PMC:7247521 / 40394-41457 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"696","span":{"begin":238,"end":246},"obj":"Species"},{"id":"697","span":{"begin":809,"end":817},"obj":"Species"},{"id":"698","span":{"begin":830,"end":847},"obj":"Species"},{"id":"699","span":{"begin":6,"end":39},"obj":"Disease"},{"id":"700","span":{"begin":98,"end":107},"obj":"Disease"},{"id":"701","span":{"begin":120,"end":155},"obj":"Disease"},{"id":"702","span":{"begin":157,"end":161},"obj":"Disease"},{"id":"703","span":{"begin":167,"end":177},"obj":"Disease"},{"id":"704","span":{"begin":202,"end":207},"obj":"Disease"},{"id":"705","span":{"begin":257,"end":291},"obj":"Disease"},{"id":"706","span":{"begin":371,"end":379},"obj":"Disease"},{"id":"707","span":{"begin":619,"end":627},"obj":"Disease"},{"id":"708","span":{"begin":686,"end":691},"obj":"Disease"},{"id":"709","span":{"begin":799,"end":808},"obj":"Disease"},{"id":"710","span":{"begin":818,"end":826},"obj":"Disease"},{"id":"711","span":{"begin":925,"end":933},"obj":"Disease"}],"attributes":[{"id":"A696","pred":"tao:has_database_id","subj":"696","obj":"Tax:9606"},{"id":"A697","pred":"tao:has_database_id","subj":"697","obj":"Tax:9606"},{"id":"A698","pred":"tao:has_database_id","subj":"698","obj":"Tax:2697049"},{"id":"A699","pred":"tao:has_database_id","subj":"699","obj":"MESH:C000657245"},{"id":"A700","pred":"tao:has_database_id","subj":"700","obj":"MESH:D007239"},{"id":"A701","pred":"tao:has_database_id","subj":"701","obj":"MESH:D012128"},{"id":"A702","pred":"tao:has_database_id","subj":"702","obj":"MESH:D012128"},{"id":"A703","pred":"tao:has_database_id","subj":"703","obj":"MESH:D018805"},{"id":"A704","pred":"tao:has_database_id","subj":"704","obj":"MESH:D003643"},{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"MESH:D009102"},{"id":"A706","pred":"tao:has_database_id","subj":"706","obj":"MESH:C000657245"},{"id":"A707","pred":"tao:has_database_id","subj":"707","obj":"MESH:C000657245"},{"id":"A708","pred":"tao:has_database_id","subj":"708","obj":"MESH:D005334"},{"id":"A709","pred":"tao:has_database_id","subj":"709","obj":"MESH:D011014"},{"id":"A710","pred":"tao:has_database_id","subj":"710","obj":"MESH:D007239"},{"id":"A711","pred":"tao:has_database_id","subj":"711","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T597","span":{"begin":6,"end":17},"obj":"NCBITaxon:11118"},{"id":"T598","span":{"begin":19,"end":28},"obj":"SP_7"},{"id":"T599","span":{"begin":60,"end":64},"obj":"UBERON:0002048"},{"id":"T600","span":{"begin":69,"end":82},"obj":"UBERON:0002405"},{"id":"T601","span":{"begin":126,"end":137},"obj":"UBERON:0001004"},{"id":"T602","span":{"begin":202,"end":207},"obj":"GO:0016265"},{"id":"T603","span":{"begin":263,"end":268},"obj":"UBERON:0000062"},{"id":"T604","span":{"begin":329,"end":334},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T605","span":{"begin":371,"end":379},"obj":"SP_7"},{"id":"T606","span":{"begin":430,"end":434},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T607","span":{"begin":619,"end":627},"obj":"SP_7"},{"id":"T608","span":{"begin":836,"end":847},"obj":"NCBITaxon:11118"},{"id":"T609","span":{"begin":925,"end":933},"obj":"SP_7"},{"id":"T610","span":{"begin":945,"end":957},"obj":"CHEBI:52217;CHEBI:52217"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T156","span":{"begin":60,"end":64},"obj":"Body_part"},{"id":"T157","span":{"begin":69,"end":82},"obj":"Body_part"},{"id":"T158","span":{"begin":263,"end":268},"obj":"Body_part"}],"attributes":[{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma67498"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T45","span":{"begin":60,"end":64},"obj":"Body_part"},{"id":"T46","span":{"begin":69,"end":82},"obj":"Body_part"},{"id":"T47","span":{"begin":263,"end":268},"obj