PMC:7271924 / 17768-19166 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7271924","sourcedb":"PMC","sourceid":"7271924","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7271924","text":"Several Gram-negative pathogens including members of the genera Neisseria and Moraxella have evolved two-component systems that can extract iron from the host LF and transferrin (157). N. meningitidis is a principal cause of bacterial meningitis in children. While the majority of pathogenic bacteria employ siderophores to chelate and scavenge iron (158), Neisseria has evolved a series of protein transporters that directly hijack iron sequestered in host transferrin, lactoferrin, and hemoglobin (159). The system consists of a membrane-bound transporter that extracts and transports iron across the outer membrane (TbpA for transferrin and LbpA for lactoferrin), and a lipoprotein that delivers iron-loaded lactoferrin/transferrin to the transporter (TbpB for transferrin and LbpB for lactoferrin) (157). LbpB binds the N-lobe of lactoferrin, whereas TbpB binds the C-lobe of transferrin (157). However, more than 90% of LF in human milk is in the form of apolactoferrin (160), which competes with siderophilic bacteria for ferric iron, and disrupts the proliferation of these microbial and other pathogens. Similarly LF supplements may play an important role to counteract bacterial processes. LF is consequently a significant element of host defense (19), and its levels may vary in health and during disease. It is hence known to be a modulator of innate and adaptive immune responses (161).","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T305","span":{"begin":78,"end":87},"obj":"NCBITaxon:39107"},{"id":"T306","span":{"begin":166,"end":177},"obj":"PR:000016261"},{"id":"T307","span":{"begin":225,"end":234},"obj":"NCBITaxon:2"},{"id":"T308","span":{"begin":292,"end":300},"obj":"NCBITaxon:2"},{"id":"T309","span":{"begin":308,"end":320},"obj":"CHEBI:26672;CHEBI:26672"},{"id":"T310","span":{"begin":438,"end":449},"obj":"GO:0051235"},{"id":"T311","span":{"begin":453,"end":457},"obj":"GO:0018995"},{"id":"T312","span":{"begin":458,"end":469},"obj":"PR:000016261"},{"id":"T313","span":{"begin":471,"end":482},"obj":"PR:000009978"},{"id":"T314","span":{"begin":531,"end":539},"obj":"GO:0016020"},{"id":"T315","span":{"begin":603,"end":617},"obj":"GO:0019867"},{"id":"T316","span":{"begin":619,"end":623},"obj":"PR:000022758"},{"id":"T317","span":{"begin":628,"end":639},"obj":"PR:000016261"},{"id":"T318","span":{"begin":653,"end":664},"obj":"PR:000009978"},{"id":"T319","span":{"begin":711,"end":722},"obj":"PR:000009978"},{"id":"T320","span":{"begin":723,"end":734},"obj":"PR:000016261"},{"id":"T321","span":{"begin":755,"end":759},"obj":"PR:P34123"},{"id":"T322","span":{"begin":764,"end":775},"obj":"PR:000016261"},{"id":"T323","span":{"begin":789,"end":800},"obj":"PR:000009978"},{"id":"T324","span":{"begin":834,"end":845},"obj":"PR:000009978"},{"id":"T325","span":{"begin":855,"end":859},"obj":"PR:P34123"},{"id":"T326","span":{"begin":880,"end":891},"obj":"PR:000016261"},{"id":"T327","span":{"begin":931,"end":936},"obj":"SP_6;NCBITaxon:9606"},{"id":"T328","span":{"begin":937,"end":941},"obj":"UBERON:0001913"},{"id":"T329","span":{"begin":1015,"end":1023},"obj":"NCBITaxon:2"},{"id":"T330","span":{"begin":1028,"end":1039},"obj":"CHEBI:30808;CHEBI:30808"},{"id":"T331","span":{"begin":1058,"end":1071},"obj":"GO:0008283"},{"id":"T332","span":{"begin":1178,"end":1187},"obj":"NCBITaxon:2"},{"id":"T333","span":{"begin":1243,"end":1247},"obj":"GO:0006968"},{"id":"T334","span":{"begin":1248,"end":1255},"obj":"GO:0006952"},{"id":"T335","span":{"begin":1355,"end":1361},"obj":"GO:0045087"},{"id":"T336","span":{"begin":1366,"end":1374},"obj":"GO:0002250"},{"id":"T337","span":{"begin":1375,"end":1381},"obj":"GO:0002250;UBERON:0002405"},{"id":"T338","span":{"begin":1382,"end":1391},"obj":"GO:0002250"},{"id":"T26947","span":{"begin":78,"end":87},"obj":"NCBITaxon:39107"},{"id":"T65420","span":{"begin":166,"end":177},"obj":"PR:000016261"},{"id":"T21588","span":{"begin":225,"end":234},"obj":"NCBITaxon:2"},{"id":"T49891","span":{"begin":292,"end":300},"obj":"NCBITaxon:2"},{"id":"T30797","span":{"begin":308,"end":320},"obj":"CHEBI:26672;CHEBI:26672"},{"id":"T12367","span":{"begin":438,"end":449},"obj":"GO:0051235"},{"id":"T80327","span":{"begin":453,"end":457},"obj":"GO:0018995"