PMC:7252096 / 70271-71748
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T844 | 677-681 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T845 | 711-716 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T846 | 729-736 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T847 | 828-832 | Body_part | denotes | Lung | http://purl.org/sig/ont/fma/fma7195 |
| T848 | 897-904 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T849 | 961-966 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T850 | 1032-1039 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T143 | 828-832 | Body_part | denotes | Lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T295 | 98-106 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T296 | 98-102 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T297 | 337-352 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T298 | 343-352 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T299 | 438-446 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T300 | 438-442 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T301 | 462-470 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T302 | 462-466 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T303 | 824-827 | Disease | denotes | HCA | http://purl.obolibrary.org/obo/MONDO_0018902 |
| T304 | 1078-1087 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T305 | 1360-1368 | Disease | denotes | allergic | http://purl.obolibrary.org/obo/MONDO_0004980 |
| T306 | 1386-1396 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T307 | 1422-1430 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T308 | 1422-1426 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1227 | 541-546 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T1228 | 677-681 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T1229 | 711-716 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1230 | 811-812 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T1231 | 828-832 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | Lung |
| T1232 | 828-832 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | Lung |
| T1233 | 961-966 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1234 | 1109-1110 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1235 | 1265-1272 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T1236 | 1297-1298 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T88878 | 318-322 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T38002 | 323-333 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T82405 | 425-433 | Chemical | denotes | reagents | http://purl.obolibrary.org/obo/CHEBI_33893 |
| T86567 | 1288-1290 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T45 | 166-173 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T46 | 337-352 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T47 | 509-524 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T48 | 525-546 | http://purl.obolibrary.org/obo/GO_0009615 | denotes | response to the virus |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T450 | 0-353 | Sentence | denotes | Altogether, we anticipate that comprehensive characterization of the putative cellular targets of SARS-CoV-2 will be critical to understand basic mechanisms of viral tropism and disease pathophysiology, inform differential susceptibility among vulnerable populations, and potentially suggest unanticipated targets for drug inhibitors of viral infection. |
| T451 | 354-491 | Sentence | denotes | The cellular targets we nominate will need to be confirmed by specific reagents for SARS-CoV-2, as done for SARS-CoV (Ding et al., 2004). |
| T452 | 492-665 | Sentence | denotes | Furthermore, the transcriptional response to the virus will need to be rigorously characterized in appropriate in vitro and in vivo model systems (Blanco-Melo et al., 2020). |
| T453 | 666-810 | Sentence | denotes | We provide gene lists associated with target cells in specific tissues and diseases to aid the community in understanding this emergent disease. |
| T454 | 811-990 | Sentence | denotes | A concurrent HCA Lung Biological Network study assessing ACE2 and TMPRSS2 across more tissues also identified enrichment in nasal goblet and ciliated cells (Sungnak et al., 2020). |
| T455 | 991-1193 | Sentence | denotes | Other studies are considering additional tissues; co-variates such as age, sex, and co-infection state; and represent a large coordinated international effort to the ongoing crisis (Pinto et al., 2020). |
| T456 | 1194-1477 | Sentence | denotes | One study in particular identified upregulation of ACE2 by respiratory viruses and TMPRSS2 by IL-13 in a pediatric cohort, suggesting further links to how underlying allergic conditions or co-infections might modulate these two SARS-CoV-2-related host factors (Sajuthi et al., 2020). |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2081 | 868-872 | Gene | denotes | ACE2 | Gene:59272 |
| 2082 | 877-884 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 2083 | 1245-1249 | Gene | denotes | ACE2 | Gene:59272 |
| 2084 | 1277-1284 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 2085 | 1288-1293 | Gene | denotes | IL-13 | Gene:3596 |
| 2086 | 98-108 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2087 | 438-448 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2088 | 462-470 | Species | denotes | SARS-CoV | Tax:694009 |
| 2089 | 1422-1432 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2090 | 1253-1264 | Species | denotes | respiratory | Tax:12814 |
| 2091 | 160-173 | Disease | denotes | viral tropism | |
| 2092 | 337-352 | Disease | denotes | viral infection | MESH:D001102 |
| 2093 | 1075-1087 | Disease | denotes | co-infection | MESH:D060085 |
| 2094 | 1360-1379 | Disease | denotes | allergic conditions | MESH:D004342 |
| 2095 | 1383-1396 | Disease | denotes | co-infections | MESH:D060085 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32413319-15141376-20790554 | 485-489 | 15141376 | denotes | 2004 |