":"Body_part"}],"attributes":[{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A46","pred":"uberon_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A47","pred":"uberon_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T79","span":{"begin":18,"end":39},"obj":"Disease"},{"id":"T80","span":{"begin":30,"end":39},"obj":"Disease"},{"id":"T81","span":{"begin":98,"end":107},"obj":"Disease"},{"id":"T82","span":{"begin":120,"end":155},"obj":"Disease"},{"id":"T83","span":{"begin":126,"end":155},"obj":"Disease"},{"id":"T84","span":{"begin":157,"end":161},"obj":"Disease"},{"id":"T85","span":{"begin":371,"end":379},"obj":"Disease"},{"id":"T86","span":{"begin":619,"end":627},"obj":"Disease"},{"id":"T87","span":{"begin":799,"end":808},"obj":"Disease"},{"id":"T88","span":{"begin":925,"end":933},"obj":"Disease"}],"attributes":[{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T336","span":{"begin":60,"end":64},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T337","span":{"begin":60,"end":64},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T338","span":{"begin":69,"end":82},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T339","span":{"begin":226,"end":227},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T340","span":{"begin":263,"end":268},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T341","span":{"begin":412,"end":413},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T342","span":{"begin":447,"end":448},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T343","span":{"begin":560,"end":563},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T344","span":{"begin":564,"end":565},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T345","span":{"begin":972,"end":973},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T346","span":{"begin":1040,"end":1041},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T334","span":{"begin":329,"end":334},"obj":"Chemical"},{"id":"T335","span":{"begin":430,"end":434},"obj":"Chemical"},{"id":"T336","span":{"begin":546,"end":554},"obj":"Chemical"},{"id":"T337","span":{"begin":556,"end":559},"obj":"Chemical"}],"attributes":[{"id":"A334","pred":"chebi_id","subj":"T334","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A335","pred":"chebi_id","subj":"T335","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A336","pred":"chebi_id","subj":"T336","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A337","pred":"chebi_id","subj":"T337","obj":"http://purl.obolibrary.org/obo/CHEBI_145500"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T22","span":{"begin":91,"end":107},"obj":"Phenotype"},{"id":"T23","span":{"begin":126,"end":146},"obj":"Phenotype"},{"id":"T24","span":{"begin":686,"end":691},"obj":"Phenotype"},{"id":"T25","span":{"begin":799,"end":808},"obj":"Phenotype"}],"attributes":[{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0032169"},{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"LitCovid-sentences","denotations":[{"id":"T310","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T311","span":{"begin":91,"end":212},"obj":"Sentence"},{"id":"T312","span":{"begin":213,"end":297},"obj":"Sentence"},{"id":"T313","span":{"begin":298,"end":380},"obj":"Sentence"},{"id":"T314","span":{"begin":381,"end":503},"obj":"Sentence"},{"id":"T315","span":{"begin":504,"end":725},"obj":"Sentence"},{"id":"T316","span":{"begin":726,"end":871},"obj":"Sentence"},{"id":"T317","span":{"begin":872,"end":1063},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}

{"project":"2_test","denotations":[{"id":"32554251-32007143-6393505","span":{"begin":209,"end":210},"obj":"32007143"},{"id":"32554251-31978945-6393506","span":{"begin":293,"end":295},"obj":"31978945"}],"text":"Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective."}