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PMC:7247521 / 35290-37273 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
558 5-9 Gene denotes ACE2 Gene:59272
559 14-19 Gene denotes CD147 Gene:682
570 1101-1105 Gene denotes ACE2 Gene:59272
571 1110-1115 Gene denotes CD147 Gene:682
572 1184-1188 Gene denotes ACE2 Gene:59272
573 1193-1198 Gene denotes CD147 Gene:682
574 1416-1420 Gene denotes ACE2 Gene:59272
575 1458-1463 Gene denotes CD147 Gene:682
576 1506-1510 Gene denotes ACE2 Gene:59272
577 1405-1414 Disease denotes pneumonia MESH:D011014
578 1534-1541 Disease denotes colonic MESH:D003110
579 1565-1572 Disease denotes colonic MESH:D003110
600 129-133 Gene denotes ACE2 Gene:59272
601 138-143 Gene denotes CD147 Gene:682
602 208-212 Gene denotes ACE2 Gene:59272
603 217-222 Gene denotes CD147 Gene:682
604 296-300 Gene denotes ACE2 Gene:59272
605 462-467 Gene denotes CD147 Gene:682
606 687-691 Gene denotes ACE2 Gene:59272
607 720-725 Gene denotes CD147 Gene:682
608 828-832 Gene denotes ACE2 Gene:59272
609 1059-1063 Gene denotes ACE2 Gene:59272
610 1068-1073 Gene denotes CD147 Gene:682
611 76-85 Species denotes 2019-nCov Tax:2697049
612 637-646 Species denotes 2019-nCov Tax:2697049
613 1037-1046 Species denotes 2019-nCov Tax:2697049
614 524-540 Disease denotes atrial appendage MESH:D018280
615 624-633 Disease denotes pneumonia MESH:D011014
616 731-740 Disease denotes pneumonia MESH:D011014
617 836-843 Disease denotes colonic MESH:D003110
618 1013-1021 Disease denotes COVID-19 MESH:C000657245
619 1048-1057 Disease denotes pneumonia MESH:D011014

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T457 5-9 G_3;PG_10;PR:000003622 denotes ACE2
T458 14-19 PR:000001324 denotes CD147
T459 20-30 GO:0010467 denotes expression
T460 38-45 UBERON:0000479 denotes tissues
T461 53-63 GO:0010467 denotes expression
T462 64-69 SO:0000704 denotes genes
T463 76-85 SP_7 denotes 2019-nCov
T464 102-109 UBERON:0000479 denotes tissues
T465 114-120 UBERON:0000062 denotes organs
T466 129-133 G_3;PG_10;PR:000003622 denotes ACE2
T467 138-143 PR:000001324 denotes CD147
T468 177-187 GO:0010467 denotes expression
T469 208-212 G_3;PG_10;PR:000003622 denotes ACE2
T470 217-222 PR:000001324 denotes CD147
T471 233-240 UBERON:0000479 denotes tissues
T472 274-284 GO:0010467 denotes expression
T473 285-292 UBERON:0000479 denotes tissues
T474 296-300 G_3;PG_10;PR:000003622 denotes ACE2
T475 315-320 UBERON:0002116 denotes ileum
T476 322-328 UBERON:0000473 denotes testis
T477 330-338 UBERON:0004877 denotes visceral
T478 340-347 UBERON:0003688 denotes omentum
T479 350-364 UBERON:0002084 denotes left ventricle
T480 369-382 UBERON:0001225 denotes kidney cortex
T481 420-424 UBERON:0002048 denotes lung
T482 440-450 GO:0010467 denotes expression
T483 451-458 UBERON:0000479 denotes tissues
T484 462-467 PR:000001324 denotes CD147
T485 473-479 UBERON:0000473 denotes testis
T486 481-489 UBERON:0004877 denotes visceral
T487 491-498 UBERON:0003688 denotes omentum
T488 501-515 UBERON:0002084 denotes left ventricle
T489 517-522 UBERON:0000947 denotes aorta
T490 524-540 UBERON:0006618 denotes atrial appendage
T491 557-568 CL:0000057 denotes fibroblasts
T492 637-646 SP_7 denotes 2019-nCov
T493 667-677 GO:0010467 denotes expression
T494 678-683 SO:0000704 denotes genes
T495 687-691 G_3;PG_10;PR:000003622 denotes ACE2
T496 700-710 GO:0010467 denotes expression
T497 711-716 SO:0000704 denotes genes
T498 720-725 PR:000001324 denotes CD147
T499 808-818 GO:0010467 denotes expression
T500 819-824 SO:0000704 denotes genes
T501 828-832 G_3;PG_10;PR:000003622 denotes ACE2
T502 836-843 UBERON:0001155;CL:0011108 denotes colonic
T503 844-854 CL:0011108;UBERON:0002424 denotes epithelial
T504 855-860 CL:0011108 denotes cells
T505 1013-1021 SP_7 denotes COVID-19
T506 1037-1046 SP_7 denotes 2019-nCov
T507 1059-1063 G_3;PG_10;PR:000003622 denotes ACE2
T508 1068-1073 PR:000001324 denotes CD147
T538 1101-1105 G_3;PG_10;PR:000003622 denotes ACE2
T539 1110-1115 PR:000001324 denotes CD147
T540 1116-1126 GO:0010467 denotes expression
T541 1134-1141 UBERON:0000479 denotes tissues
T542 1149-1159 GO:0010467 denotes expression
T543 1160-1165 SO:0000704 denotes genes
T544 1184-1188 G_3;PG_10;PR:000003622 denotes ACE2
T545 1193-1198 PR:000001324 denotes CD147
T546 1199-1209 GO:0010467 denotes expression
T547 1220-1227 UBERON:0000479 denotes tissues
T548 1233-1243 GO:0010467 denotes expression
T549 1326-1336 GO:0010467 denotes expression
T550 1337-1344 UBERON:0000479 denotes tissues
T551 1416-1420 G_3;PG_10;PR:000003622 denotes ACE2
T552 1424-1434 GO:0010467 denotes expression
T553 1435-1440 SO:0000704 denotes genes
T554 1442-1446 G_3;PG_10;PR:000003622 denotes ACE2
T555 1458-1463 PR:000001324 denotes CD147
T556 1467-1477 GO:0010467 denotes expression
T557 1478-1483 SO:0000704 denotes genes
T558 1485-1490 PR:000001324 denotes CD147
T559 1506-1510 G_3;PG_10;PR:000003622 denotes ACE2
T560 1514-1524 GO:0010467 denotes expression
T561 1525-1530 SO:0000704 denotes genes
T562 1534-1541 UBERON:0001155;CL:0011108 denotes colonic
T563 1542-1552 CL:0011108;UBERON:0000483 denotes epithelial
T564 1553-1558 CL:0011108 denotes cells
T565 1560-1564 G_3;PG_10;PR:000003622 denotes ACE2
T566 1565-1572 UBERON:0001155 denotes colonic

