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PMC:7243768 / 27329-30999 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1054 5-15 Species denotes SARS-CoV-2 Tax:2697049
1055 18-31 Disease denotes heart disease MESH:D006331
1072 32-36 Gene denotes ACE2 Gene:59272
1073 200-204 Gene denotes ACE2 Gene:59272
1074 281-285 Gene denotes ACE2 Gene:59272
1075 232-242 Species denotes SARS-CoV-2 Tax:2697049
1076 487-495 Species denotes patients Tax:9606
1077 571-579 Species denotes patients Tax:9606
1078 861-869 Species denotes patients Tax:9606
1079 159-171 Disease denotes hypertension MESH:D006973
1080 176-192 Disease denotes type II diabetes MESH:D003924
1081 402-422 Disease denotes SARS-CoV-2 infection MESH:C000657245
1082 433-445 Disease denotes hypertensive MESH:D006973
1083 562-570 Disease denotes COVID-19 MESH:C000657245
1084 599-611 Disease denotes hypertension MESH:D006973
1085 706-718 Disease denotes hypertensive MESH:D006973
1086 832-847 Disease denotes viral infection MESH:D001102
1087 900-908 Disease denotes infected MESH:D007239
1099 1009-1013 Gene denotes ACE2 Gene:59272
1100 993-1003 Species denotes SARS-CoV-2 Tax:2697049
1101 1173-1183 Species denotes SARS-CoV-2 Tax:2697049
1102 1225-1233 Species denotes SARS-CoV Tax:694009
1103 1235-1243 Species denotes SARS-CoV Tax:694009
1104 1350-1360 Species denotes SARS-CoV-2 Tax:2697049
1105 1540-1548 Species denotes patients Tax:9606
1106 1070-1082 Disease denotes heart injury MESH:D006335
1107 1258-1279 Disease denotes cardiovascular damage MESH:D002318
1108 1456-1479 Disease denotes acute coronary syndrome MESH:D054058
1109 1563-1571 Disease denotes COVID-19 MESH:C000657245
1143 1588-1592 Gene denotes ACE2 Gene:59272
1144 1867-1870 Gene denotes ACE Gene:1636
1145 1943-1957 Gene denotes angiotensin II Gene:183
1146 1999-2003 Gene denotes ACE2 Gene:59272
1147 2022-2052 Gene denotes angiotensin II type 1 receptor Gene:185
1148 2073-2083 Gene denotes profilin-1 Gene:5216
1149 2099-2103 Gene denotes ACE2 Gene:59272
1150 2131-2145 Gene denotes angiotensin II Gene:183
1151 2200-2204 Gene denotes ACE2 Gene:59272
1152 2325-2329 Gene denotes ACE2 Gene:59272
1153 2338-2342 Gene denotes ACE2 Gene:59272
1154 2367-2370 Gene denotes ACE Gene:1636
1155 2403-2417 Gene denotes angiotensin II Gene:183
1156 2546-2550 Gene denotes ACE2 Gene:59272
1157 2597-2601 Gene denotes ACE2 Gene:59272
1158 2651-2655 Gene denotes ACE2 Gene:59272
1159 2703-2707 Gene denotes ACE2 Gene:59272
1160 2726-2729 Gene denotes ACE Gene:1636
1161 2929-2959 Gene denotes angiotensin II type 1 receptor Gene:185
1162 2527-2541 Gene denotes angiotensin II Gene:183
1163 1631-1639 Species denotes patients Tax:9606
1164 1654-1664 Species denotes SARS-CoV-2 Tax:2697049
1165 2557-2567 Species denotes SARS-CoV 2 Tax:2697049
1166 2275-2285 Chemical denotes lisinopril MESH:D017706
1167 2290-2298 Chemical denotes losartan MESH:D019808
1168 1640-1648 Disease denotes infected MESH:D007239
1169 1686-1701 Disease denotes cardiac failure MESH:D006333
1170 2830-2837 Disease denotes atrophy MESH:D001284
1171 2845-2853 Disease denotes fibrosis MESH:D005355
1172 2860-2872 Disease denotes inflammation MESH:D007249
1173 2971-2978 Disease denotes atrophy MESH:D001284
1174 2984-2992 Disease denotes fibrosis MESH:D005355
1175 2998-3010 Disease denotes inflammation MESH:D007249
1185 3411-3415 Gene denotes ACE2 Gene:59272
1186 3532-3537 Gene denotes renin Gene:5972
1187 3370-3375 Gene denotes renin Gene:5972
1188 3258-3266 Species denotes patients Tax:9606
1189 3637-3645 Species denotes patients Tax:9606
1190 3337-3346 Chemical denotes Aliskiren MESH:C446481
1191 3279-3287 Disease denotes COVID-19 MESH:C000657245
1192 3480-3500 Disease denotes diabetic nephropathy MESH:D003928
1193 3628-3636 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T256 18-23 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T257 63-84 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T258 134-139 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T259 268-272 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T260 318-323 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T261 339-344 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T262 1070-1075 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T263 1124-1138 Body_part denotes T-helper cells http://purl.org/sig/ont/fma/fma70572
T264 1133-1138 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T265 1150-1158 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T266 1616-1625 Body_part denotes pericytes http://purl.org/sig/ont/fma/fma63174
T267 2073-2081 Body_part denotes profilin http://purl.org/sig/ont/fma/fma67123
T268 2343-2347 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T269 2584-2588 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T270 2688-2695 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T271 2796-2802 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T272 2919-2923 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T273 3113-3119 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T274 3437-3442 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T125 18-23 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T126 63-84 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T127 134-139 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T128 318-323 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T129 1070-1075 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T130 2796-2802 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T131 2919-2923 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T132 