PMC:7247483 / 489-1238 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7247483","sourcedb":"PMC","sourceid":"7247483","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7247483","text":"The traditional detection methods used for fungal infection, such as culture methods and histopathology, might bring unpredictable biosafety issues, since the relevant specimens cannot be inactivated. Therefore, serological assays for fungal antigens, including (1,3)-β-D-glucan (G), galactomannan (GM), and mannan (Mn) tests commonly used for serological diagnosis fungal infection.1 , 2 The sensitivity of G test in invasive Candida and Aspergillus infection is 70%–80%, and the specificity is 70%–80%. The serum GM detection is as sensitive as 70%–80%. The sensitivity of mannan detection is 58% and the specificity is 93%. When the combined detection of mannan antigen and antibody can improve the sensitivity of 83% and the specificity of 86%.3","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":284,"end":297},"obj":"https://glytoucan.org/Structures/Glycans/G93424OB"},{"id":"T2","span":{"begin":299,"end":301},"obj":"https://glytoucan.org/Structures/Glycans/G93424OB"},{"id":"T3","span":{"begin":515,"end":517},"obj":"https://glytoucan.org/Structures/Glycans/G93424OB"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T2","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T3","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":509,"end":514},"obj":"Body_part"},{"id":"T2","span":{"begin":677,"end":685},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62871"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":509,"end":514},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T13","span":{"begin":43,"end":59},"obj":"Disease"},{"id":"T14","span":{"begin":50,"end":59},"obj":"Disease"},{"id":"T15","span":{"begin":366,"end":382},"obj":"Disease"},{"id":"T16","span":{"begin":373,"end":382},"obj":"Disease"},{"id":"T17","span":{"begin":451,"end":460},"obj":"Disease"}],"attributes":[{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0002041"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0002041"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T2","span":{"begin":320,"end":325},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T3","span":{"begin":410,"end":414},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":242,"end":250},"obj":"Chemical"},{"id":"T2","span":{"begin":272,"end":278},"obj":"Chemical"},{"id":"T3","span":{"begin":284,"end":297},"obj":"Chemical"},{"id":"T4","span":{"begin":299,"end":301},"obj":"Chemical"},{"id":"T6","span":{"begin":308,"end":314},"obj":"Chemical"},{"id":"T7","span":{"begin":316,"end":318},"obj":"Chemical"},{"id":"T9","span":{"begin":515,"end":517},"obj":"Chemical"},{"id":"T11","span":{"begin":575,"end":581},"obj":"Chemical"},{"id":"T12","span":{"begin":658,"end":664},"obj":"Chemical"},{"id":"T13","span":{"begin":665,"end":672},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_37163"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A5","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_28808"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_18291"},{"id":"A8","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_28808"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A10","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_28808"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_28808"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":0,"end":200},"obj":"Sentence"},{"id":"T8","span":{"begin":201,"end":504},"obj":"Sentence"},{"id":"T9","span":{"begin":505,"end":555},"obj":"Sentence"},{"id":"T10","span":{"begin":556,"end":626},"obj":"Sentence"},{"id":"T11","span":{"begin":627,"end":749},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":284,"end":297},"obj":"GlycoEpitope"},{"id":"T2","span":{"begin":299,"end":301},"obj":"GlycoEpitope"},{"id":"T3","span":{"begin":515,"end":517},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"id":"A2","pred":"glyco_epitope_db_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#93ece8","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ecce93"},{"id":"LitCovid-PD-UBERON","color":"#b393ec"},{"id":"LitCovid-PD-MONDO","color":"#93ec99"},{"id":"LitCovid-PD-CLO","color":"#ec93a6"},{"id":"LitCovid-PD-CHEBI","color":"#93c0ec"},{"id":"LitCovid-sentences","color":"#daec93"},{"id":"LitCovid-PD-GlycoEpitope","color":"#e493ec"}]}]}}