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LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"361","span":{"begin":626,"end":630},"obj":"Gene"},{"id":"362","span":{"begin":432,"end":437},"obj":"Species"},{"id":"363","span":{"begin":517,"end":522},"obj":"Species"},{"id":"364","span":{"begin":719,"end":724},"obj":"Species"},{"id":"365","span":{"begin":775,"end":778},"obj":"Species"},{"id":"366","span":{"begin":377,"end":382},"obj":"Chemical"},{"id":"367","span":{"begin":605,"end":607},"obj":"Chemical"},{"id":"368","span":{"begin":689,"end":693},"obj":"Chemical"},{"id":"369","span":{"begin":263,"end":271},"obj":"Disease"},{"id":"370","span":{"begin":679,"end":687},"obj":"Disease"},{"id":"371","span":{"begin":785,"end":793},"obj":"Disease"},{"id":"372","span":{"begin":806,"end":820},"obj":"Disease"},{"id":"373","span":{"begin":826,"end":844},"obj":"Disease"},{"id":"374","span":{"begin":857,"end":865},"obj":"Disease"},{"id":"375","span":{"begin":384,"end":390},"obj":"CellLine"}],"attributes":[{"id":"A361","pred":"tao:has_database_id","subj":"361","obj":"Gene:6582"},{"id":"A362","pred":"tao:has_database_id","subj":"362","obj":"Tax:9606"},{"id":"A363","pred":"tao:has_database_id","subj":"363","obj":"Tax:9606"},{"id":"A364","pred":"tao:has_database_id","subj":"364","obj":"Tax:9606"},{"id":"A365","pred":"tao:has_database_id","subj":"365","obj":"Tax:10116"},{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"MESH:D013667"},{"id":"A369","pred":"tao:has_database_id","subj":"369","obj":"MESH:D064420"},{"id":"A370","pred":"tao:has_database_id","subj":"370","obj":"MESH:D064420"},{"id":"A371","pred":"tao:has_database_id","subj":"371","obj":"MESH:D064420"},{"id":"A372","pred":"tao:has_database_id","subj":"372","obj":"MESH:D056486"},{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"MESH:D012871"},{"id":"A374","pred":"tao:has_database_id","subj":"374","obj":"MESH:D064420"},{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"CVCL:0025"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fig. 7 Chemical properties statistics of hub components in the formulae. A: Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad. Caco2: Caco-2 Permeability,HIA: Intestinal Absorption (Human), Skin: Skin Permeability, VDss: volume of distribution, FU: Fraction Unbound (Human), BBB: Blood Brain Barrier permeability, CNS: Central Nervous System permeability,TC: Total Clearance, OCT2: Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD: Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50: Oral Rat Acute Toxicity (LD50), HT: Hepatotoxicity, SS: Skin Sensitisation, MT: Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

