/efo/EFO_0000374 denotes conjunctiva
T167 1457-1462 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T168 1502-1507 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T169 1749-1755 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T170 1757-1761 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T171 1757-1761 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T172 1774-1779 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T173 1781-1786 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T174 1788-1793 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T175 1788-1793 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T176 1788-1793 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T177 1788-1793 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T44 161-168 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45 223-230 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 1089-1095 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T47 1155-1162 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T76 0-197 Sentence denotes Expression of the gene for ACE2 has been shown in corneal and conjunctival epithelial cells, and preliminary evidence has been presented for the presence of the protein associated with these cells.
T77 198-453 Sentence denotes 40 The isolated surface protein S240 of SARS‐CoV can bind to conjunctival epithelial and fibroblast cells and corneal epithelial cells, with this binding inhibited by soluble ACE2, indicating that the binding was being mediated through cell‐surface ACE2.
T78 454-689 Sentence denotes 31 However, the authors did note that ‘the amount of ACE2 expressed in conjunctival and corneal cells and tissues (was) less than that in heart, lung tissues and Vero E6 cells’, and was approximately 50 per cent that of Vero E6 cells.
T79 690-834 Sentence denotes 31 Another paper provided evidence of expression of mRNA for ACE2 in corneal epithelium with no evidence provided of mRNA from the conjunctiva.
T80 835-1059 Sentence denotes 41 The normalised expression of ACE2 in the corneal epithelial mRNA was only 20‐28 units, compared to > 400 units in the testes, > 200 units in the small intestine terminal ileum and > 100 units in the heart left ventricle.
T81 1060-1231 Sentence denotes 41 The previously mentioned serine protease TMPRSS2 or Furin, which appear to prime the spike protein, had not been reported in tears or on corneal or conjunctival cells.
T82 1232-1533 Sentence denotes However, 15 per cent of superficial conjunctival cells have been shown to have “greater‐than‐zero expression” of the gene for TMPRSS2, three per cent of cells in superficial conjunctiva and one per cent of limbal superficial cells have “greater‐than‐zero expression” of genes of both TMPRSS2 and ACE2.
T83 1534-1804 Sentence denotes The mean level of expression of mRNA for ACE2 or TMPRSS2 in any ocular tissue was approximately 0.6 per cent, whereas the mean level of expression was greater (1.2–1.4 per cent) in most other tissues (such as nasal cavity, lung parenchyma, ileum, colon, heart) examined.
T84 1805-1807 Sentence denotes 42