PMC:7247521 / 43581-44500 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"771","span":{"begin":223,"end":227},"obj":"Gene"},{"id":"772","span":{"begin":302,"end":306},"obj":"Gene"},{"id":"773","span":{"begin":507,"end":511},"obj":"Gene"},{"id":"774","span":{"begin":48,"end":57},"obj":"Species"},{"id":"775","span":{"begin":482,"end":491},"obj":"Species"},{"id":"776","span":{"begin":84,"end":95},"obj":"Disease"},{"id":"777","span":{"begin":493,"end":502},"obj":"Disease"},{"id":"778","span":{"begin":591,"end":599},"obj":"Disease"},{"id":"779","span":{"begin":732,"end":740},"obj":"Disease"},{"id":"780","span":{"begin":774,"end":795},"obj":"Disease"},{"id":"781","span":{"begin":797,"end":803},"obj":"Disease"},{"id":"782","span":{"begin":805,"end":831},"obj":"Disease"},{"id":"783","span":{"begin":833,"end":870},"obj":"Disease"},{"id":"784","span":{"begin":872,"end":896},"obj":"Disease"},{"id":"785","span":{"begin":906,"end":913},"obj":"Disease"}],"attributes":[{"id":"A771","pred":"tao:has_database_id","subj":"771","obj":"Gene:59272"},{"id":"A772","pred":"tao:has_database_id","subj":"772","obj":"Gene:59272"},{"id":"A773","pred":"tao:has_database_id","subj":"773","obj":"Gene:59272"},{"id":"A774","pred":"tao:has_database_id","subj":"774","obj":"Tax:2697049"},{"id":"A775","pred":"tao:has_database_id","subj":"775","obj":"Tax:2697049"},{"id":"A776","pred":"tao:has_database_id","subj":"776","obj":"MESH:D009461"},{"id":"A777","pred":"tao:has_database_id","subj":"777","obj":"MESH:D011014"},{"id":"A778","pred":"tao:has_database_id","subj":"778","obj":"MESH:C000657245"},{"id":"A779","pred":"tao:has_database_id","subj":"779","obj":"MESH:C000657245"},{"id":"A780","pred":"tao:has_database_id","subj":"780","obj":"MESH:D007249"},{"id":"A781","pred":"tao:has_database_id","subj":"781","obj":"MESH:D001249"},{"id":"A782","pred":"tao:has_database_id","subj":"782","obj":"MESH:D015212"},{"id":"A783","pred":"tao:has_database_id","subj":"783","obj":"MESH:D029424"},{"id":"A784","pred":"tao:has_database_id","subj":"784","obj":"MESH:D002780"},{"id":"A785","pred":"tao:has_database_id","subj":"785","obj":"MESH:D007079"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Currently, a number of studies have showed that 2019-nCov can cause multiple organs dysfunction, including liver [34], pancreas [35], kidney [36], throat and rectum [37], which may be the reason that a wide distribution of ACE2 across these tissues [38]. In agreement with these results, we found that ACE2 was highly expressed in terminal ileum, testis, adipose visceral omentum, heart left ventricle, kidney cortex and thyroid, etc., and QFPD has only 15.33 % common targets with 2019-nCov, pneumonia and ACE2 related genes. These results indicate that the effective treatment of QFPD for COVID-19 may be through a holistic treatment. Moreover, TTD analysis further displayed that QFPD targets were significantly enriched in many COVID-19 related disease, such as chronic inflammatory diseases, asthma, inflammatory bowel disease, chronic obstructive pulmonary disease, intrahepatic cholestasis, chronic ileitis, etc."}

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{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T350","span":{"begin":647,"end":650},"obj":"Chemical"}],"attributes":[{"id":"A350","pred":"chebi_id","subj":"T350","obj":"http://purl.obolibrary.org/obo/CHEBI_73659"}],"text":"Currently, a number of studies have showed that 2019-nCov can cause multiple organs dysfunction, including liver [34], pancreas [35], kidney [36], throat and rectum [37], which may be the reason that a wide distribution of ACE2 across these tissues [38]. In agreement with these results, we found that ACE2 was highly expressed in terminal ileum, testis, adipose visceral omentum, heart left ventricle, kidney cortex and thyroid, etc., and QFPD has only 15.33 % common targets with 2019-nCov, pneumonia and ACE2 related genes. These results indicate that the effective treatment of QFPD for COVID-19 may be through a holistic treatment. Moreover, TTD analysis further displayed that QFPD targets were significantly enriched in many COVID-19 related disease, such as chronic inflammatory diseases, asthma, inflammatory bowel disease, chronic obstructive pulmonary disease, intrahepatic cholestasis, chronic ileitis, etc."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T26","span":{"begin":493,"end":502},"obj":"Phenotype"},{"id":"T27","span":{"begin":797,"end":803},"obj":"Phenotype"},{"id":"T28","span":{"begin":805,"end":831},"obj":"Phenotype"},{"id":"T29","span":{"begin":833,"end":870},"obj":"Phenotype"},{"id":"T30","span":{"begin":872,"end":896},"obj":"Phenotype"},{"id":"T31","span":{"begin":906,"end":913},"obj":"Phenotype"}],"attributes":[{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0002037"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0001406"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0032564"}],"text":"Currently, a number of studies have showed that 2019-nCov can cause multiple organs dysfunction, including liver [34], pancreas [35], kidney [36], throat and rectum [37], which may be the reason that a wide distribution of ACE2 across these tissues [38]. In agreement with these results, we found that ACE2 was highly expressed in terminal ileum, testis, adipose visceral omentum, heart left ventricle, kidney cortex and thyroid, etc., and QFPD has only 15.33 % common targets with 2019-nCov, pneumonia and ACE2 related genes. These results indicate that the effective treatment of QFPD for COVID-19 may be through a holistic treatment. Moreover, TTD analysis further displayed that QFPD targets were significantly enriched in many COVID-19 related disease, such as chronic inflammatory diseases, asthma, inflammatory bowel disease, chronic obstructive pulmonary disease, intrahepatic cholestasis, chronic ileitis, etc."}

{"project":"LitCovid-sentences","denotations":[{"id":"T327","span":{"begin":0,"end":254},"obj":"Sentence"},{"id":"T328","span":{"begin":255,"end":526},"obj":"Sentence"},{"id":"T329","span":{"begin":527,"end":636},"obj":"Sentence"},{"id":"T330","span":{"begin":637,"end":919},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Currently, a number of studies have showed that 2019-nCov can cause multiple organs dysfunction, including liver [34], pancreas [35], kidney [36], throat and rectum [37], which may be the reason that a wide distribution of ACE2 across these tissues [38]. In agreement with these results, we found that ACE2 was highly expressed in terminal ileum, testis, adipose visceral omentum, heart left ventricle, kidney cortex and thyroid, etc., and QFPD has only 15.33 % common targets with 2019-nCov, pneumonia and ACE2 related genes. These results indicate that the effective treatment of QFPD for COVID-19 may be through a holistic treatment. Moreover, TTD analysis further displayed that QFPD targets were significantly enriched in many COVID-19 related disease, such as chronic inflammatory diseases, asthma, inflammatory bowel disease, chronic obstructive pulmonary disease, intrahepatic cholestasis, chronic ileitis, etc."}