Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage. Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2]. In addition, a number of patients presented multi-organ damage and dysfunction [28]. However, there are no specific drugs or vaccine for the treatment of the COVID-19. This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29]. Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30]. It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31]. Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective.