PMC:7264932 / 1064-2573
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
50 | 1052-1055 | Gene | denotes | CRP | Gene:1401 |
51 | 1072-1076 | Gene | denotes | IL-6 | Gene:3569 |
52 | 687-694 | Species | denotes | Patient | Tax:9606 |
53 | 743-750 | Species | denotes | Patient | Tax:9606 |
54 | 918-939 | Species | denotes | Aspergillus fumigatus | Tax:746128 |
55 | 940-961 | Species | denotes | Aspergillus fumigatus | Tax:746128 |
56 | 962-972 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
57 | 723-741 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
58 | 1217-1230 | Disease | denotes | Renal failure | MESH:D051437 |
59 | 1266-1298 | Disease | denotes | invasive pulmonary aspergillosis | MESH:D055744 |
61 | 617-630 | Chemical | denotes | galactomannan | MESH:C012990 |
66 | 1349-1352 | Gene | denotes | CRP | Gene:1401 |
67 | 1354-1372 | Gene | denotes | C-reactive protein | Gene:1401 |
68 | 1374-1378 | Gene | denotes | IL-6 | Gene:3569 |
69 | 1400-1432 | Disease | denotes | invasive pulmonary aspergillosis | MESH:D055744 |
79 | 46-54 | Species | denotes | patients | Tax:9606 |
80 | 97-112 | Species | denotes | influenza virus | Tax:11309 |
81 | 117-148 | Species | denotes | respiratory syncytial virus); a | Tax:1439707 |
82 | 303-324 | Species | denotes | Aspergillus fumigatus | Tax:746128 |
83 | 377-385 | Species | denotes | patients | Tax:9606 |
84 | 275-288 | Chemical | denotes | galactomannan | MESH:C012990 |
85 | 60-68 | Disease | denotes | COVID-19 | MESH:C000657245 |
86 | 201-206 | Disease | denotes | fever | MESH:D005334 |
87 | 473-491 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T4 | 397-402 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
T5 | 659-664 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T6 | 861-866 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T7 | 1161-1170 | Body_part | denotes | Leucocyte | http://purl.org/sig/ont/fma/fma62852 |
T8 | 1196-1207 | Body_part | denotes | Lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
T9 | 1365-1372 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T10 | 1380-1393 | Body_part | denotes | interleukin 6 | http://purl.org/sig/ont/fma/fma264829 |
T11 | 1380-1391 | Body_part | denotes | interleukin | http://purl.org/sig/ont/fma/fma86578 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 397-402 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
T2 | 659-664 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T3 | 861-866 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T14 | 201-206 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
T15 | 357-360 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
T16 | 482-491 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
T17 | 518-521 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
T18 | 723-741 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
T19 | 1037-1040 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
T20 | 1217-1230 | Phenotype | denotes | Renal failure | http://purl.obolibrary.org/obo/HP_0000083 |
T21 | 1266-1298 | Phenotype | denotes | invasive pulmonary aspergillosis | http://purl.obolibrary.org/obo/HP_0020103 |
T22 | 1395-1398 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
T23 | 1400-1432 | Phenotype | denotes | invasive pulmonary aspergillosis | http://purl.obolibrary.org/obo/HP_0020103 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T20 | 60-68 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T21 | 97-106 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T22 | 473-481 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T23 | 482-491 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
T24 | 723-741 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
T25 | 962-970 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T26 | 1093-1096 | Disease | denotes | PCT | http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104 |
T28 | 1217-1230 | Disease | denotes | Renal failure | http://purl.obolibrary.org/obo/MONDO_0001106 |
T29 | 1285-1298 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
T30 | 1419-1432 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
T31 | 1490-1493 | Disease | denotes | PCT | http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4 | 107-112 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T5 | 139-144 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T6 | 147-148 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T7 | 207-208 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T8 | 395-396 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T9 | 397-402 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
