PMC:7258756 / 17105-17870 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"258","span":{"begin":681,"end":686},"obj":"Gene"},{"id":"259","span":{"begin":442,"end":447},"obj":"Gene"},{"id":"260","span":{"begin":174,"end":179},"obj":"Gene"},{"id":"261","span":{"begin":82,"end":87},"obj":"Gene"},{"id":"262","span":{"begin":118,"end":122},"obj":"Gene"},{"id":"263","span":{"begin":7,"end":17},"obj":"Species"},{"id":"264","span":{"begin":485,"end":495},"obj":"Species"},{"id":"265","span":{"begin":535,"end":545},"obj":"Species"},{"id":"266","span":{"begin":581,"end":591},"obj":"Species"},{"id":"267","span":{"begin":401,"end":409},"obj":"Chemical"}],"attributes":[{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"Gene:43740568"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"Gene:43740568"},{"id":"A260","pred":"tao:has_database_id","subj":"260","obj":"Gene:43740568"},{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"Gene:43740568"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"Gene:6195"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"Tax:2697049"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"Tax:2697049"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"Tax:2697049"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"Tax:2697049"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"MESH:D014443"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Indian SARS-CoV-2 sequences showed two changes 408 Arg→Ile and 930 Ala→Val in the spike protein compared to the Wuhan Hu-1 sequence. The mutations were further mapped on the spike protein model of the Indian sequence (Supplementary Fig. 1 (available from http://www.ijmr.org.in/articles/2020/151/2/images/IndianJMedRes_2020_151_2_200_281471_sm6.pdf)). Deletion of a three-nucleotide stretch, encoding tyrosine residue at position 144, of the spike gene was also observed in the Indian SARS-CoV-2 from case 1 when compared to the other SARS-CoV-2 sequences. As noted in the earlier SARS-CoV-2 sequences, both the Indian sequences possessed the polybasic cleavage site (RRAR) in the spike protein at the junction of S1 and S2, the two subunits of the spike protein19."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T88","span":{"begin":88,"end":95},"obj":"Body_part"},{"id":"T89","span":{"begin":180,"end":187},"obj":"Body_part"},{"id":"T90","span":{"begin":372,"end":382},"obj":"Body_part"},{"id":"T91","span":{"begin":401,"end":409},"obj":"Body_part"},{"id":"T92","span":{"begin":448,"end":452},"obj":"Body_part"},{"id":"T93","span":{"begin":687,"end":694},"obj":"Body_part"}],"attributes":[{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A92","pred":"fma_id","subj":"T92","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Indian SARS-CoV-2 sequences showed two changes 408 Arg→Ile and 930 Ala→Val in the spike protein compared to the Wuhan Hu-1 sequence. The mutations were further mapped on the spike protein model of the Indian sequence (Supplementary Fig. 1 (available from http://www.ijmr.org.in/articles/2020/151/2/images/IndianJMedRes_2020_151_2_200_281471_sm6.pdf)). Deletion of a three-nucleotide stretch, encoding tyrosine residue at position 144, of the spike gene was also observed in the Indian SARS-CoV-2 from case 1 when compared to the other SARS-CoV-2 sequences. As noted in the earlier SARS-CoV-2 sequences, both the Indian sequences possessed the polybasic cleavage site (RRAR) in the spike protein at the junction of S1 and S2, the two subunits of the spike protein19."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T141","span":{"begin":7,"end":15},"obj":"Disease"},{"id":"T142","span":{"begin":7,"end":11},"obj":"Disease"},{"id":"T143","span":{"begin":485,"end":493},"obj":"Disease"},{"id":"T144","span":{"begin":485,"end":489},"obj":"Disease"},{"id":"T145","span":{"begin":535,"end":543},"obj":"Disease"},{"id":"T146","span":{"begin":535,"end":539},"obj":"Disease"},{"id":"T147","span":{"begin":581,"end":589},"obj":"Disease"},{"id":"T148","span":{"begin":581,"end":585},"obj":"Disease"}],"attributes":[{"id":"A141","pred":"mondo_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Indian SARS-CoV-2 sequences showed two changes 408 Arg→Ile and 930 Ala→Val in the spike protein compared to the Wuhan Hu-1 sequence. The mutations were further mapped on the spike protein model of the Indian sequence (Supplementary Fig. 1 (available from http://www.ijmr.org.in/articles/2020/151/2/images/IndianJMedRes_2020_151_2_200_281471_sm6.pdf)). Deletion of a three-nucleotide stretch, encoding tyrosine residue at position 144, of the spike gene was also observed in the Indian SARS-CoV-2 from case 1 when compared to the other SARS-CoV-2 sequences. As noted in the earlier SARS-CoV-2 sequences, both the Indian sequences possessed the polybasic cleavage site (RRAR) in the spike protein at the junction of S1 and S2, the two subunits of the spike protein19."