},{"id":"T77009","span":{"begin":458,"end":469},"obj":"PR:000016261"},{"id":"T40949","span":{"begin":471,"end":482},"obj":"PR:000009978"},{"id":"T66596","span":{"begin":531,"end":539},"obj":"GO:0016020"},{"id":"T73998","span":{"begin":603,"end":617},"obj":"GO:0019867"},{"id":"T64162","span":{"begin":619,"end":623},"obj":"PR:000022758"},{"id":"T34393","span":{"begin":628,"end":639},"obj":"PR:000016261"},{"id":"T65453","span":{"begin":653,"end":664},"obj":"PR:000009978"},{"id":"T27946","span":{"begin":711,"end":722},"obj":"PR:000009978"},{"id":"T46165","span":{"begin":723,"end":734},"obj":"PR:000016261"},{"id":"T57015","span":{"begin":755,"end":759},"obj":"PR:P34123"},{"id":"T55928","span":{"begin":764,"end":775},"obj":"PR:000016261"},{"id":"T97295","span":{"begin":789,"end":800},"obj":"PR:000009978"},{"id":"T99285","span":{"begin":834,"end":845},"obj":"PR:000009978"},{"id":"T38439","span":{"begin":855,"end":859},"obj":"PR:P34123"},{"id":"T87300","span":{"begin":880,"end":891},"obj":"PR:000016261"},{"id":"T90222","span":{"begin":931,"end":936},"obj":"SP_6;NCBITaxon:9606"},{"id":"T78826","span":{"begin":937,"end":941},"obj":"UBERON:0001913"},{"id":"T31225","span":{"begin":1015,"end":1023},"obj":"NCBITaxon:2"},{"id":"T47845","span":{"begin":1028,"end":1039},"obj":"CHEBI:30808;CHEBI:30808"},{"id":"T96516","span":{"begin":1058,"end":1071},"obj":"GO:0008283"},{"id":"T81850","span":{"begin":1178,"end":1187},"obj":"NCBITaxon:2"},{"id":"T70301","span":{"begin":1243,"end":1247},"obj":"GO:0006968"},{"id":"T95712","span":{"begin":1248,"end":1255},"obj":"GO:0006952"},{"id":"T65079","span":{"begin":1355,"end":1361},"obj":"GO:0045087"},{"id":"T33909","span":{"begin":1366,"end":1374},"obj":"GO:0002250"},{"id":"T42958","span":{"begin":1375,"end":1381},"obj":"GO:0002250;UBERON:0002405"},{"id":"T16651","span":{"begin":1382,"end":1391},"obj":"GO:0002250"}],"attributes":[{"subj":"T305","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T306","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T307","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T308","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T309","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T310","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T311","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T312","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T313","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T314","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T315","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T316","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T317","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T318","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T319","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T320","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T321","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T322","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T323","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T324","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T325","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T326","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T327","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T328","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T329","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T330","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T331","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T332","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T333","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T334","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T335","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T336","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T337","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T338","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26947","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65420","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T21588","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49891","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30797","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T12367","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80327","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T77009","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