LitCovid-PMC-OGER-BB

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T290","span":{"begin":312,"end":321},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T291","span":{"begin":377,"end":382},"obj":"CL_1"},{"id":"T292","span":{"begin":384,"end":390},"obj":"CL_1"},{"id":"T293","span":{"begin":409,"end":419},"obj":"UBERON:0000160"},{"id":"T294","span":{"begin":432,"end":437},"obj":"SP_6;NCBITaxon:9606"},{"id":"T295","span":{"begin":517,"end":522},"obj":"SP_6;NCBITaxon:9606"},{"id":"T296","span":{"begin":530,"end":541},"obj":"UBERON:0000120"},{"id":"T297","span":{"begin":564,"end":567},"obj":"UBERON:0001017"},{"id":"T298","span":{"begin":569,"end":591},"obj":"UBERON:0001017"},{"id":"T299","span":{"begin":626,"end":630},"obj":"PR:000013036"},{"id":"T300","span":{"begin":632,"end":637},"obj":"UBERON:0002113"},{"id":"T301","span":{"begin":638,"end":652},"obj":"CHEBI:25697;CHEBI:25697;PR:000014988"},{"id":"T302","span":{"begin":653,"end":666},"obj":"PR:000014988"},{"id":"T303","span":{"begin":719,"end":724},"obj":"SP_6;NCBITaxon:9606"},{"id":"T304","span":{"begin":727,"end":731},"obj":"PR:P11308"},{"id":"T305","span":{"begin":738,"end":742},"obj":"PR:P11308"},{"id":"T306","span":{"begin":770,"end":774},"obj":"UBERON:0000165"},{"id":"T307","span":{"begin":775,"end":778},"obj":"NCBITaxon:10114"},{"id":"T308","span":{"begin":846,"end":848},"obj":"UBERON:0001448"}],"text":"Fig. 7 Chemical properties statistics of hub components in the formulae. A: Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad. Caco2: Caco-2 Permeability,HIA: Intestinal Absorption (Human), Skin: Skin Permeability, VDss: volume of distribution, FU: Fraction Unbound (Human), BBB: Blood Brain Barrier permeability, CNS: Central Nervous System permeability,TC: Total Clearance, OCT2: Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD: Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50: Oral Rat Acute Toxicity (LD50), HT: Hepatotoxicity, SS: Skin Sensitisation, MT: Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T74","span":{"begin":409,"end":419},"obj":"Body_part"},{"id":"T75","span":{"begin":440,"end":444},"obj":"Body_part"},{"id":"T76","span":{"begin":446,"end":450},"obj":"Body_part"},{"id":"T77","span":{"begin":530,"end":535},"obj":"Body_part"},{"id":"T78","span":{"begin":536,"end":541},"obj":"Body_part"},{"id":"T79","span":{"begin":564,"end":567},"obj":"Body_part"},{"id":"T80","span":{"begin":569,"end":591},"obj":"Body_part"},{"id":"T81","span":{"begin":577,"end":591},"obj":"Body_part"},{"id":"T82","span":{"begin":826,"end":830},"obj":"Body_part"}],"attributes":[{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma7157"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma7163"}],"text":"Fig. 7 Chemical properties statistics of hub components in the formulae. A: Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad. Caco2: Caco-2 Permeability,HIA: Intestinal Absorption (Human), Skin: Skin Permeability, VDss: volume of distribution, FU: Fraction Unbound (Human), BBB: Blood Brain Barrier permeability, CNS: Central Nervous System permeability,TC: Total Clearance, OCT2: Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD: Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50: Oral Rat Acute Toxicity (LD50), HT: Hepatotoxicity, SS: Skin Sensitisation, MT: Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T18","span":{"begin":440,"end":444},"obj":"Body_part"},{"id":"T19","span":{"begin":446,"end":450},"obj":"Body_part"},{"id":"T20","span":{"begin":530,"end":549},"obj":"Body_part"},{"id":"T21","span":{"begin":564,"end":567},"obj":"Body_part"},{"id":"T22","span":{"begin":569,"end":591},"obj":"Body_part"},{"id":"T23","span":{"begin":826,"end":830},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000120"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"}],"text":"Fig. 7 Chemical properties statistics of hub components in the formulae. A: Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad. Caco2: Caco-2 Permeability,HIA: Intestinal Absorption (Human), Skin: Skin Permeability, VDss: volume of distribution, FU: Fraction Unbound (Human), BBB: Blood Brain Barrier permeability, CNS: Central Nervous System permeability,TC: Total Clearance, OCT2: Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD: Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50: Oral Rat Acute Toxicity (LD50), HT: Hepatotoxicity, SS: Skin Sensitisation, MT: Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T152","span":{"begin":646,"end":652},"obj":"Chemical"},{"id":"T153","span":{"begin":734,"end":736},"obj":"Chemical"},{"id":"T154","span":{"begin":749,"end":751},"obj":"Chemical"},{"id":"T155","span":{"begin":822,"end":824},"obj":"Chemical"},{"id":"T156","span":{"begin":846,"end":848},"obj":"Chemical"}],"attributes":[{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_36916"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_73653"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_73614"}],"text":"Fig. 7 Chemical properties statistics of hub components in the formulae. A: Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad. Caco2: Caco-2 Permeability,HIA: Intestinal Absorption (Human), Skin: Skin Permeability, VDss: volume of distribution, FU: Fraction Unbound (Human), BBB: Blood Brain Barrier permeability, CNS: Central Nervous System permeability,TC: Total Clearance, OCT2: Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD: Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50: Oral Rat Acute Toxicity (LD50), HT: Hepatotoxicity, SS: Skin Sensitisation, MT: Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T96","span":{"begin":409,"end":430},"obj":"http://purl.obolibrary.org/obo/GO_0050892"},{"id":"T97","span":{"begin":638,"end":664},"obj":"http://purl.obolibrary.org/obo/GO_0015695"}],"text":"Fig. 7 Chemical properties statistics of hub components in the formulae. A: Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad. Caco2: Caco-2 Permeability,HIA: Intestinal Absorption (Human), Skin: Skin Permeability, VDss: volume of distribution, FU: Fraction Unbound (Human), BBB: Blood Brain Barrier permeability, CNS: Central Nervous System permeability,TC: Total Clearance, OCT2: Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD: Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50: Oral Rat Acute Toxicity (LD50), HT: Hepatotoxicity, SS: Skin Sensitisation, MT: Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T175","span":{"begin":0,"end":72},"obj":"Sentence"},{"id":"T176","span":{"begin":73,"end":75},"obj":"Sentence"},{"id":"T177","span":{"begin":76,"end":376},"obj":"Sentence"},{"id":"T178","span":{"begin":377,"end":383},"obj":"Sentence"},{"id":"T179","span":{"begin":384,"end":408},"obj":"Sentence"},{"id":"T180","span":{"begin":409,"end":445},"obj":"Sentence"},{"id":"T181","span":{"begin":446,"end":498},"obj":"Sentence"},{"id":"T182","span":{"begin":499,"end":529},"obj":"Sentence"},{"id":"T183","span":{"begin":530,"end":568},"obj":"Sentence"},{"id":"T184","span":{"begin":569,"end":608},"obj":"Sentence"},{"id":"T185","span":{"begin":609,"end":631},"obj":"Sentence"},{"id":"T186","span":{"begin":632,"end":694},"obj":"Sentence"},{"id":"T187","span":{"begin":695,"end":769},"obj":"Sentence"},{"id":"T188","span":{"begin":770,"end":805},"obj":"Sentence"},{"id":"T189","span":{"begin":806,"end":825},"obj":"Sentence"},{"id":"T190","span":{"begin":826,"end":849},"obj":"Sentence"},{"id":"T191","span":{"begin":850,"end":997},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fig. 7 Chemical properties statistics of hub components in the formulae. A: Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad. Caco2: Caco-2 Permeability,HIA: Intestinal Absorption (Human), Skin: Skin Permeability, VDss: volume of distribution, FU: Fraction Unbound (Human), BBB: Blood Brain Barrier permeability, CNS: Central Nervous System permeability,TC: Total Clearance, OCT2: Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD: Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50: Oral Rat Acute Toxicity (LD50), HT: Hepatotoxicity, SS: Skin Sensitisation, MT: Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

PMC:7247521 / 26033-27030 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7247521 / 26033-27030 JSON TXT