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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 158-166 Species denotes patients Tax:9606
3 0-8 Disease denotes Covid-19 MESH:C000657245
12 654-685 Gene denotes Angiotensin Converting Enzyme-2 Gene:59272
13 687-692 Gene denotes ACE-2 Gene:59272
14 862-867 Gene denotes ACE-2 Gene:59272
15 238-246 Species denotes patients Tax:9606
16 513-523 Species denotes SARS-CoV-2 Tax:2697049
17 996-1004 Species denotes patients Tax:9606
18 568-579 Chemical denotes Aldosterone MESH:D000450
19 178-186 Disease denotes Covid-19 MESH:C000657245
42 2639-2643 Gene denotes IL-6 Gene:3569
43 2645-2650 Gene denotes IL-10 Gene:3586
44 2656-2661 Gene denotes TNF-α Gene:7124
45 1288-1337 Species denotes Severe Acute Respiratory Syndrome - Coronavirus-2 Tax:2697049
46 1339-1349 Species denotes SARS-CoV-2 Tax:2697049
47 1377-1385 Species denotes patients Tax:9606
48 1489-1497 Species denotes patients Tax:9606
49 1701-1709 Species denotes patients Tax:9606
50 2141-2149 Species denotes patients Tax:9606
51 2923-2930 Species denotes persons Tax:9606
52 2043-2047 Chemical denotes LMWH MESH:D006495
53 1147-1160 Disease denotes viral disease MESH:D001102
54 1756-1795 Disease denotes disseminated intravascular coagulopathy MESH:D004211
55 1797-1800 Disease denotes DIC MESH:D004211
56 1805-1823 Disease denotes pulmonary embolism MESH:D011655
57 1962-1968 Disease denotes Sepsis MESH:D018805
58 2768-2780 Disease denotes hypertension MESH:D006973
59 2782-2790 Disease denotes diabetes MESH:D003920
60 2792-2799 Disease denotes obesity MESH:D009765
61 2801-2838 Disease denotes chronic obstructive pulmonary disease MESH:D029424
62 2843-2866 Disease denotes cardiovascular diseases MESH:D002318
63 2868-2871 Disease denotes CVD MESH:D002318
72 3011-3021 Species denotes SARS-Cov-2 Tax:2697049
73 3030-3038 Species denotes patients Tax:9606
74 3075-3083 Species denotes patients Tax:9606
75 3370-3378 Species denotes patients Tax:9606
76 3522-3530 Species denotes patients Tax:9606
77 3488-3497 Disease denotes infection MESH:D007239
78 3740-3761 Disease denotes Analyzing the disease MESH:D003141
79 3778-3787 Disease denotes infection MESH:D007239
94 5812-5817 Gene denotes ACE-2 Gene:59272
95 6175-6189 Gene denotes Angiotensin II Gene:183
96 6191-6194 Gene denotes AII Gene:183
97 6236-6240 Gene denotes ACE2 Gene:59272
98 6314-6319 Gene denotes ACE-2 Gene:59272
99 6383-6388 Gene denotes ACE-2 Gene:59272
100 6463-6468 Gene denotes ACE-2 Gene:59272
101 6242-6252 Species denotes SARS-CoV-2 Tax:2697049
102 6439-6449 Species denotes SARS-CoV-2 Tax:2697049
103 6105-6128 Chemical denotes Angiotensin Aldosterone
104 6200-6211 Chemical denotes Aldosterone MESH:D000450
105 5855-5867 Disease denotes inflammation MESH:D007249
106 5951-5959 Disease denotes fibrosis MESH:D005355
107 6020-6032 Disease denotes hypertension MESH:D006973
144 3906-3937 Gene denotes Angiotensin Converting Enzyme-2 Gene:59272
145 3939-3944 Gene denotes ACE-2 Gene:59272
146 4126-4157 Gene denotes Angiotensin I Converting Enzyme Gene:1636
147 4159-4162 Gene denotes ACE Gene:1636
148 4181-4195 Gene denotes Angiotensin II Gene:183
149 4197-4200 Gene denotes AII Gene:183
150 4229-4242 Gene denotes angiotensin I Gene:183
151 4260-4274 Gene denotes Angiotensin II Gene:183
152 4510-4515 Gene denotes ACE-2 Gene:59272
153 4891-4896 Gene denotes ACE-2 Gene:59272
154 5056-5059 Gene denotes ACE Gene:1636
155 5064-5069 Gene denotes ACE-2 Gene:59272
156 5158-5163 Gene denotes ACE-2 Gene:59272
157 5181-5184 Gene denotes ACE Gene:1636
158 5185-5190 Gene denotes ACE-2 Gene:59272
159 5606-5611 Gene denotes ACE-2 Gene:59272
160 4565-4568 Gene denotes AII Gene:183
161 3868-3878 Species denotes SARS-CoV-2 Tax:2697049
162 3886-3891 Species denotes human Tax:9606
163 4853-4863 Species denotes SARS-CoV-2 Tax:2697049
164 5285-5293 Species denotes patients Tax:9606
165 5491-5499 Species denotes patients Tax:9606
166 5613-5623 Species denotes SARS-CoV-2 Tax:2697049
167 4053-4064 Chemical denotes Aldosterone MESH:D000450
168 4343-4354 Chemical denotes aldosterone MESH:D000450
169 4461-4466 Chemical denotes water MESH:D014867
170 4482-4490 Disease denotes fibrosis MESH:D005355
171 4786-4794 Disease denotes fibrosis MESH:D005355
172 5299-5311 Disease denotes hypertension MESH:D006973
173 5313-5320 Disease denotes obesity MESH:D009765
174 5322-5345 Disease denotes cardiovascular diseases MESH:D002318
175 5347-5350 Disease denotes CVD MESH:D002318
176 5357-5365 Disease denotes diabetes MESH:D003920
177 5482-5490 Disease denotes Covid-19 MESH:C000657245
178 5573-5581 Disease denotes diabetes MESH:D003920
179 5707-5715 Disease denotes infected MESH:D007239
182 6537-6542 Gene denotes ACE-2 Gene:59272
183 6546-6561 Disease denotes viral infection MESH:D001102
193 6690-6695 Gene denotes ACE-2 Gene:59272
194 6753-6760 Gene denotes TMPRSS2 Gene:7113
195 6804-6811 Gene denotes TMPRSS2 Gene:7113
196 6869-6874 Gene denotes ACE-2 Gene:59272
197 6936-6941 Gene denotes ACE-2 Gene:59272
198 6584-6589 Species denotes Cov-2 Tax:2697049
199 6697-6707 Species denotes SARS-CoV-2 Tax:2697049
200 6773-6779 Chemical denotes serine MESH:D012694
201 7000-7008 Disease denotes infected MESH:D007239
224 7113-7118 Gene denotes ACE-2 Gene:59272
225 7198-7203 Gene denotes ACE-2 Gene:59272
226 7389-7394 Gene denotes ACE-2 Gene:59272
227 7600-7605 Gene denotes ACE-2 Gene:59272
228 7754-7757 Gene denotes ACE Gene:1636
229 7824-7827 Gene denotes ACE Gene:1636
230 7828-7833 Gene denotes ACE-2 Gene:59272
231 7950-7953 Gene denotes ACE Gene:1636
232 7958-7963 Gene denotes ACE-2 Gene:59272
233 8054-8059 Gene denotes ACE-2 Gene:59272
234 7450-7458 Species denotes patients Tax:9606
235 7488-7498 Species denotes SARS-CoV-2 Tax:2697049
236 7587-7595 Species denotes patients Tax:9606
237 7628-7636 Species denotes patients Tax:9606
238 8271-8281 Species denotes SARS-CoV-2 Tax:2697049
239 7148-7157 Disease denotes infection MESH:D007239
240 7441-7449 Disease denotes infected MESH:D007239
241 7642-7654 Disease denotes hypertension MESH:D006973
242 7656-7659 Disease denotes CVD MESH:D002318
243 7661-7668 Disease denotes obesity MESH:D009765
244 7680-7688 Disease denotes diabetes MESH:D003920
245 8137-8145 Disease denotes Covid-19 MESH:C000657245
262 9001-9013 Gene denotes antithrombin Gene:462
263 9015-9017 Gene denotes AT Gene:462
264 8376-8384 Species denotes patients Tax:9606
265 8502-8510 Species denotes patients Tax:9606
266 8822-8830 Species denotes patients Tax:9606
267 9505-9515 Species denotes SARS-CoV-2 Tax:2697049
268 8779-8807 Chemical denotes low molecular weight heparin MESH:D006495
269 8367-8375 Disease denotes Covid-19 MESH:C000657245
270 8481-8484 Disease denotes DIC MESH:D004211
271 8695-8712 Disease denotes blood coagulation MESH:D001778
272 9037-9053 Disease denotes thrombocytopenia MESH:D013921
273 9071-9081 Disease denotes leucopenia MESH:C536227
274 9362-9374 Disease denotes inflammation MESH:D007249
275 9466-9484 Disease denotes hypercoagulability MESH:D019851
276 9519-9527 Disease denotes infected MESH:D007239
277 9596-9612 Disease denotes RAAS dysfunction MESH:C535612
286 9740-9747 Gene denotes TMPRSS2 Gene:7113
287 9753-9758 Gene denotes ACE-2 Gene:59272
288 9825-9830 Gene denotes ACE-2 Gene:59272
289 9973-9981 Species denotes patients Tax:9606
290 10099-10107 Species denotes patients Tax:9606
291 10354-10362 Species denotes patients Tax:9606
292 10644-10652 Species denotes patients Tax:9606
293 10607-10616 Disease denotes infection MESH:D007239
306 10826-10831 Gene denotes ACE-2 Gene:59272
307 11138-11143 Gene denotes ACE-2 Gene:59272
308 11224-11229 Gene denotes ACE-2 Gene:59272
309 11395-11400 Gene denotes ACE-2 Gene:59272
310 11496-11501 Gene denotes ACE-2 Gene:59272
311 11976-11981 Gene denotes ACE-2 Gene:59272
312 12093-12098 Gene denotes ACE-2 Gene:59272
313 11326-11341 Disease denotes viral infection MESH:D001102
314 11702-11720 Disease denotes hypercoagulability MESH:D019851
315 11791-11803 Disease denotes hypertension MESH:D006973
316 11870-11881 Disease denotes haemostasis MESH:D020141
317 11883-11893 Disease denotes thrombosis MESH:D013927
329 12394-12399 Gene denotes ACE-2 Gene:59272
330 12528-12533 Gene denotes ACE-2 Gene:59272
331 12779-12784 Gene denotes ACE-2 Gene:59272
332 13096-13101 Gene denotes ACE-2 Gene:59272
333 13515-13520 Gene denotes ACE-2 Gene:59272
334 12507-12526 Gene denotes S2 or nucleoprotein Gene:6187
335 12426-12436 Species denotes SARS-CoV-2 Tax:2697049
336 12622-12632 Species denotes SARS-CoV-2 Tax:2697049
337 12963-12971 Species denotes patients Tax:9606
338 13262-13270 Species denotes patients Tax:9606
339 12954-12962 Disease denotes Covid-19 MESH:C000657245
360 14902-14907 Gene denotes ACE-2 Gene:59272
361 15064-15069 Gene denotes ACE-2 Gene:59272
362 15174-15178 Gene denotes ACE2 Gene:59272
363 15853-15857 Gene denotes ACE2 Gene:59272
364 13888-13894 Species denotes People Tax:9606
365 14173-14179 Species denotes people Tax:9606
366 14471-14479 Species denotes patients Tax:9606
367 15118-15126 Species denotes SARS-CoV Tax:694009
368 15137-15147 Species denotes SARS-CoV-2 Tax:2697049
369 16218-16226 Species denotes patients Tax:9606
370 13753-13761 Disease denotes COVID-19 MESH:C000657245
371 13918-13926 Disease denotes COVID-19 MESH:C000657245
372 14626-14635 Disease denotes infection MESH:D007239
373 14853-14868 Disease denotes viral infection MESH:D001102
374 15190-15198 Disease denotes COVID-19 MESH:C000657245
375 15398-15417 Disease denotes infectious diseases MESH:D003141
