PMC:7271924 / 17768-19166
Annnotations
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T305 | 78-87 | NCBITaxon:39107 | denotes | Moraxella |
T306 | 166-177 | PR:000016261 | denotes | transferrin |
T307 | 225-234 | NCBITaxon:2 | denotes | bacterial |
T308 | 292-300 | NCBITaxon:2 | denotes | bacteria |
T309 | 308-320 | CHEBI:26672;CHEBI:26672 | denotes | siderophores |
T310 | 438-449 | GO:0051235 | denotes | sequestered |
T311 | 453-457 | GO:0018995 | denotes | host |
T312 | 458-469 | PR:000016261 | denotes | transferrin |
T313 | 471-482 | PR:000009978 | denotes | lactoferrin |
T314 | 531-539 | GO:0016020 | denotes | membrane |
T315 | 603-617 | GO:0019867 | denotes | outer membrane |
T316 | 619-623 | PR:000022758 | denotes | TbpA |
T317 | 628-639 | PR:000016261 | denotes | transferrin |
T318 | 653-664 | PR:000009978 | denotes | lactoferrin |
T319 | 711-722 | PR:000009978 | denotes | lactoferrin |
T320 | 723-734 | PR:000016261 | denotes | transferrin |
T321 | 755-759 | PR:P34123 | denotes | TbpB |
T322 | 764-775 | PR:000016261 | denotes | transferrin |
T323 | 789-800 | PR:000009978 | denotes | lactoferrin |
T324 | 834-845 | PR:000009978 | denotes | lactoferrin |
T325 | 855-859 | PR:P34123 | denotes | TbpB |
T326 | 880-891 | PR:000016261 | denotes | transferrin |
T327 | 931-936 | SP_6;NCBITaxon:9606 | denotes | human |
T328 | 937-941 | UBERON:0001913 | denotes | milk |
T329 | 1015-1023 | NCBITaxon:2 | denotes | bacteria |
T330 | 1028-1039 | CHEBI:30808;CHEBI:30808 | denotes | ferric iron |
T331 | 1058-1071 | GO:0008283 | denotes | proliferation |
T332 | 1178-1187 | NCBITaxon:2 | denotes | bacterial |
T333 | 1243-1247 | GO:0006968 | denotes | host |
T334 | 1248-1255 | GO:0006952 | denotes | defense |
T335 | 1355-1361 | GO:0045087 | denotes | innate |
T336 | 1366-1374 | GO:0002250 | denotes | adaptive |
T337 | 1375-1381 | GO:0002250;UBERON:0002405 | denotes | immune |
T338 | 1382-1391 | GO:0002250 | denotes | responses |
T26947 | 78-87 | NCBITaxon:39107 | denotes | Moraxella |
T65420 | 166-177 | PR:000016261 | denotes | transferrin |
T21588 | 225-234 | NCBITaxon:2 | denotes | bacterial |
T49891 | 292-300 | NCBITaxon:2 | denotes | bacteria |
T30797 | 308-320 | CHEBI:26672;CHEBI:26672 | denotes | siderophores |
T12367 | 438-449 | GO:0051235 | denotes | sequestered |
T80327 | 453-457 | GO:0018995 | denotes | host |
T77009 | 458-469 | PR:000016261 | denotes | transferrin |
T40949 | 471-482 | PR:000009978 | denotes | lactoferrin |
T66596 | 531-539 | GO:0016020 | denotes | membrane |
T73998 | 603-617 | GO:0019867 | denotes | outer membrane |
T64162 | 619-623 | PR:000022758 | denotes | TbpA |
T34393 | 628-639 | PR:000016261 | denotes | transferrin |
T65453 | 653-664 | PR:000009978 | denotes | lactoferrin |
T27946 | 711-722 | PR:000009978 | denotes | lactoferrin |
T46165 | 723-734 | PR:000016261 | denotes | transferrin |
T57015 | 755-759 | PR:P34123 | denotes | TbpB |
T55928 | 764-775 | PR:000016261 | denotes | transferrin |
T97295 | 789-800 | PR:000009978 | denotes | lactoferrin |
T99285 | 834-845 | PR:000009978 | denotes | lactoferrin |
T38439 | 855-859 | PR:P34123 | denotes | TbpB |
T87300 | 880-891 | PR:000016261 | denotes | transferrin |
T90222 | 931-936 | SP_6;NCBITaxon:9606 | denotes | human |
T78826 | 937-941 | UBERON:0001913 | denotes | milk |
T31225 | 1015-1023 | NCBITaxon:2 | denotes | bacteria |
T47845 | 1028-1039 | CHEBI:30808;CHEBI:30808 | denotes | ferric iron |
T96516 | 1058-1071 | GO:0008283 | denotes | proliferation |
T81850 | 1178-1187 | NCBITaxon:2 | denotes | bacterial |
T70301 | 1243-1247 | GO:0006968 | denotes | host |
T95712 | 1248-1255 | GO:0006952 | denotes | defense |
T65079 | 1355-1361 | GO:0045087 | denotes | innate |
T33909 | 1366-1374 | GO:0002250 | denotes | adaptive |
T42958 | 1375-1381 | GO:0002250;UBERON:0002405 | denotes | immune |
T16651 | 1382-1391 | GO:0002250 | denotes | responses |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
428 | 166-177 | Gene | denotes | transferrin | Gene:7018 |
429 | 458-469 | Gene | denotes | transferrin | Gene:7018 |
430 | 471-482 | Gene | denotes | lactoferrin | Gene:280846 |
431 | 619-623 | Gene | denotes | TbpA | Gene:7276 |
432 | 628-639 | Gene | denotes | transferrin | Gene:7018 |
433 | 653-664 | Gene | denotes | lactoferrin | Gene:280846 |
