PMC:7243768 / 2293-3408 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"105","span":{"begin":913,"end":916},"obj":"Gene"},{"id":"106","span":{"begin":393,"end":397},"obj":"Species"},{"id":"107","span":{"begin":540,"end":550},"obj":"Species"}],"attributes":[{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"Gene:92521"},{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"Tax:11118"},{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T11","span":{"begin":35,"end":43},"obj":"Body_part"},{"id":"T12","span":{"begin":114,"end":126},"obj":"Body_part"},{"id":"T13","span":{"begin":259,"end":265},"obj":"Body_part"},{"id":"T14","span":{"begin":267,"end":270},"obj":"Body_part"},{"id":"T15","span":{"begin":370,"end":376},"obj":"Body_part"},{"id":"T16","span":{"begin":386,"end":389},"obj":"Body_part"},{"id":"T17","span":{"begin":434,"end":437},"obj":"Body_part"},{"id":"T18","span":{"begin":530,"end":534},"obj":"Body_part"},{"id":"T19","span":{"begin":645,"end":653},"obj":"Body_part"},{"id":"T20","span":{"begin":682,"end":685},"obj":"Body_part"},{"id":"T21","span":{"begin":686,"end":692},"obj":"Body_part"},{"id":"T22","span":{"begin":798,"end":802},"obj":"Body_part"},{"id":"T23","span":{"begin":810,"end":817},"obj":"Body_part"},{"id":"T24","span":{"begin":834,"end":872},"obj":"Body_part"},{"id":"T25","span":{"begin":851,"end":872},"obj":"Body_part"},{"id":"T26","span":{"begin":884,"end":891},"obj":"Body_part"},{"id":"T27","span":{"begin":905,"end":911},"obj":"Body_part"},{"id":"T28","span":{"begin":917,"end":925},"obj":"Body_part"},{"id":"T29","span":{"begin":935,"end":938},"obj":"Body_part"},{"id":"T30","span":{"begin":993,"end":1027},"obj":"Body_part"},{"id":"T31","span":{"begin":1006,"end":1027},"obj":"Body_part"},{"id":"T32","span":{"begin":1091,"end":1110},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma80351"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma84806"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma70022"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T10","span":{"begin":496,"end":500},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002415"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T39","span":{"begin":540,"end":548},"obj":"Disease"},{"id":"T40","span":{"begin":540,"end":544},"obj":"Disease"}],"attributes":[{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T29","span":{"begin":5,"end":10},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T30","span":{"begin":61,"end":66},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T31","span":{"begin":159,"end":160},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T32","span":{"begin":161,"end":169},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T33","span":{"begin":175,"end":176},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T34","span":{"begin":320,"end":328},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T35","span":{"begin":337,"end":338},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T36","span":{"begin":401,"end":402},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T37","span":{"begin":461,"end":463},"obj":"http://purl.obolibrary.org/obo/CLO_0007074"},{"id":"T38","span":{"begin":461,"end":463},"obj":"http://purl.obolibrary.org/obo/CLO_0051988"},{"id":"T39","span":{"begin":494,"end":495},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T40","span":{"begin":496,"end":500},"obj":"http://purl.obolibrary.org/obo/UBERON_0002415"},{"id":"T41","span":{"begin":530,"end":534},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T42","span":{"begin":622,"end":626},"obj":"http://purl.obolibrary.org/obo/CLO_0007653"},{"id":"T43","span":{"begin":711,"end":712},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T44","span":{"begin":732,"end":733},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T45","span":{"begin":798,"end":802},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T46","span":{"begin":834,"end":843},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T47","span":{"begin":956,"end":957},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T4","span":{"begin":35,"end":43},"obj":"Chemical"},{"id":"T5","span":{"begin":114,"end":126},"obj":"Chemical"},{"id":"T6","span":{"begin":645,"end":653},"obj":"Chemical"},{"id":"T7","span":{"begin":810,"end":817},"obj":"Chemical"},{"id":"T8","span":{"begin":884,"end":891},"obj":"Chemical"},{"id":"T9","span":{"begin":917,"end":925},"obj":"Chemical"}],"attributes":[{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T3","span":{"begin":1066,"end":1076},"obj":"http://purl.obolibrary.org/obo/GO_0006887"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T19","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"T20","span":{"begin":82,"end":219},"obj":"Sentence"},{"id":"T21","span":{"begin":220,"end":271},"obj":"Sentence"},{"id":"T22","span":{"begin":272,"end":381},"obj":"Sentence"},{"id":"T23","span":{"begin":382,"end":505},"obj":"Sentence"},{"id":"T24","span":{"begin":506,"end":654},"obj":"Sentence"},{"id":"T25","span":{"begin":655,"end":743},"obj":"Sentence"},{"id":"T26","span":{"begin":744,"end":912},"obj":"Sentence"},{"id":"T27","span":{"begin":913,"end":1028},"obj":"Sentence"},{"id":"T28","span":{"begin":1029,"end":1115},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}

{"project":"2_test","denotations":[{"id":"32450165-31967327-66451000","span":{"begin":502,"end":503},"obj":"31967327"}],"text":"This virus possesses four distinct proteins that provide the virus its structure. The outermost layer consists of glycoprotein spikes followed by an envelope, a membrane, and a nucleocapsid layer towards the inner side. The nucleocapsid layer holds the viral genome, RNA. The nucleocapsid layer, envelope, and the spike membrane provide a protective layer for the viral genome [5]. The RNA of CoVs is a single-stranded positive-sense RNA (+ssRNA), which is ~30 kb possessing 5′-cap and 3′-poly-A tail [6]. After entering the host cell, the SARS-CoV-2 undergoes replication by using the host's machinery and synthesizes N, M, E, and S structural proteins. The negative strand of the RNA genome is produced using a positive-strand as a template. At the time of the process of replication in the host cell, the M protein attaches to the membranes of the endoplasmic reticulum, and the N protein binds to the genome. Nsp proteins help the RNA to assemble into a helical structure which enters the lumen of the endoplasmic reticulum. The viral progenies produced undergo exocytosis and enter the extracellular space [7]."}