PMC:7247521 / 39449-40378
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7247521","sourcedb":"PMC","sourceid":"7247521","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7247521","text":"Next, to illustrate the mechanism of QFPD against COVID-19, a formula-attacked target-KEGG pathway network was constructed (Fig. 12 ). This network showed that MSXG, SGMH, XCH, WLS and Others interacted with 8 drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf), and 24 drug-attacked nodes in the COVID-19 network were related to Graft-versus-host disease, cytokine-cytokine receptor interaction, asthma, influenza A, inflammatory bowel disease, JAK-STAT signaling, etc.\nFig. 12 Disturbance analysis of QFPD for COVID-19 network. A: Venn diagram of the five formulae’ attacked targets. B: Formula-attacked target-KEGG pathway network; green square: formula, yellow diamond: attacked target, red circle: KEGG pathways. The bigger the size of the nodes is, the higher the degree is. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)","divisions":[{"label":"label","span":{"begin":489,"end":496}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"649","span":{"begin":530,"end":538},"obj":"Disease"},{"id":"665","span":{"begin":231,"end":236},"obj":"Gene"},{"id":"666","span":{"begin":238,"end":242},"obj":"Gene"},{"id":"667","span":{"begin":244,"end":248},"obj":"Gene"},{"id":"668","span":{"begin":250,"end":254},"obj":"Gene"},{"id":"669","span":{"begin":256,"end":259},"obj":"Gene"},{"id":"670","span":{"begin":261,"end":267},"obj":"Gene"},{"id":"671","span":{"begin":269,"end":273},"obj":"Gene"},{"id":"672","span":{"begin":275,"end":278},"obj":"Gene"},{"id":"673","span":{"begin":423,"end":432},"obj":"Species"},{"id":"674","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"675","span":{"begin":172,"end":175},"obj":"Disease"},{"id":"676","span":{"begin":315,"end":323},"obj":"Disease"},{"id":"677","span":{"begin":348,"end":373},"obj":"Disease"},{"id":"678","span":{"begin":415,"end":421},"obj":"Disease"},{"id":"679","span":{"begin":436,"end":462},"obj":"Disease"}],"attributes":[{"id":"A649","pred":"tao:has_database_id","subj":"649","obj":"MESH:C000657245"},{"id":"A665","pred":"tao:has_database_id","subj":"665","obj":"Gene:991"},{"id":"A666","pred":"tao:has_database_id","subj":"666","obj":"Gene:3620"},{"id":"A667","pred":"tao:has_database_id","subj":"667","obj":"Gene:3458"},{"id":"A668","pred":"tao:has_database_id","subj":"668","obj":"Gene:3586"},{"id":"A669","pred":"tao:has_database_id","subj":"669","obj":"Gene:3569"},{"id":"A670","pred":"tao:has_database_id","subj":"670","obj":"Gene:5734"},{"id":"A671","pred":"tao:has_database_id","subj":"671","obj":"Gene:6688"},{"id":"A672","pred":"tao:has_database_id","subj":"672","obj":"Gene:7124"},{"id":"A673","pred":"tao:has_database_id","subj":"673","obj":"Tax:11320"},{"id":"A674","pred":"tao:has_database_id","subj":"674","obj":"MESH:C000657245"},{"id":"A676","pred":"tao:has_database_id","subj":"676","obj":"MESH:C000657245"},{"id":"A677","pred":"tao:has_database_id","subj":"677","obj":"MESH:D006086"},{"id":"A678","pred":"tao:has_database_id","subj":"678","obj":"MESH:D001249"},{"id":"A679","pred":"tao:has_database_id","subj":"679","obj":"MESH:D015212"},{"subj":"649","pred":"source","obj":"LitCovid-PubTator"},{"subj":"665","pred":"source","obj":"LitCovid-PubTator"},{"subj":"666","pred":"source","obj":"LitCovid-PubTator"},{"subj":"667","pred":"source","obj":"LitCovid-PubTator"},{"subj":"668","pred":"source","obj":"LitCovid-PubTator"},{"subj":"669","pred":"source","obj":"LitCovid-PubTator"},{"subj":"670","pred":"source","obj":"LitCovid-PubTator"},{"subj":"671","pred":"source","obj":"LitCovid-PubTator"},{"subj":"672","pred":"source","obj":"LitCovid-PubTator"},{"subj":"673","pred":"source","obj":"LitCovid-PubTator"},{"subj":"674","pred":"source","obj":"LitCovid-PubTator"},{"subj":"675","pred":"source","obj":"LitCovid-PubTator"},{"subj":"676","pred":"source","obj":"LitCovid-PubTator"},{"subj":"677","pred":"source","obj":"LitCovid-PubTator"},{"subj":"678","pred":"source","obj":"LitCovid-PubTator"},{"subj":"679","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T582","span":{"begin":50,"end":58},"obj":"SP_7"},{"id":"T583","span":{"begin":210,"end":214},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T584","span":{"begin":231,"end":236},"obj":"PR:000005188"},{"id":"T585","span":{"begin":238,"end":242},"obj":"PR:000009030"},{"id":"T586","span":{"begin":244,"end":248},"obj":"PR:000000017"},{"id":"T587","span":{"begin":250,"end":254},"obj":"PR:000001471"},{"id":"T588","span":{"begin":261,"end":267},"obj":"PR:000001548"},{"id":"T589","span":{"begin":269,"end":273},"obj":"PR:000001944"},{"id":"T590","span":{"begin":275,"end":278},"obj":"PR:000000134"},{"id":"T591","span":{"begin":288,"end":292},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