PMC:7252096 / 25915-26785 JSONTXT

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    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T312","span":{"begin":14,"end":19},"obj":"Body_part"},{"id":"T313","span":{"begin":74,"end":79},"obj":"Body_part"},{"id":"T314","span":{"begin":109,"end":114},"obj":"Body_part"},{"id":"T315","span":{"begin":154,"end":156},"obj":"Body_part"},{"id":"T317","span":{"begin":174,"end":179},"obj":"Body_part"},{"id":"T318","span":{"begin":345,"end":361},"obj":"Body_part"},{"id":"T319","span":{"begin":356,"end":361},"obj":"Body_part"},{"id":"T320","span":{"begin":405,"end":420},"obj":"Body_part"},{"id":"T87682","span":{"begin":416,"end":420},"obj":"Body_part"},{"id":"T322","span":{"begin":465,"end":470},"obj":"Body_part"},{"id":"T323","span":{"begin":474,"end":478},"obj":"Body_part"},{"id":"T324","span":{"begin":518,"end":523},"obj":"Body_part"},{"id":"T325","span":{"begin":541,"end":546},"obj":"Body_part"},{"id":"T326","span":{"begin":684,"end":695},"obj":"Body_part"},{"id":"T327","span":{"begin":837,"end":842},"obj":"Body_part"},{"id":"T328","span":{"begin":863,"end":868},"obj":"Body_part"}],"attributes":[{"id":"A312","pred":"fma_id","subj":"T312","obj":"http://purl.org/sig/ont/fma/fma7208"},{"id":"A313","pred":"fma_id","subj":"T313","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma7208"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma13443"},{"id":"A316","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma68615"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A321","pred":"fma_id","subj":"T87682","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma62122"},{"id":"A327","pred":"fma_id","subj":"T327","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A328","pred":"fma_id","subj":"T328","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Human and NHP Ileum, Related to Figure 3\n(A). Top: tSNE projection of all cells from healthy pediatric human ileum within a previously-unpublished 10x 3′ v2 dataset (115,569 cells). Black: higher expression of ACE2 (left), TMPRSS2 (right). Bottom: Corresponding violin plots of expression values for ACE2 (left) and TMPRSS2 (right). Solid line: epithelial cells.\n(B). Co-expression of ACE2 and TMPRSS2 by epithelial cell subset. Number indicates % of ACE2+TMPRSS2+ cells by cell subset.\n(C). tSNE projection of 13,689 cells as in Figure 3D, cells colored by co-expression of ACE2 and TMPRSS2 (black).\n(D). Expression of ACE2 and canonical interferon-responsive genes among absorptive enterocytes from Healthy (n = 2) and SHIV-infected, anti-retroviral treated animals (n = 3). Bonferroni-adjusted p-values by Wilcoxon test (healthy: 510 cells, SHIV-infected: 636 cells)."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T51","span":{"begin":14,"end":19},"obj":"Body_part"},{"id":"T52","span":{"begin":109,"end":114},"obj":"Body_part"}],"attributes":[{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0002116"}],"text":"Human and NHP Ileum, Related to Figure 3\n(A). Top: tSNE projection of all cells from healthy pediatric human ileum within a previously-unpublished 10x 3′ v2 dataset (115,569 cells). Black: higher expression of ACE2 (left), TMPRSS2 (right). Bottom: Corresponding violin plots of expression values for ACE2 (left) and TMPRSS2 (right). Solid line: epithelial cells.\n(B). Co-expression of ACE2 and TMPRSS2 by epithelial cell subset. Number indicates % of ACE2+TMPRSS2+ cells by cell subset.\n(C). tSNE projection of 13,689 cells as in Figure 3D, cells colored by co-expression of ACE2 and TMPRSS2 (black).\n(D). Expression of ACE2 and canonical interferon-responsive genes among absorptive enterocytes from Healthy (n = 2) and SHIV-infected, anti-retroviral treated animals (n = 3). Bonferroni-adjusted p-values by Wilcoxon test (healthy: 510 cells, SHIV-infected: 636 cells)."