PMC:7264098 / 21057-23119 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7264098","sourcedb":"PMC","sourceid":"7264098","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7264098","text":"Factors Affecting the Quality of MSC\nThe successful translation of MSC-based therapies into the clinic for treatment of COVID-19-induced lung injuries is dependent on a number of factors. In addition to desirable therapeutic effects, it is also important to understand the mechanism of action and the influence of various in vivo environments on the integrity of these cells. Stem cells can be environmentally preconditioned by certain stimuli such as hypoxia or ischemia, which can induce certain signaling pathways to improve engraftment, survival, and function of transplanted cells in harsh environments within the injured lung (Sart et al., 2014; Kim et al., 2015; Saparov et al., 2016). Other methods of preconditioning stem cells include the formation of three-dimensional stem cell aggregates that lead to enhanced extracellular matrix secretion, anti-inflammatory properties and cell survival (Bartosh et al., 2010; Sart et al., 2014). Pre-treatment of MSCs with various pharmacological factors can, in fact, improve therapeutic effects and tissue repair capabilities (Hu and Li, 2018).\nFurthermore, bioengineering approaches such as the use of bioreactors can overcome the limitations of a large scale production of stem cells necessary for transplantation and maintenance of the stemness during and after delivery to patients (Madl et al., 2018). Therefore, these technologies can accelerate the transition from bench to bedside without compromising the quality of the stem cells reaching patients. For example, tuneable materials can be used as an artificial niche to expand or differentiate stem cells to mature cell types (Yang et al., 2014; Madl et al., 2017). Materials such as hydrogels used as carriers for stem cells can also lead to enhanced regenerative response by regulating fate and activity of transplanted stem cells (Engler et al., 2006; Chaudhuri et al., 2016). These approaches are currently less widely used for pulmonary applications compared to other target organs and thus future investigations will lead to innovative 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