PMC:7271924 / 28556-30124 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7271924","sourcedb":"PMC","sourceid":"7271924","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7271924","text":"Lactoferrin clearly has immunological benefits, as well as having an important antibacterial and antiviral role. Because it is known to interfere with some of the receptors used by coronaviruses, it may contribute usefully to the prevention and treatment of coronavirus infections. Figure 6 shows a possible scheme on how LF might interfere with SARS-CoV-2 binding. The binding of LF to HSPGs prevents the first contact between virus and host cells and thus prevents subsequent infection (99). HSPGs themselves are not sufficient for SARS-CoV entry. However, in SARS-CoV infections, the HSPGs play an important role in the process of cell entry (99). The anchoring sites provided by HSPGs permit initial contact between the virus and host cells and the concentration of virus particles on cell surface. SARS-CoV bound to HSPGs then rolls onto the cell membrane and scans for specific entry receptors, which leads to subsequent cell entry (99). LF enhances natural killer cell activity and stimulates neutrophil aggregation and adhesion in immune defense (135) and can restrict the entry of the virus into host cells during infection. We suggest that this process might be the same for COVID-19 (see Figure 6 for a visual representation), thereby offering useful strategies for prevention and treatment. Currently, there is also a renewed interest in ACE2 and HSPG blocking, as discussed in the introduction (5–8). LF may therefore be an excellent supplement to take, not only as a contribution to prevention but perhaps as a therapy in the event COVID-19 is diagnosed.","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T520","span":{"begin":0,"end":11},"obj":"PR:000009978"},{"id":"T521","span":{"begin":181,"end":194},"obj":"NCBITaxon:11118"},{"id":"T522","span":{"begin":258,"end":269},"obj":"NCBITaxon:11118"},{"id":"T523","span":{"begin":346,"end":356},"obj":"SP_7"},{"id":"T524","span":{"begin":428,"end":433},"obj":"NCBITaxon:10239"},{"id":"T525","span":{"begin":534,"end":542},"obj":"SP_10"},{"id":"T526","span":{"begin":562,"end":570},"obj":"SP_10"},{"id":"T527","span":{"begin":634,"end":644},"obj":"GO:0035376"},{"id":"T528","span":{"begin":724,"end":729},"obj":"NCBITaxon:10239"},{"id":"T529","span":{"begin":770,"end":775},"obj":"NCBITaxon:10239"},{"id":"T530","span":{"begin":789,"end":801},"obj":"GO:0009986"},{"id":"T531","span":{"begin":803,"end":811},"obj":"SP_10"},{"id":"T532","span":{"begin":847,"end":860},"obj":"GO:0005886"},{"id":"T533","span":{"begin":927,"end":937},"obj":"GO:0035376"},{"id":"T534","span":{"begin":956,"end":975},"obj":"CL:0000623"},{"id":"T535","span":{"begin":1000,"end":1010},"obj":"CL:0000775"},{"id":"T536","span":{"begin":1039,"end":1045},"obj":"UBERON:0002405"},{"id":"T537","span":{"begin":1046,"end":1053},"obj":"GO:0006952"},{"id":"T538","span":{"begin":1081,"end":1089},"obj":"GO:0035376"},{"id":"T539","span":{"begin":1094,"end":1099},"obj":"NCBITaxon:10239"},{"id":"T540","span":{"begin":1185,"end":1193},"obj":"SP_7"},{"id":"T541","span":{"begin":1214,"end":1220},"obj":"GO:0007601"},{"id":"T542","span":{"begin":1350,"end":1354},"obj":"G_3;PG_10;PR:000003622"},{"id":"T543","span":{"begin":1546,"end":1554},"obj":"SP_7"},{"id":"T66976","span":{"begin":0,"end":11},"obj":"PR:000009978"},{"id":"T92245","span":{"begin":181,"end":194},"obj":"NCBITaxon:11118"},{"id":"T54356","span":{"begin":258,"end":269},"obj":"NCBITaxon:11118"},{"id":"T26051","span":{"begin":346,"end":356},"obj":"SP_7"},{"id":"T99342","span":{"begin":428,"end":433},"obj":"NCBITaxon:10239"},{"id":"T68308","span":{"begin":534,"end":542},"obj":"SP_10"},{"id":"T39819","span":{"begin":562,"end":570},"obj":"SP_10"},{"id":"T81448","span":{"begin":634,"end":644},"obj":"GO:0035376"},{"id":"T82315","span":{"begin":724,"end":729},"obj":"NCBITaxon:10239"},{"id":"T15886","span":{"begin":770,"end":775},"obj":"NCBITaxon:10239"},{"id":"T76531","span":{"begin":789,"end":801},"obj":"GO:0009986"},{"id":"T49656","span":{"begin":803,"end":811},"obj":"SP_10"},{"id":"T95560","span":{"begin":847,"end":860},"obj":"GO:0005886"},{"id":"T81157","span":{"begin":927,"end":937},"obj":"GO:0035376"},{"id":"T16593","span":{"begin":956,"end":975},"obj":"CL:0000623"},{"id":"T26835","span":{"begin":1000,"end":1010},"obj":"CL:0000775"},{"id":"T92368","span":{"begin":1039,"end":1045},"obj":"UBERON:0002405"},{"id":"T25486","span":{"begin":1046,"end":1053},"obj":"GO:0006952"},{"id":"T28995","span":{"begin":1081,"end":1089},"obj":"GO:0035376"},{"id":"T87059","span":{"begin":1094,"end":1099},"obj":"NCBITaxon:10239"},{"id":"T26492","span":{"begin":1185,"end":1193},"obj":"SP_7"},{"id":"T46616","span":{"begin":1214,"end":1220},"obj":"GO