PMC:7243778 / 25925-26779 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243778","sourcedb":"PMC","sourceid":"7243778","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243778","text":"Due to the high similarity of S proteins from SARS-CoV and MERS-CoV [73], their specific cross-nAbs were tested against SARS-CoV-2 infection in the COVID-19 outbreak. Serum Abs from recovered SARS-CoV patients could efficiently cross-neutralize SARS-CoV-2 but with lower efficiency as compared to SARS-CoV [92]. Cross-reactive Abs against SARS-CoV-2 S protein mostly target non-RBD regions [93]. Using simulation technique, the binding of five Abs against SARS-CoV, six Abs anti-MERS-CoV to RBD of SARS-CoV-2 was predicted with Rosetta antibody-antigen docking protocols. The amino acid position 445–449 (VGGNY) and 470–486 (TEIYQAGSTPCNGVEGF) were found to be conserved in SARS-CoV-2. 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