3113-3119 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T133 3437-3442 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T314 5-13 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T315 5-9 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T316 18-31 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T317 159-171 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T318 176-192 Disease denotes type II diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T319 184-192 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T320 232-240 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T321 232-236 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T322 402-410 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T323 402-406 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T324 413-422 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T325 562-570 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T326 599-611 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T327 832-847 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T328 838-847 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T329 993-1001 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T330 993-997 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T331 1076-1082 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T332 1173-1181 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T333 1173-1177 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 1225-1233 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T335 1225-1229 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 1235-1243 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T337 1235-1239 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T338 1350-1358 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T339 1350-1354 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T340 1456-1479 Disease denotes acute coronary syndrome http://purl.obolibrary.org/obo/MONDO_0005542
T341 1563-1571 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T342 1654-1662 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T343 1654-1658 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T344 1686-1701 Disease denotes cardiac failure http://purl.obolibrary.org/obo/MONDO_0005252
T345 2557-2565 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T346 2557-2561 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T347 2803-2809 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T348 2860-2872 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T349 2998-3010 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T350 3120-3126 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T351 3279-3287 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T352 3480-3500 Disease denotes diabetic nephropathy http://purl.obolibrary.org/obo/MONDO_0005016
T353 3489-3500 Disease denotes nephropathy http://purl.obolibrary.org/obo/MONDO_0005240
T354 3628-3636 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T379 18-23 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T380 18-23 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T381 18-23 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T382 18-23 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T383 43-44 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T384 63-84 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
T385 63-84 http://www.ebi.ac.uk/efo/EFO_0000791 denotes cardiovascular system
T386 134-139 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T387 134-139 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T388 134-139 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T389 134-139 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T390 268-272 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T391 318-323 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T392 318-323 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T393 318-323 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T394 318-323 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T395 339-344 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T396 357-358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T397 459-462 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T398 921-926 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T399 1023-1024 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T400 1025-1031 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T401 1070-1075 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T402 1070-1075 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T403 1070-1075 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T404 1070-1075 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T405 1124-1138 http://purl.obolibrary.org/obo/CL_0000912 denotes T-helper cells
T406 1148-1149 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T407 1184-1187 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T408 1188-1189 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T409 1390-1391 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T410 1987-1995 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T411 2146-2154 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T412 2224-2232 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T413 2313-2321 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T414 2584-2588 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T415 2755-2762 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus's