T592","span":{"begin":315,"end":323},"obj":"SP_7"},{"id":"T593","span":{"begin":436,"end":454},"obj":"UBERON:0000160"},{"id":"T594","span":{"begin":464,"end":482},"obj":"GO:0007259"},{"id":"T596","span":{"begin":530,"end":538},"obj":"SP_7"}],"attributes":[{"subj":"T582","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T583","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T584","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T585","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T586","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T587","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T588","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T589","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T590","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T591","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T592","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T593","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T594","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T596","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T153","span":{"begin":375,"end":383},"obj":"Body_part"},{"id":"T154","span":{"begin":384,"end":392},"obj":"Body_part"},{"id":"T155","span":{"begin":449,"end":454},"obj":"Body_part"}],"attributes":[{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma7199"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"T73","span":{"begin":315,"end":323},"obj":"Disease"},{"id":"T74","span":{"begin":348,"end":373},"obj":"Disease"},{"id":"T75","span":{"begin":415,"end":421},"obj":"Disease"},{"id":"T76","span":{"begin":423,"end":432},"obj":"Disease"},{"id":"T77","span":{"begin":436,"end":462},"obj":"Disease"},{"id":"T78","span":{"begin":530,"end":538},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0013730"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0004979"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T331","span":{"begin":60,"end":61},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T332","span":{"begin":433,"end":434},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T333","span":{"begin":473,"end":482},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T334","span":{"begin":548,"end":549},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T335","span":{"begin":604,"end":605},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"attributes":[{"subj":"T331","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T331","span":{"begin":210,"end":214},"obj":"Chemical"},{"id":"T332","span":{"begin":288,"end":292},"obj":"Chemical"},{"id":"T333","span":{"begin":683,"end":690},"obj":"Chemical"}],"attributes":[{"id":"A331","pred":"chebi_id","subj":"T331","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A332","pred":"chebi_id","subj":"T332","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A333","pred":"chebi_id","subj":"T333","obj":"http://purl.obolibrary.org/obo/CHEBI_33417"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T20","span":{"begin":415,"end":421},"obj":"Phenotype"},{"id":"T21","span":{"begin":436,"end":462},"obj":"Phenotype"}],"attributes":[{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0002037"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T104","span":{"begin":473,"end":482},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"attributes":[{"subj":"T104","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T301","span":{"begin":0,"end":134},"obj":"Sentence"},{"id":"T302","span":{"begin":135,"end":488},"obj":"Sentence"},{"id":"T303","span":{"begin":489,"end":547},"obj":"Sentence"},{"id":"T304","span":{"begin":548,"end":550},"obj":"Sentence"},{"id":"T305","span":{"begin":551,"end":603},"obj":"Sentence"},{"id":"T306","span":{"begin":604,"end":606},"obj":"Sentence"},{"id":"T307","span":{"begin":607,"end":735},"obj":"Sentence"},{"id":"T308","span":{"begin":736,"end":929},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T301","pred":"source","obj":"LitCovid-sentences"},{"subj":"T302","pred":"source","obj":"LitCovid-sentences"},{"subj":"T303","pred":"source","obj":"LitCovid-sentences"},{"subj":"T304","pred":"source","obj":"LitCovid-sentences"},{"subj":"T305","pred":"source","obj":"LitCovid-sentences"},{"subj":"T306","pred":"source","obj":"LitCovid-sentences"},{"subj":"T307","pred":"source","obj":"LitCovid-sentences"},{"subj":"T308","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecb093","default":true},{"id":"LitCovid-PMC-OGER-BB","color":"#9693ec"},{"id":"LitCovid-PD-FMA-UBERON","color":"#a9ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93c3"},{"id":"LitCovid-PD-CLO","color":"#93ddec"},{"id":"LitCovid-PD-CHEBI","color":"#ece093"},{"id":"LitCovid-PD-HP","color":"#c693ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecac"},{"id":"LitCovid-sentences","color":"#ec9393"}]}]}}