T40949","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66596","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T73998","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T64162","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34393","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65453","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27946","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T46165","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T57015","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T55928","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T97295","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T99285","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38439","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T87300","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T90222","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T78826","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31225","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T47845","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T96516","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81850","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T70301","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T95712","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65079","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T33909","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T42958","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T16651","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"428","span":{"begin":166,"end":177},"obj":"Gene"},{"id":"429","span":{"begin":458,"end":469},"obj":"Gene"},{"id":"430","span":{"begin":471,"end":482},"obj":"Gene"},{"id":"431","span":{"begin":619,"end":623},"obj":"Gene"},{"id":"432","span":{"begin":628,"end":639},"obj":"Gene"},{"id":"433","span":{"begin":653,"end":664},"obj":"Gene"},{"id":"434","span":{"begin":711,"end":722},"obj":"Gene"},{"id":"435","span":{"begin":723,"end":734},"obj":"Gene"},{"id":"436","span":{"begin":764,"end":775},"obj":"Gene"},{"id":"437","span":{"begin":789,"end":800},"obj":"Gene"},{"id":"438","span":{"begin":834,"end":845},"obj":"Gene"},{"id":"439","span":{"begin":880,"end":891},"obj":"Gene"},{"id":"440","span":{"begin":609,"end":617},"obj":"Gene"},{"id":"441","span":{"begin":185,"end":200},"obj":"Species"},{"id":"442","span":{"begin":249,"end":257},"obj":"Species"},{"id":"443","span":{"begin":931,"end":936},"obj":"Species"},{"id":"444","span":{"begin":531,"end":539},"obj":"Gene"},{"id":"445","span":{"begin":140,"end":144},"obj":"Chemical"},{"id":"446","span":{"begin":345,"end":349},"obj":"Chemical"},{"id":"447","span":{"begin":433,"end":437},"obj":"Chemical"},{"id":"448","span":{"begin":587,"end":591},"obj":"Chemical"},{"id":"449","span":{"begin":699,"end":703},"obj":"Chemical"},{"id":"450","span":{"begin":1028,"end":1039},"obj":"Chemical"},{"id":"451","span":{"begin":57,"end":73},"obj":"Disease"},{"id":"452","span":{"begin":225,"end":245},"obj":"Disease"},{"id":"453","span":{"begin":357,"end":366},"obj":"Disease"}],"attributes":[{"id":"A428","pred":"tao:has_database_id","subj":"428","obj":"Gene:7018"},{"id":"A429","pred":"tao:has_database_id","subj":"429","obj":"Gene:7018"},{"id":"A430","pred":"tao:has_database_id","subj":"430","obj":"Gene:280846"},{"id":"A431","pred":"tao:has_database_id","subj":"431","obj":"Gene:7276"},{"id":"A432","pred":"tao:has_database_id","subj":"432","obj":"Gene:7018"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"Gene:280846"},{"id":"A434","pred":"tao:has_database_id","subj":"434","obj":"Gene:280846"},{"id":"A435","pred":"tao:has_database_id","subj":"435","obj":"Gene:7018"},{"id":"A436","pred":"tao:has_database_id","subj":"436","obj":"Gene:7018"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Gene:280846"},{"id":"A438","pred":"tao:has_database_id","subj":"438","obj":"Gene:280846"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"Gene:7018"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"Gene:43740571"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"Tax:487"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Tax:9606"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Tax:9606"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Gene:43740571"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"MESH:D007