PMC:7252096 / 62134-62903 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T791","span":{"begin":48,"end":52},"obj":"Body_part"},{"id":"T792","span":{"begin":100,"end":107},"obj":"Body_part"},{"id":"T793","span":{"begin":139,"end":144},"obj":"Body_part"},{"id":"T794","span":{"begin":390,"end":397},"obj":"Body_part"},{"id":"T795","span":{"begin":502,"end":509},"obj":"Body_part"},{"id":"T796","span":{"begin":549,"end":562},"obj":"Body_part"},{"id":"T797","span":{"begin":549,"end":553},"obj":"Body_part"},{"id":"T798","span":{"begin":602,"end":609},"obj":"Body_part"},{"id":"T799","span":{"begin":675,"end":690},"obj":"Body_part"}],"attributes":[{"id":"A791","pred":"fma_id","subj":"T791","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A792","pred":"fma_id","subj":"T792","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A793","pred":"fma_id","subj":"T793","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A794","pred":"fma_id","subj":"T794","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A795","pred":"fma_id","subj":"T795","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A796","pred":"fma_id","subj":"T796","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A797","pred":"fma_id","subj":"T797","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A798","pred":"fma_id","subj":"T798","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A799","pred":"fma_id","subj":"T799","obj":"http://purl.org/sig/ont/fma/fma63841"}],"text":"Whether ACE2 and TMPRSS2 are needed on the same cell or soluble proteases can activate SARS-CoV-2 S protein to invade ACE2 single-positive cells is an area of active inquiry (Coutard et al., 2020, Letko et al., 2020). Importantly, rapidly evolving literature has identified that SARS-CoV-2-S might have a furin cleavage site, leading to a broader set of host proteases that could mediate S protein activation (Bugge et al., 2009, Coutard et al., 2020, Walls et al., 2020). However, because an active S protein has a finite lifetime to find a target cell membrane, the timing and cellular location of S protein activation is key to consider. Activation events proximal to the plasma membrane have been shown to be most effective for SARS-CoV entry (Shulla et al., 2011)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T233","span":{"begin":87,"end":95},"obj":"Disease"},{"id":"T234","span":{"begin":87,"end":91},"obj":"Disease"},{"id":"T235","span":{"begin":279,"end":287},"obj":"Disease"},{"id":"T236","span":{"begin":279,"end":283},"obj":"Disease"},{"id":"T237","span":{"begin":732,"end":740},"obj":"Disease"},{"id":"T238","span":{"begin":732,"end":736},"obj":"Disease"}],"attributes":[{"id":"A233","pred":"mondo_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A236","pred":"mondo_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Whether ACE2 and TMPRSS2 are needed on the same cell or soluble proteases can activate SARS-CoV-2 S protein to invade ACE2 single-positive cells is an area of active inquiry (Coutard et al., 2020, Letko et al., 2020). Importantly, rapidly evolving literature has identified that SARS-CoV-2-S might have a furin cleavage site, leading to a broader set of host proteases that could mediate S protein activation (Bugge et al., 2009, Coutard et al., 2020, Walls et al., 2020). However, because an active S protein has a finite lifetime to find a target cell membrane, the timing and cellular location of S protein activation is key to consider. Activation events proximal to the plasma membrane have been shown to be most effective for SARS-CoV entry (Shulla et al., 2011)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1122","span":{"begin":48,"end":52},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1123","span":{"begin":78,"end":86},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1124","span":{"begin":139,"end":144},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1125","span":{"begin":159,"end":165},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1126","span":{"begin":259,"end":262},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T1127","span":{"begin":303,"end":304},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1128","span":{"begin":337,"end":338},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1129","span":{"begin":398,"end":408},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1130","span":{"begin":493,"end":499},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1131","span":{"begin":510,"end":513},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T1132","span":{"begin":514,"end":515},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1133","span":{"begin":540,"end":541},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1134","span":{"begin":549,"end":553},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1135","span":{"begin":554,"end":562},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T1136","span":{"begin":610,"end":620},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1137","span":{"begin":641,"end":651},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1138","span":{"begin":675,"end":681},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T1139","span":{"begin":682,"end":690},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"Whether ACE2 and TMPRSS2 are needed on the same cell or soluble proteases can activate SARS-CoV-2 S protein to invade ACE2 single-positive cells is an area of active inquiry (Coutard et al., 2020, Letko et al., 2020). Importantly, rapidly evolving literature has identified that SARS-CoV-2-S might have a furin cleavage site, leading to a broader set of host proteases that could mediate S protein activation (Bugge et al., 2009, Coutard et al., 2020, Walls et al., 2020). However, because an active S protein has a finite lifetime to find a target cell membrane, the timing and cellular location of S protein activation is key to consider. Activation events proximal to the plasma membrane have been shown to be most effective for SARS-CoV entry (Shulla et al., 