PMC:7243778 / 26780-27660 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"662","span":{"begin":473,"end":478},"obj":"Gene"},{"id":"663","span":{"begin":713,"end":718},"obj":"Gene"},{"id":"664","span":{"begin":30,"end":38},"obj":"Species"},{"id":"665","span":{"begin":43,"end":53},"obj":"Species"},{"id":"666","span":{"begin":273,"end":283},"obj":"Species"},{"id":"667","span":{"begin":299,"end":307},"obj":"Species"},{"id":"668","span":{"begin":801,"end":811},"obj":"Species"},{"id":"669","span":{"begin":855,"end":863},"obj":"Species"}],"attributes":[{"id":"A662","pred":"tao:has_database_id","subj":"662","obj":"Gene:43740568"},{"id":"A663","pred":"tao:has_database_id","subj":"663","obj":"Gene:43740568"},{"id":"A664","pred":"tao:has_database_id","subj":"664","obj":"Tax:694009"},{"id":"A665","pred":"tao:has_database_id","subj":"665","obj":"Tax:2697049"},{"id":"A666","pred":"tao:has_database_id","subj":"666","obj":"Tax:2697049"},{"id":"A667","pred":"tao:has_database_id","subj":"667","obj":"Tax:694009"},{"id":"A668","pred":"tao:has_database_id","subj":"668","obj":"Tax:2697049"},{"id":"A669","pred":"tao:has_database_id","subj":"669","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues. This change has an important impact on the cross-reactivity of nAbs. This difference was observed using bioinformatic approaches of epitope analysis. The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV. Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic. The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions. The divergence of spike proteins is considered as a major change in the antibody epitopes. The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T119","span":{"begin":247,"end":255},"obj":"Body_part"},{"id":"T120","span":{"begin":409,"end":417},"obj":"Body_part"},{"id":"T121","span":{"begin":479,"end":487},"obj":"Body_part"},{"id":"T122","span":{"begin":648,"end":656},"obj":"Body_part"},{"id":"T123","span":{"begin":719,"end":727},"obj":"Body_part"},{"id":"T124","span":{"begin":767,"end":775},"obj":"Body_part"}],"attributes":[{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues. This change has an important impact on the cross-reactivity of nAbs. This difference was observed using bioinformatic approaches of epitope analysis. The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV. Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic. The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions. The divergence of spike proteins is considered as a major change in the antibody epitopes. The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T115","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"T116","span":{"begin":43,"end":51},"obj":"Disease"},{"id":"T117","span":{"begin":273,"end":281},"obj":"Disease"},{"id":"T118","span":{"begin":299,"end":307},"obj":"Disease"},{"id":"T119","span":{"begin":801,"end":809},"obj":"Disease"},{"id":"T120","span":{"begin":855,"end":863},"obj":"Disease"}],"attributes":[{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A118","pred":"mondo_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues. This change has an important impact on the cross-reactivity of nAbs. This difference was observed using bioinformatic approaches of epitope analysis. The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV. Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic. The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions. The divergence of spike proteins is considered as a major change in the antibody epitopes. The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T325","span":{"begin":105,"end":108},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T326","span":{"begin":386,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T327","span":{"begin":745,"end":746},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues. This change has an important impact on the cross-reactivity of nAbs. This difference was observed using bioinformatic approaches of epitope analysis. The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV. Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic. The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions. The divergence of spike proteins is considered as a major change in the antibody epitopes. The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T153","span":{"begin":225,"end":232},"obj":"Chemical"},{"id":"T154","span":{"begin":256,"end":263},"obj":"Chemical"},{"id":"T155","span":{"begin":418,"end":425},"obj":"Chemical"},{"id":"T156","span":{"begin":479,"end":487},"obj":"Chemical"},{"id":"T157","span":{"begin":580,"end":587},"obj":"Chemical"},{"id":"T158","span":{"begin":719,"end":727},"obj":"Chemical"}],"attributes":[{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A157","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A158","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues. This change has an important impact on the cross-reactivity of nAbs. This difference was observed using bioinformatic approaches of epitope analysis. The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV. Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic. The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions. The divergence of spike proteins is considered as a major change in the antibody epitopes. The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T208","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T209","span":{"begin":93,"end":161},"obj":"Sentence"},{"id":"T210","span":{"begin":162,"end":242},"obj":"Sentence"},{"id":"T211","span":{"begin":243,"end":308},"obj":"Sentence"},{"id":"T212","span":{"begin":309,"end":512},"obj":"Sentence"},{"id":"T213","span":{"begin":513,"end":694},"obj":"Sentence"},{"id":"T214","span":{"begin":695,"end":785},"obj":"Sentence"},{"id":"T215","span":{"begin":786,"end":880},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues. This change has an important impact on the cross-reactivity of nAbs. This difference was observed using bioinformatic approaches of epitope analysis. The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV. Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic. The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions. The divergence of spike proteins is considered as a major change in the antibody epitopes. The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95]."}