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T117 38-45 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T118 102-109 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T119 233-240 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T120 285-292 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T121 306-320 Body_part denotes terminal ileum http://purl.org/sig/ont/fma/fma14966
T122 322-328 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T123 340-347 Body_part denotes omentum http://purl.org/sig/ont/fma/fma14650
T124 350-364 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T125 369-375 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T126 376-382 Body_part denotes cortex http://purl.org/sig/ont/fma/fma61109
T127 420-424 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T128 451-458 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T129 473-479 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T130 491-498 Body_part denotes omentum http://purl.org/sig/ont/fma/fma14650
T131 501-515 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T132 517-522 Body_part denotes aorta http://purl.org/sig/ont/fma/fma3734
T133 557-568 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T134 752-760 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T135 787-795 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T136 844-860 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T137 855-860 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T138 1134-1141 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T139 1220-1227 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T140 1337-1344 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T141 1363-1371 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T142 1542-1558 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T143 1553-1558 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T144 1645-1653 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T145 1710-1714 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T146 1824-1832 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T34 114-120 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T35 315-320 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T36 322-328 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T37 340-347 Body_part denotes omentum http://purl.obolibrary.org/obo/UBERON_0003688
T38 369-375 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T39 376-382 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T40 420-424 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T41 473-479 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T42 491-498 Body_part denotes omentum http://purl.obolibrary.org/obo/UBERON_0003688
T43 517-522 Body_part denotes aorta http://purl.obolibrary.org/obo/UBERON_0000947
T44 531-540 Body_part denotes appendage http://purl.obolibrary.org/obo/UBERON_0000026

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T63 624-633 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T64 731-740 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T65 1013-1021 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T66 1048-1057 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T67 1405-1414 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T292 64-69 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T293 114-120 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T294 250-251 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T295 315-320 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T296 322-328 http://www.ebi.ac.uk/efo/EFO_0000984 denotes testis
T297 340-347 http://purl.obolibrary.org/obo/UBERON_0003688 denotes omentum
T298 369-375 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T299 369-375 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T300 369-375 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T301 376-382 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T302 420-424 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T303 420-424 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T304 473-479 http://www.ebi.ac.uk/efo/EFO_0000984 denotes testis
T305 491-498 http://purl.obolibrary.org/obo/UBERON_0003688 denotes omentum
T306 517-522 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aorta
T307 531-540 http://purl.obolibrary.org/obo/UBERON_0000026 denotes appendage
T308 531-540 http://www.ebi.ac.uk/efo/EFO_0000799 denotes appendage
T309 557-568 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T310 678-683 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T311 711-716 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T312 819-824 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T313 836-843 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T314 844-854 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T315 855-860 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T316 1160-1165 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T317 1167-1168 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T318 1346-1347 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T319 1435-1440 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T320 1478-1483 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T321 1525-1530 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T322 1534-1541 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T323 1542-1552 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T324 1553-1558 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T314 752-760 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T315 787-795 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T316 1269-1273 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T317 1363-1371 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T318 1645-1653 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T319 1663-1668 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T320 1824-1832 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T16 624-633 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T17 731-740 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T18 1048-1057 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T19 1405-1414 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T259 0-69 Sentence denotes 3.7 ACE2 and CD147 expression across tissues and co-expression genes
T260 70-241 Sentence denotes Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues.
T261 242-425 Sentence denotes Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung.
T262 426-569 Sentence denotes And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts.
T263 570-861 Sentence denotes Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells.
T264 862-1092 Sentence denotes Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.
T265 1093-1166 Sentence denotes Fig. 10 ACE2 and CD147 expression across tissues and co-expression genes.
T266 1167-1169 Sentence denotes A:
T267 1170-1228 Sentence denotes Radar plot of ACE2 and CD147 expression across 53 tissues.
T268 1229-1286 Sentence denotes The expression values were converted to base-2 logarithm.
T269 1287-1345 Sentence denotes Red triangle and square mean the top 5 expression tissues.
T270 1346-1348 Sentence denotes B:
T271 1349-1574 Sentence denotes UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic).
T272 1575-1673 Sentence denotes The horizontal bar graph at the bottom left shows the total number of proteins for each group set.
T273 1674-1763 Sentence denotes Circles and vertical lines in the x-axis mark the corresponding data sets being compared.
T274 1764-1983 Sentence denotes The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)