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PMC:7253235 / 13540-14946 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
485 199-202 Gene denotes BNP Gene:4879
486 447-451 Gene denotes HER2 Gene:2064
487 401-409 Species denotes patients Tax:9606
488 475-483 Species denotes patients Tax:9606
489 533-541 Species denotes patients Tax:9606
490 1221-1228 Species denotes patient Tax:9606
491 581-596 Gene denotes tyrosine kinase Gene:7294
492 420-434 Chemical denotes anthracyclines MESH:D018943
493 639-648 Chemical denotes ponatinib MESH:C545373
494 653-668 Chemical denotes fluoropyridines
495 676-690 Chemical denotes 5-fluorouracil MESH:D005472
496 1075-1086 Chemical denotes carfilzomib MESH:C524865
497 235-249 Disease denotes cardiotoxicity MESH:D066126
498 255-261 Disease denotes cancer MESH:D009369
499 383-397 Disease denotes cardiotoxicity MESH:D066126
500 703-717 Disease denotes cardiotoxicity MESH:D066126
501 733-760 Disease denotes coronary ischemia/vasospasm MESH:D003329
502 1024-1037 Disease denotes heart failure MESH:D006333
503 1092-1103 Disease denotes myocarditis MESH:D009205
504 1214-1220 Disease denotes cancer MESH:D009369
505 1249-1257 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T22 186-194 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T23 581-589 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T24 959-967 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T25 1024-1029 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T18 1024-1029 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T147 255-261 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T148 742-750 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T149 1024-1037 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T150 1092-1103 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T151 1214-1220 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T152 1249-1257 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T84 514-516 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T85 827-829 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T86 1016-1019 http://purl.obolibrary.org/obo/CLO_0002199 denotes CAR
T87 1024-1029 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T88 1024-1029 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T89 1024-1029 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T90 1024-1029 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T91 1149-1151 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T92 1212-1213 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 1315-1316 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T11 199-202 Chemical denotes BNP http://purl.obolibrary.org/obo/CHEBI_80234
T12 420-434 Chemical denotes anthracyclines http://purl.obolibrary.org/obo/CHEBI_48120|http://purl.obolibrary.org/obo/CHEBI_49322
T14 581-607 Chemical denotes tyrosine kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_38637
T15 581-589 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T16 597-607 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T17 639-648 Chemical denotes ponatinib http://purl.obolibrary.org/obo/CHEBI_78543
T18 676-690 Chemical denotes 5-fluorouracil http://purl.obolibrary.org/obo/CHEBI_46345
T19 999-1006 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T20 1043-1063 Chemical denotes proteasome inhibitor http://purl.obolibrary.org/obo/CHEBI_52726
T21 1054-1063 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T22 1075-1086 Chemical denotes carfilzomib http://purl.obolibrary.org/obo/CHEBI_65347
T23 1127-1136 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T6 590-607 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitors

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T83 27-35 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T84 255-261 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T85 751-760 Phenotype denotes vasospasm http://purl.obolibrary.org/obo/HP_0025637
T86 959-984 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T87 1024-1037 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T88 1092-1103 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T89 1214-1220 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T84 0-162 Sentence denotes In addition, in the cardio-oncology population, elevated cardiac biomarkers can pose an additional layer of complexity and challenge when dealing with management.
T85 163-312 Sentence denotes Abnormal elevations of troponin and BNP biomarkers can be indicative of cardiotoxicity from cancer physiology or from the treatments themselves [32].
T86 313-518 Sentence denotes Some elevations may be non-specific and are reflective of subclinical cardiotoxicity in patients receiving anthracyclines and/or anti-HER2 agents in which stable patients can be medically managed [33, 34].
T87 519-834 Sentence denotes However, some patients receiving other agents such as certain tyrosine kinase inhibitors with prothrombotic risk (i.e., ponatinib) or fluoropyridines (i.e., 5-fluorouracil) may suffer cardiotoxicity in the form of coronary ischemia/vasospasm, which may warrant more invasive diagnostic/treatment strategies [35–37].
T88 835-1153 Sentence denotes Elevated cardiac biomarkers have also been associated with worse outcomes and or cardiac hemodynamic instability, including cytokine release syndrome from chimeric antigen therapy (CAR-T), heart failure from proteasome inhibitor use (i.e., carfilzomib), or myocarditis from immune checkpoint inhibitor therapy [38–41].
T89 1154-1406 Sentence denotes Some of these disease processes may confound treatment of a cancer patient also afflicted with COVID-19, and thus, multidisciplinary assessment, particularly by a cardio-oncologist, may be essential to provide optimal care in this high-risk population.

2_test

Id Subject Object Predicate Lexical cue
32462289-28421484-24380940 308-310 28421484 denotes 32
32462289-31959034-24380941 514-516 31959034 denotes 34
32462289-27022039-24380942 827-829 27022039 denotes 35
32462289-29977352-24380942 827-829 29977352 denotes 35
32462289-31875699-24380942 827-829 31875699 denotes 35
32462289-29567210-24380943 1146-1148 29567210 denotes 38
32462289-29285538-24380943 1146-1148 29285538 denotes 38
32462289-29536852-24380943 1146-1148 29536852 denotes 38