PMC:7271924 / 8612-9929 JSON TXT

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LitCovid-PMC-OGER-BB

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"241","span":{"begin":377,"end":407},"obj":"Gene"},{"id":"242","span":{"begin":409,"end":414},"obj":"Gene"},{"id":"1477","span":{"begin":460,"end":480},"obj":"Gene"},{"id":"1479","span":{"begin":771,"end":774},"obj":"Chemical"},{"id":"1481","span":{"begin":752,"end":769},"obj":"Chemical"}],"attributes":[{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"Gene:4035"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"Gene:4035"},{"id":"A1477","pred":"tao:has_database_id","subj":"1477","obj":"Gene:7097"},{"id":"A1479","pred":"tao:has_database_id","subj":"1479","obj":"MESH:D006025"},{"id":"A1481","pred":"tao:has_database_id","subj":"1481","obj":"MESH:D006025"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T24","span":{"begin":941,"end":950},"obj":"Body_part"},{"id":"T25","span":{"begin":1003,"end":1009},"obj":"Body_part"},{"id":"T26","span":{"begin":1104,"end":1110},"obj":"Body_part"}],"attributes":[{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T104","span":{"begin":43,"end":53},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T105","span":{"begin":101,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T106","span":{"begin":260,"end":270},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T107","span":{"begin":281,"end":291},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T108","span":{"begin":281,"end":291},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T109","span":{"begin":292,"end":302},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T110","span":{"begin":303,"end":308},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T111","span":{"begin":581,"end":610},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T112","span":{"begin":612,"end":617},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T113","span":{"begin":630,"end":634},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T114","span":{"begin":704,"end":705},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T115","span":{"begin":941,"end":950},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T116","span":{"begin":941,"end":950},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T111","span":{"begin":0,"end":2},"obj":"Chemical"},{"id":"T112","span":{"begin":131,"end":133},"obj":"Chemical"},{"id":"T113","span":{"begin":355,"end":357},"obj":"Chemical"},{"id":"T114","span":{"begin":377,"end":380},"obj":"Chemical"},{"id":"T115","span":{"begin":398,"end":405},"obj":"Chemical"},{"id":"T116","span":{"begin":564,"end":566},"obj":"Chemical"},{"id":"T117","span":{"begin":581,"end":596},"obj":"Chemical"},{"id":"T118","span":{"begin":581,"end":588},"obj":"Chemical"},{"id":"T119","span":{"begin":589,"end":596},"obj":"Chemical"},{"id":"T120","span":{"begin":597,"end":610},"obj":"Chemical"},{"id":"T121","span":{"begin":668,"end":682},"obj":"Chemical"},{"id":"T122","span":{"begin":711,"end":718},"obj":"Chemical"},{"id":"T123","span":{"begin":752,"end":769},"obj":"Chemical"},{"id":"T124","span":{"begin":771,"end":774},"obj":"Chemical"},{"id":"T126","span":{"begin":1199,"end":1201},"obj":"Chemical"}],"attributes":[{"id":"A111","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A112","pred":"chebi_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A113","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_39026"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_37396"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_33839"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_18085"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_143889"},{"id":"A125","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_18085"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T16","span":{"begin":377,"end":389},"obj":"http://purl.obolibrary.org/obo/GO_0005041"},{"id":"T17","span":{"begin":524,"end":529},"obj":"http://purl.obolibrary.org/obo/GO_0038147"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T68","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"T69","span":{"begin":108,"end":211},"obj":"Sentence"},{"id":"T70","span":{"begin":212,"end":334},"obj":"Sentence"},{"id":"T71","span":{"begin":335,"end":550},"obj":"Sentence"},{"id":"T72","span":{"begin":551,"end":800},"obj":"Sentence"},{"id":"T73","span":{"begin":801,"end":813},"obj":"Sentence"},{"id":"T74","span":{"begin":814,"end":1111},"obj":"Sentence"},{"id":"T75","span":{"begin":1112,"end":1317},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

LitCovid-PD-GlycoEpitope

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T3","span":{"begin":581,"end":596},"obj":"GlycoEpitope"}],"attributes":[{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