376 15650-15660 Disease denotes thrombosis MESH:D013927
377 15662-15669 Disease denotes bruises MESH:D003288
378 15894-15929 Disease denotes acute respiratory distress syndrome MESH:D012128
379 16209-16217 Disease denotes COVID 19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 439-447 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T2 640-652 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T3 710-715 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T4 906-913 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T5 2176-2180 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T6 2320-2323 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T7 2533-2541 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T8 2621-2630 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T9 3578-3584 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T10 3659-3667 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T11 3892-3897 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T12 3966-3973 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T13 4009-4014 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T14 4417-4422 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T15 4495-4501 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T16 4709-4714 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T17 4735-4740 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T18 4767-4773 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T19 4798-4803 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T20 4808-4813 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T21 4922-4927 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T22 4940-4954 Body_part denotes alveolar cells http://purl.org/sig/ont/fma/fma62499
T23 4949-4954 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 4980-4987 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T25 5000-5015 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T26 5017-5025 Body_part denotes pancreas http://purl.org/sig/ont/fma/fma7198
T27 5027-5032 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T28 5034-5039 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T29 5044-5049 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T30 5102-5107 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T31 5716-5721 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 5828-5833 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T33 5923-5927 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T34 5929-5934 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T35 5939-5944 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T36 5973-5977 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T37 5992-6004 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T38 6051-6057 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T39 6261-6266 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T40 6276-6280 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T41 6281-6306 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T42 6301-6306 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T43 6452-6459 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T44 6568-6575 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T45 6593-6600 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T46 6744-6751 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 6773-6779 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T48 6812-6816 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T49 6835-6842 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T50 6883-6890 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T51 7009-7022 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T52 7009-7013 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T53 7045-7048 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T54 7102-7109 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T55 7230-7242 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T56 7230-7234 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 7360-7364 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T58 7431-7436 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T59 7531-7538 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T60 7571-7576 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T61 7797-7801 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T62 8596-8602 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T63 8629-8633 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T64 8695-8700 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T65 8800-8807 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T66 9091-9102 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T67 9143-9148 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T68 9201-9208 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T69 9282-9287 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T70 9379-9388 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T71 9528-9533 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T72 9644-9648 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T73 9709-9716 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 9767-9779 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T75 9767-9771 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T76 9799-9806 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T77 9854-9859 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T78 9959-9964 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T79 9984-9987 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T80 9992-9995 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T81 10028-10036 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T82 10050-10057 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T83 10670-10678 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T84 10870-10877 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T85 11184-11188 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 11189-11196 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T87 11408-11416 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T88 11464-11477 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T89 11481-11486 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T90 11515-11520 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T91 11600-11608 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T92 11628-11634 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T93 11732-11738 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T94 11988-11995 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T95 12040-12044 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T96 12045-12052 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T97 12439-12446 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T98 12633-12641 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T99 12676-12683 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T100 12810-12817 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T101 13036-13044 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T102 13402-13409 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T103 13543-13550 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T104 14418-14426 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T105 14639-14644 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T106 14680-14693 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T107 14884-14889 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 15037-15042 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T109 15047-15054 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T110 15451-15458 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T111 15499-15507 Body_part denotes Platelet http://purl.org/sig/ont/fma/fma62851
T112 16162-16168 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2176-2180 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T2 3578-3584 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 4009-4014 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 4417-4422 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T5 4495-4501 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T6 4709-4714 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T7 4735-4740 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T8 4767-4773 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 4798-4803 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T10 5000-5015 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T11 5006-5015 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T12 5017-5025 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264