501"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"MESH:D007501"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"MESH:D007501"},{"id":"A448","pred":"tao:has_database_id","subj":"448","obj":"MESH:D007501"},{"id":"A449","pred":"tao:has_database_id","subj":"449","obj":"MESH:D007501"},{"id":"A451","pred":"tao:has_database_id","subj":"451","obj":"MESH:D006069"},{"id":"A452","pred":"tao:has_database_id","subj":"452","obj":"MESH:D016920"},{"id":"A453","pred":"tao:has_database_id","subj":"453","obj":"MESH:D006069"},{"subj":"428","pred":"source","obj":"LitCovid-PubTator"},{"subj":"429","pred":"source","obj":"LitCovid-PubTator"},{"subj":"430","pred":"source","obj":"LitCovid-PubTator"},{"subj":"431","pred":"source","obj":"LitCovid-PubTator"},{"subj":"432","pred":"source","obj":"LitCovid-PubTator"},{"subj":"433","pred":"source","obj":"LitCovid-PubTator"},{"subj":"434","pred":"source","obj":"LitCovid-PubTator"},{"subj":"435","pred":"source","obj":"LitCovid-PubTator"},{"subj":"436","pred":"source","obj":"LitCovid-PubTator"},{"subj":"437","pred":"source","obj":"LitCovid-PubTator"},{"subj":"438","pred":"source","obj":"LitCovid-PubTator"},{"subj":"439","pred":"source","obj":"LitCovid-PubTator"},{"subj":"440","pred":"source","obj":"LitCovid-PubTator"},{"subj":"441","pred":"source","obj":"LitCovid-PubTator"},{"subj":"442","pred":"source","obj":"LitCovid-PubTator"},{"subj":"443","pred":"source","obj":"LitCovid-PubTator"},{"subj":"444","pred":"source","obj":"LitCovid-PubTator"},{"subj":"445","pred":"source","obj":"LitCovid-PubTator"},{"subj":"446","pred":"source","obj":"LitCovid-PubTator"},{"subj":"447","pred":"source","obj":"LitCovid-PubTator"},{"subj":"448","pred":"source","obj":"LitCovid-PubTator"},{"subj":"449","pred":"source","obj":"LitCovid-PubTator"},{"subj":"450","pred":"source","obj":"LitCovid-PubTator"},{"subj":"451","pred":"source","obj":"LitCovid-PubTator"},{"subj":"452","pred":"source","obj":"LitCovid-PubTator"},{"subj":"453","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T201","span":{"begin":391,"end":398},"obj":"Body_part"},{"id":"T202","span":{"begin":488,"end":498},"obj":"Body_part"},{"id":"T203","span":{"begin":673,"end":684},"obj":"Body_part"},{"id":"T204","span":{"begin":937,"end":941},"obj":"Body_part"}],"attributes":[{"id":"A201","pred":"fma_id","subj":"T201","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A202","pred":"fma_id","subj":"T202","obj":"http://purl.org/sig/ont/fma/fma62293"},{"id":"A203","pred":"fma_id","subj":"T203","obj":"http://purl.org/sig/ont/fma/fma63169"},{"id":"A204","pred":"fma_id","subj":"T204","obj":"http://purl.org/sig/ont/fma/fma62100"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T36","span":{"begin":826,"end":830},"obj":"Body_part"},{"id":"T37","span":{"begin":872,"end":876},"obj":"Body_part"},{"id":"T38","span":{"begin":937,"end":941},"obj":"Body_part"}],"attributes":[{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_3010752"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_3010752"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T31","span":{"begin":225,"end":245},"obj":"Disease"},{"id":"T32","span":{"begin":235,"end":245},"obj":"Disease"}],"attributes":[{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0006670"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0004796"},{"id":"A33","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0021108"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T234","span":{"begin":204,"end":205},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T235","span":{"begin":292,"end":300},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T236","span":{"begin":367,"end":370},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T237","span":{"begin":379,"end":380},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T238","span":{"begin":529,"end":530},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T239","span":{"begin":531,"end":539},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T240","span":{"begin":609,"end":617},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T241","span":{"begin":671,"end":672},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T242","span":{"begin":931,"end":936},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T243","span":{"begin":1015,"end":1023},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T244","span":{"begin":1218,"end":1219},