PMC:7264932 / 1064-2573 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7264932","sourcedb":"PMC","sourceid":"7264932","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7264932","text":"In the initial bronchoalveolar lavage of both patients only COVID-19 was found (PCR negative for influenza virus and respiratory syncytial virus); a follow-up bronchoalveolar lavage because of ongoing fever a few days later (days 5 and 6 after ICU admission) showed elevated galactomannan and growth of Aspergillus fumigatus in standard culture, suggesting IPA (Table 1 ). All patients received a chest computed tomography scan before ICU admittance with typical signs for COVID-19 pneumonia but no specific signs for IPA. Follow-up computed tomography scans were not performed for safety reasons.\nTable 1 Results of galactomannan (bronchoalveolar lavage and serum) and standard culture\nPatient 1(80 years, male, suspected pulmonary fibrosis) Patient 2(70 years, male, no risk factors)\nGalactomannan from BAL (ODI; normal range \u003c1.0) 6.3 6.1\nGalactomannan from serum (ODI; normal range \u003c0.5) 1.5 \u003c0.5\nStandard culture Aspergillus fumigatus Aspergillus fumigatus\nSARS-CoV-2 (at follow up) positive positive\nLaboratory parameters, mean at IPA diagnosis\n CRP (mg/dL) 26 5.1\n IL-6 (pg/mL) 460 82\n PCT (ng/mL) 3.7 0.4\n D-Dimer (μg/L) 4820 14 151\n LDH (U/L) 481 530\n Leucocyte count (G/L) 10.38 14.55\n Lymphocytes (%) 15 7\nRenal failure Yes Yes\nClassical risk factors for invasive pulmonary aspergillosis No No\nAbbreviations: BAL, bronchoalveolar lavage; CRP, C-reactive protein; IL-6, interleukin 6; IPA, invasive pulmonary aspergillosis; LDH, lactate dehydrogenase; ODI, optical density index; 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