PMC:7247521 / 44501-45479
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
791 | 642-651 | Gene | denotes | X2 and O2 | |
792 | 791-800 | Species | denotes | 2019-nCov | Tax:2697049 |
793 | 17-35 | Chemical | denotes | ADMETox prediction | |
794 | 411-419 | Disease | denotes | toxicity | MESH:D064420 |
795 | 867-875 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T677 | 76-80 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T678 | 120-124 | CHEBI:23888;CHEBI:23888;GO:0017144 | denotes | drug |
T679 | 125-136 | GO:0032502 | denotes | development |
T680 | 198-207 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
T681 | 319-325 | CHEBI:30563;CHEBI:30563 | denotes | silico |
T682 | 326-330 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T683 | 362-378 | UBERON:0005409 | denotes | gastrointestinal |
T684 | 743-752 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
T685 | 791-800 | SP_7 | denotes | 2019-nCov |
T686 | 867-875 | SP_7 | denotes | COVID-19 |
T14 | 791-800 | SP_7 | denotes | 2019-nCov |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T187 | 829-837 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T103 | 867-875 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T401 | 74-75 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T402 | 340-344 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
T403 | 638-640 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T404 | 679-682 | http://purl.obolibrary.org/obo/CLO_0007875 | denotes | MS1 |
T405 | 679-682 | http://purl.obolibrary.org/obo/CLO_0052410 | denotes | MS1 |
T406 | 959-960 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T351 | 76-80 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T352 | 120-124 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T353 | 255-257 | Chemical | denotes | MW | http://purl.obolibrary.org/obo/CHEBI_74709 |
T354 | 326-330 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T355 | 634-636 | Chemical | denotes | M3 | http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453 |
T357 | 649-651 | Chemical | denotes | O2 | http://purl.obolibrary.org/obo/CHEBI_15379 |
T358 | 829-837 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T331 | 0-150 | Sentence | denotes | It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39]. |
T332 | 151-390 | Sentence | denotes | In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 & XLOGP ≤ 3.5 & Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption. |
T333 | 391-568 | Sentence | denotes | Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD. |
T334 | 569-903 | Sentence | denotes | Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy. |
T335 | 904-978 | Sentence | denotes | However, these newly monomer components should provide a further research. |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T9 | 695-698 | GlycoEpitope | denotes | WO1 | http://www.glycoepitope.jp/epitopes/AN0690 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32554251-31745103-6393509 | 146-148 | 31745103 | denotes | 39 |