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{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T39","span":{"begin":194,"end":198},"obj":"Body_part"},{"id":"T40","span":{"begin":217,"end":222},"obj":"Body_part"},{"id":"T41","span":{"begin":224,"end":229},"obj":"Body_part"},{"id":"T42","span":{"begin":235,"end":241},"obj":"Body_part"},{"id":"T43","span":{"begin":335,"end":340},"obj":"Body_part"},{"id":"T44","span":{"begin":804,"end":810},"obj":"Body_part"},{"id":"T45","span":{"begin":880,"end":885},"obj":"Body_part"}],"attributes":[{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A44","pred":"uberon_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T37","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"T38","span":{"begin":22,"end":69},"obj":"Disease"},{"id":"T39","span":{"begin":22,"end":55},"obj":"Disease"},{"id":"T40","span":{"begin":71,"end":79},"obj":"Disease"},{"id":"T41","span":{"begin":89,"end":97},"obj":"Disease"},{"id":"T42","span":{"begin":115,"end":150},"obj":"Disease"},{"id":"T43","span":{"begin":121,"end":150},"obj":"Disease"},{"id":"T44","span":{"begin":152,"end":156},"obj":"Disease"},{"id":"T45","span":{"begin":174,"end":189},"obj":"Disease"},{"id":"T46","span":{"begin":538,"end":543},"obj":"Disease"},{"id":"T47","span":{"begin":886,"end":893},"obj":"Disease"},{"id":"T48","span":{"begin":1042,"end":1050},"obj":"Disease"},{"id":"T49","span":{"begin":1058,"end":1066},"obj":"Disease"}],"attributes":[{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0006932"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0019065"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T275","span":{"begin":194,"end":198},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T276","span":{"begin":194,"end":198},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T277","span":{"begin":217,"end":222},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T278","span":{"begin":217,"end":222},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T279","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T280","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T281","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T282","span":{"begin":224,"end":229},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T283","span":{"begin":235,"end":241},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T284","span":{"begin":235,"end":241},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T285","span":{"begin":235,"end":241},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T286","span":{"begin":286,"end":287},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T287","span":{"begin":375,"end":379},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T288","span":{"begin":387,"end":391},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T289","span":{"begin":413,"end":450},"obj":"http://purl.obolibrary.org/obo/PR_000005932"},{"id":"T290","span":{"begin":452,"end":457},"obj":"http://purl.obolibrary.org/obo/PR_000005932"},{"id":"T291","span":{"begin":568,"end":584},"obj":"http://purl.obolibrary.org/obo/PR_000000017"},{"id":"T292","span":{"begin":612,"end":620},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T293","span":{"begin":694,"end":695},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T294","span":{"begin":716,"end":718},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T295","span":{"begin":780,"end":788},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T296","span":{"begin":804,"end":810},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T297","span":{"begin":815,"end":817},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T298","span":{"begin":894,"end":895},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T299","span":{"begin":942,"end":944},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T300","span":{"begin":1051,"end":1053},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T246","span":{"begin":364,"end":366},"obj":"Chemical"},{"id":"T249","span":{"begin":368,"end":370},"obj":"Chemical"},{"id":"T252","span":{"begin":375,"end":377},"obj":"Chemical"},{"id":"T255","span":{"begin":381,"end":383},"obj":"Chemical"},{"id":"T258","span":{"begin":387,"end":389},"obj":"Chemical"},{"id":"T261","span":{"begin":393,"end":395},"obj":"Chemical"},{"id":"T264","span":{"begin":399,"end":401},"obj":"Chemical"},{"id":"T267","span":{"begin":406,"end":408},"obj":"Chemical"},{"id":"T270","span":{"begin":510,"end":512},"obj":"Chemical"},{"id":"T271","span":{"begin":519,"end":529},"obj":"Chemical"},{"id":"T272","span":{"begin":531,"end":534},"obj":"Chemical"},{"id":"T273","span":{"begin":568,"end":603},"obj":"Chemical"},{"id":"T274","span":{"begin":579,"end":584},"obj":"Chemical"},{"id":"T275","span":{"begin":593,"end":600},"obj":"Chemical"},{"id":"T276","span":{"begin":637,"end":644},"obj":"Chemical"},{"id":"T277","span":{"begin":679,"end":686},"obj":"Chemical"},{"id":"T278","span":{"begin":713,"end":715},"obj":"Chemical"},{"id":"T281","span":{"begin":742,"end":744},"obj":"Chemical"},{"id":"T284","span":{"begin":766,"end":779},"obj":"Chemical"},{"id":"T285","span":{"begin":780,"end":788},"obj":"Chemical"},{"id":"T286","span":{"begin":812,"end":814},"obj":"Chemical"},{"id":"T289","span":{"begin":870,"end":878},"obj":"Chemical"},{"id":"T290","span":{"begin":880,"end":895},"obj":"Chemical"},{"id":"T291","span":{"begin":901,"end":904},"obj":"Chemical"},{"id":"T294","span":{"begin":913,"end":920},"obj":"Chemical"},{"id":"T295","span":{"begin":939,"end":941},"obj":"Chemical"}],"attributes":[{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