T13 5027-5032 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T14 5034-5039 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T15 5044-5049 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T16 5102-5107 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T17 5828-5833 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T18 5908-5914 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T19 5923-5927 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T20 5929-5934 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T21 5939-5944 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T22 6051-6057 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T23 6276-6280 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 7431-7436 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T25 7571-7576 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T26 8596-8602 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T27 8629-8633 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T28 8695-8700 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T29 9143-9148 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T30 9282-9287 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T31 9311-9317 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T32 9854-9859 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T33 9959-9964 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T34 11464-11477 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T35 11536-11542 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T36 11628-11634 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T37 11732-11738 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T38 14649-14655 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T39 14680-14693 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 412-422 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T2 513-521 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 1147-1160 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T4 1288-1337 Disease denotes Severe Acute Respiratory Syndrome - Coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 1288-1321 Disease denotes Severe Acute Respiratory Syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T6 1339-1347 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 1783-1795 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T8 1805-1823 Disease denotes pulmonary embolism http://purl.obolibrary.org/obo/MONDO_0005279
T9 1825-1827 Disease denotes PE http://purl.obolibrary.org/obo/MONDO_0005279
T10 1834-1852 Disease denotes multiorgan failure http://purl.obolibrary.org/obo/MONDO_0043726
T11 2768-2780 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T12 2782-2790 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T13 2792-2799 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T14 2801-2838 Disease denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005002
T15 2821-2838 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T16 2843-2872 Disease denotes cardiovascular diseases (CVD) http://purl.obolibrary.org/obo/MONDO_0004995
T17 3011-3015 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T18 3488-3497 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T19 3778-3787 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20 3868-3876 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 4407-4431 Disease denotes increased blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T22 4502-4508 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T23 4853-4861 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 5017-5025 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T25 5299-5311 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T26 5313-5320 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T27 5322-5351 Disease denotes cardiovascular diseases (CVD) http://purl.obolibrary.org/obo/MONDO_0004995
T28 5357-5365 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T29 5566-5581 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T30 5573-5581 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T31 5613-5621 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 5855-5867 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T33 6020-6032 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T34 6058-6064 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T35 6242-6250 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 6439-6447 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 6546-6561 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T38 6552-6561 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 6697-6705 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 7148-7157 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 7488-7496 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 7642-7654 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T43 7661-7668 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T44 7673-7688 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T45 7680-7688 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T46 8271-8279 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 8643-8661 Disease denotes multiorgan failure http://purl.obolibrary.org/obo/MONDO_0043726
T48 9037-9053 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T49 9071-9081 Disease denotes leucopenia http://purl.obolibrary.org/obo/MONDO_0003785
T50 9362-9374 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T51 9466-9484 Disease denotes hypercoagulability http://purl.obolibrary.org/obo/MONDO_0002305
T52 9505-9513 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 10607-10616 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 11326-11341 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T55 11332-11341 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T56 11635-11641 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T57 11702-11720 Disease denotes hypercoagulability http://purl.obolibrary.org/obo/MONDO_0002305
T58 11739-11745 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T59 11791-11803 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T60 11883-11893 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T61 12426-12434 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 12622-12630 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 13753-13761 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T64 13918-13926 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T65 14626-14635 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 14853-14868 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T67 14859-14868 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T68 15118-15126 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 15137-15145 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 15190-15198 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T71 15398-15408 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T72 15464-15473 Disease denotes varicella http://purl.obolibrary.org/obo/MONDO_0005700
T73 15629-15634 Disease denotes Lupus http://purl.obolibrary.org/obo/MONDO_0004670
T74 15650-15660 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T75 15894-15929 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T76 15900-15929 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T77 16209-16217 Disease denotes COVID 19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 18-28 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T2 524-527 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 528-529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 622-630 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T5 710-715 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 1022-1023 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 1275-1280 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T8 1593-1594 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 1639-1649 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T10 1675-1678 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T11 2176-2180 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T12 2181-2182 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 2485-2493 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T14 2495-2496 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 2531-2532 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 2680-2681 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 3886-3897 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T18 3947-3948 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 3949-3957 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T20 3988-3989 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 4009-4014 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T22 4009-4014 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T23 4092-4095 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T24 4202-4203 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 4244-4245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 4275-4278 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T27 4417-4422 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T28 4417-4422 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T29 4589-4590 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T30 4654-4656 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T31 4709-4714 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T32 4709-4714 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T33 4735-4740 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T34 4735-4740 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T35 4798-4803 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T36 4798-4803 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T37 4808-4813 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T38 4922-4927 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T39 4929-4939 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T40 4949-4954 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T41 5000-5015 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T42 5017-5025 http://purl.obolibrary.org/obo/UBERON_0001264 denotes pancreas
