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PMC:7247521 / 18135-19674 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
260 102-116 Gene denotes oxidoreductase Gene:8630
261 555-559 Gene denotes PPAR Gene:5465
262 127-132 Chemical denotes lipid MESH:D008055
263 152-157 Chemical denotes lipid MESH:D008055
264 429-436 Chemical denotes dteroid
265 525-532 Chemical denotes steroid MESH:D013256
266 579-587 Chemical denotes arginine MESH:D001120
267 592-599 Chemical denotes proline MESH:D011392
268 1030-1042 Chemical denotes beta-Alanine MESH:D015091
269 769-773 Disease denotes acne MESH:D000152
270 781-791 Disease denotes 'S disease MESH:D000755
271 793-820 Disease denotes benign prostate hyperplasia MESH:D011470
272 822-846 Disease denotes intrahepatic cholestasis MESH:D002780
273 851-863 Disease denotes brain injury MESH:D001930
274 940-943 Disease denotes XCH
275 1110-1130 Disease denotes parasitic infections MESH:D010272
276 1179-1191 Disease denotes hypertension MESH:D006973
277 1202-1205 Disease denotes XCH
278 1259-1282 Disease denotes ovarian steroidogenesis MESH:D010049
279 1295-1316 Disease denotes inflammatory diseases MESH:D007249

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T178 127-132 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T179 133-150 GO:0006629 denotes metabolic process
T180 152-157 CHEBI:18059;CHEBI:18059 denotes lipid
T181 173-181 CHEBI:36357;CHEBI:36357 denotes molecule
T182 182-199 GO:0044281 denotes metabolic process
T183 201-220 GO:0042592 denotes homeostatic process
T184 253-271 GO:0008283 denotes cell proliferation
T185 429-436 CHEBI:26537;CHEBI:26537 denotes dteroid
T186 437-449 GO:0006695 denotes biosynthesis
T187 525-532 GO:0006695;CHEBI:26764;CHEBI:26764 denotes steroid
T188 533-540 CHEBI:26764;CHEBI:26764;GO:0042446 denotes hormone
T189 541-553 GO:0042446 denotes biosynthesis
T190 579-587 GO:0006520 denotes arginine
T191 592-610 GO:0006560 denotes proline metabolism
T192 800-808 UBERON:0002367 denotes prostate
T193 822-834 UBERON:0002107 denotes intrahepatic
T194 851-856 UBERON:0000955 denotes brain
T195 998-1017 UBERON:0001016 denotes neurological system
T196 1030-1042 GO:0006635 denotes beta-Alanine
T197 1043-1053 GO:0019482 denotes metabolism
T198 1084-1092 GO:0016020 denotes membrane
T199 1138-1141 UBERON:0000970 denotes eye
T200 1168-1174 GO:0007623 denotes rhythm
T201 1207-1214 GO:0005634 denotes nucleic
T202 1259-1266 UBERON:0000992 denotes ovarian
T203 1267-1282 GO:0006694 denotes steroidogenesis

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T39 127-132 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T40 152-157 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T41 253-257 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T42 525-540 Body_part denotes steroid hormone http://purl.org/sig/ont/fma/fma83353
T43 579-587 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763
T44 592-599 Body_part denotes proline http://purl.org/sig/ont/fma/fma82761
T45 800-808 Body_part denotes prostate http://purl.org/sig/ont/fma/fma9600
T46 851-856 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T47 1035-1042 Body_part denotes Alanine http://purl.org/sig/ont/fma/fma82749
T48 1084-1105 Body_part denotes membrane organization http://purl.org/sig/ont/fma/fma7145
T49 1138-1141 Body_part denotes eye http://purl.org/sig/ont/fma/fma54448

