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PMC:7253235 / 24625-27612 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
847 0-11 Species denotes Coronavirus Tax:11118
861 1161-1165 Gene denotes NSP2 Gene:6253
862 1170-1174 Gene denotes NSP3 Gene:10044
863 62-75 Species denotes Coronaviruses Tax:11118
864 201-214 Species denotes Coronaviridae Tax:11118
865 260-273 Species denotes coronaviruses Tax:11118
866 298-303 Species denotes human Tax:9606
867 458-468 Species denotes SARS-COV-2 Tax:2697049
868 512-515 Species denotes CoV Tax:11118
869 403-423 Disease denotes respiratory symptoms MESH:D012818
870 818-826 Disease denotes COVID-19 MESH:C000657245
871 827-836 Disease denotes infection MESH:D007239
872 929-948 Disease denotes SARS-CoV infections MESH:C000657245
873 1281-1289 Disease denotes COVID-19 MESH:C000657245
895 1347-1378 Gene denotes Angiotensin-Converting Enzyme 2 Gene:59272
896 1767-1771 Gene denotes ACE2 Gene:59272
897 2014-2018 Gene denotes ACE2 Gene:59272
898 1564-1577 Species denotes coronaviruses Tax:11118
899 1729-1737 Species denotes patients Tax:9606
900 1813-1821 Species denotes patients Tax:9606
901 1967-1975 Species denotes SARS-CoV Tax:694009
902 2064-2069 Species denotes human Tax:9606
903 2073-2078 Species denotes human Tax:9606
904 2168-2176 Species denotes SARS-CoV Tax:694009
905 2259-2265 Species denotes humans Tax:9606
906 1313-1321 Disease denotes COVID-19 MESH:C000657245
907 1495-1507 Disease denotes hypertension MESH:D006973
908 1512-1520 Disease denotes diabetes MESH:D003920
909 1585-1593 Disease denotes COVID-19 MESH:C000657245
910 1672-1692 Disease denotes respiratory symptoms MESH:D012818
911 1743-1765 Disease denotes cardiovascular disease MESH:D002318
912 1809-1812 Disease denotes CVD MESH:D002318
913 1899-1911 Disease denotes hypertension MESH:D006973
914 2343-2347 Disease denotes MERS MESH:D018352
915 2449-2458 Disease denotes pneumonia MESH:D011014
931 2719-2723 Gene denotes IL-2 Gene:3558
932 2725-2729 Gene denotes IL-7 Gene:3574
933 2731-2736 Gene denotes IL-10 Gene:3586
934 2738-2743 Gene denotes G-CSF Gene:1440
935 2745-2750 Gene denotes IP-10 Gene:3627
936 2752-2757 Gene denotes MCP-1 Gene:6347
937 2759-2765 Gene denotes MIP-1A Gene:6348
938 2771-2776 Gene denotes TNF-a Gene:7124
939 2548-2556 Species denotes patients Tax:9606
940 2604-2612 Species denotes patients Tax:9606
941 2668-2676 Species denotes patients Tax:9606
942 2682-2690 Species denotes patients Tax:9606
943 2835-2843 Disease denotes COVID-19 MESH:C000657245
944 2844-2853 Disease denotes infection MESH:D007239
945 2855-2859 Disease denotes ARDS MESH:D012128