T43 5027-5032 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T44 5027-5032 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T45 5027-5032 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T46 5027-5032 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T47 5034-5039 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T48 5034-5039 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T49 5044-5049 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T50 5044-5049 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T51 5102-5107 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T52 5102-5107 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T53 5519-5520 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 5716-5721 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T55 5828-5833 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T56 5828-5833 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T57 5908-5914 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T58 5923-5927 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T59 5923-5927 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T60 5929-5934 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T61 5929-5934 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T62 5929-5934 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T63 5929-5934 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T64 5939-5944 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T65 5939-5944 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T66 5967-5968 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 5973-5977 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T68 6081-6091 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T69 6261-6266 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T70 6276-6280 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T71 6290-6300 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T72 6301-6306 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T73 6611-6612 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 6666-6669 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T75 6670-6671 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 6735-6743 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T77 6762-6763 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 6764-6772 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T79 6812-6816 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T80 6924-6926 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T81 6947-6949 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T82 6947-6949 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T83 7009-7013 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T84 7014-7022 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T85 7122-7123 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 7214-7215 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 7230-7234 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T88 7270-7271 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 7283-7284 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 7303-7305 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T91 7342-7349 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T92 7360-7364 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T93 7409-7410 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 7431-7436 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T95 7431-7436 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T96 7509-7511 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T97 7544-7549 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T98 7550-7553 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T99 7571-7576 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T100 7571-7576 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T101 7612-7613 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T102 7773-7779 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3], [4
T103 7849-7850 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 7897-7899 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T105 8112-8114 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T106 8287-8297 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T107 8312-8322 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T108 8340-8341 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 8415-8416 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 8516-8517 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 8629-8633 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T112 8629-8633 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T113 8695-8700 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T114 8695-8700 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T115 8713-8723 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T116 8921-8933 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombine
T117 8947-8956 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T118 9143-9148 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T119 9143-9148 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T120 9149-9159 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T121 9259-9269 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T122 9282-9287 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T123 9282-9287 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T124 9311-9317 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T125 9528-9533 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T126 9594-9595 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T127 9638-9643 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T128 9644-9648 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T129 9656-9657 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 9767-9771 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T131 9854-9859 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T132 9854-9859 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T133 9914-9916 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T134 9929-9934 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T135 9959-9964 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T136 9959-9964 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T137 10258-10259 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 10260-10265 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T139 10801-10802 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T140 10830-10834 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2, a
T141 10861-10863 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T142 10956-10957 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 11184-11188 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T144 11464-11477 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T145 11481-11486 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T146 11515-11520 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T147 11536-11542 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T148 11668-11676 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T149 12004-12006 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T150 12040-12044 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T151 12367-12374 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T152 12472-12474 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T153 12507-12509 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T154 12507-12509 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T155 12645-12652 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T156 12688-12690 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T157 12730-12731 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T158 12825-12827 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T159 13394-13395 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T160 13415-13416 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T161 13554-13556 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T162 13770-13778 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T163 14074-14079 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T164 14243-14248 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T165 14639-14644 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T166 14649-14655 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T167 14680-14693 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T168 14695-14696 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T169 14884-14889 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T170 14924-14925 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 15037-15042 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T172 15148-15151 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T173 15152-15153 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T174 15207-15217 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T175 15266-15267 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T176 15480-15492 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombine
T177 16099-16100 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T178 16162-16168 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T179 16172-16173 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 556-567 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T2 568-579 Chemical denotes Aldosterone http://purl.obolibrary.org/obo/CHEBI_27584
T3 640-652 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T4 654-665 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T5 906-913 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 1797-1800 Chemical denotes DIC http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092
