The traditional detection methods used for fungal infection, such as culture methods and histopathology, might bring unpredictable biosafety issues, since the relevant specimens cannot be inactivated. Therefore, serological assays for fungal antigens, including (1,3)-β-D-glucan (G), galactomannan (GM), and mannan (Mn) tests commonly used for serological diagnosis fungal infection.1 , 2 The sensitivity of G test in invasive Candida and Aspergillus infection is 70%–80%, and the specificity is 70%–80%. The serum GM detection is as sensitive as 70%–80%. The sensitivity of mannan detection is 58% and the specificity is 93%. When the combined detection of mannan antigen and antibody can improve the sensitivity of 83% and the specificity of 86%.3