434 | 711-722 | Gene | denotes | lactoferrin | Gene:280846 |
435 | 723-734 | Gene | denotes | transferrin | Gene:7018 |
436 | 764-775 | Gene | denotes | transferrin | Gene:7018 |
437 | 789-800 | Gene | denotes | lactoferrin | Gene:280846 |
438 | 834-845 | Gene | denotes | lactoferrin | Gene:280846 |
439 | 880-891 | Gene | denotes | transferrin | Gene:7018 |
440 | 609-617 | Gene | denotes | membrane | Gene:43740571 |
441 | 185-200 | Species | denotes | N. meningitidis | Tax:487 |
442 | 249-257 | Species | denotes | children | Tax:9606 |
443 | 931-936 | Species | denotes | human | Tax:9606 |
444 | 531-539 | Gene | denotes | membrane | Gene:43740571 |
445 | 140-144 | Chemical | denotes | iron | MESH:D007501 |
446 | 345-349 | Chemical | denotes | iron | MESH:D007501 |
447 | 433-437 | Chemical | denotes | iron | MESH:D007501 |
448 | 587-591 | Chemical | denotes | iron | MESH:D007501 |
449 | 699-703 | Chemical | denotes | iron | MESH:D007501 |
450 | 1028-1039 | Chemical | denotes | ferric iron | |
451 | 57-73 | Disease | denotes | genera Neisseria | MESH:D006069 |
452 | 225-245 | Disease | denotes | bacterial meningitis | MESH:D016920 |
453 | 357-366 | Disease | denotes | Neisseria | MESH:D006069 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T201 | 391-398 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T202 | 488-498 | Body_part | denotes | hemoglobin | http://purl.org/sig/ont/fma/fma62293 |
T203 | 673-684 | Body_part | denotes | lipoprotein | http://purl.org/sig/ont/fma/fma63169 |
T204 | 937-941 | Body_part | denotes | milk | http://purl.org/sig/ont/fma/fma62100 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T36 | 826-830 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
T37 | 872-876 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
T38 | 937-941 | Body_part | denotes | milk | http://purl.obolibrary.org/obo/UBERON_0001913 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T31 | 225-245 | Disease | denotes | bacterial meningitis | http://purl.obolibrary.org/obo/MONDO_0006670 |
T32 | 235-245 | Disease | denotes | meningitis | http://purl.obolibrary.org/obo/MONDO_0004796|http://purl.obolibrary.org/obo/MONDO_0021108 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T234 | 204-205 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T235 | 292-300 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
T236 | 367-370 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T237 | 379-380 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T238 | 529-530 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T239 | 531-539 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T240 | 609-617 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T241 | 671-672 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T242 | 931-936 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T243 | 1015-1023 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
T244 | 1218-1219 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T245 | 1340-1341 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T224 | 140-144 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
T225 | 159-161 | Chemical | denotes | LF | http://purl.obolibrary.org/obo/CHEBI_73585 |
T226 | 308-320 | Chemical | denotes | siderophores | http://purl.obolibrary.org/obo/CHEBI_26672 |
T227 | 345-349 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
T228 | 391-398 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T229 | 433-437 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
T230 | 488-498 | Chemical | denotes | hemoglobin | http://purl.obolibrary.org/obo/CHEBI_35143 |
T231 | 587-591 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
T232 | 673-684 | Chemical | denotes | lipoprotein | http://purl.obolibrary.org/obo/CHEBI_6495 |
T233 | 699-703 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
T234 | 925-927 | Chemical | denotes | LF | http://purl.obolibrary.org/obo/CHEBI_73585 |
T235 | 1028-1039 | Chemical | denotes | ferric iron | http://purl.obolibrary.org/obo/CHEBI_29034 |
T236 | 1035-1039 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
T237 | 1122-1124 | Chemical | denotes | LF | http://purl.obolibrary.org/obo/CHEBI_73585 |