:0007601"},{"id":"T7529","span":{"begin":1350,"end":1354},"obj":"G_3;PG_10;PR:000003622"},{"id":"T50501","span":{"begin":1546,"end":1554},"obj":"SP_7"}],"attributes":[{"subj":"T520","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T521","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T522","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T523","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T524","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T525","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T526","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T527","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T528","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T529","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T530","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T531","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T532","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T533","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T534","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T535","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T536","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T537","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T538","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T539","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T540","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T541","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T542","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T543","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66976","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T92245","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T54356","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26051","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T99342","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T68308","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T39819","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81448","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T82315","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T15886","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T76531","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49656","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T95560","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81157","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T16593","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26835","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T92368","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T25486","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28995","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T87059","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26492","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T46616","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7529","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50501","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"750","span":{"begin":0,"end":11},"obj":"Gene"},{"id":"751","span":{"begin":1350,"end":1354},"obj":"Gene"},{"id":"752","span":{"begin":1359,"end":1363},"obj":"Gene"},{"id":"753","span":{"begin":852,"end":860},"obj":"Gene"},{"id":"754","span":{"begin":181,"end":194},"obj":"Species"},{"id":"755","span":{"begin":346,"end":356},"obj":"Species"},{"id":"756","span":{"begin":534,"end":542},"obj":"Species"},{"id":"757","span":{"begin":803,"end":811},"obj":"Species"},{"id":"758","span":{"begin":258,"end":280},"obj":"Disease"},{"id":"759","span":{"begin":478,"end":487},"obj":"Disease"},{"id":"760","span":{"begin":562,"end":581},"obj":"Disease"},{"id":"761","span":{"begin":1123,"end":1132},"obj":"Disease"},{"id":"762","span":{"begin":1185,"end":1193},"obj":"Disease"},{"id":"763","span":{"begin":1546,"end":1554},"obj":"Disease"}],"attributes":[{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"Gene:280846"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Gene:59272"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Gene:6383"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"Gene:43740571"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Tax:11118"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"Tax:2697049"},{"id":"A756","pred":"tao:has_database_id","subj":"756","obj":"Tax:694009"},{"id":"A757","pred":"tao:has_database_id","subj":"757","obj":"Tax:694009"},{"id":"A758","pred":"tao:has_database_id","subj":"758","obj":"MESH:D018352"},{"id":"A759","pred":"tao:has_database_id","subj":"759","obj":"MESH:D007239"},{"id":"A760","pred":"tao:has_database_id","subj":"760","obj":"MESH:C000657245"},{"id":"A761","pred":"tao:has_database_id","subj":"761","obj":"MESH:D007239"},{"id":"A762","pred":"tao:has_database_id","subj":"