T10 | 707-711 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
T11 | 707-711 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
T12 | 763-767 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
T13 | 763-767 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
T14 | 1078-1080 | http://purl.obolibrary.org/obo/CLO_0008426 | denotes | pg |
T15 | 1161-1170 | http://purl.obolibrary.org/obo/CL_0000738 | denotes | Leucocyte |
T16 | 1380-1393 | http://purl.obolibrary.org/obo/PR_000001393 | denotes | interleukin 6 |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T8 | 275-288 | Chemical | denotes | galactomannan | http://purl.obolibrary.org/obo/CHEBI_27680 |
T9 | 357-360 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
T11 | 518-521 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
T13 | 617-630 | Chemical | denotes | galactomannan | http://purl.obolibrary.org/obo/CHEBI_27680 |
T14 | 707-711 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
T15 | 763-767 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
T16 | 805-808 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
T17 | 1037-1040 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
T19 | 1072-1074 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T21 | 1320-1323 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
T22 | 1365-1372 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T23 | 1374-1376 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T25 | 1395-1398 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
T27 | 1439-1446 | Chemical | denotes | lactate | http://purl.obolibrary.org/obo/CHEBI_24996 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 293-299 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T1 | 275-288 | GlycoEpitope | denotes | galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
T2 | 617-630 | GlycoEpitope | denotes | galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
T3 | 786-799 | GlycoEpitope | denotes | Galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
T4 | 842-855 | GlycoEpitope | denotes | Galactomannan | http://www.glycoepitope.jp/epitopes/EP0510 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T7 | 0-372 | Sentence | denotes | In the initial bronchoalveolar lavage of both patients only COVID-19 was found (PCR negative for influenza virus and respiratory syncytial virus); a follow-up bronchoalveolar lavage because of ongoing fever a few days later (days 5 and 6 after ICU admission) showed elevated galactomannan and growth of Aspergillus fumigatus in standard culture, suggesting IPA (Table 1 ). |
T8 | 373-522 | Sentence | denotes | All patients received a chest computed tomography scan before ICU admittance with typical signs for COVID-19 pneumonia but no specific signs for IPA. |
T9 | 523-597 | Sentence | denotes | Follow-up computed tomography scans were not performed for safety reasons. |
T10 | 598-686 | Sentence | denotes | Table 1 Results of galactomannan (bronchoalveolar lavage and serum) and standard culture |
T11 | 687-785 | Sentence | denotes | Patient 1(80 years, male, suspected pulmonary fibrosis) Patient 2(70 years, male, no risk factors) |
T12 | 786-841 | Sentence | denotes | Galactomannan from BAL (ODI; normal range <1.0) 6.3 6.1 |
T13 | 842-900 | Sentence | denotes | Galactomannan from serum (ODI; normal range <0.5) 1.5 <0.5 |
T14 | 901-961 | Sentence | denotes | Standard culture Aspergillus fumigatus Aspergillus fumigatus |
T15 | 962-1005 | Sentence | denotes | SARS-CoV-2 (at follow up) positive positive |
T16 | 1006-1050 | Sentence | denotes | Laboratory parameters, mean at IPA diagnosis |
T17 | 1051-1070 | Sentence | denotes | CRP (mg/dL) 26 5.1 |
T18 | 1071-1091 | Sentence | denotes | IL-6 (pg/mL) 460 82 |
T19 | 1092-1112 | Sentence | denotes | PCT (ng/mL) 3.7 0.4 |
T20 | 1113-1140 | Sentence | denotes | D-Dimer (μg/L) 4820 14 151 |
T21 | 1141-1159 | Sentence | denotes | LDH (U/L) 481 530 |
T22 | 1160-1194 | Sentence | denotes | Leucocyte count (G/L) 10.38 14.55 |
T23 | 1195-1216 | Sentence | denotes | Lymphocytes (%) 15 7 |
T24 | 1217-1238 | Sentence | denotes | Renal failure Yes Yes |
T25 | 1239-1304 | Sentence | denotes | Classical risk factors for invasive pulmonary aspergillosis No No |
T26 | 1305-1509 | Sentence | denotes | Abbreviations: BAL, bronchoalveolar lavage; CRP, C-reactive protein; IL-6, interleukin 6; IPA, invasive pulmonary aspergillosis; LDH, lactate dehydrogenase; ODI, optical density index; PCT, procalcitonin. |