T416 3215-3218 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T417 3348-3349 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T418 3437-3442 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T419 3437-3442 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T420 3457-3460 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T421 3501-3507 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T422 3605-3606 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T120 181-183 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T121 512-516 Chemical denotes ACEi http://purl.obolibrary.org/obo/CHEBI_35457
T122 624-628 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T123 632-636 Chemical denotes ACEi http://purl.obolibrary.org/obo/CHEBI_35457
T124 651-662 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T125 1777-1795 Chemical denotes mineralocorticoids http://purl.obolibrary.org/obo/CHEBI_25354
T126 1908-1919 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T127 1943-1957 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T130 1943-1954 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T131 1955-1957 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T132 2008-2018 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T133 2022-2036 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T136 2022-2033 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T137 2034-2036 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T138 2131-2145 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T141 2131-2142 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T142 2143-2145 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T143 2275-2285 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T144 2290-2298 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T145 2403-2417 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T148 2403-2414 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T149 2415-2417 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T150 2436-2447 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T151 2457-2471 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T154 2457-2468 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T155 2469-2471 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T156 2488-2498 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T157 2527-2541 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T160 2527-2538 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T161 2539-2541 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T162 2688-2695 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T163 2879-2886 Chemical denotes oxidant http://purl.obolibrary.org/obo/CHEBI_63248
T164 2929-2943 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T167 2929-2940 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T168 2941-2943 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T169 3016-3023 Chemical denotes oxidant http://purl.obolibrary.org/obo/CHEBI_63248
T170 3180-3184 Chemical denotes ACEi http://purl.obolibrary.org/obo/CHEBI_35457
T171 3196-3214 Chemical denotes mineralocorticoids http://purl.obolibrary.org/obo/CHEBI_25354
T172 3357-3366 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T173 3559-3568 Chemical denotes aliskiren http://purl.obolibrary.org/obo/CHEBI_601027

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T42 134-155 http://purl.obolibrary.org/obo/GO_0007507 denotes heart and development
T43 832-847 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T44 1095-1110 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T45 2158-2167 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T46 2390-2399 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T47 2422-2432 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T48 2513-2523 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T49 2860-2872 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T50 2892-2904 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T51 2998-3010 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T52 3055-3071 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T185 0-31 Sentence denotes 6.1 SARS-CoV-2 – heart disease
T186 32-193 Sentence denotes ACE2 plays a vital role in the cardiovascular system and is mainly involved in the functioning of the heart and development of hypertension and type II diabetes.
T187 194-423 Sentence denotes Since ACE2 is the main target for the SARS-CoV-2 to enter inside the host cell and the ACE2 is also highly expressed in the heart apart from the lungs, indicating a chance of developing cardiac issues during SARS-CoV-2 infection.
T188 424-557 Sentence denotes The anti-hypertensive therapy that has been prescribed for the patients is the usage of ACEi and ARBs should be carefully considered.
T189 558-811 Sentence denotes The COVID-19 patients with comorbidities hypertension, taking the drug of ACEi or blocker of angiotensin receptor, need to switch off to other anti-hypertensive medications found to be controversial and require further studies this co-morbid conditions.
T190 812-969 Sentence denotes The severity of the viral infection is higher in patients with comorbidities than those infected only by the virus without any predisposed health issue [85].
T191 970-1168 Sentence denotes The interaction of the SARS-CoV-2 with ACE2 triggers a signal, which might be the reason to develop heart injury through the immune response triggered by T-helper cells creating a cytokine response.
T192 1169-1234 Sentence denotes The SARS-CoV-2 has a structural similarity with that of SARS-CoV.
