PMC:7253482 / 13216-13798 JSONTXT

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SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T80","span":{"begin":43,"end":51},"obj":"Body_part"},{"id":"T81","span":{"begin":77,"end":84},"obj":"Body_part"},{"id":"T82","span":{"begin":125,"end":132},"obj":"Body_part"},{"id":"T83","span":{"begin":255,"end":262},"obj":"Body_part"}],"attributes":[{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T111","span":{"begin":43,"end":51},"obj":"Chemical"},{"id":"T112","span":{"begin":77,"end":84},"obj":"Chemical"},{"id":"T113","span":{"begin":125,"end":132},"obj":"Chemical"},{"id":"T114","span":{"begin":162,"end":169},"obj":"Chemical"},{"id":"T115","span":{"begin":231,"end":238},"obj":"Chemical"},{"id":"T116","span":{"begin":255,"end":262},"obj":"Chemical"},{"id":"T117","span":{"begin":401,"end":408},"obj":"Chemical"},{"id":"T118","span":{"begin":532,"end":539},"obj":"Chemical"}],"attributes":[{"id":"A111","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A112","pred":"chebi_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/CHEBI_37684"},{"id":"A113","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_37684"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T94","span":{"begin":15,"end":19},"obj":"Species"},{"id":"T95","span":{"begin":364,"end":368},"obj":"Species"}],"attributes":[{"id":"A94","pred":"ncbi_taxonomy_id","subj":"T94","obj":"NCBItxid:694009"},{"id":"A95","pred":"ncbi_taxonomy_id","subj":"T95","obj":"NCBItxid:1335626"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T81","span":{"begin":0,"end":190},"obj":"Sentence"},{"id":"T82","span":{"begin":191,"end":369},"obj":"Sentence"},{"id":"T83","span":{"begin":370,"end":582},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T46","span":{"begin":15,"end":19},"obj":"Disease"}],"attributes":[{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"510","span":{"begin":15,"end":19},"obj":"Disease"},{"id":"500","span":{"begin":77,"end":84},"obj":"Chemical"},{"id":"501","span":{"begin":125,"end":132},"obj":"Chemical"},{"id":"502","span":{"begin":162,"end":169},"obj":"Chemical"},{"id":"503","span":{"begin":213,"end":225},"obj":"Chemical"},{"id":"504","span":{"begin":231,"end":238},"obj":"Chemical"},{"id":"505","span":{"begin":286,"end":292},"obj":"Chemical"},{"id":"506","span":{"begin":323,"end":329},"obj":"Chemical"},{"id":"511","span":{"begin":364,"end":368},"obj":"Disease"},{"id":"507","span":{"begin":383,"end":395},"obj":"Chemical"},{"id":"508","span":{"begin":401,"end":408},"obj":"Chemical"},{"id":"499","span":{"begin":466,"end":479},"obj":"Species"},{"id":"509","span":{"begin":532,"end":539},"obj":"Chemical"}],"attributes":[{"id":"A511","pred":"pubann:denotes","subj":"511","obj":"MESH:D018352"},{"id":"A500","pred":"pubann:denotes","subj":"500","obj":"MESH:D008358"},{"id":"A506","pred":"pubann:denotes","subj":"506","obj":"MESH:D011134"},{"id":"A505","pred":"pubann:denotes","subj":"505","obj":"MESH:D011134"},{"id":"A499","pred":"pubann:denotes","subj":"499","obj":"Tax:11118"},{"id":"A502","pred":"pubann:denotes","subj":"502","obj":"MESH:D011134"},{"id":"A508","pred":"pubann:denotes","subj":"508","obj":"MESH:D011134"},{"id":"A504","pred":"pubann:denotes","subj":"504","obj":"MESH:D011134"},{"id":"A509","pred":"pubann:denotes","subj":"509","obj":"MESH:D011134"},{"id":"A501","pred":"pubann:denotes","subj":"501","obj":"MESH:D008358"},{"id":"A510","pred":"pubann:denotes","subj":"510","obj":"MESH:D045169"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T3636","span":{"begin":41,"end":51},"obj":"Protein"}],"attributes":[{"id":"A3636","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9UIP0"},{"id":"A3637","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9UIN9"},{"id":"A3638","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9UIN8"},{"id":"A3639","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9UIN7"},{"id":"A3640","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9UIN6"},{"id":"A3641","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9UBH8"},{"id":"A3642","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NRH8"},{"id":"A3643","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NRH7"},{"id":"A3644","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NRH6"},{"id":"A3645","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NRH5"},{"id":"A3646","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NRH4"},{"id":"A3647","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NPG5"},{"id":"A3648","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NPE0"},{"id":"A3649","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q9NP52"},{"id":"A3650","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q95IF9"},{"id":"A3651","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q8N5P3"},{"id":"A3652","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q8IZU6"},{"id":"A3653","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q8IZU5"},{"id":"A3654","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q8IZU4"},{"id":"A3655","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q86Z04"},{"id":"A3656","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q7YR44"},{"id":"A3657","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q7LA71"},{"id":"A3658","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q7LA70"},{"id":"A3659","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q5STD2"},{"id":"A3660","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q5SQ85"},{"id":"A3661","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q1XI16"},{"id":"A3662","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q1XI12"},{"id":"A3663","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/Q15517"},{"id":"A3664","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/O43509"},{"id":"A3665","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/O19084"},{"id":"A3666","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/B0UYZ7"},{"id":"A3667","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/B0S7V2"},{"id":"A3668","pred":"uniprot_id","subj":"T3636","obj":"https://www.uniprot.org/uniprot/A5A6L9"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T33","span":{"begin":437,"end":450},"obj":"http://purl.obolibrary.org/obo/GO_0045087"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T30","span":{"begin":437,"end":450},"obj":"http://purl.obolibrary.org/obo/GO_0045087"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T34","span":{"begin":437,"end":450},"obj":"http://purl.obolibrary.org/obo/GO_0045087"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sentences","denotations":[{"id":"T81","span":{"begin":0,"end":190},"obj":"Sentence"},{"id":"T82","span":{"begin":191,"end":369},"obj":"Sentence"},{"id":"T83","span":{"begin":370,"end":582},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}

{"project":"LitCovid-sample-Glycan","denotations":[{"id":"T47","span":{"begin":77,"end":84},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"T48","span":{"begin":125,"end":132},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"}],"text":"Interestingly, SARS and HKU1 (SI Fig. 2) S proteins did not exhibit specific mannose clusters that contribute to the overall mannose abundance, but only isolated glycans were underprocessed. We speculate that the oligomannose-type glycans here arise from protein-directed inhibition of glycan processing, as opposed to the glycan-influenced processing observed on MERS. Importantly, oligomannose-type glycans has also been implicated in innate immune recognition of coronaviruses by lectins47,48 that recognise these underprocessed glycans as pathogen-associated molecular patterns."}