T8 1825-1827 Chemical denotes PE http://purl.obolibrary.org/obo/CHEBI_16038|http://purl.obolibrary.org/obo/CHEBI_17553|http://purl.obolibrary.org/obo/CHEBI_74762
T11 2639-2641 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T13 2645-2647 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T15 3906-3917 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T16 3966-3973 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 4041-4052 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T18 4053-4064 Chemical denotes Aldosterone http://purl.obolibrary.org/obo/CHEBI_27584
T19 4126-4139 Chemical denotes Angiotensin I http://purl.obolibrary.org/obo/CHEBI_2718
T20 4126-4137 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T21 4181-4195 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T22 4193-4195 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T23 4197-4200 Chemical denotes AII http://purl.obolibrary.org/obo/CHEBI_2719
T24 4229-4240 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T25 4260-4274 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T26 4272-4274 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T27 4343-4354 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T29 4452-4454 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T30 4461-4466 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T31 4565-4568 Chemical denotes AII http://purl.obolibrary.org/obo/CHEBI_2719
T32 4572-4583 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T33 5208-5215 Chemical denotes essence http://purl.obolibrary.org/obo/CHEBI_48318
T34 5992-6004 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T35 6105-6116 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T36 6117-6128 Chemical denotes Aldosterone http://purl.obolibrary.org/obo/CHEBI_27584
T37 6175-6189 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T38 6187-6189 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T39 6191-6194 Chemical denotes AII http://purl.obolibrary.org/obo/CHEBI_2719
T40 6200-6211 Chemical denotes Aldosterone http://purl.obolibrary.org/obo/CHEBI_27584
T41 6452-6459 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T42 6568-6575 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T43 6593-6600 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T44 6744-6751 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45 6773-6779 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T46 6835-6842 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T47 6883-6890 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T48 6947-6949 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T49 7102-7109 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T50 7531-7538 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T51 7758-7760 Chemical denotes AI http://purl.obolibrary.org/obo/CHEBI_73805|http://purl.obolibrary.org/obo/CHEBI_74007|http://purl.obolibrary.org/obo/CHEBI_74088
T54 7856-7865 Chemical denotes indicator http://purl.obolibrary.org/obo/CHEBI_47867
T55 8481-8484 Chemical denotes DIC http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092
T57 8735-8748 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T58 8800-8807 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T59 8940-8942 Chemical denotes PT http://purl.obolibrary.org/obo/CHEBI_141395
T60 9709-9716 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T61 9799-9806 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T62 10028-10036 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T63 10050-10057 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T64 10870-10877 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T65 11027-11035 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T66 11099-11106 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T67 11189-11196 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68 11352-11359 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T69 11408-11416 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T70 11988-11995 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T71 12045-12052 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T72 12439-12446 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T73 12507-12509 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T74 12633-12641 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T75 12645-12652 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T76 12676-12683 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T77 12810-12817 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T78 13402-13409 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 13543-13550 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T80 15451-15458 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 18-42 http://purl.obolibrary.org/obo/GO_1900048 denotes activation of hemostasis
T2 32-42 http://purl.obolibrary.org/obo/GO_0007599 denotes hemostasis
T3 448-463 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T4 1639-1667 http://purl.obolibrary.org/obo/GO_1900048 denotes Activation of the hemostasis
T5 1657-1667 http://purl.obolibrary.org/obo/GO_0007599 denotes hemostasis
T6 2270-2285 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T7 2504-2525 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T8 3114-3129 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T9 3996-4023 http://purl.obolibrary.org/obo/GO_0008217 denotes regulator of blood pressure
T10 4389-4405 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction
T11 4685-4699 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilatation
T12 4709-4734 http://purl.obolibrary.org/obo/GO_0008217 denotes blood pressure, regulates
T13 5102-5119 http://purl.obolibrary.org/obo/GO_0008015 denotes blood circulation
T14 5818-5842 http://purl.obolibrary.org/obo/GO_0008217 denotes regulates blood pressure
T15 5855-5867 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T16 5869-5877 http://purl.obolibrary.org/obo/GO_0035810 denotes diuresis
T17 6546-6561 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T18 8287-8311 http://purl.obolibrary.org/obo/GO_1900048 denotes Activation of hemostasis
T19 8301-8311 http://purl.obolibrary.org/obo/GO_0007599 denotes hemostasis
T20 8312-8336 http://purl.obolibrary.org/obo/GO_1900048 denotes Activation of hemostasis
T21 8326-8336 http://purl.obolibrary.org/obo/GO_0007599 denotes hemostasis
T22 8695-8712 http://purl.obolibrary.org/obo/GO_0007596 denotes blood coagulation
T23 8701-8712 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T24 8874-8885 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T25 9282-9299 http://purl.obolibrary.org/obo/GO_0008015 denotes blood circulation
T26 9333-9348 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T27 9362-9374 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T28 9618-9633 http://purl.obolibrary.org/obo/GO_0006955 denotes Immune response
T29 10788-10797 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T30 11264-11279 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T31 11326-11341 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T32 11668-11687 http://purl.obolibrary.org/obo/GO_1900048 denotes activate hemostasis
T33 11677-11687 http://purl.obolibrary.org/obo/GO_0007599 denotes hemostasis
T34 11777-11787 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T35 14853-14868 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T36 15207-15231 http://purl.obolibrary.org/obo/GO_1900048 denotes activation of hemostasis
T37 15221-15231 http://purl.obolibrary.org/obo/GO_0007599 denotes hemostasis
T38 15439-15450 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes Covid-19, induced activation of hemostasis, and immune reactions:
T2 66-167 Sentence denotes Can an auto-immune reaction contribute to the delayed severe complications observed in some patients?
T3 169-177 Sentence denotes Abstract
T4 178-329 Sentence denotes Covid-19 is characterized by weak symptoms in most affected patients whilst severe clinical complications, with frequent fatal issues, occur in others.
T5 330-388 Sentence denotes Disease severity is associated with age and comorbidities.
T6 389-512 Sentence denotes Understanding of viral infectious mechanisms, and antibody immune response, can help to better control disease progression.
T7 513-732 Sentence denotes SARS-CoV-2 has a major impact on the Renin Angiotensin Aldosterone System (RAAS), through its binding to the membrane cellular glycoprotein, Angiotensin Converting Enzyme-2 (ACE-2), then infecting cells for replication.
T8 733-914 Sentence denotes This report hypothesizes the possible implication of an autoimmune response, induced by generation of allo- or autoantibodies to ACE-2, or to its complexes with viral spike protein.
T9 915-1005 Sentence denotes This could contribute to some delayed severe complications occurring in affected patients.
T10 1006-1068 Sentence denotes We also propose a strategy for investigating this eventuality.
T11 1070-1085 Sentence denotes 1 Introduction
T12 1086-1244 Sentence denotes Fast and extended knowledge is becoming available on the new viral disease that emerged in December 2019, causing enormous challenges at international levels.
T13 1245-1638 Sentence denotes The pathology of this obscure virus, named Severe Acute Respiratory Syndrome - Coronavirus-2 (SARS-CoV-2), is characterized by many patients remaining asymptomatic or with only benign symptoms, but this disease becomes life-threatening in some patients and requires hospitalization in intensive care units or resuscitation [1,2], and is often with a fatal outcome, yet to be fully established.