762","obj":"MESH:C000657245"},{"id":"A763","pred":"tao:has_database_id","subj":"763","obj":"MESH:C000657245"},{"subj":"750","pred":"source","obj":"LitCovid-PubTator"},{"subj":"751","pred":"source","obj":"LitCovid-PubTator"},{"subj":"752","pred":"source","obj":"LitCovid-PubTator"},{"subj":"753","pred":"source","obj":"LitCovid-PubTator"},{"subj":"754","pred":"source","obj":"LitCovid-PubTator"},{"subj":"755","pred":"source","obj":"LitCovid-PubTator"},{"subj":"756","pred":"source","obj":"LitCovid-PubTator"},{"subj":"757","pred":"source","obj":"LitCovid-PubTator"},{"subj":"758","pred":"source","obj":"LitCovid-PubTator"},{"subj":"759","pred":"source","obj":"LitCovid-PubTator"},{"subj":"760","pred":"source","obj":"LitCovid-PubTator"},{"subj":"761","pred":"source","obj":"LitCovid-PubTator"},{"subj":"762","pred":"source","obj":"LitCovid-PubTator"},{"subj":"763","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T322","span":{"begin":387,"end":392},"obj":"Body_part"},{"id":"T323","span":{"begin":443,"end":448},"obj":"Body_part"},{"id":"T324","span":{"begin":494,"end":499},"obj":"Body_part"},{"id":"T325","span":{"begin":587,"end":592},"obj":"Body_part"},{"id":"T326","span":{"begin":634,"end":638},"obj":"Body_part"},{"id":"T327","span":{"begin":683,"end":688},"obj":"Body_part"},{"id":"T328","span":{"begin":739,"end":744},"obj":"Body_part"},{"id":"T329","span":{"begin":789,"end":801},"obj":"Body_part"},{"id":"T330","span":{"begin":789,"end":793},"obj":"Body_part"},{"id":"T331","span":{"begin":821,"end":826},"obj":"Body_part"},{"id":"T332","span":{"begin":847,"end":860},"obj":"Body_part"},{"id":"T333","span":{"begin":847,"end":851},"obj":"Body_part"},{"id":"T334","span":{"begin":927,"end":931},"obj":"Body_part"},{"id":"T335","span":{"begin":956,"end":975},"obj":"Body_part"},{"id":"T336","span":{"begin":971,"end":975},"obj":"Body_part"},{"id":"T337","span":{"begin":1000,"end":1010},"obj":"Body_part"},{"id":"T338","span":{"begin":1110,"end":1115},"obj":"Body_part"},{"id":"T339","span":{"begin":1359,"end":1363},"obj":"Body_part"}],"attributes":[{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A327","pred":"fma_id","subj":"T327","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A328","pred":"fma_id","subj":"T328","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A330","pred":"fma_id","subj":"T330","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A331","pred":"fma_id","subj":"T331","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A332","pred":"fma_id","subj":"T332","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A333","pred":"fma_id","subj":"T333","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A334","pred":"fma_id","subj":"T334","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A335","pred":"fma_id","subj":"T335","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A336","pred":"fma_id","subj":"T336","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A337","pred":"fma_id","subj":"T337","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A338","pred":"fma_id","subj":"T338","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A339","pred":"fma_id","subj":"T339","obj":"http://purl.org/sig/ont/fma/fma82834"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T338","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T339","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T104","span":{"begin":270,"end":280},"obj":"Disease"},{"id":"T105","span":{"begin":346,"end":354},"obj":"Disease"},{"id":"T106","span":{"begin":478,"end":487},"obj":"Disease"},{"id":"T107","span":{"begin":534,"end":542},"obj":"Disease"},{"id":"T108","span":{"begin":562,"end":570},"obj":"Disease"},{"id":"T109","span":{"begin":571,"end":581},"obj":"Disease"},{"id":"T110","span":{"begin":803,"end":811},"obj":"Disease"},{"id":"T111","span":{"begin":1123,"end":1132},"obj":"Disease"},{"id":"T112","span":{"begin":1185,"end":1193},"obj":"Disease"},{"id":"T113","span":{"begin":1546,"end":1554},"obj":"Disease"}],"attributes":[{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T379","span":{"begin":20,"end":23},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T380","span":{"begin":297,"end":298},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T381","span":{"begin":387,"end":392},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T382","span":{"begin":428,"end":433},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T383","span":{"begin":443,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T384","span":{"begin":494,"end":499},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T385","span":{"begin":587,"end":592},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T386","span":{"begin":634,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T387","span":{"begin":683,"end":688},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T388","span":