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T245","span":{"begin":1340,"end":1341},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T234","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T224","span":{"begin":140,"end":144},"obj":"Chemical"},{"id":"T225","span":{"begin":159,"end":161},"obj":"Chemical"},{"id":"T226","span":{"begin":308,"end":320},"obj":"Chemical"},{"id":"T227","span":{"begin":345,"end":349},"obj":"Chemical"},{"id":"T228","span":{"begin":391,"end":398},"obj":"Chemical"},{"id":"T229","span":{"begin":433,"end":437},"obj":"Chemical"},{"id":"T230","span":{"begin":488,"end":498},"obj":"Chemical"},{"id":"T231","span":{"begin":587,"end":591},"obj":"Chemical"},{"id":"T232","span":{"begin":673,"end":684},"obj":"Chemical"},{"id":"T233","span":{"begin":699,"end":703},"obj":"Chemical"},{"id":"T234","span":{"begin":925,"end":927},"obj":"Chemical"},{"id":"T235","span":{"begin":1028,"end":1039},"obj":"Chemical"},{"id":"T236","span":{"begin":1035,"end":1039},"obj":"Chemical"},{"id":"T237","span":{"begin":1122,"end":1124},"obj":"Chemical"},{"id":"T238","span":{"begin":1199,"end":1201},"obj":"Chemical"}],"attributes":[{"id":"A224","pred":"chebi_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A225","pred":"chebi_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A226","pred":"chebi_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/CHEBI_26672"},{"id":"A227","pred":"chebi_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A228","pred":"chebi_id","subj":"T228","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A229","pred":"chebi_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A230","pred":"chebi_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/CHEBI_35143"},{"id":"A231","pred":"chebi_id","subj":"T231","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A232","pred":"chebi_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/CHEBI_6495"},{"id":"A233","pred":"chebi_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A234","pred":"chebi_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_29034"},{"id":"A236","pred":"chebi_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A237","pred":"chebi_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"id":"A238","pred":"chebi_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/CHEBI_73585"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T225","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T226","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T227","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T42","span":{"begin":391,"end":411},"obj":"http://purl.obolibrary.org/obo/GO_0015031"},{"id":"T43","span":{"begin":546,"end":557},"obj":"http://purl.obolibrary.org/obo/GO_0006810"},{"id":"T44","span":{"begin":576,"end":586},"obj":"http://purl.obolibrary.org/obo/GO_0006810"},{"id":"T45","span":{"begin":723,"end":753},"obj":"http://purl.obolibrary.org/obo/GO_0033572"},{"id":"T46","span":{"begin":742,"end":753},"obj":"http://purl.obolibrary.org/obo/GO_0006810"},{"id":"T47","span":{"begin":1366,"end":1391},"obj":"http://purl.obolibrary.org/obo/GO_0002250"}],"attributes":[{"subj":"T42","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T144","span":{"begin":0,"end":184},"obj":"Sentence"},{"id":"T145","span":{"begin":185,"end":258},"obj":"Sentence"},{"id":"T146","span":{"begin":259,"end":505},"obj":"Sentence"},{"id":"T147","span":{"begin":506,"end":808},"obj":"Sentence"},{"id":"T148","span":{"begin":809,"end":898},"obj":"Sentence"},{"id":"T149","span":{"begin":899,"end":1111},"obj":"Sentence"},{"id":"T150","span":{"begin":1112,"end":1198},"obj":"Sentence"},{"id":"T151","span":{"begin":1199,"end":1315},"obj":"Sentence"},{"id":"T152","span":{"begin":1316,"end":1398},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T144","pred":"source","obj":"LitCovid-sentences"},{"subj":"T145","pred":"source","obj":"LitCovid-sentences"},{"subj":"T146","pred":"source","obj":"LitCovid-sentences"},{"subj":"T147","pred":"source","obj":"LitCovid-sentences"},{"subj":"T148","pred":"source","obj":"LitCovid-sentences"},{"subj":"T149","pred":"source","obj":"LitCovid-sentences"},{"subj":"T150","pred":"source","obj":"LitCovid-sentences"},{"subj":"T151","pred":"source","obj":"LitCovid-sentences"},{"subj":"T152","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":235,"end":245},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0001287"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