T14 1639-1857 Sentence denotes Activation of the hemostasis system has been observed in many patients with severe complications, with occurrence of disseminated intravascular coagulopathy (DIC) or pulmonary embolism (PE), and multiorgan failure [3].
T15 1858-1961 Sentence denotes DDimer is frequently elevated, and the disease prognosis worsens with its increasing concentration [2].
T16 1962-2003 Sentence denotes Sepsis can also be present in some cases.
T17 2004-2122 Sentence denotes Anticoagulant therapy, especially with LMWH, can improve the disease evolution and reduce the lethality incidence [4].
T18 2123-2421 Sentence denotes In addition, many patients with severe complications face a sudden worsening, starting 7 to > 14 days after the preliminary symptoms, although the immune response is effective with the presence of IgG and/or IgMs and is expected to fight the disease by controlling its pathological evolution [5,6].
T19 2422-2552 Sentence denotes This worsening is associated with an exacerbated immunological activity, a strong inflammatory response, and a cytokine storm [7].
T20 2553-2662 Sentence denotes New therapeutic approaches rely on controlling the pro-inflammatory cytokines, mainly IL-6, IL-10, and TNF-α.
T21 2663-2873 Sentence denotes Lastly, there is a strong association of disease severity with age and presence of comorbidities, mainly hypertension, diabetes, obesity, chronic obstructive pulmonary disease and cardiovascular diseases (CVD).
T22 2874-2968 Sentence denotes However, complications can also occur in younger persons without any known risk factors [1,2].
T23 2970-2992 Sentence denotes 2 Disease development
T24 2993-3251 Sentence denotes Understanding how SARS-Cov-2 infects patients, how disease develops, and why some patients have this delayed exacerbated immune response, is of major importance for better disease management and control, and for implementing promising therapeutic strategies.
T25 3252-3445 Sentence denotes Association with age and existing pathologies is now well-documented, but the causes explaining the disease course in patients with severe or lethal complications are not completely understood.
T26 3446-3627 Sentence denotes Viral load (increased tendency with age), infection development in affected patients, age, presence of comorbidities, and extent of tissue injuries contribute to this evolution [8].
T27 3628-3739 Sentence denotes However, the paradoxal delayed cytokine storm associated with the amplified immune reaction deserves attention.
T28 3740-3867 Sentence denotes Analyzing the disease development and infection mechanisms can help to elaborate an hypothesis to understand this complication.
T29 3868-4079 Sentence denotes SARS-CoV-2 enters human cells through Angiotensin Converting Enzyme-2 (ACE-2), a membrane surface protein [9], which is a major regulator of blood pressure and of the Renin Angiotensin Aldosterone System (RAAS).
T30 4080-4259 Sentence denotes This enzyme has an opposite effect to that of Angiotensin I Converting Enzyme (ACE), which generates Angiotensin II (AII: a nonapeptide) by cleaving angiotensin I (a decapeptide).
T31 4260-4509 Sentence denotes Angiotensin II has many pleiotropic effects by acting on its receptors, leading to aldosterone production and, finally, inducing vasoconstriction, increased blood pressure and volume (through Na + and water reabsorption), fibrosis and tissue injury.
T32 4510-4671 Sentence denotes ACE-2 opposes and regulates these effects, by cleaving AII to Angiotensin 1–7 [A (1–7)], which acts through its binding to Mas Receptor [[10], [11], [12], [13]].
T33 4672-4819 Sentence denotes This induces vasodilatation, reduces blood pressure, regulates blood volume, and protects from tissue damages and fibrosis in liver and lungs [13].
T34 4820-4890 Sentence denotes RAAS function and implication in SARS-CoV-2 are summarized in Fig. 1 .
T35 4891-5050 Sentence denotes ACE-2 is highly distributed in lungs (epithelial alveolar cells), but also in some other tissues such as the small intestine, pancreas, heart, liver and brain.
T36 5051-5176 Sentence denotes Both ACE and ACE-2 soluble forms can be present in blood circulation at low concentrations (< 10 ng/mL for ACE-2 in normals).
T37 5177-5378 Sentence denotes The ACE/ACE-2 ratio is then of essence for maintaining the right balance of the RAAS, and it is impaired in patients with hypertension, obesity, cardiovascular diseases (CVD), and diabetes for example.
T38 5379-5506 Sentence denotes Interestingly, the presence of these pathologies highly increases the risk for severe complications in Covid-19 patients [1,2].
T39 5507-5582 Sentence denotes Noteworthy, a dysfunction of RAAS can favor development of type 2 diabetes.
T40 5583-5676 Sentence denotes Through its binding to ACE-2, SARS-CoV-2 interferes in the RAAS, and can impact its function.
T41 5677-5804 Sentence denotes In addition to destruction of infected cells, this binding probably impacts RAAS balance and contributes to the disease course.
T42 5805-5960 Sentence denotes Fig. 1 ACE-2 regulates blood pressure and volume, inflammation, diuresis, N+/K + balance, and protects organs (mainly lung, heart and liver) from fibrosis.
T43 5961-6212 Sentence denotes It is a key cell transmembrane glycoprotein which prevents hypertension and protects from tissue injury by opposing the activation of the Renin Angiotensin Aldosterone System (RAAS), and the deleterious effects of Angiotensin II (AII) and Aldosterone.
T44 6213-6407 Sentence denotes Through its binding to ACE2, SARS-CoV-2 infects cells, such as lung alveolar epithelial cells (where ACE-2 is highly expressed), and interferes in the RAAS, by impacting ACE-2 beneficial action.
T45 6408-6524 Sentence denotes We hypothesize that binding of SARS-CoV-2 S Protein to ACE-2 could induce generation of allo- or/and autoantibodies.
T46 6526-6561 Sentence denotes 3 Role of ACE-2 in viral infection
T47 6562-6696 Sentence denotes The S Protein of SRAS Cov-2 (S Protein) presents a sequence, named Receptor Binding Domain (RBD), which has a high affinity for ACE-2.
T48 6697-6875 Sentence denotes SARS-CoV-2 is first primed by another membrane protein, TMPRSS2 (a membrane serine protease encoded by the TMPRSS2 gene), which cleaves S Protein and favors its binding to ACE-2.