T193 1235-1307 Sentence denotes SARS-CoV caused severe cardiovascular damage during its pandemic period.
T194 1308-1417 Sentence denotes Therefore, it is essential to investigate SARS-CoV-2 treatment options and ensure a cardio-protective effect.
T195 1418-1577 Sentence denotes The age and the predisposition of the acute coronary syndrome are the two critical factors which need to be considered in patients affected with COVID-19 [85].
T196 1578-1763 Sentence denotes Since the ACE2 is highly expressed in pericytes, the patients infected with SARS-CoV-2 and predisposed with cardiac failure are more susceptible to develop severe cardiac problems [86].
T197 1764-2109 Sentence denotes The usage of mineralocorticoids receptor blocker can attenuates oxidative stress, reduces the level of ACE with the augmented production of the angiotensin 1–7 and attenuates the angiotensin II generation and increases the activity of ACE2 The antagonist of angiotensin II type 1 receptor, have modulates the profilin-1 expression and ACE2 [87].
T198 2110-2244 Sentence denotes The selective of the angiotensin II activity or synthesis mediated the augmented level of ACE2 expression and its activity in cardiac.
T199 2245-2348 Sentence denotes Still, the combination of the lisinopril and losartan increases the activity of ACE2 but not ACE2 mRNA.
T200 2349-2556 Sentence denotes The inhibition of ACE results in reduced formation of angiotensin II and metabolism of angiotensin 1–7, the angiotensin II type 1 receptor antagonist increases the metabolism of angiotensin II via ACE2 [88].
T201 2557-2730 Sentence denotes SARS-CoV 2 enters into the cell via the ACE2 receptor; this causes the decreased level of the ACE2 due to the binding of the spike protein to the ACE2 and no changes in ACE.
T202 2731-2905 Sentence denotes This process causes the virus's entry, replicates it, and causes tissue injury via decreasing anti-atrophy, anti0-fibrosis, anti-inflammation, anti-oxidant, and vasodilation.
T203 2906-3157 Sentence denotes On the other hand, the angiotensin II type 1 receptor causes pro-atrophy, pro-fibrosis, pro-inflammation, pro-oxidant, severe myocardial remodeling, vasoconstriction and vascular permeability which leads to tissue injury [89] (represented in Table 1).
T204 3158-3336 Sentence denotes Therefore, the use of ACEi, ARBs, and mineralocorticoids has shown to have an impact on the cardiac patients affected by COVID-19, but the exact mechanism behind it is not clear.
T205 3337-3520 Sentence denotes Aliskiren, a direct inhibitor of renin, resulted in reduced expression of ACE2 besides reducing the blood pressure that has been elucidated in diabetic nephropathy animal models [90].
T206 3521-3670 Sentence denotes Therefore, renin blockers, especially aliskiren, need to be further investigated as a treatment option for COVID-19 patients with comorbidities [91].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T138 159-171 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T139 176-192 Phenotype denotes type II diabetes http://purl.obolibrary.org/obo/HP_0005978
T140 599-611 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T141 816-847 Phenotype denotes severity of the viral infection http://purl.obolibrary.org/obo/HP_0031691
T142 1686-1701 Phenotype denotes cardiac failure http://purl.obolibrary.org/obo/HP_0001635
T143 1828-1844 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T144 3489-3500 Phenotype denotes nephropathy http://purl.obolibrary.org/obo/HP_0000112

2_test

Id Subject Object Predicate Lexical cue
32450165-32231330-66451073 965-967 32231330 denotes 85
32450165-32231330-66451074 1573-1575 32231330 denotes 85
32450165-32227090-66451075 1759-1761 32227090 denotes 86
32450165-16179584-66451076 2105-2107 16179584 denotes 87
32450165-15897343-66451077 2552-2554 15897343 denotes 88
32450165-30554582-66451078 3516-3518 30554582 denotes 90