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T63745","span":{"begin":0,"end":5},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T54544","span":{"begin":14,"end":19},"obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"T32257","span":{"begin":42,"end":43},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T13453","span":{"begin":74,"end":79},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T98229","span":{"begin":103,"end":108},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T85540","span":{"begin":109,"end":114},"obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"T33298","span":{"begin":122,"end":123},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T98131","span":{"begin":174,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T94550","span":{"begin":345,"end":355},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T88352","span":{"begin":356,"end":361},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T25360","span":{"begin":364,"end":365},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T50898","span":{"begin":405,"end":415},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T57631","span":{"begin":416,"end":420},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T33621","span":{"begin":465,"end":470},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T56038","span":{"begin":474,"end":478},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T38142","span":{"begin":518,"end":523},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7647","span":{"begin":541,"end":546},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T40176","span":{"begin":661,"end":666},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T53351","span":{"begin":760,"end":767},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T18464","span":{"begin":818,"end":822},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T46734","span":{"begin":837,"end":842},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T89430","span":{"begin":863,"end":868},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Human and NHP Ileum, Related to Figure 3\n(A). Top: tSNE projection of all cells from healthy pediatric human ileum within a previously-unpublished 10x 3′ v2 dataset (115,569 cells). Black: higher expression of ACE2 (left), TMPRSS2 (right). Bottom: Corresponding violin plots of expression values for ACE2 (left) and TMPRSS2 (right). Solid line: epithelial cells.\n(B). Co-expression of ACE2 and TMPRSS2 by epithelial cell subset. Number indicates % of ACE2+TMPRSS2+ cells by cell subset.\n(C). tSNE projection of 13,689 cells as in Figure 3D, cells colored by co-expression of ACE2 and TMPRSS2 (black).\n(D). Expression of ACE2 and canonical interferon-responsive genes among absorptive enterocytes from Healthy (n = 2) and SHIV-infected, anti-retroviral treated animals (n = 3). Bonferroni-adjusted p-values by Wilcoxon test (healthy: 510 cells, SHIV-infected: 636 cells)."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T98","span":{"begin":368,"end":370},"obj":"Chemical"},{"id":"T99","span":{"begin":639,"end":649},"obj":"Chemical"}],"attributes":[{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_27638"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"}],"text":"Human and NHP Ileum, Related to Figure 3\n(A). Top: tSNE projection of all cells from healthy pediatric human ileum within a previously-unpublished 10x 3′ v2 dataset (115,569 cells). Black: higher expression of ACE2 (left), TMPRSS2 (right). Bottom: Corresponding violin plots of expression values for ACE2 (left) and TMPRSS2 (right). Solid line: epithelial cells.\n(B). Co-expression of ACE2 and TMPRSS2 by epithelial cell subset. Number indicates % of ACE2+TMPRSS2+ cells by cell subset.\n(C). tSNE projection of 13,689 cells as in Figure 3D, cells colored by co-expression of ACE2 and TMPRSS2 (black).\n(D). Expression of ACE2 and canonical interferon-responsive genes among absorptive enterocytes from Healthy (n = 2) and SHIV-infected, anti-retroviral treated animals (n = 3). Bonferroni-adjusted p-values by Wilcoxon test (healthy: 510 cells, SHIV-infected: 636 cells)."