PMC:7253233 / 1115-2089 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"72","span":{"begin":0,"end":8},"obj":"Species"},{"id":"73","span":{"begin":320,"end":328},"obj":"Species"},{"id":"74","span":{"begin":548,"end":556},"obj":"Species"},{"id":"75","span":{"begin":747,"end":755},"obj":"Species"},{"id":"76","span":{"begin":920,"end":938},"obj":"Species"},{"id":"77","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"78","span":{"begin":59,"end":67},"obj":"Disease"},{"id":"79","span":{"begin":96,"end":104},"obj":"Disease"},{"id":"80","span":{"begin":148,"end":156},"obj":"Disease"},{"id":"81","span":{"begin":375,"end":383},"obj":"Disease"},{"id":"82","span":{"begin":434,"end":454},"obj":"Disease"},{"id":"83","span":{"begin":513,"end":534},"obj":"Disease"},{"id":"84","span":{"begin":576,"end":584},"obj":"Disease"},{"id":"85","span":{"begin":649,"end":662},"obj":"Disease"},{"id":"86","span":{"begin":683,"end":730},"obj":"Disease"},{"id":"87","span":{"begin":899,"end":916},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"Tax:9606"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"Tax:9606"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"Tax:9606"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"Tax:9606"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"Tax:2697049"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"MESH:C000657245"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"MESH:D012640"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"MESH:D012640"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"MESH:D012640"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"MESH:D012640"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"MESH:D001927"},{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"MESH:D009422"},{"id":"A84","pred":"tao:has_database_id","subj":"84","obj":"MESH:C000657245"},{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"MESH:D009102"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"MESH:D004211"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T4","span":{"begin":649,"end":654},"obj":"Body_part"},{"id":"T5","span":{"begin":718,"end":723},"obj":"Body_part"},{"id":"T6","span":{"begin":799,"end":804},"obj":"Body_part"},{"id":"T7","span":{"begin":805,"end":810},"obj":"Body_part"},{"id":"T8","span":{"begin":852,"end":860},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":649,"end":654},"obj":"Body_part"},{"id":"T6","span":{"begin":718,"end":723},"obj":"Body_part"},{"id":"T7","span":{"begin":799,"end":818},"obj":"Body_part"},{"id":"T8","span":{"begin":799,"end":804},"obj":"Body_part"},{"id":"T9","span":{"begin":805,"end":810},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0000120"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T14","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"T15","span":{"begin":440,"end":454},"obj":"Disease"},{"id":"T16","span":{"begin":576,"end":584},"obj":"Disease"},{"id":"T17","span":{"begin":636,"end":662},"obj":"Disease"},{"id":"T18","span":{"begin":697,"end":709},"obj":"Disease"},{"id":"T19","span":{"begin":718,"end":730},"obj":"Disease"},{"id":"T20","span":{"begin":724,"end":730},"obj":"Disease"},{"id":"T21","span":{"begin":920,"end":924},"obj":"Disease"}],"attributes":[{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005560"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0043726"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0001531"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0043510"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T15","span":{"begin":649,"end":654},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T16","span":{"begin":718,"end":723},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T17","span":{"begin":718,"end":723},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T18","span":{"begin":799,"end":804},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T19","span":{"begin":799,"end":804},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T20","span":{"begin":805,"end":810},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T21","span":{"begin":805,"end":810},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T4","span":{"begin":240,"end":249},"obj":"Chemical"}],"attributes":[{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_35717"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":782,"end":791},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T9","span":{"begin":59,"end":67},"obj":"Phenotype"},{"id":"T10","span":{"begin":96,"end":104},"obj":"Phenotype"},{"id":"T11","span":{"begin":140,"end":156},"obj":"Phenotype"},{"id":"T12","span":{"begin":375,"end":383},"obj":"Phenotype"},{"id":"T13","span":{"begin":434,"end":454},"obj":"Phenotype"},{"id":"T14","span":{"begin":697,"end":709},"obj":"Phenotype"}],"attributes":[{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0020219"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0001250"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0006846"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0003256"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}

{"project":"LitCovid-sentences","denotations":[{"id":"T15","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"T16","span":{"begin":131,"end":305},"obj":"Sentence"},{"id":"T17","span":{"begin":306,"end":492},"obj":"Sentence"},{"id":"T18","span":{"begin":493,"end":731},"obj":"Sentence"},{"id":"T19","span":{"begin":732,"end":871},"obj":"Sentence"},{"id":"T20","span":{"begin":872,"end":974},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial. Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination. Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions. The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established."}