PMC:7243768 / 18752-20375 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV 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