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T116","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/CLO_0037067"},{"id":"T117","span":{"begin":364,"end":365},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T118","span":{"begin":448,"end":452},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T119","span":{"begin":702,"end":710},"obj":"http://purl.obolibrary.org/obo/UBERON_0007651"},{"id":"T120","span":{"begin":714,"end":716},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T121","span":{"begin":721,"end":723},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T122","span":{"begin":721,"end":723},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"}],"text":"Indian SARS-CoV-2 sequences showed two changes 408 Arg→Ile and 930 Ala→Val in the spike protein compared to the Wuhan Hu-1 sequence. The mutations were further mapped on the spike protein model of the Indian sequence (Supplementary Fig. 1 (available from http://www.ijmr.org.in/articles/2020/151/2/images/IndianJMedRes_2020_151_2_200_281471_sm6.pdf)). Deletion of a three-nucleotide stretch, encoding tyrosine residue at position 144, of the spike gene was also observed in the Indian SARS-CoV-2 from case 1 when compared to the other SARS-CoV-2 sequences. As noted in the earlier SARS-CoV-2 sequences, both the Indian sequences possessed the polybasic cleavage site (RRAR) in the spike protein at the junction of S1 and S2, the two subunits of the spike protein19."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T75","span":{"begin":51,"end":54},"obj":"Chemical"},{"id":"T77","span":{"begin":55,"end":58},"obj":"Chemical"},{"id":"T79","span":{"begin":67,"end":70},"obj":"Chemical"},{"id":"T81","span":{"begin":71,"end":74},"obj":"Chemical"},{"id":"T83","span":{"begin":88,"end":95},"obj":"Chemical"},{"id":"T84","span":{"begin":180,"end":187},"obj":"Chemical"},{"id":"T85","span":{"begin":372,"end":382},"obj":"Chemical"},{"id":"T86","span":{"begin":401,"end":417},"obj":"Chemical"},{"id":"T87","span":{"begin":401,"end":409},"obj":"Chemical"},{"id":"T88","span":{"begin":687,"end":694},"obj":"Chemical"},{"id":"T89","span":{"begin":721,"end":723},"obj":"Chemical"}],"attributes":[{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A76","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_29952"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_17191"},{"id":"A78","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_30009"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_16977"},{"id":"A80","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_46217"},{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_16414"},{"id":"A82","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_30015"},{"id":"A83","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A84","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A85","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A86","pred":"chebi_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/CHEBI_32789"},{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A88","pred":"chebi_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"}],"text":"Indian SARS-CoV-2 sequences showed two changes 408 Arg→Ile and 930 Ala→Val in the spike protein compared to the Wuhan Hu-1 sequence. The mutations were further mapped on the spike protein model of the Indian sequence (Supplementary Fig. 1 (available from http://www.ijmr.org.in/articles/2020/151/2/images/IndianJMedRes_2020_151_2_200_281471_sm6.pdf)). Deletion of a three-nucleotide stretch, encoding tyrosine residue at position 144, of the spike gene was also observed in the Indian SARS-CoV-2 from case 1 when compared to the other SARS-CoV-2 sequences. As noted in the earlier SARS-CoV-2 sequences, both the Indian sequences possessed the polybasic cleavage site (RRAR) in the spike protein at the junction of S1 and S2, the two subunits of the spike protein19."}

{"project":"LitCovid-sentences","denotations":[{"id":"T131","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T132","span":{"begin":133,"end":351},"obj":"Sentence"},{"id":"T133","span":{"begin":352,"end":556},"obj":"Sentence"},{"id":"T134","span":{"begin":557,"end":765},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Indian SARS-CoV-2 sequences showed two changes 408 Arg→Ile and 930 Ala→Val in the spike protein compared to the Wuhan Hu-1 sequence. The mutations were further mapped on the spike protein model of the Indian sequence (Supplementary Fig. 1 (available from http://www.ijmr.org.in/articles/2020/151/2/images/IndianJMedRes_2020_151_2_200_281471_sm6.pdf)). Deletion of a three-nucleotide stretch, encoding tyrosine residue at position 144, of the spike gene was also observed in the Indian SARS-CoV-2 from case 1 when compared to the other SARS-CoV-2 sequences. As noted in the earlier SARS-CoV-2 sequences, both the Indian sequences possessed the polybasic cleavage site (RRAR) in the spike protein at the junction of S1 and S2, the two subunits of the spike protein19."}