2011)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T45155","span":{"begin":100,"end":107},"obj":"Chemical"},{"id":"T93849","span":{"begin":390,"end":397},"obj":"Chemical"},{"id":"T68136","span":{"begin":502,"end":509},"obj":"Chemical"},{"id":"T97753","span":{"begin":602,"end":609},"obj":"Chemical"}],"attributes":[{"id":"A81433","pred":"chebi_id","subj":"T45155","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A48745","pred":"chebi_id","subj":"T93849","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A20642","pred":"chebi_id","subj":"T68136","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A88809","pred":"chebi_id","subj":"T97753","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Whether ACE2 and TMPRSS2 are needed on the same cell or soluble proteases can activate SARS-CoV-2 S protein to invade ACE2 single-positive cells is an area of active inquiry (Coutard et al., 2020, Letko et al., 2020). Importantly, rapidly evolving literature has identified that SARS-CoV-2-S might have a furin cleavage site, leading to a broader set of host proteases that could mediate S protein activation (Bugge et al., 2009, Coutard et al., 2020, Walls et al., 2020). However, because an active S protein has a finite lifetime to find a target cell membrane, the timing and cellular location of S protein activation is key to consider. Activation events proximal to the plasma membrane have been shown to be most effective for SARS-CoV entry (Shulla et al., 2011)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T417","span":{"begin":0,"end":217},"obj":"Sentence"},{"id":"T418","span":{"begin":218,"end":472},"obj":"Sentence"},{"id":"T419","span":{"begin":473,"end":640},"obj":"Sentence"},{"id":"T420","span":{"begin":641,"end":769},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Whether ACE2 and TMPRSS2 are needed on the same cell or soluble proteases can activate SARS-CoV-2 S protein to invade ACE2 single-positive cells is an area of active inquiry (Coutard et al., 2020, Letko et al., 2020). Importantly, rapidly evolving literature has identified that SARS-CoV-2-S might have a furin cleavage site, leading to a broader set of host proteases that could mediate S protein activation (Bugge et al., 2009, Coutard et al., 2020, Walls et al., 2020). However, because an active S protein has a finite lifetime to find a target cell membrane, the timing and cellular location of S protein activation is key to consider. Activation events proximal to the plasma membrane have been shown to be most effective for SARS-CoV entry (Shulla et al., 2011)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1819","span":{"begin":8,"end":12},"obj":"Gene"},{"id":"1820","span":{"begin":17,"end":24},"obj":"Gene"},{"id":"1821","span":{"begin":118,"end":122},"obj":"Gene"},{"id":"1822","span":{"begin":305,"end":310},"obj":"Gene"},{"id":"1823","span":{"begin":500,"end":501},"obj":"Gene"},{"id":"1824","span":{"begin":388,"end":389},"obj":"Gene"},{"id":"1825","span":{"begin":290,"end":291},"obj":"Gene"},{"id":"1826","span":{"begin":98,"end":99},"obj":"Gene"},{"id":"1827","span":{"begin":87,"end":97},"obj":"Species"},{"id":"1828","span":{"begin":279,"end":289},"obj":"Species"},{"id":"1829","span":{"begin":732,"end":740},"obj":"Species"}],"attributes":[{"id":"A1819","pred":"tao:has_database_id","subj":"1819","obj":"Gene:59272"},{"id":"A1820","pred":"tao:has_database_id","subj":"1820","obj":"Gene:7113"},{"id":"A1821","pred":"tao:has_database_id","subj":"1821","obj":"Gene:59272"},{"id":"A1822","pred":"tao:has_database_id","subj":"1822","obj":"Gene:5045"},{"id":"A1823","pred":"tao:has_database_id","subj":"1823","obj":"Gene:43740568"},{"id":"A1824","pred":"tao:has_database_id","subj":"1824","obj":"Gene:43740568"},{"id":"A1825","pred":"tao:has_database_id","subj":"1825","obj":"Gene:43740568"},{"id":"A1826","pred":"tao:has_database_id","subj":"1826","obj":"Gene:43740568"},{"id":"A1827","pred":"tao:has_database_id","subj":"1827","obj":"Tax:2697049"},{"id":"A1828","pred":"tao:has_database_id","subj":"1828","obj":"Tax:2697049"},{"id":"A1829","pred":"tao:has_database_id","subj":"1829","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Whether ACE2 and TMPRSS2 are needed on the same cell or soluble proteases can activate SARS-CoV-2 S protein to invade ACE2 single-positive cells is an area of active inquiry (Coutard et al., 2020, Letko et al., 2020). Importantly, rapidly evolving literature has identified that SARS-CoV-2-S might have a furin cleavage site, leading to a broader set of host proteases that could mediate S protein activation (Bugge et al., 2009, Coutard et al., 2020, Walls et al., 2020). However, because an active S protein has a finite lifetime to find a target cell membrane, the timing and cellular location of S protein activation is key to consider. Activation events proximal to the plasma membrane have been shown to be most effective for SARS-CoV entry (Shulla et al., 2011)."}

{"project":"2_test","denotations":[{"id":"32413319-32057769-20790509","span":{"begin":191,"end":195},"obj":"32057769"},{"id":"32413319-32094589-20790510","span":{"begin":211,"end":215},"obj":"32094589"},{"id":"32413319-19487698-20790511","span":{"begin":424,"end":428},"obj":"19487698"},{"id":"32413319-32057769-20790512","span":{"begin":446,"end":450},"obj":"32057769"},{"id":"32413319-32155444-20790513","span":{"begin":466,"end":470},"obj":"32155444"},{"id":"32413319-21068237-20790514","span":{"begin":763,"end":767},"obj":"21068237"}],"text":"Whether ACE2 and TMPRSS2 are needed on the same cell or soluble proteases can activate SARS-CoV-2 S protein to invade ACE2 single-positive cells is an area of active inquiry (Coutard et al., 2020, Letko et al., 2020). Importantly, rapidly evolving literature has identified that SARS-CoV-2-S might have a furin cleavage site, leading to a broader set of host proteases that could mediate S protein activation (Bugge et al., 2009, Coutard et al., 2020, Walls et al., 2020). However, because an active S protein has a finite lifetime to find a target cell membrane, the timing and cellular location of S protein activation is key to consider. Activation events proximal to the plasma membrane have been shown to be most effective for SARS-CoV entry (Shulla et al., 2011)."}