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T42 158-161 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T43 692-699 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 732-737 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T45 960-966 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T46 1032-1035 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T47 1060-1068 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T48 1432-1436 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T49 1438-1448 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T50 1454-1459 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T51 1460-1466 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T52 1612-1627 Body_part denotes lung parenchyma http://purl.org/sig/ont/fma/fma27360
T53 1641-1657 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T54 1652-1657 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55 1982-1989 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 2412-2420 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T57 2568-2576 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T58 2702-2708 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T59 2719-2723 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T60 2740-2743 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T61 2796-2804 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T31 1432-1436 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T32 1454-1459 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T33 1460-1466 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T34 1612-1627 Body_part denotes lung parenchyma http://purl.obolibrary.org/obo/UBERON_0008946
T35 1612-1616 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T36 1617-1627 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T264 458-462 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T265 818-826 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T266 827-836 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T267 929-937 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T268 938-948 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T269 1236-1246 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T270 1281-1289 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T271 1313-1321 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T272 1495-1507 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T273 1512-1520 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T274 1585-1593 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T275 1743-1765 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T276 1899-1911 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T277 1967-1975 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T278 2168-2176 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T279 2348-2352 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T280 2449-2458 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T281 2835-2843 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T282 2844-2853 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T283 2855-2859 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T160 80-81 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T161 162-169 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T162 298-303 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T163 508-511 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T164 547-550 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T165 593-598 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T166 654-655 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T167 732-737 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T168 758-759 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T169 798-807 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T170 837-840 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T171 841-842 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T172 1086-1087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T173 1149-1157 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T174 1377-1381 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2, a
T175 1382-1390 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T176 1432-1436 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T177 1432-1436 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T178 1438-1448 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T179 1438-1448 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T180 1454-1459 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T181 1454-1459 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T182 1454-1459 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T183 1454-1459 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T184 1549-1550 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 1612-1616 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T186 1612-1616 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T187 1641-1651 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T188 1652-1657 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T189 2064-2069 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T190 2073-2078 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T191 2259-2265 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T192 2270-2276 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T193 2468-2469 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 2702-2708 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T195 2719-2723 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T196 2738-2743 http://purl.obolibrary.org/obo/PR_000005932 denotes G-CSF
T197 2775-2776 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T35 329-334 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T36 339-343 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T37 692-699 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T38 1060-1068 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T39 1347-1358 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T40 1851-1862 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T41 1982-1989 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T42 2719-2721 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T44 2725-2727 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T46 2731-2733 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T48 2745-2750 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T49 2745-2747 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T50 2752-2755 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T7 710-737 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry into host cells
T8 716-731 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into host
T9 1100-1112 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T10 1772-1781 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T11 2386-2407 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T155 1495-1507 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T156 1743-1765 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T157 1899-1911 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T158 2449-2458 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T160 0-61 Sentence denotes Coronavirus Structure and Foundation for Treatment Strategies
T161 62-246 Sentence denotes Coronaviruses are a large collection of single-stranded enveloped, non-segmented positive-sense RNA viruses that fall within the family of Coronaviridae and the order nidovirales [55].
T162 247-437 Sentence denotes Six specific coronaviruses have been identified as human-susceptible, among which alpha and beta subsets demonstrated lower pathogenicity and caused milder respiratory symptoms respectively.
T163 438-603 Sentence denotes Genomic analysis of SARS-COV-2 showcased 96.2% shared sequencing with bat CoV RATG13, thus positing that the bat variant served as the natural host of the virus [4].
T164 604-813 Sentence denotes However, the severe acute syndromes belong to the B-genus, with envelope-anchored spike protein mediating viral entry into host cells by first binding to a host receptor and subsequently fusing membranes [56].
T165 814-949 Sentence denotes The COVID-19 infection has a well-defined capsular structure with 14 binding residues, with 8 conserved from prior SARS-CoV infections.
T166 950-1124 Sentence denotes The viral genome contains several open reading frames, with majority of the viral RNA-encoding non-structural proteins (NSPs) that play a role in the pathogenesis of disease.
T167 1125-1295 Sentence denotes Recent research studies focusing on NSP2 and NSP3 demonstrated an in vivo role that these subunits may play in infectious capability and differentiation of COVID-19 [57].
T168 1296-1467 Sentence denotes Mechanistically, COVID-19 is found to be linked to Angiotensin-Converting Enzyme 2, a membrane-bound aminopeptidase highly expressed in lung, intestinal, and heart tissue.
T169 1468-1584 Sentence denotes Beyond being implicated in hypertension and diabetes, ACE-2 further functions as a receptor for coronaviruses [58•].
T170 1585-1766 Sentence denotes COVID-19 translocates into lung parenchyma via damaging epithelial cells, resulting in respiratory symptoms, with symptom severity worsening in patients with cardiovascular disease.
T171 1767-1912 Sentence denotes ACE2 secretion is noted to be elevated in CVD patients due to increased reliance on angiotensin-receptor blockers for management of hypertension.
T172 1913-2101 Sentence denotes At the receptor level, the receptor-binding domain of SARS-CoV spike protein specifically recognizes ACE2, which contributes to both cross-species and human-to-human transmission [59, 60].
T173 2102-2313 Sentence denotes Documented variability is demonstrated between various strains of SARS-CoV in terms of binding affinity and viral attachment, which is preserved across both humans and animal models of disease transmission [61].
T174 2314-2464 Sentence denotes The preserved domains across MERS/SARS may contribute to the heightened inflammatory response and cytokine milieu that leads to severe pneumonia [62].
T175 2465-2645 Sentence denotes On a molecular level, specific associations and descriptive characteristics of the patients identified cytokine abnormalities in ICU-level patients versus non-ICU–level admissions.
T176 2646-2783 Sentence denotes Compared with non-ICU patients, ICU patients had higher plasma levels of IL-2, IL-7, IL-10, G-CSF, IP-10, MCP-1, MIP-1A, and TNF-a [63•].
T177 2784-2987 Sentence denotes Though this cytokine thumbprint is being linked to COVID-19 infection, ARDS similarly showcases elevations in inflammatory markers, questioning origin and role of virally mediated hyperinflammation [64].

2_test

Id Subject Object Predicate Lexical cue
32462289-19430490-24380951 242-244 19430490 denotes 55
32462289-32015507-24380952 600-601 32015507 denotes 4
32462289-15165741-24380953 1579-1581 15165741 denotes 58
32462289-25428871-24380954 2093-2095 25428871 denotes 59
32462289-15791205-24380955 2309-2311 15791205 denotes 61
32462289-32192578-24380956 2983-2985 32192578 denotes 64