T49 6876-7078 Sentence denotes This S Protein is then separated in 2 subunits, S1 bound to ACE-2, and S2, which helps the viral envelope to merge with the infected cell membrane, permitting the viral RNA entrance and replication [9].
T50 7079-7182 Sentence denotes The binding of viral S Protein to ACE-2 is a critical phenomenon for infection and disease progression.
T51 7183-7375 Sentence denotes Interestingly, ACE-2, which is a transmembrane cell surface expressed enzyme, can form a dimer with a high affinity for S1 trimers, which increases binding of viruses and their cell entry [9].
T52 7376-7437 Sentence denotes In addition, ACE-2 is present in a soluble form in the blood.
T53 7438-7596 Sentence denotes In infected patients, it could circulate bound to SARS-CoV-2 or to the S1 subunit of viral S Protein, and virus has been detected in blood from some patients.
T54 7597-7914 Sentence denotes As ACE-2 plays a major role in patients with hypertension, CVD, obesity, or type 2 diabetes, by opposing the harmful effects of the RAAS, mainly through the ACE-AI [[1], [2], [3], [4], [5], [6], [7]] axis and Mas Receptor, the ACE/ACE-2 ratio could be a good indicator of disease progression [[10], [11], [12], [13]].
T55 7915-8014 Sentence denotes Lastly, there are polymorphisms of ACE and ACE-2 which increase the risk to develop these diseases.
T56 8015-8282 Sentence denotes From these considerations, the role of ACE-2 (and impairment of its function when complexed with S1) can be important for Covid-19 clinical complications, especially those associated with comorbidities, and not only because it is the entrance receptor for SARS-CoV-2.
T57 8284-8311 Sentence denotes 4 Activation of hemostasis
T58 8312-8458 Sentence denotes Activation of hemostasis is a major event occurring in Covid-19 patients with severe complications and a need for intensive care or resuscitation.
T59 8459-8581 Sentence denotes From the Yang report, DIC develops in most patients with a fatal outcome, whilst it remains rare in those who survive [1].
T60 8582-8724 Sentence denotes The extensive tissue damage, especially in the lung, and the multiorgan failure can be causes for this extensive blood coagulation activation.
T61 8725-8868 Sentence denotes Use of an anticoagulant therapy, as, for example with low molecular weight heparin, improves the patients’ outcome and reduces lethality [3,4].
T62 8869-9108 Sentence denotes Many coagulation assays are impacted with prolonged prothrombine time (PT) or activated partial thromboplastin time (APTT), reduced antithrombin (AT), elevated DDimer, thrombocytopenia, associated with leucopenia, and low lymphocytes [14].
T63 9109-9318 Sentence denotes Mechanisms that cause this direct blood activation can be multiple, and involve the damaged tissues’ debris or released procoagulants, or exposure of activating surfaces to blood circulation in damaged organs.
T64 9319-9485 Sentence denotes The amplified immune response itself, with inflammation and cytokines release and the cross talks with other response modifiers, can contribute to hypercoagulability.
T65 9486-9613 Sentence denotes The entry mode for SARS-CoV-2 in infected cells leads one to suspect the involvement of all side effects of a RAAS dysfunction.
T66 9615-9633 Sentence denotes 5 Immune response
T67 9634-9811 Sentence denotes For virus cell entry, a strong complex is first formed between the viral S protein, primed and cleaved by TMPRSS2, and ACE-2, at the cell surface which exposes this protein [9].
T68 9812-9983 Sentence denotes In addition, ACE-2 is also present in the blood at low concentration where it could be complexed with S1 or with the virus itself (detected in the blood of some patients).
T69 9984-10158 Sentence denotes IgM and IgG antibodies to the various viral proteins, including S Protein RBD and nucleoprotein can be detected in patients several days after the onset of symptoms [5,6,15].
T70 10159-10309 Sentence denotes With the present data available, this serological positivity sometimes develops concomitantly with a virus load detectable by PCR, or some days later.
T71 10310-10532 Sentence denotes One to 2 weeks after the onset of symptoms, patients have IgMs and/or IgGs, with little delay between generation of IgGs and IgMs. IgMs tend to decrease after 2 weeks, whilst IgGs continue increasing or stabilize [5,6,15].
T72 10533-10629 Sentence denotes The presence of these antibodies is expected to control, reverse and stop infection progression.
T73 10630-10720 Sentence denotes Surprisingly, patients with the highest antibody concentration were the most critical [5].
T74 10722-10783 Sentence denotes 6 Hypothesis on the induction of an auto-immune complication
T75 10784-11117 Sentence denotes The formation of a strong complex between ACE-2, a self-component, and viral S1 (or S Protein), constitutes the basic context for developing allo-antibodies and generating a delayed autoimmune response, with antibodies first targeted to viral antigens, but which can extend to the associated self-component through epitope spreading.
T76 11118-11230 Sentence denotes Then, antibodies to ACE-2 could develop, or eventually to another cell protein close to or complexed with ACE-2.
T77 11231-11544 Sentence denotes We then hypothesize that an allo-immune response can follow the initial immune reaction to the viral infection, and that epitope spreading can induce antibodies to ACE-2, or to proteins with which it is complexed, thus targeting the immune system to cells exposing ACE-2 (abundant in lungs and some other organs).
T78 11545-11658 Sentence denotes This delayed autoimmune response can contribute to the cytokine storm and generate tissue injury and destruction.
T79 11659-11921 Sentence denotes This can activate hemostasis, beyond acute hypercoagulability, stimulate tissue injury, and totally impair the body’s regulation of hypertension and physiological defense mechanisms such as existing pathways of haemostasis/ thrombosis and inflammatory processes.
T80 11922-12134 Sentence denotes We do not know, at this stage, if interaction between ACE-2 and S Protein, or its S1 subunit or with another viral or cell protein, can induce structural modifications of ACE-2 and expose cryptic or neo-epitopes.
T81 12135-12249 Sentence denotes This possibility needs to be considered as it could yet stimulate the immune reaction and generate autoantibodies.
T82 12251-12300 Sentence denotes 7 Strategy for investigating allo/autoantibodies
T83 12301-12527 Sentence denotes We are convinced that this hypothesis could be easily explored by testing allo-antibodies to ACE-2, or to its complexes with SARS-CoV-2 S Protein or its cleaved subunits, S1, and eventually associated with S2 or nucleoprotein.
