> top > docs > PMC:7243778 > spans > 12246-13855 > annotations

PMC:7243778 / 12246-13855 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
287 49-53 Gene denotes scFv Gene:652070
288 76-79 Gene denotes ACE Gene:1636
289 362-366 Gene denotes scFv Gene:652070
290 1102-1106 Gene denotes scFv Gene:652070
291 1412-1416 Gene denotes scFv Gene:652070
292 669-672 Gene denotes fab Gene:2187
293 4-9 Species denotes human Tax:9606
294 264-274 Species denotes SARS-CoV-2 Tax:2697049
295 807-815 Species denotes SARS-CoV Tax:694009
296 991-999 Species denotes SARS-CoV Tax:694009
297 1170-1178 Species denotes SARS-CoV Tax:694009
298 1375-1385 Species denotes SARS-CoV-2 Tax:2697049
299 1460-1468 Species denotes SARS-CoV Tax:694009
300 1551-1559 Species denotes SARS-CoV Tax:694009
301 654-659 Species denotes human Tax:9606
302 1071-1076 Species denotes human Tax:9606
303 1323-1331 Species denotes SARS-CoV Tax:694009
304 939-943 Gene denotes S3.1 Gene:3354
305 200-206 Chemical denotes lysine MESH:D008239
306 330-333 Chemical denotes nAb
307 503-506 Chemical denotes 80R
308 799-803 Chemical denotes D408
309 826-830 Chemical denotes m396
310 1117-1123 Chemical denotes CR3014
311 1226-1232 Chemical denotes CR3014
312 1392-1398 Chemical denotes CR3022
313 1541-1547 Chemical denotes CR3014
314 597-602 Mutation denotes D480A p.D480A
315 480-485 Mutation denotes D480A p.D480A
316 1583-1588 Mutation denotes P426L p.P426L
317 1238-1243 Mutation denotes P426L p.P426L

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T53 55-63 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T54 200-206 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T55 660-668 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T56 1033-1037 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920
T57 1088-1096 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T58 1262-1274 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T59 1364-1371 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T41 264-272 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 807-815 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 991-999 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 1170-1178 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 1323-1331 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 1375-1383 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 1460-1468 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 1551-1559 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T138 4-9 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T139 105-107 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T140 310-315 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T141 317-319 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T142 349-350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 578-579 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 637-639 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T145 644-647 http://purl.obolibrary.org/obo/CLO_0054064 denotes 491
T146 654-659 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T147 701-703 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T148 738-739 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 821-823 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T150 1058-1060 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T151 1071-1076 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T152 1133-1135 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T153 1209-1214 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 1387-1389 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T155 1482-1484 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T156 1502-1503 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T59 97-104 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T60 200-206 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T62 229-236 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T63 404-411 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T64 629-636 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T65 740-744 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T67 1125-1132 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T68 1262-1274 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T69 1364-1371 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 1474-1481 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T99 0-217 Sentence denotes The human single-chain variable region fragment (scFv) antibody 80R blocked ACE-RBD interaction (epitope aa 324–503) [32] but some 80R-escape variants were found with the mutations mostly locating at lysine D480 [33].
T100 218-321 Sentence denotes The target epitope of 80R is not conserved in SARS-CoV-2 then it does not affect this novel virus [34].
T101 322-451 Sentence denotes Another nAb generated from a non-immune scFv library, named 256, could bind to an epitope of RBD but did not inhibit RBD binding.
T102 452-523 Sentence denotes 256 is weak but specific to D480A-muted strains of 80R-escape variants.
T103 524-1062 Sentence denotes Some engineered broad nAbs, fm6 and fm39, also showed a high affinity to D480A-muted strains [33]. m396 (epitope aa 482–491) from human antibody fab library was cross-reactive [35] and used the D95 of m396 to form a salt bridge with R395 or an electrostatic interaction with D408 of SARS-CoV RBD [34]. m396 potently neutralized GD03 strain isolated from the second outbreak which resisted neutralization by 80R and S3.1. m396 also neutralized isolates from the first SARS-CoV outbreak (Urbani, Tor2) and from palm civets (SZ3, SZ16) [36].
T104 1063-1280 Sentence denotes Another human monoclonal antibody from scFv libraries CR3014 (epitope aa 318–510) showed potent effects on SARS-CoV neutralization; however, this virus can escape CR3014 upon P426L mutation in the S glycoprotein [37].
T105 1281-1391 Sentence denotes Same as 80R, m396 and CR3014 RBD-specific SARS-CoV antibodies failed to bind the S protein of SARS-CoV-2 [34].
T106 1392-1609 Sentence denotes CR3022, always from scFv libraries, could bind noncompetitively the SARS-CoV RBD (epitope aa 318–510) and had a synergistic neutralizing effect with CR3014 on SARS-CoV, even with the escaped P426L-muted variants [37].

2_test

Id Subject Object Predicate Lexical cue
32450171-15857975-66454457 118-120 15857975 denotes 32
32450171-32065055-66454458 317-319 32065055 denotes 34
32450171-16597622-66454459 701-703 16597622 denotes 35
32450171-32065055-66454460 821-823 32065055 denotes 34
32450171-17620608-66454461 1058-1060 17620608 denotes 36
32450171-32065055-66454462 1387-1389 32065055 denotes 34