PMC:7234792 / 11016-12058 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"223","span":{"begin":452,"end":460},"obj":"Species"},{"id":"224","span":{"begin":792,"end":800},"obj":"Species"},{"id":"225","span":{"begin":1001,"end":1008},"obj":"Species"},{"id":"226","span":{"begin":39,"end":47},"obj":"Disease"},{"id":"227","span":{"begin":282,"end":290},"obj":"Disease"},{"id":"228","span":{"begin":488,"end":496},"obj":"Disease"},{"id":"229","span":{"begin":747,"end":755},"obj":"Disease"}],"attributes":[{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"Tax:9606"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"Tax:9606"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"Tax:9606"},{"id":"A226","pred":"tao:has_database_id","subj":"226","obj":"MESH:C000657245"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"MESH:C000657245"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"MESH:C000657245"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T79","span":{"begin":107,"end":115},"obj":"Body_part"}],"attributes":[{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":39,"end":47},"obj":"Disease"},{"id":"T73","span":{"begin":282,"end":290},"obj":"Disease"},{"id":"T74","span":{"begin":488,"end":496},"obj":"Disease"},{"id":"T75","span":{"begin":747,"end":755},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T146","span":{"begin":21,"end":22},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T147","span":{"begin":100,"end":101},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T148","span":{"begin":232,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T149","span":{"begin":241,"end":243},"obj":"http://purl.obolibrary.org/obo/CLO_0008192"},{"id":"T150","span":{"begin":305,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T151","span":{"begin":708,"end":717},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T152","span":{"begin":930,"end":932},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T89","span":{"begin":158,"end":169},"obj":"Chemical"},{"id":"T90","span":{"begin":241,"end":243},"obj":"Chemical"}],"attributes":[{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_50803"},{"id":"A91","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_53793"},{"id":"A92","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_73425"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":146,"end":169},"obj":"http://purl.obolibrary.org/obo/GO_0046677"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T41","span":{"begin":107,"end":121},"obj":"Phenotype"}],"attributes":[{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}

{"project":"LitCovid-sentences","denotations":[{"id":"T69","span":{"begin":0,"end":291},"obj":"Sentence"},{"id":"T70","span":{"begin":292,"end":443},"obj":"Sentence"},{"id":"T71","span":{"begin":444,"end":594},"obj":"Sentence"},{"id":"T72","span":{"begin":595,"end":1042},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This case represents a presentation of COVID-19 with atypical features, including sudden onset with a mild cytokine storm profile, apparent early response to antibiotics followed by rapid clinical worsening, and two negative RT-PCR tests of NP swabs, which delayed the diagnosis of COVID-19. However, for a disease that was unknown only 5 months ago, it might also be too early for clinicians to be certain of which manifestations are typical. In most patients requiring hospitalisation, COVID-19 is diagnosed by positive RT-PCR,1 and bronchoscopy is rarely required to establish the diagnosis. As noted by the American Association of Bronchology and Interventional Pulmonology, “bronchoscopy should have an extremely limited role in diagnosis of COVID-19 and only be considered in intubated patients if upper respiratory samples are negative and other diagnosis is considered that would significantly change clinical management.”18 We agree with this statement, and feel that the presentation in our patient necessitated use of bronchoscopy."}