T84 12528-12729 Sentence denotes ACE-2 is now available in the recombinant form, even if still very expensive, and recombinant SARS-CoV-2 proteins or peptide sequences, including S Protein and S1, are available from various suppliers.
T85 12730-13024 Sentence denotes A capture ELISA, designed by coating recombinant ACE-2, or its complexes with S-Protein or its S1 subunit, or eventually the viral nucleoprotein, onto the plate could be designed for capturing possible antibodies present in Covid-19 patients, especially those with delayed severe complications.
T86 13025-13119 Sentence denotes Binding of antibody to these components, in the presence or absence of ACE-2 must be compared.
T87 13120-13296 Sentence denotes This approach can allow the measurement amount of the kinetic course of these antibodies during the pathological evolution, and eventually in patients following their recovery.
T88 13297-13439 Sentence denotes If present, these antibodies are expected to be alloantibodies, as induced by the association of a viral protein with a body’s self-component.
T89 13440-13591 Sentence denotes However, if immuno stimulation is first induced by neo-epitopes exposed on ACE-2 when complexed with S Protein or S1, the response could be autoimmune.
T90 13592-13651 Sentence denotes Laboratory investigations can clarify these considerations.
T91 13653-13667 Sentence denotes 8 Conclusions
T92 13668-13887 Sentence denotes This concise manuscript is intended to spotlight some of the factors involved in the COVID-19 process focusing on our current efforts to shine some light by proving laboratory evidence to support our working hypothesis.
T93 13888-14068 Sentence denotes People respond differently to COVID-19 some without major clinical problems, others, especially older population or with comorbidities, develop severe or fatal complications [1,2].
T94 14069-14352 Sentence denotes This virus does not recognize age or rank and where the individual variability appears to matter is how people respond to viral infectivity: the good responders overcome the virus by developing high affinity antibodies, whereas the poor responders are doomed to severe health Issues.
T95 14353-14558 Sentence denotes It is nevertheless more than intriguing to note that the highest antibody concentrations are noted in the most severe patients, and this does not always correspond to the viral load detected by PCR [5,15].
T96 14559-14834 Sentence denotes We emphasize that, in addition to the viral deleterious effects of infection in lungs and organs, and stimulation of the immune system, a possible rebound trigger could be induced by an autoimmune response, especially when complications are delayed from the initial symptoms.
T97 14835-15070 Sentence denotes The mechanisms of viral infection and entry into cells through the ACE-2 receptor create a unique context for development of allo- or autoantibodies, which can induce their harmful effect on the body’s cells and tissues exposing ACE-2.
T98 15071-15179 Sentence denotes This mode of action is similar to that of 2002 SARS-CoV [16], but SARS-CoV-2 has a higher affinity for ACE2.
T99 15180-15329 Sentence denotes Therefore COVID-19-induced activation of hemostasis and immune reactions remains, for a while, in the spotlight to be fully proven without any doubt.
T100 15330-15534 Sentence denotes Autoimmune complications, although rare, have been observed in many infectious diseases, as for example anti-coagulation Protein S in varicella, anti-prothrombine, anti-Platelet Factor 4, anti-FXIII, etc.
T101 15535-15671 Sentence denotes Autoantibodies are investigated only because of the associated clinical syndromes induced (as Lupus Anticoagulant, thrombosis, bruises).
T102 15672-15840 Sentence denotes Understanding the various routes of pathology development can help to design the most efficient diagnostic tools and therapeutic approaches as recently reviewed [9,12].
T103 15841-15930 Sentence denotes Recombinant ACE2 is being developed for treating the acute respiratory distress syndrome.
T104 15931-16069 Sentence denotes Other strategies in the spirit of unities in these massive risky periods, in the real crisis time, requiring prompt action, are warranted.
T105 16070-16227 Sentence denotes Specific recommendations for a standardized preparation, and an optimal use of convalescent plasma at a global level are greatly needed in COVID 19 patients.
T106 16228-16315 Sentence denotes This will be helpful in designing future clinical trials in this area of investigation.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1783-1795 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T2 1805-1823 Phenotype denotes pulmonary embolism http://purl.obolibrary.org/obo/HP_0002204
T3 1825-1827 Phenotype denotes PE http://purl.obolibrary.org/obo/HP_0002204
T4 1962-1968 Phenotype denotes Sepsis http://purl.obolibrary.org/obo/HP_0100806
T5 2533-2547 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T6 2768-2780 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 2792-2799 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T8 2801-2838 Phenotype denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/HP_0006510
T9 2843-2866 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T10 3659-3673 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T11 4407-4431 Phenotype denotes increased blood pressure http://purl.obolibrary.org/obo/HP_0032263
T12 5299-5311 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 5313-5320 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T14 5322-5345 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T15 5566-5581 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T16 6020-6032 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T17 7642-7654 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T18 7661-7668 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T19 7673-7688 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T20 8911-8938 Phenotype denotes prolonged prothrombine time http://purl.obolibrary.org/obo/HP_0008151
T21 8940-8942 Phenotype denotes PT http://purl.obolibrary.org/obo/HP_0008151
T22 9020-9035 Phenotype denotes elevated DDimer http://purl.obolibrary.org/obo/HP_0033106
T23 9037-9053 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T24 9466-9484 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724
T25 11600-11614 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T26 11702-11720 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724
T27 11791-11803 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T28 15629-15648 Phenotype denotes Lupus Anticoagulant http://purl.obolibrary.org/obo/HP_0025343
T29 15900-15920 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

2_test

Id Subject Object Predicate Lexical cue
32387238-32125455-142271858 3975-3976 32125455 denotes 9
32387238-21148624-142271859 4648-4650 21148624 denotes 10
32387238-27081112-142271860 4660-4662 27081112 denotes 12
32387238-32125455-142271861 7075-7076 32125455 denotes 9
32387238-32125455-142271862 7372-7373 32125455 denotes 9
32387238-21148624-142271863 7891-7893 21148624 denotes 10
32387238-27081112-142271864 7903-7905 27081112 denotes 12
32387238-32125455-142271865 9808-9809 32125455 denotes 9
32387238-32105090-142271866 15128-15130 32105090 denotes 16
32387238-32125455-142271867 15834-15835 32125455 denotes 9
32387238-27081112-142271868 15836-15838 27081112 denotes 12