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T158","span":{"begin":41,"end":45},"obj":"Sentence"},{"id":"T159","span":{"begin":46,"end":181},"obj":"Sentence"},{"id":"T160","span":{"begin":182,"end":239},"obj":"Sentence"},{"id":"T161","span":{"begin":240,"end":247},"obj":"Sentence"},{"id":"T162","span":{"begin":248,"end":332},"obj":"Sentence"},{"id":"T163","span":{"begin":333,"end":362},"obj":"Sentence"},{"id":"T164","span":{"begin":363,"end":367},"obj":"Sentence"},{"id":"T165","span":{"begin":368,"end":428},"obj":"Sentence"},{"id":"T166","span":{"begin":429,"end":486},"obj":"Sentence"},{"id":"T167","span":{"begin":487,"end":600},"obj":"Sentence"},{"id":"T168","span":{"begin":601,"end":605},"obj":"Sentence"},{"id":"T169","span":{"begin":606,"end":776},"obj":"Sentence"},{"id":"T170","span":{"begin":777,"end":832},"obj":"Sentence"},{"id":"T171","span":{"begin":833,"end":858},"obj":"Sentence"},{"id":"T172","span":{"begin":859,"end":870},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Human and NHP Ileum, Related to Figure 3\n(A). Top: tSNE projection of all cells from healthy pediatric human ileum within a previously-unpublished 10x 3′ v2 dataset (115,569 cells). Black: higher expression of ACE2 (left), TMPRSS2 (right). Bottom: Corresponding violin plots of expression values for ACE2 (left) and TMPRSS2 (right). Solid line: epithelial cells.\n(B). Co-expression of ACE2 and TMPRSS2 by epithelial cell subset. Number indicates % of ACE2+TMPRSS2+ cells by cell subset.\n(C). tSNE projection of 13,689 cells as in Figure 3D, cells colored by co-expression of ACE2 and TMPRSS2 (black).\n(D). Expression of ACE2 and canonical interferon-responsive genes among absorptive enterocytes from Healthy (n = 2) and SHIV-infected, anti-retroviral treated animals (n = 3). Bonferroni-adjusted p-values by Wilcoxon test (healthy: 510 cells, SHIV-infected: 636 cells)."}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"675","span":{"begin":0,"end":5},"obj":"Species"},{"id":"681","span":{"begin":210,"end":214},"obj":"Gene"},{"id":"682","span":{"begin":223,"end":230},"obj":"Gene"},{"id":"683","span":{"begin":300,"end":304},"obj":"Gene"},{"id":"684","span":{"begin":316,"end":323},"obj":"Gene"},{"id":"685","span":{"begin":103,"end":108},"obj":"Species"},{"id":"690","span":{"begin":385,"end":389},"obj":"Gene"},{"id":"691","span":{"begin":394,"end":401},"obj":"Gene"},{"id":"692","span":{"begin":451,"end":455},"obj":"Gene"},{"id":"693","span":{"begin":456,"end":463},"obj":"Gene"},{"id":"696","span":{"begin":575,"end":579},"obj":"Gene"},{"id":"697","span":{"begin":584,"end":591},"obj":"Gene"},{"id":"702","span":{"begin":620,"end":624},"obj":"Gene"},{"id":"703","span":{"begin":639,"end":649},"obj":"Gene"},{"id":"704","span":{"begin":721,"end":734},"obj":"Disease"},{"id":"705","span":{"begin":844,"end":857},"obj":"Disease"}],"attributes":[{"id":"A675","pred":"tao:has_database_id","subj":"675","obj":"Tax:9606"},{"id":"A681","pred":"tao:has_database_id","subj":"681","obj":"Gene:59272"},{"id":"A682","pred":"tao:has_database_id","subj":"682","obj":"Gene:7113"},{"id":"A683","pred":"tao:has_database_id","subj":"683","obj":"Gene:59272"},{"id":"A684","pred":"tao:has_database_id","subj":"684","obj":"Gene:7113"},{"id":"A685","pred":"tao:has_database_id","subj":"685","obj":"Tax:9606"},{"id":"A690","pred":"tao:has_database_id","subj":"690","obj":"Gene:59272"},{"id":"A691","pred":"tao:has_database_id","subj":"691","obj":"Gene:7113"},{"id":"A692","pred":"tao:has_database_id","subj":"692","obj":"Gene:59272"},{"id":"A693","pred":"tao:has_database_id","subj":"693","obj":"Gene:7113"},{"id":"A696","pred":"tao:has_database_id","subj":"696","obj":"Gene:59272"},{"id":"A697","pred":"tao:has_database_id","subj":"697","obj":"Gene:7113"},{"id":"A702","pred":"tao:has_database_id","subj":"702","obj":"Gene:59272"},{"id":"A703","pred":"tao:has_database_id","subj":"703","obj":"Gene:3439"},{"id":"A704","pred":"tao:has_database_id","subj":"704","obj":"MESH:D007239"},{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Human and NHP Ileum, Related to Figure 3\n(A). Top: tSNE projection of all cells from healthy pediatric human ileum within a previously-unpublished 10x 3′ v2 dataset (115,569 cells). Black: higher expression of ACE2 (left), TMPRSS2 (right). Bottom: Corresponding violin plots of expression values for ACE2 (left) and TMPRSS2 (right). Solid line: epithelial cells.\n(B). Co-expression of ACE2 and TMPRSS2 by epithelial cell subset. Number indicates % of ACE2+TMPRSS2+ cells by cell subset.\n(C). tSNE projection of 13,689 cells as in Figure 3D, cells colored by co-expression of ACE2 and TMPRSS2 (black).\n(D). Expression of ACE2 and canonical interferon-responsive genes among absorptive enterocytes from Healthy (n = 2) and SHIV-infected, anti-retroviral treated animals (n = 3). Bonferroni-adjusted p-values by Wilcoxon test (healthy: 510 cells, SHIV-infected: 636 cells)."}