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T14 851-856 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T15 1084-1105 Body_part denotes membrane organization http://purl.obolibrary.org/obo/UBERON_0000094
T16 1138-1141 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T46 769-773 Disease denotes acne http://purl.obolibrary.org/obo/MONDO_0011438
T47 775-791 Disease denotes Behcet'S disease http://purl.obolibrary.org/obo/MONDO_0007191
T48 793-820 Disease denotes benign prostate hyperplasia http://purl.obolibrary.org/obo/MONDO_0010811
T49 809-820 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T50 822-846 Disease denotes intrahepatic cholestasis http://purl.obolibrary.org/obo/MONDO_0019072
T51 835-846 Disease denotes cholestasis http://purl.obolibrary.org/obo/MONDO_0001751
T52 851-863 Disease denotes brain injury http://purl.obolibrary.org/obo/MONDO_0043510
T53 857-863 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T54 1110-1130 Disease denotes parasitic infections http://purl.obolibrary.org/obo/MONDO_0005135
T55 1179-1191 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T56 1295-1316 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T106 25-27 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T107 117-125 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T108 222-228 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T109 240-257 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity and cell
T110 465-474 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T111 560-569 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T112 640-641 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T113 851-856 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T114 851-856 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T115 1084-1092 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T116 1093-1105 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T117 1138-1141 http://www.ebi.ac.uk/efo/EFO_0000827 denotes eye
T118 1249-1257 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T119 1332-1335 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T120 1523-1524 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T121 1532-1533 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T75 127-132 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T76 152-157 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T77 173-181 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T78 496-502 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T79 525-540 Chemical denotes steroid hormone http://purl.obolibrary.org/obo/CHEBI_26764
T80 525-532 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T81 533-540 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T82 579-587 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T85 592-599 Chemical denotes proline http://purl.obolibrary.org/obo/CHEBI_17203|http://purl.obolibrary.org/obo/CHEBI_26271
T87 615-618 Chemical denotes ABC http://purl.obolibrary.org/obo/CHEBI_421707
T88 657-660 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T89 974-977 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T90 1030-1042 Chemical denotes beta-Alanine http://purl.obolibrary.org/obo/CHEBI_16958
T91 1030-1034 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T92 1035-1042 Chemical denotes Alanine http://purl.obolibrary.org/obo/CHEBI_16449
T93 1207-1219 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T94 1215-1219 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T95 1479-1482 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T96 1535-1538 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T11 769-773 Phenotype denotes acne http://purl.obolibrary.org/obo/HP_0001061
T12 793-820 Phenotype denotes benign prostate hyperplasia http://purl.obolibrary.org/obo/HP_0008711
T13 822-846 Phenotype denotes intrahepatic cholestasis http://purl.obolibrary.org/obo/HP_0001406
T14 1179-1191 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T30 117-150 http://purl.obolibrary.org/obo/GO_0045834 denotes activity, lipid metabolic process
T31 127-150 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolic process
T32 133-150 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T33 167-199 http://purl.obolibrary.org/obo/GO_0044281 denotes small molecule metabolic process
T34 182-199 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T35 201-220 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostatic process
T36 240-271 http://purl.obolibrary.org/obo/GO_0008284 denotes activity and cell proliferation
T37 253-271 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T38 437-449 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T39 451-482 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T40 451-482 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T41 451-482 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T42 465-482 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T43 465-474 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 533-553 http://purl.obolibrary.org/obo/GO_0042446 denotes hormone biosynthesis
T45 541-553 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T46 555-577 http://purl.obolibrary.org/obo/GO_0035357 denotes PPAR signaling pathway
T47 560-577 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T48 560-569 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T49 592-610 http://purl.obolibrary.org/obo/GO_0006560 denotes proline metabolism
T50 600-610 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T51 615-631 http://purl.obolibrary.org/obo/GO_0140359 denotes ABC transporters
T52 998-1025 http://purl.obolibrary.org/obo/GO_0050877 denotes neurological system process
T53 1011-1025 http://purl.obolibrary.org/obo/GO_0003008 denotes system process
T54 1030-1053 http://purl.obolibrary.org/obo/GO_0019482 denotes beta-Alanine metabolism
T55 1043-1053 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T56 1084-1105 http://purl.obolibrary.org/obo/GO_0061024 denotes membrane organization
T57 1158-1174 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T58 1168-1174 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T59 1207-1257 http://purl.obolibrary.org/obo/GO_0003700 denotes nucleic acid binding transcription factor activity
T60 1228-1248 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T61 1228-1241 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T62 1267-1282 http://purl.obolibrary.org/obo/GO_0006694 denotes steroidogenesis
T63 1336-1345 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T102 0-272 Sentence denotes As shown in Fig. 2 , the 11 enriched GO terms of the targets in all five formulae were found, such as oxidoreductase activity, lipid metabolic process, lipid binding, small molecule metabolic process, homeostatic process, signal transducer activity and cell proliferation.
T103 273-643 Sentence denotes Furthermore, the results of pathway enrichment analysis showed that the 7 KEGG pathways were significantly related to more than 4 formula groups, including dteroid biosynthesis, adipocytokine signaling pathway, neuroactive ligand-receptor interaction, steroid hormone biosynthesis, PPAR signaling pathway, arginine and proline metabolism and ABC transporters (Fig. 3 A).
T104 644-874 Sentence denotes In addition, TTD analysis showed that the 8 diseases were significantly association with more than 3 formula groups, such as acne, Behcet'S disease, benign prostate hyperplasia, intrahepatic cholestasis and brain injury (Fig. 3B).
T105 875-984 Sentence denotes However, the five formulae contained their specific (MSXG, SGMH, XCH, WLS and Others) GO, KEGG and TTD terms.
T106 985-1378 Sentence denotes For example, neurological system process and beta-Alanine metabolism terms were specific for MXSG; membrane organization and parasitic infections of the eye terms for SGMH; circadian rhythm and hypertension terms for XCH; nucleic acid binding transcription factor activity, ovarian steroidogenesis and chronic inflammatory diseases terms for WLS; fat digestion and absorption terms for Others.
T107 1379-1447 Sentence denotes Fig. 2 Bubble plot of the GO analysis of the five formulae’ targets.
T108 1448-1522 Sentence denotes Fig. 3 Bubble plot of the KEGG/TTD analysis of the five formulae’ targets.
T109 1523-1539 Sentence denotes A: KEGG, B: TTD.