A247","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A248","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A250","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A251","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A253","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A254","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A256","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A257","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A259","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A260","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A262","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A263","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A265","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A266","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A267","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A268","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A269","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_52998"},{"id":"A270","pred":"chebi_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A271","pred":"chebi_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A272","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A273","pred":"chebi_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A274","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"},{"id":"A275","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A276","pred":"chebi_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/CHEBI_16541"},{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A279","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A280","pred":"chebi_i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is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T48","span":{"begin":544,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T49","span":{"begin":544,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T50","span":{"begin":544,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T51","span":{"begin":544,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T52","span":{"begin":967,"end":976},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T162","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T163","span":{"begin":84,"end":250},"obj":"Sentence"},{"id":"T164","span":{"begin":251,"end":712},"obj":"Sentence"},{"id":"T165","span":{"begin":713,"end":811},"obj":"Sentence"},{"id":"T166","span":{"begin":812,"end":1082},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":121,"end":141},"obj":"Phenotype"},{"id":"T9","span":{"begin":174,"end":189},"obj":"Phenotype"},{"id":"T10","span":{"begin":235,"end":249},"obj":"Phenotype"},{"id":"T11","span":{"begin":288,"end":302},"obj":"Phenotype"},{"id":"T12","span":{"begin":538,"end":543},"obj":"Phenotype"},{"id":"T13","span":{"begin":997,"end":1003},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0100598"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0000112"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0000969"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"MyTest","denotations":[{"id":"32574271-32192578-34514716","span":{"begin":304,"end":307},"obj":"32192578"},{"id":"32574271-28778104-34514717","span":{"begin":309,"end":312},"obj":"28778104"},{"id":"32574271-32205092-34514718","span":{"begin":707,"end":710},"obj":"32205092"},{"id":"32574271-31022687-34514719","span":{"begin":922,"end":925},"obj":"31022687"},{"id":"32574271-14990596-34514720","span":{"begin":1028,"end":1031},"obj":"14990596"},{"id":"32574271-32205092-34514721","span":{"begin":1077,"end":1080},"obj":"32205092"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"TEST0","denotations":[{"id":"32574271-220-227-2882308","span":{"begin":304,"end":307},"obj":"[\"32192578\"]"},{"id":"32574271-58-65-2882309","span":{"begin":309,"end":312},"obj":"[\"28778104\"]"},{"id":"32574271-224-231-2882310","span":{"begin":707,"end":710},"obj":"[\"32205092\"]"},{"id":"32574271-110-117-2882311","span":{"begin":922,"end":925},"obj":"[\"31022687\"]"},{"id":"32574271-216-223-2882312","span":{"begin":1028,"end":1031},"obj":"[\"14990596\"]"},{"id":"32574271-234-241-2882313","span":{"begin":1077,"end":1080},"obj":"[\"32205092\"]"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}

{"project":"2_test","denotations":[{"id":"32574271-32192578-34514716","span":{"begin":304,"end":307},"obj":"32192578"},{"id":"32574271-28778104-34514717","span":{"begin":309,"end":312},"obj":"28778104"},{"id":"32574271-32205092-34514718","span":{"begin":707,"end":710},"obj":"32205092"},{"id":"32574271-31022687-34514719","span":{"begin":922,"end":925},"obj":"31022687"},{"id":"32574271-14990596-34514720","span":{"begin":1028,"end":1031},"obj":"14990596"},{"id":"32574271-32205092-34514721","span":{"begin":1077,"end":1080},"obj":"32205092"}],"text":"COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome (ARDS), which leads to pulmonary edema and lung failure, and have liver, heart, and kidney damages. These symptoms are associated with a cytokine storm (166, 167) manifesting elevated serum levels of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon (IFN)γ, tumor necrosis factor (TNF)α, Interferon gamma-induced protein 10 (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. IL-22 also upregulates mucins, fibrinogen, anti-apoptotic proteins, serum amyloid A, and LPS binding protein (169); therefore, IL-22 may contribute to the formation of life-threatening oedema with mucins and fibrin (170), seen in SARS-CoV-22 and SARS-CoV patients (168)."}