{"begin":724,"end":729},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T389","span":{"begin":739,"end":744},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T390","span":{"begin":770,"end":775},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T391","span":{"begin":789,"end":793},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T392","span":{"begin":821,"end":826},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T393","span":{"begin":847,"end":851},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T394","span":{"begin":852,"end":860},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T395","span":{"begin":927,"end":931},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T396","span":{"begin":956,"end":975},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T397","span":{"begin":976,"end":984},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T398","span":{"begin":1094,"end":1099},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T399","span":{"begin":1110,"end":1115},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T400","span":{"begin":1212,"end":1213},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T401","span":{"begin":1328,"end":1329},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T402","span":{"begin":1479,"end":1480},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T403","span":{"begin":1523,"end":1524},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T379","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T380","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T381","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T382","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T383","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T384","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T385","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T386","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T387","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T388","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T389","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T390","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T391","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T392","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T393","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T394","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T395","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T396","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T397","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T398","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T399","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T400","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T401","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T402","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T403","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T354","span":{"begin":97,"end":106},"obj":"Chemical"},{"id":"T355","span":{"begin":322,"end":324},"obj":"Chemical"},{"id":"T356","span":{"begin":381,"end":383},"obj":"Chemical"},{"id":"T357","span":{"begin":944,"end":946},"obj":"Chemical"},{"id":"T358","span":{"begin":1414,"end":1416},"obj":"Chemical"}],"attributes":[{"id":"A354","pred":"chebi_id","subj":"T354","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A355","pred":"chebi_id","subj":"T355","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A356","pred":"chebi_id","subj":"T356","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A357","pred":"chebi_id","subj":"T357","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A358","pred":"chebi_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"subj":"T354","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T355","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T356","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T357","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T358","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T64","span":{"begin":956,"end":984},"obj":"http://purl.obolibrary.org/obo/GO_0030101"},{"id":"T65","span":{"begin":1000,"end":1022},"obj":"http://purl.obolibrary.org/obo/GO_0070488"}],"attributes":[{"subj":"T64","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T224","span":{"begin":0,"end":112},"obj":"Sentence"},{"id":"T225","span":{"begin":113,"end":281},"obj":"Sentence"},{"id":"T226","span":{"begin":282,"end":365},"obj":"Sentence"},{"id":"T227","span":{"begin":366,"end":493},"obj":"Sentence"},{"id":"T228","span":{"begin":494,"end":549},"obj":"Sentence"},{"id":"T229","span":{"begin":550,"end":650},"obj":"Sentence"},{"id":"T230","span":{"begin":651,"end":802},"obj":"Sentence"},{"id":"T231","span":{"begin":803,"end":943},"obj":"Sentence"},{"id":"T232","span":{"begin":944,"end":1133},"obj":"Sentence"},{"id":"T233