PMC:7247521 / 44501-45479 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"791","span":{"begin":642,"end":651},"obj":"Gene"},{"id":"792","span":{"begin":791,"end":800},"obj":"Species"},{"id":"793","span":{"begin":17,"end":35},"obj":"Chemical"},{"id":"794","span":{"begin":411,"end":419},"obj":"Disease"},{"id":"795","span":{"begin":867,"end":875},"obj":"Disease"}],"attributes":[{"id":"A792","pred":"tao:has_database_id","subj":"792","obj":"Tax:2697049"},{"id":"A794","pred":"tao:has_database_id","subj":"794","obj":"MESH:D064420"},{"id":"A795","pred":"tao:has_database_id","subj":"795","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T677","span":{"begin":76,"end":80},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T678","span":{"begin":120,"end":124},"obj":"CHEBI:23888;CHEBI:23888;GO:0017144"},{"id":"T679","span":{"begin":125,"end":136},"obj":"GO:0032502"},{"id":"T680","span":{"begin":198,"end":207},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T681","span":{"begin":319,"end":325},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T682","span":{"begin":326,"end":330},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T683","span":{"begin":362,"end":378},"obj":"UBERON:0005409"},{"id":"T684","span":{"begin":743,"end":752},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T685","span":{"begin":791,"end":800},"obj":"SP_7"},{"id":"T686","span":{"begin":867,"end":875},"obj":"SP_7"},{"id":"T14","span":{"begin":791,"end":800},"obj":"SP_7"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T187","span":{"begin":829,"end":837},"obj":"Body_part"}],"attributes":[{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T103","span":{"begin":867,"end":875},"obj":"Disease"}],"attributes":[{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T401","span":{"begin":74,"end":75},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T402","span":{"begin":340,"end":344},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T403","span":{"begin":638,"end":640},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T404","span":{"begin":679,"end":682},"obj":"http://purl.obolibrary.org/obo/CLO_0007875"},{"id":"T405","span":{"begin":679,"end":682},"obj":"http://purl.obolibrary.org/obo/CLO_0052410"},{"id":"T406","span":{"begin":959,"end":960},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T351","span":{"begin":76,"end":80},"obj":"Chemical"},{"id":"T352","span":{"begin":120,"end":124},"obj":"Chemical"},{"id":"T353","span":{"begin":255,"end":257},"obj":"Chemical"},{"id":"T354","span":{"begin":326,"end":330},"obj":"Chemical"},{"id":"T355","span":{"begin":634,"end":636},"obj":"Chemical"},{"id":"T357","span":{"begin":649,"end":651},"obj":"Chemical"},{"id":"T358","span":{"begin":829,"end":837},"obj":"Chemical"}],"attributes":[{"id":"A351","pred":"chebi_id","subj":"T351","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A352","pred":"chebi_id","subj":"T352","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A353","pred":"chebi_id","subj":"T353","obj":"http://purl.obolibrary.org/obo/CHEBI_74709"},{"id":"A354","pred":"chebi_id","subj":"T354","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A355","pred":"chebi_id","subj":"T355","obj":"http://purl.obolibrary.org/obo/CHEBI_51083"},{"id":"A356","pred":"chebi_id","subj":"T355","obj":"http://purl.obolibrary.org/obo/CHEBI_53453"},{"id":"A357","pred":"chebi_id","subj":"T357","obj":"http://purl.obolibrary.org/obo/CHEBI_15379"},{"id":"A358","pred":"chebi_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"LitCovid-sentences","denotations":[{"id":"T331","span":{"begin":0,"end":150},"obj":"Sentence"},{"id":"T332","span":{"begin":151,"end":390},"obj":"Sentence"},{"id":"T333","span":{"begin":391,"end":568},"obj":"Sentence"},{"id":"T334","span":{"begin":569,"end":903},"obj":"Sentence"},{"id":"T335","span":{"begin":904,"end":978},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T9","span":{"begin":695,"end":698},"obj":"GlycoEpitope"}],"attributes":[{"id":"A9","pred":"glyco_epitope_db_id","subj":"T9","obj":"http://www.glycoepitope.jp/epitopes/AN0690"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}

{"project":"2_test","denotations":[{"id":"32554251-31745103-6393509","span":{"begin":146,"end":148},"obj":"31745103"}],"text":"It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 \u0026 XLOGP ≤ 3.5 \u0026 Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. However, these newly monomer components should provide a further research."}