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LitCovid-PubTator

LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T96","span":{"begin":218,"end":222},"obj":"Body_part"}],"attributes":[{"id":"A96","pred":"uberon_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV infection."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T238","span":{"begin":5,"end":13},"obj":"Disease"},{"id":"T239","span":{"begin":5,"end":9},"obj":"Disease"},{"id":"T240","span":{"begin":73,"end":88},"obj":"Disease"},{"id":"T241","span":{"begin":79,"end":88},"obj":"Disease"},{"id":"T242","span":{"begin":223,"end":229},"obj":"Disease"},{"id":"T243","span":{"begin":254,"end":263},"obj":"Disease"},{"id":"T244","span":{"begin":421,"end":426},"obj":"Disease"},{"id":"T245","span":{"begin":689,"end":697},"obj":"Disease"},{"id":"T246","span":{"begin":689,"end":693},"obj":"Disease"},{"id":"T247","span":{"begin":817,"end":825},"obj":"Disease"},{"id":"T248","span":{"begin":817,"end":821},"obj":"Disease"},{"id":"T249","span":{"begin":1604,"end":1622},"obj":"Disease"},{"id":"T250","span":{"begin":1604,"end":1608},"obj":"Disease"},{"id":"T251","span":{"begin":1613,"end":1622},"obj":"Disease"}],"attributes":[{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A239","pred":"mondo_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A240","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A241","pred":"mondo_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A242","pred":"mondo_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A243","pred":"mondo_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A244","pred":"mondo_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A245","pred":"mondo_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A246","pred":"mondo_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A247","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A248","pred":"mondo_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A249","pred":"mondo_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A250","pred":"mondo_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A251","pred":"mondo_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV infection."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T285","span":{"begin":34,"end":39},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T286","span":{"begin":126,"end":131},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T287","span":{"begin":218,"end":222},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T288","span":{"begin":218,"end":222},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T289","span":{"begin":396,"end":409},"obj":"http://purl.obolibrary.org/obo/PR_000001393"},{"id":"T290","span":{"begin":620,"end":623},"obj":"http://purl.obolibrary.org/obo/CLO_0009645"},{"id":"T291","span":{"begin":620,"end":623},"obj":"http://purl.obolibrary.org/obo/CLO_0050824"},{"id":"T292","span":{"begin":782,"end":792},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T293","span":{"begin":793,"end":798},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T294","span":{"begin":1018,"end":1023},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T295","span":{"begin":1184,"end":1189},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"}],"text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV infection."}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T26","span":{"begin":73,"end":88},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T27","span":{"begin":427,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T28","span":{"begin":427,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T29","span":{"begin":427,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T30","span":{"begin":427,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0001906"}],"text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV infection."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T130","span":{"begin":0,"end":29},"obj":"Sentence"},{"id":"T131","span":{"begin":30,"end":248},"obj":"Sentence"},{"id":"T132","span":{"begin":249,"end":659},"obj":"Sentence"},{"id":"T133","span":{"begin":660,"end":771},"obj":"Sentence"},{"id":"T134","span":{"begin":772,"end":880},"obj":"Sentence"},{"id":"T135","span":{"begin":881,"end":1057},"obj":"Sentence"},{"id":"T136","span":{"begin":1058,"end":1471},"obj":"Sentence"},{"id":"T137","span":{"begin":1472,"end":1623},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV infection."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T98","span":{"begin":180,"end":194},"obj":"Phenotype"},{"id":"T99","span":{"begin":421,"end":426},"obj":"Phenotype"},{"id":"T100","span":{"begin":1538,"end":1552},"obj":"Phenotype"}],"attributes":[{"id":"A98","pred":"hp_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A99","pred":"hp_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A100","pred":"hp_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV infection."}

2_test

{"project":"2_test","denotations":[{"id":"32450165-15919935-66451044","span":{"begin":652,"end":654},"obj":"15919935"},{"id":"32450165-15860669-66451045","span":{"begin":655,"end":657},"obj":"15860669"},{"id":"32450165-15860669-66451046","span":{"begin":873,"end":875},"obj":"15860669"},{"id":"32450165-16501078-66451047","span":{"begin":876,"end":878},"obj":"16501078"}],"text":"4.7 SARS-CoV-immunopathology\nThe human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57].\nAlong with the chemokines and pro-inflammatory cytokine, there is an elevated level of the IFN inclusive of IFN-α and IFN-γ, stimulatory genes of IFN include CCL-2 and CXCL-10. There is an exacerbation of the IFN, chemokines such as TNF, IFN-γ, IL-6 and CCL5, pro-inflammatory cytokines and stimulatory genes of interferon such as an interferon-induced protein with tetratricopeptide repeats 1) IFIT1, radical S-adenosyl methionine domain containing 2 (RSAD2) and CXCL10 in the TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll-like receptors 3 (TLR3) deficient mice [58]. The deregulation of the cytokine or chemokine response causes the cytokine storm, leading to the immunopathological changes and the SARS-CoV infection."}

PMC:7243768 / 18752-20375 JSONTXT

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PMC:7243768 / 18752-20375 JSON TXT