","span":{"begin":1134,"end":1302},"obj":"Sentence"},{"id":"T234","span":{"begin":1303,"end":1413},"obj":"Sentence"},{"id":"T235","span":{"begin":1414,"end":1568},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T224","pred":"source","obj":"LitCovid-sentences"},{"subj":"T225","pred":"source","obj":"LitCovid-sentences"},{"subj":"T226","pred":"source","obj":"LitCovid-sentences"},{"subj":"T227","pred":"source","obj":"LitCovid-sentences"},{"subj":"T228","pred":"source","obj":"LitCovid-sentences"},{"subj":"T229","pred":"source","obj":"LitCovid-sentences"},{"subj":"T230","pred":"source","obj":"LitCovid-sentences"},{"subj":"T231","pred":"source","obj":"LitCovid-sentences"},{"subj":"T232","pred":"source","obj":"LitCovid-sentences"},{"subj":"T233","pred":"source","obj":"LitCovid-sentences"},{"subj":"T234","pred":"source","obj":"LitCovid-sentences"},{"subj":"T235","pred":"source","obj":"LitCovid-sentences"}]},{"project":"MyTest","denotations":[{"id":"32574271-21887302-34514761","span":{"begin":489,"end":491},"obj":"21887302"},{"id":"32574271-21887302-34514762","span":{"begin":646,"end":648},"obj":"21887302"},{"id":"32574271-21887302-34514763","span":{"begin":939,"end":941},"obj":"21887302"},{"id":"32574271-15655079-34514764","span":{"begin":1055,"end":1058},"obj":"15655079"},{"id":"32574271-32228252-34514765","span":{"begin":1408,"end":1409},"obj":"32228252"},{"id":"32574271-32334062-34514765","span":{"begin":1408,"end":1409},"obj":"32334062"},{"id":"32574271-32333836-34514765","span":{"begin":1408,"end":1409},"obj":"32333836"},{"id":"32574271-32395702-34514765","span":{"begin":1408,"end":1409},"obj":"32395702"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32574271-21887302-34514761","pred":"source","obj":"MyTest"},{"subj":"32574271-21887302-34514762","pred":"source","obj":"MyTest"},{"subj":"32574271-21887302-34514763","pred":"source","obj":"MyTest"},{"subj":"32574271-15655079-34514764","pred":"source","obj":"MyTest"},{"subj":"32574271-32228252-34514765","pred":"source","obj":"MyTest"},{"subj":"32574271-32334062-34514765","pred":"source","obj":"MyTest"},{"subj":"32574271-32333836-34514765","pred":"source","obj":"MyTest"},{"subj":"32574271-32395702-34514765","pred":"source","obj":"MyTest"}]},{"project":"TEST0","denotations":[{"id":"32574271-123-129-2882353","span":{"begin":489,"end":491},"obj":"[\"21887302\"]"},{"id":"32574271-96-102-2882354","span":{"begin":646,"end":648},"obj":"[\"21887302\"]"},{"id":"32574271-136-142-2882355","span":{"begin":939,"end":941},"obj":"[\"21887302\"]"},{"id":"32574271-111-118-2882356","span":{"begin":1055,"end":1058},"obj":"[\"15655079\"]"},{"id":"32574271-105-110-2882357","span":{"begin":1408,"end":1409},"obj":"[\"32228252\", \"32334062\", \"32333836\", \"32395702\"]"}],"attributes":[{"subj":"32574271-123-129-2882353","pred":"source","obj":"TEST0"},{"subj":"32574271-96-102-2882354","pred":"source","obj":"TEST0"},{"subj":"32574271-136-142-2882355","pred":"source","obj":"TEST0"},{"subj":"32574271-111-118-2882356","pred":"source","obj":"TEST0"},{"subj":"32574271-105-110-2882357","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"32574271-21887302-34514761","span":{"begin":489,"end":491},"obj":"21887302"},{"id":"32574271-21887302-34514762","span":{"begin":646,"end":648},"obj":"21887302"},{"id":"32574271-21887302-34514763","span":{"begin":939,"end":941},"obj":"21887302"},{"id":"32574271-15655079-34514764","span":{"begin":1055,"end":1058},"obj":"15655079"},{"id":"32574271-32228252-34514765","span":{"begin":1408,"end":1409},"obj":"32228252"},{"id":"32574271-32334062-34514765","span":{"begin":1408,"end":1409},"obj":"32334062"},{"id":"32574271-32333836-34514765","span":{"begin":1408,"end":1409},"obj":"32333836"},{"id":"32574271-32395702-34514765","span":{"begin":1408,"end":1409},"obj":"32395702"}],"attributes":[{"subj":"32574271-21887302-34514761","pred":"source","obj":"2_test"},{"subj":"32574271-21887302-34514762","pred":"source","obj":"2_test"},{"subj":"32574271-21887302-34514763","pred":"source","obj":"2_test"},{"subj":"32574271-15655079-34514764","pred":"source","obj":"2_test"},{"subj":"32574271-32228252-34514765","pred":"source","obj":"2_test"},{"subj":"32574271-32334062-34514765","pred":"source","obj":"2_test"},{"subj":"32574271-32333836-34514765","pred":"source","obj":"2_test"},{"subj":"32574271-32395702-34514765","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#93b7ec","default":true},{"id":"LitCovid-PubTator","color":"#d1ec93"},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93eb"},{"id":"LitCovid-PD-MONDO","color":"#93ecd3"},{"id":"LitCovid-PD-CLO","color":"#ecb993"},{"id":"LitCovid-PD-CHEBI","color":"#9f93ec"},{"id":"LitCovid-PD-GO-BP","color":"#a1ec93"},{"id":"LitCovid-sentences","color":"#ec93bb"},{"id":"MyTest","color":"#93d5ec"},{"id":"TEST0","color":"#ece993"},{"id":"2_test","color":"#cf93ec"}]}]}}