PMC:7247521 / 18135-19674 JSONTXT

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In addition, TTD analysis showed that the 8 diseases were significantly association with more than 3 formula groups, such as acne, Behcet'S disease, benign prostate hyperplasia, intrahepatic cholestasis and brain injury (Fig. 3B). However, the five formulae contained their specific (MSXG, SGMH, XCH, WLS and Others) GO, KEGG and TTD terms. For example, neurological system process and beta-Alanine metabolism terms were specific for MXSG; membrane organization and parasitic infections of the eye terms for SGMH; circadian rhythm and hypertension terms for XCH; nucleic acid binding transcription factor activity, ovarian steroidogenesis and chronic inflammatory diseases terms for WLS; fat digestion and absorption terms for Others.\nFig. 2 Bubble plot of the GO analysis of the five formulae’ targets.\nFig. 3 Bubble plot of the KEGG/TTD analysis of the five formulae’ targets. 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