PMC:7253233 / 2091-2647 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"99","span":{"begin":55,"end":63},"obj":"Species"},{"id":"100","span":{"begin":279,"end":287},"obj":"Species"},{"id":"101","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"102","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"103","span":{"begin":93,"end":101},"obj":"Disease"},{"id":"104","span":{"begin":149,"end":168},"obj":"Disease"},{"id":"105","span":{"begin":262,"end":277},"obj":"Disease"},{"id":"106","span":{"begin":311,"end":319},"obj":"Disease"},{"id":"107","span":{"begin":345,"end":359},"obj":"Disease"},{"id":"108","span":{"begin":431,"end":440},"obj":"Disease"},{"id":"109","span":{"begin":502,"end":510},"obj":"Disease"}],"attributes":[{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"Tax:9606"},{"id":"A100","pred":"tao:has_database_id","subj":"100","obj":"Tax:9606"},{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"MESH:D012640"},{"id":"A102","pred":"tao:has_database_id","subj":"102","obj":"MESH:C000657245"},{"id":"A103","pred":"tao:has_database_id","subj":"103","obj":"MESH:D012640"},{"id":"A104","pred":"tao:has_database_id","subj":"104","obj":"MESH:D001523"},{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"MESH:D001102"},{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"MESH:D012640"},{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"MESH:D001927"},{"id":"A108","pred":"tao:has_database_id","subj":"108","obj":"MESH:D004827"},{"id":"A109","pred":"tao:has_database_id","subj":"109","obj":"MESH:D012640"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T9","span":{"begin":176,"end":181},"obj":"Body_part"},{"id":"T10","span":{"begin":182,"end":187},"obj":"Body_part"},{"id":"T11","span":{"begin":227,"end":235},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T10","span":{"begin":176,"end":195},"obj":"Body_part"},{"id":"T11","span":{"begin":176,"end":181},"obj":"Body_part"},{"id":"T12","span":{"begin":182,"end":187},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0000120"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T22","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"T23","span":{"begin":262,"end":277},"obj":"Disease"},{"id":"T24","span":{"begin":268,"end":277},"obj":"Disease"},{"id":"T25","span":{"begin":345,"end":359},"obj":"Disease"}],"attributes":[{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0005560"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T22","span":{"begin":176,"end":181},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T23","span":{"begin":176,"end":181},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T24","span":{"begin":182,"end":187},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T25","span":{"begin":182,"end":187},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T26","span":{"begin":248,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":196,"end":205},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T3","span":{"begin":262,"end":277},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":18,"end":38},"obj":"Phenotype"},{"id":"T16","span":{"begin":93,"end":101},"obj":"Phenotype"},{"id":"T17","span":{"begin":311,"end":319},"obj":"Phenotype"},{"id":"T18","span":{"begin":345,"end":359},"obj":"Phenotype"},{"id":"T19","span":{"begin":502,"end":510},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0011145"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0001298"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0001250"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}

{"project":"LitCovid-sentences","denotations":[{"id":"T21","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T22","span":{"begin":12,"end":86},"obj":"Sentence"},{"id":"T23","span":{"begin":87,"end":278},"obj":"Sentence"},{"id":"T24","span":{"begin":279,"end":449},"obj":"Sentence"},{"id":"T25","span":{"begin":450,"end":556},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Conclusions\nAcute symptomatic seizures are possible in patients with COVID-19 disease. These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection. Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population."}