"MyTest","denotations":[{"id":"32574271-25286931-34514697","span":{"begin":179,"end":182},"obj":"25286931"},{"id":"32574271-18675317-34514698","span":{"begin":351,"end":354},"obj":"18675317"},{"id":"32574271-10383753-34514699","span":{"begin":500,"end":503},"obj":"10383753"},{"id":"32574271-25286931-34514700","span":{"begin":803,"end":806},"obj":"25286931"},{"id":"32574271-25286931-34514701","span":{"begin":893,"end":896},"obj":"25286931"},{"id":"32574271-7359228-34514702","span":{"begin":976,"end":979},"obj":"7359228"},{"id":"32574271-28914813-34514703","span":{"begin":1257,"end":1259},"obj":"28914813"},{"id":"32574271-27234406-34514704","span":{"begin":1393,"end":1396},"obj":"27234406"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32574271-25286931-34514697","pred":"source","obj":"MyTest"},{"subj":"32574271-18675317-34514698","pred":"source","obj":"MyTest"},{"subj":"32574271-10383753-34514699","pred":"source","obj":"MyTest"},{"subj":"32574271-25286931-34514700","pred":"source","obj":"MyTest"},{"subj":"32574271-25286931-34514701","pred":"source","obj":"MyTest"},{"subj":"32574271-7359228-34514702","pred":"source","obj":"MyTest"},{"subj":"32574271-28914813-34514703","pred":"source","obj":"MyTest"},{"subj":"32574271-27234406-34514704","pred":"source","obj":"MyTest"}]},{"project":"TEST0","denotations":[{"id":"32574271-179-186-2882289","span":{"begin":179,"end":182},"obj":"[\"25286931\"]"},{"id":"32574271-92-99-2882290","span":{"begin":351,"end":354},"obj":"[\"18675317\"]"},{"id":"32574271-235-242-2882291","span":{"begin":500,"end":503},"obj":"[\"10383753\"]"},{"id":"32574271-231-238-2882292","span":{"begin":803,"end":806},"obj":"[\"25286931\"]"},{"id":"32574271-84-91-2882293","span":{"begin":893,"end":896},"obj":"[\"25286931\"]"},{"id":"32574271-77-84-2882294","span":{"begin":976,"end":979},"obj":"[\"7359228\"]"},{"id":"32574271-58-64-2882295","span":{"begin":1257,"end":1259},"obj":"[\"28914813\"]"},{"id":"32574271-77-84-2882296","span":{"begin":1393,"end":1396},"obj":"[\"27234406\"]"}],"attributes":[{"subj":"32574271-179-186-2882289","pred":"source","obj":"TEST0"},{"subj":"32574271-92-99-2882290","pred":"source","obj":"TEST0"},{"subj":"32574271-235-242-2882291","pred":"source","obj":"TEST0"},{"subj":"32574271-231-238-2882292","pred":"source","obj":"TEST0"},{"subj":"32574271-84-91-2882293","pred":"source","obj":"TEST0"},{"subj":"32574271-77-84-2882294","pred":"source","obj":"TEST0"},{"subj":"32574271-58-64-2882295","pred":"source","obj":"TEST0"},{"subj":"32574271-77-84-2882296","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"32574271-25286931-34514697","span":{"begin":179,"end":182},"obj":"25286931"},{"id":"32574271-18675317-34514698","span":{"begin":351,"end":354},"obj":"18675317"},{"id":"32574271-10383753-34514699","span":{"begin":500,"end":503},"obj":"10383753"},{"id":"32574271-25286931-34514700","span":{"begin":803,"end":806},"obj":"25286931"},{"id":"32574271-25286931-34514701","span":{"begin":893,"end":896},"obj":"25286931"},{"id":"32574271-7359228-34514702","span":{"begin":976,"end":979},"obj":"7359228"},{"id":"32574271-28914813-34514703","span":{"begin":1257,"end":1259},"obj":"28914813"},{"id":"32574271-27234406-34514704","span":{"begin":1393,"end":1396},"obj":"27234406"}],"attributes":[{"subj":"32574271-25286931-34514697","pred":"source","obj":"2_test"},{"subj":"32574271-18675317-34514698","pred":"source","obj":"2_test"},{"subj":"32574271-10383753-34514699","pred":"source","obj":"2_test"},{"subj":"32574271-25286931-34514700","pred":"source","obj":"2_test"},{"subj":"32574271-25286931-34514701","pred":"source","obj":"2_test"},{"subj":"32574271-7359228-34514702","pred":"source","obj":"2_test"},{"subj":"32574271-28914813-34514703","pred":"source","obj":"2_test"},{"subj":"32574271-27234406-34514704","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#c0ec93","default":true},{"id":"LitCovid-PubTator","color":"#ec93db"},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ece3"},{"id":"LitCovid-PD-UBERON","color":"#ecc993"},{"id":"LitCovid-PD-MONDO","color":"#af93ec"},{"id":"LitCovid-PD-CLO","color":"#93ec95"},{"id":"LitCovid-PD-CHEBI","color":"#ec93aa"},{"id":"LitCovid-PD-GO-BP","color":"#93c4ec"},{"id":"LitCovid-sentences","color":"#deec93"},{"id":"LitCovid-PD-HP","color":"#df93ec"},{"id":"MyTest","color":"#93ecc5"},{"id":"TEST0","color":"#ecab93"},{"id":"2_test","color":"#9394ec"}]}]}}