MyTest

{"project":"MyTest","denotations":[{"id":"32574271-21935933-34514598","span":{"begin":326,"end":328},"obj":"21935933"},{"id":"32574271-16261254-34514599","span":{"begin":330,"end":332},"obj":"16261254"},{"id":"32574271-22292499-34514600","span":{"begin":372,"end":374},"obj":"22292499"},{"id":"32574271-10066755-34514601","span":{"begin":422,"end":424},"obj":"10066755"},{"id":"32574271-15178744-34514601","span":{"begin":422,"end":424},"obj":"15178744"},{"id":"32574271-26506094-34514601","span":{"begin":422,"end":424},"obj":"26506094"},{"id":"32574271-18670097-34514602","span":{"begin":455,"end":457},"obj":"18670097"},{"id":"32574271-29410669-34514603","span":{"begin":495,"end":497},"obj":"29410669"},{"id":"32574271-28075616-34514604","span":{"begin":532,"end":534},"obj":"28075616"},{"id":"32574271-21690215-34514605","span":{"begin":784,"end":786},"obj":"21690215"},{"id":"32574271-25187545-34514606","span":{"begin":788,"end":790},"obj":"25187545"},{"id":"32574271-2849510-34514607","span":{"begin":792,"end":794},"obj":"2849510"},{"id":"32574271-21887302-34514608","span":{"begin":796,"end":798},"obj":"21887302"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

TEST0

{"project":"TEST0","denotations":[{"id":"32574271-114-120-2882190","span":{"begin":326,"end":328},"obj":"[\"21935933\"]"},{"id":"32574271-118-124-2882191","span":{"begin":330,"end":332},"obj":"[\"16261254\"]"},{"id":"32574271-37-43-2882192","span":{"begin":372,"end":374},"obj":"[\"22292499\"]"},{"id":"32574271-87-93-2882193","span":{"begin":422,"end":424},"obj":"[\"10066755\", \"15178744\", \"26506094\"]"},{"id":"32574271-120-126-2882194","span":{"begin":455,"end":457},"obj":"[\"18670097\"]"},{"id":"32574271-160-166-2882195","span":{"begin":495,"end":497},"obj":"[\"29410669\"]"},{"id":"32574271-197-203-2882196","span":{"begin":532,"end":534},"obj":"[\"28075616\"]"},{"id":"32574271-233-239-2882197","span":{"begin":784,"end":786},"obj":"[\"21690215\"]"},{"id":"32574271-237-243-2882198","span":{"begin":788,"end":790},"obj":"[\"25187545\"]"},{"id":"32574271-228-234-2882199","span":{"begin":792,"end":794},"obj":"[\"2849510\"]"},{"id":"32574271-232-238-2882200","span":{"begin":796,"end":798},"obj":"[\"21887302\"]"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

2_test

{"project":"2_test","denotations":[{"id":"32574271-21935933-34514598","span":{"begin":326,"end":328},"obj":"21935933"},{"id":"32574271-16261254-34514599","span":{"begin":330,"end":332},"obj":"16261254"},{"id":"32574271-22292499-34514600","span":{"begin":372,"end":374},"obj":"22292499"},{"id":"32574271-10066755-34514601","span":{"begin":422,"end":424},"obj":"10066755"},{"id":"32574271-15178744-34514601","span":{"begin":422,"end":424},"obj":"15178744"},{"id":"32574271-26506094-34514601","span":{"begin":422,"end":424},"obj":"26506094"},{"id":"32574271-18670097-34514602","span":{"begin":455,"end":457},"obj":"18670097"},{"id":"32574271-29410669-34514603","span":{"begin":495,"end":497},"obj":"29410669"},{"id":"32574271-28075616-34514604","span":{"begin":532,"end":534},"obj":"28075616"},{"id":"32574271-21690215-34514605","span":{"begin":784,"end":786},"obj":"21690215"},{"id":"32574271-25187545-34514606","span":{"begin":788,"end":790},"obj":"25187545"},{"id":"32574271-2849510-34514607","span":{"begin":792,"end":794},"obj":"2849510"},{"id":"32574271-21887302-34514608","span":{"begin":796,"end":798},"obj":"21887302"}],"text":"LF is thought to exert its main biological activities following interaction with receptors on target cells. There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). See Table 2. Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104)."}

PMC:7271924 / 8612-9929 JSONTXT

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PMC:7271924 / 8612-9929 JSON TXT