T238 | 1199-1201 | Chemical | denotes | LF | http://purl.obolibrary.org/obo/CHEBI_73585 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T42 | 391-411 | http://purl.obolibrary.org/obo/GO_0015031 | denotes | protein transporters |
T43 | 546-557 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
T44 | 576-586 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transports |
T45 | 723-753 | http://purl.obolibrary.org/obo/GO_0033572 | denotes | transferrin to the transporter |
T46 | 742-753 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
T47 | 1366-1391 | http://purl.obolibrary.org/obo/GO_0002250 | denotes | adaptive immune responses |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T144 | 0-184 | Sentence | denotes | Several Gram-negative pathogens including members of the genera Neisseria and Moraxella have evolved two-component systems that can extract iron from the host LF and transferrin (157). |
T145 | 185-258 | Sentence | denotes | N. meningitidis is a principal cause of bacterial meningitis in children. |
T146 | 259-505 | Sentence | denotes | While the majority of pathogenic bacteria employ siderophores to chelate and scavenge iron (158), Neisseria has evolved a series of protein transporters that directly hijack iron sequestered in host transferrin, lactoferrin, and hemoglobin (159). |
T147 | 506-808 | Sentence | denotes | The system consists of a membrane-bound transporter that extracts and transports iron across the outer membrane (TbpA for transferrin and LbpA for lactoferrin), and a lipoprotein that delivers iron-loaded lactoferrin/transferrin to the transporter (TbpB for transferrin and LbpB for lactoferrin) (157). |
T148 | 809-898 | Sentence | denotes | LbpB binds the N-lobe of lactoferrin, whereas TbpB binds the C-lobe of transferrin (157). |
T149 | 899-1111 | Sentence | denotes | However, more than 90% of LF in human milk is in the form of apolactoferrin (160), which competes with siderophilic bacteria for ferric iron, and disrupts the proliferation of these microbial and other pathogens. |
T150 | 1112-1198 | Sentence | denotes | Similarly LF supplements may play an important role to counteract bacterial processes. |
T151 | 1199-1315 | Sentence | denotes | LF is consequently a significant element of host defense (19), and its levels may vary in health and during disease. |
T152 | 1316-1398 | Sentence | denotes | It is hence known to be a modulator of innate and adaptive immune responses (161). |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T6 | 235-245 | Phenotype | denotes | meningitis | http://purl.obolibrary.org/obo/HP_0001287 |
MyTest
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32574271-25286931-34514697 | 179-182 | 25286931 | denotes | 157 |
32574271-18675317-34514698 | 351-354 | 18675317 | denotes | 158 |
32574271-10383753-34514699 | 500-503 | 10383753 | denotes | 159 |
32574271-25286931-34514700 | 803-806 | 25286931 | denotes | 157 |
32574271-25286931-34514701 | 893-896 | 25286931 | denotes | 157 |
32574271-7359228-34514702 | 976-979 | 7359228 | denotes | 160 |
32574271-28914813-34514703 | 1257-1259 | 28914813 | denotes | 19 |
32574271-27234406-34514704 | 1393-1396 | 27234406 | denotes | 161 |
TEST0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32574271-179-186-2882289 | 179-182 | ["25286931"] | denotes | 157 |
32574271-92-99-2882290 | 351-354 | ["18675317"] | denotes | 158 |
32574271-235-242-2882291 | 500-503 | ["10383753"] | denotes | 159 |
32574271-231-238-2882292 | 803-806 | ["25286931"] | denotes | 157 |
32574271-84-91-2882293 | 893-896 | ["25286931"] | denotes | 157 |
32574271-77-84-2882294 | 976-979 | ["7359228"] | denotes | 160 |
32574271-58-64-2882295 | 1257-1259 | ["28914813"] | denotes | 19 |
32574271-77-84-2882296 | 1393-1396 | ["27234406"] | denotes | 161 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32574271-25286931-34514697 | 179-182 | 25286931 | denotes | 157 |
32574271-18675317-34514698 | 351-354 | 18675317 | denotes | 158 |
32574271-10383753-34514699 | 500-503 | 10383753 | denotes | 159 |
32574271-25286931-34514700 | 803-806 | 25286931 | denotes | 157 |
32574271-25286931-34514701 | 893-896 | 25286931 | denotes | 157 |
32574271-7359228-34514702 | 976-979 | 7359228 | denotes | 160 |
32574271-28914813-34514703 | 1257-1259 | 28914813 | denotes | 19 |
32574271-27234406-34514704 | 1393-1396 | 27234406 | denotes | 161 |