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PMC:7247521 / 26033-27030 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
361 626-630 Gene denotes OCT2 Gene:6582
362 432-437 Species denotes Human Tax:9606
363 517-522 Species denotes Human Tax:9606
364 719-724 Species denotes Human Tax:9606
365 775-778 Species denotes Rat Tax:10116
366 377-382 Chemical denotes Caco2
367 605-607 Chemical denotes TC MESH:D013667
368 689-693 Chemical denotes MTDD
369 263-271 Disease denotes toxicity MESH:D064420
370 679-687 Disease denotes toxicity MESH:D064420
371 785-793 Disease denotes Toxicity MESH:D064420
372 806-820 Disease denotes Hepatotoxicity MESH:D056486
373 826-844 Disease denotes Skin Sensitisation MESH:D012871
374 857-865 Disease denotes toxicity MESH:D064420
375 384-390 CellLine denotes Caco-2 CVCL:0025

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T290 312-321 CHEBI:36357;CHEBI:36357 denotes compounds
T291 377-382 CL_1 denotes Caco2
T292 384-390 CL_1 denotes Caco-2
T293 409-419 UBERON:0000160 denotes Intestinal
T294 432-437 SP_6;NCBITaxon:9606 denotes Human
T295 517-522 SP_6;NCBITaxon:9606 denotes Human
T296 530-541 UBERON:0000120 denotes Blood Brain
T297 564-567 UBERON:0001017 denotes CNS
T298 569-591 UBERON:0001017 denotes Central Nervous System
T299 626-630 PR:000013036 denotes OCT2
T300 632-637 UBERON:0002113 denotes Renal
T301 638-652 CHEBI:25697;CHEBI:25697;PR:000014988 denotes Organic Cation
T302 653-666 PR:000014988 denotes Transporter 2
T303 719-724 SP_6;NCBITaxon:9606 denotes Human
T304 727-731 PR:P11308 denotes hERG
T305 738-742 PR:P11308 denotes hERG
T306 770-774 UBERON:0000165 denotes Oral
T307 775-778 NCBITaxon:10114 denotes Rat
T308 846-848 UBERON:0001448 denotes MT

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T74 409-419 Body_part denotes Intestinal http://purl.org/sig/ont/fma/fma7199
T75 440-444 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T76 446-450 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T77 530-535 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T78 536-541 Body_part denotes Brain http://purl.org/sig/ont/fma/fma50801
T79 564-567 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T80 569-591 Body_part denotes Central Nervous System http://purl.org/sig/ont/fma/fma55675
T81 577-591 Body_part denotes Nervous System http://purl.org/sig/ont/fma/fma7157
T82 826-830 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T18 440-444 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T19 446-450 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T20 530-549 Body_part denotes Blood Brain Barrier http://purl.obolibrary.org/obo/UBERON_0000120
T21 564-567 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T22 569-591 Body_part denotes Central Nervous System http://purl.obolibrary.org/obo/UBERON_0001017
T23 826-830 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T167 73-74 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T168 94-95 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T169 377-382 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco2
T170 377-382 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco2
T171 377-382 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco2
T172 377-382 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco2
T173 384-390 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T174 384-390 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T175 384-390 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T176 384-390 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T177 409-419 http://purl.obolibrary.org/obo/UBERON_0000160 denotes Intestinal
T178 409-419 http://www.ebi.ac.uk/efo/EFO_0000834 denotes Intestinal
T179 432-437 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T180 440-444 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T181 440-444 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T182 440-444 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T183 440-444 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T184 440-444 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T185 446-450 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T186 446-450 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T187 446-450 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T188 446-450 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T189 446-450 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T190 517-522 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T191 530-535 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T192 530-535 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T193 536-541 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T194 536-541 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Brain
T195 564-567 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T196 564-567 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T197 564-567 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T198 569-591 http://purl.obolibrary.org/obo/UBERON_0001017 denotes Central Nervous System
T199 569-591 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Central Nervous System
T200 569-591 http://www.ebi.ac.uk/efo/EFO_0000908 denotes Central Nervous System
T201 638-645 http://purl.obolibrary.org/obo/OBI_0100026 denotes Organic
T202 638-645 http://purl.obolibrary.org/obo/UBERON_0000468 denotes Organic
T203 719-724 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T204 802-804 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T205 826-830 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T206 826-830 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T207 826-830 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T208 826-830 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T209 826-830 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T152 646-652 Chemical denotes Cation http://purl.obolibrary.org/obo/CHEBI_36916
T153 734-736 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T154 749-751 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T155 822-824 Chemical denotes SS http://purl.obolibrary.org/obo/CHEBI_73653
T156 846-848 Chemical denotes MT http://purl.obolibrary.org/obo/CHEBI_73614

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T96 409-430 http://purl.obolibrary.org/obo/GO_0050892 denotes Intestinal Absorption
T97 638-664 http://purl.obolibrary.org/obo/GO_0015695 denotes Organic Cation Transporter

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T175 0-72 Sentence denotes Fig. 7 Chemical properties statistics of hub components in the formulae.
T176 73-75 Sentence denotes A:
T177 76-376 Sentence denotes Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad.
T178 377-383 Sentence denotes Caco2:
T179 384-408 Sentence denotes Caco-2 Permeability,HIA:
T180 409-445 Sentence denotes Intestinal Absorption (Human), Skin:
T181 446-498 Sentence denotes Skin Permeability, VDss: volume of distribution, FU:
T182 499-529 Sentence denotes Fraction Unbound (Human), BBB:
T183 530-568 Sentence denotes Blood Brain Barrier permeability, CNS:
T184 569-608 Sentence denotes Central Nervous System permeability,TC:
T185 609-631 Sentence denotes Total Clearance, OCT2:
T186 632-694 Sentence denotes Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD:
T187 695-769 Sentence denotes Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50:
T188 770-805 Sentence denotes Oral Rat Acute Toxicity (LD50), HT:
T189 806-825 Sentence denotes Hepatotoxicity, SS:
T190 826-849 Sentence denotes Skin Sensitisation, MT:
T191 850-997 Sentence denotes Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)